Article
Clinical Neurology
Nicholas Murphy, Alison Killen, Rajnish Kumar Gupta, Sara Graziadio, Lynn Rochester, Michael Firbank, Mark R. Baker, Charlotte Allan, Daniel Collerton, John-Paul Taylor, Prabitha Urwyler
Summary: Visual hallucinations (VH) are a common symptom of Parkinson's disease with dementia (PDD), affecting up to 65% of cases. The decline in executive control of the visuo-perceptual system is suggested as a primary mechanism of VH generation. Differences in visual evoked potential (VEP) have been associated with VH in earlier stages of PD, but the role of bottom-up processing in VH manifestation in this condition is still unclear.
FRONTIERS IN NEUROLOGY
(2021)
Article
Chemistry, Analytical
Alfonso Maria Ponsiglione, Carlo Ricciardi, Francesco Amato, Mario Cesarelli, Giuseppe Cesarelli, Giovanni D'Addio
Summary: Neurodegenerative disorders have a negative impact on quality of life and healthcare expenditure. This study proposes a methodology to analyze and extract kinematic parameters in upper limb movements, and identifies a subset of significant parameters that could serve as potential indicators of rehabilitation outcome in Parkinson's disease.
Article
Neurosciences
Joao Valente Duarte, Rodolfo Abreu, Miguel Castelo-Branco
Summary: This study investigates the functional separation between local biological motion perception and global dynamic body perception, revealing two independent processing stages and highlighting the importance of two early dorsal and two ventral visual regions in encoding biological motion.
Article
Behavioral Sciences
Emiel Cracco, Danna Oomen, Liuba Papeo, Jan R. Wiersema
Summary: This study examines brain responses directly linked to observed movements during biological motion perception, showing that frequency tagging can distinguish between global and local processes. The results reveal how brain activity at different frequencies relates to visual processing of biological movements.
Article
Neurosciences
Nahid Zokaei, Celine R. Gillebert, Joshua J. Chauvin, Daniela Gresch, Alexander G. Board, Michal Rolinski, Michele T. Hu, Anna Christina Nobre
Summary: The study found that individuals with Parkinson's disease did not show altered temporal orienting effects in a speeded-response task, but were impaired in using temporal cues to improve perceptual discrimination in a non-speeded task. These findings suggest that deficits in temporal orienting in individuals with PD interact with specific task demands.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Geriatrics & Gerontology
Jyotsna Asthana, Bhupendra V. V. Shravage
Summary: Parkinson's disease is a common neurodegenerative disorder associated with the degeneration of dopaminergic neurons, aggregation of alpha-synuclein, and locomotor defects. Familial forms of the disease are associated with gene mutations. Despite advancements in understanding Parkinson's disease, effective therapies and preventive medicines are still unavailable. The pathophysiology of the disease is strongly related to mitochondria and the mitochondrial quality control mechanism called mitophagy. Modulating mitophagy using chemical agents and naturally occurring phytochemicals could be a potential therapeutic strategy. Drosophila melanogaster is used as a model to study the role of mitophagy modulators in Parkinson's disease and to develop potential therapeutic molecules.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Engila Khan, Ikramul Hasan, M. Emdadul Haque
Summary: Disease modeling in non-human subjects is crucial for clinical research. Animal models are necessary to replicate the disease process and understand the etiology and pathophysiology. Parkinson's disease, with its progressive nature and various disabilities, has specific pathological hallmarks that involve misfolded protein accumulation and degeneration of neurons. Extensive research has been conducted on Parkinson's disease animal models, including pharmacological and genetic manipulation induction. This review summarizes and discusses commonly used Parkinson's disease animal model systems, as well as their applications and limitations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Environmental Sciences
Sachin Kumar, Tapan Behl, Aayush Sehgal, Sridevi Chigurupati, Sukhbir Singh, Vasudevan Mani, Maha Aldubayan, Ahmed Alhowail, Satvinder Kaur, Saurabh Bhatia, Ahmed Al-Harrasi, Vetriselvan Subramaniyan, Shivkanya Fuloria, Neeraj Kumar Fuloria, Mahendran Sekar, Mohamed M. Abdel Daim
Summary: Major breakthroughs in understanding the role of biology in Parkinson's disease (PD) have identified mitochondrial dysfunction and the enzyme leucine-rich repeat kinase 2 (LRRK2) as important factors in the pathogenesis of the disease. Inhibiting LRRK2 kinase activity shows promise in preventing endolysosomal dysfunction and neurodegeneration in PD, making LRRK2 inhibitors potentially useful therapeutic targets.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Neurosciences
Tapan Behl, Sachin Kumar, Ziyad M. Althafar, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Vishnu Nayak Badavath, Shivam Yadav, Saurabh Bhatia, Ahmed Al-Harrasi, Yosif Almoshari, Mohannad A. Almikhlafi, Simona Bungau
Summary: In the past decade, researchers have found that seemingly unrelated neurodegenerative disorders, such as Parkinson's disease, share remarkable cellular and molecular biology similarities. Protein misfolding and aggregation play a role in all of these diseases, leading to the formation of inclusion bodies in cells. The discovery of disease-causing gene alterations related to the ubiquitin-proteasome pathway proteins in Parkinson's disease has strengthened the connection between this pathway and neurodegeneration. However, the specific molecular linkages between these systems and the pathogenesis of these diseases are still unknown and controversial.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Ditte Ruda, Gudmundur Einarsson, Anne Sofie Schott Andersen, Jannik Boll Matthiassen, Christoph U. Correll, Kristian Winge, Line K. H. Clemmensen, Rasmus R. Paulsen, Anne Katrine Pagsberg, Anders Fink-Jensen
Summary: The developed Motorgame was able to detect common motor symptoms in Parkinson's disease in a statistically significant and clinically meaningful way, with the strongest effects observed in the right hand, showing promise for further testing in larger samples.
FRONTIERS IN NEUROLOGY
(2021)
Article
Computer Science, Information Systems
Qiongjie Cui, Huaijiang Sun, Yue Kong, Xiaoqian Zhang, Yanmeng Li
Summary: This paper introduces a temporal convolutional generative adversarial network (TCGAN) for predicting future human poses, which outperforms traditional RNNs in both short-term and long-term predictions and is capable of generating future poses in real-time.
INFORMATION SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Nicholas J. Fiore, Yosif M. Ganat, Kapil Devkota, Rebecca Batorsky, Ming Lei, Kyongbum Lee, Lenore J. Cowen, Gist Croft, Scott A. Noggle, Thomas J. F. Nieland, David L. Kaplan
Summary: This article introduces a three-dimensional culture system using hiPSCs to study the biology of Parkinson's disease. The results show that this 3D system can mimic the molecular mechanisms of Parkinson's disease and provide insights into novel molecular interactions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Medicine, General & Internal
Xiaoming Xi, Liang Han
Summary: This article analyzes the relationship between Parkinson's disease and COVID-19 by summarizing the pathogenesis of both diseases and discussing the impact of COVID-19 on Parkinson's disease patients. It also provides principles and methods for home rehabilitation of Parkinson's disease patients during the COVID-19 pandemic.
Article
Computer Science, Artificial Intelligence
D. Castillo-Barnes, F. J. Martinez-Murcia, C. Jimenez-Mesa, J. E. Arco, D. Salas-Gonzalez, J. Ramirez, J. M. Gorriz
Summary: Parkinson's Disease (PD) is the second most prevalent neurodegenerative disorder among adults. We proposed a Computer-Aided Diagnosis (CAD) system that combines structural and functional imaging data to detect PD with 96.48% accuracy. The system utilizes Ensemble Learning methodology, image preprocessing techniques, dimensionality reduction methods, and a bagging classification schema for unbalanced data.
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
(2023)
Article
Computer Science, Artificial Intelligence
Francisco Barranco, Cornelia Fermueller, Yiannis Aloimonos, Eduardo Ros
Summary: This paper investigates the impact of avoiding optical flow estimation on structure recovery, and proposes a new method based on image gradients to solve 3D motion problems by reformulating the positive-depth constraint. Experimental results show that the method achieves higher accuracy and outperforms existing techniques based on normal flow for 3D motion estimation.
PATTERN RECOGNITION
(2021)
Review
Cardiac & Cardiovascular Systems
Kai Wang, Xiang-Qian Gao, Tao Wang, Lu-Yu Zhou
Summary: Circular RNA (circRNA) is a stable closed-loop structure that can bind and inhibit the function of microRNA (miRNA). Research has shown that circRNA plays an important role in cell senescence, proliferation, apoptosis, and signaling pathways, making it a potential biomarker and therapeutic target for cardiovascular diseases.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Psychology, Clinical
Jinping Xu, Wenfei Li, Tongjian Bai, Jiaying Li, Jinhuan Zhang, Qingmao Hu, Jiaojian Wang, Yanghua Tian, Kai Wang
Summary: This study found that electroconvulsive therapy (ECT) can selectively induce structural plasticity of the amygdala and hippocampal sub-regions in patients with major depressive disorder (MDD), and these changes are associated with the antidepressant effects of ECT. Additionally, the volume of the hippocampus-amygdala transition area (HATA) can serve as a potential biomarker to predict the effectiveness of ECT.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Chemistry, Applied
Qing-Hu Teng, Gui-Xia Sun, Fang-Ping Huang, Kai Wang, Fu-Pei Liang
Summary: A visible-light-induced cerium-catalyzed N-demethylation of N-methyl amides under air atmosphere is developed, leading to the corresponding N-demethylated amides. The excited states of [(CeCl4)2-] can activate N-methyl amides. This reaction offers a methodology to cleave the C-N bond of amides under air conditions.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Thermodynamics
Kai Wang, Inoue Junya, Chun -Yen Li, Songbai Cheng, Koji Okamoto
Summary: The effects of electron beam irradiation on critical heat flux (CHF) of aluminum surfaces in downward-facing saturated flow boiling were investigated. It was found that although the contact angle decreased greatly after irradiation, no obvious CHF and heat transfer coefficient change was observed up to a total dose of 3000 kGy. The bubble coverage was calculated and believed to be strongly associated with boiling crisis. The insensitivity of CHF in aluminum may be related to easy oxidation on the aluminum surface. This finding may be helpful for future heat transfer design and anti-accident counter-measurements in radiation environments.
APPLIED THERMAL ENGINEERING
(2023)
Article
Engineering, Electrical & Electronic
Emad Iranmanesh, Jucai Zhai, Congwei Liao, Zihao Liang, Yong Zhao, Hang Zhou, Shengdong Zhang, Charalampos Doumanidis, Anand Prakash Dwivedi, Kai Wang
Summary: This work presents a piezotronic n-p-n bipolar heterojunction transistor (PBJT) for low power AI-sound recognition. It consists of an organic polymer as Base and two inorganic piezoelectric semiconductor ZnO layers as Emitter and Collector, forming a vertically-stacked heterogeneous n-p-n BJT. The device can provide either current or voltage as an output signal and has demonstrated low frequency sound detection, mapping, and recognition using machine learning AI.
IEEE ELECTRON DEVICE LETTERS
(2023)
Review
Neurosciences
Chunyan Zhu, Ting Zhang, Qianqian Li, Xingui Chen, Kai Wang
Summary: The COVID-19 pandemic has negatively affected the physical and mental health of the public, leading to a significant increase in depression and anxiety. Physicians and researchers should focus on high-risk groups and investigate the neural mechanisms and intestinal microbiome related to depression and anxiety.
NEUROSCIENCE BULLETIN
(2023)
Article
Neurosciences
Chen Chen, Jinying Han, Shuang Zheng, Xintong Zhang, Haibo Sun, Ting Zhou, Shunyin Hu, Xiaoxiang Yan, Changqing Wang, Kai Wang, Yajuan Hu
Summary: Changes in resting-state EEG microstate parameters were observed in patients with disorders of consciousness (DOCs) after high-definition transcranial direct current stimulation (HD-tDCS), indicating an improvement in consciousness. Specifically, the duration and coverage of class C microstates significantly increased in the responsive group (RE), while these changes have not been reported in the non-responsive group (N-RE). Our findings suggest that EEG neural signatures can be used to assess consciousness states, and that improvement in brain activity dynamics is associated with the recovery of DOCs.
Review
Medicine, Research & Experimental
Meng Kong, Yanan Li, Kai Wang, Shisong Zhang, Yi Ji
Summary: Infantile hemangioma (IH) is the most common benign vascular tumor in infants, with clear disease stages and durations. Although most IHs can regress naturally, a small percentage can cause disfigurement or even be fatal. The mechanisms behind IH development are still not fully understood. Establishing stable and reliable IH models provides a standardized experimental platform for understanding its pathogenesis and developing new drugs and treatments. This article summarizes the research progress and clinical utility of various IH models, as well as the benefits and drawbacks of each. Researchers should select specific IH models based on their research objectives to achieve their anticipated experimental goals and increase the clinical relevance of their findings.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Genetics & Heredity
Jian Chen, Zijian Wang, Kaiwen Tan, Wei Huang, Junpeng Shi, Tong Li, Jiang Hu, Kai Wang, Chao Wang, Beibei Xin, Haiming Zhao, Weibin Song, Matthew B. Hufford, James C. Schnable, Weiwei Jin, Jinsheng Lai
Summary: This research achieved a complete telomere-to-telomere genome assembly of the maize Mo17 inbred line using deep coverage long-read sequencing technologies. The assembly revealed the structural features of the highly complex maize genome, particularly the repetitive regions.
Article
Materials Science, Composites
Zhenyu Wu, Kang Wang, Lin Shi, Xiaoying Cheng, Yanhong Yuan
Summary: In this paper, the impact resistance and damage tolerance of triaxial braid structure laminates at different positions were studied. Results showed that the triaxial braided fabric with quasi-isotropic properties on the impact side caused more significant matrix cracks and larger damage areas. The study provided valuable reference for failure analysis and structure optimization of composite laminates.
POLYMER COMPOSITES
(2023)
Article
Neurosciences
Yuwei Zhou, Guixian Xiao, Qing Chen, Yuyang Wang, Lu Wang, Chengjuan Xie, Kai Wang, Xingui Chen
Summary: High-definition transcranial direct current stimulation (HD-tDCS) can modulate decision-making, but the neurophysiological mechanisms behind this effect are still unclear. In this study, participants underwent anodal/sham HD-tDCS sessions targeting the left DLPFC. The results showed that anodal HD-tDCS improved decision-making function and increased P300 amplitude and theta oscillation power. Theta oscillation power may serve as a predictor of improved decision-making.
Review
Cardiac & Cardiovascular Systems
Tao Wang, Xinzhe Chen, Kai Wang, Jie Ju, Xue Yu, Shaocong Wang, Cuiyun Liu, Kun Wang
Summary: The Cre-loxP-mediated genetic lineage tracing system is crucial for tracking the fate of single-cell progeny or cell populations. Understanding the hierarchy of cardiac progenitor cells helps to uncover cell fate and origin in cardiac development. Several prospective Cre-loxP-based lineage-tracing systems have been utilized to precisely analyze the fate determination and developmental characteristics of different cardiac cell types.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Letter
Materials Science, Multidisciplinary
Jun-Cheng Yang, Zhiyuan Fu, Huili Ma, Tao Wang, Kai Wang, Lin Wu, Ben Zhong Tang, Hai-Tao Feng, Pu Chen, Qiuying Li
Summary: This study focuses on the stimuli-responsive luminescence of a novel emitter, DCzPy, which emits bluegreen fluorescence in crystal form. Upon gentle grinding, the fluorescence intensity of DCzPy is significantly enhanced with a hypsochromic shift. The emission wavelength returns to its original value after heavy grinding. Moreover, DCzPy exhibits a large bathochromic-shifted and weakened fluorescence under isotropic compression. In film form, the thermoresponsive behavior of DCzPy changes the emission from green to blue. Based on this thermo-induced fluorescence switching, a two-dimensional code for information anticounterfeiting is successfully fabricated.
ACS MATERIALS LETTERS
(2023)
Article
Materials Science, Multidisciplinary
Jun-Cheng Yang, Zhiyuan Fu, Huili Ma, Tao Wang, Qiuying Li, Kai Wang, Lin Wu, Pu Chen, Hai-Tao Feng, Ben Zhong Tang
Summary: A novel emitter (DCzPy) was synthesized and its stimuli-responsive luminescence was studied. The emitter showed bluegreen fluorescence in the crystalline state, with dramatically enhanced and hypsochromic-shifted fluorescence upon gentle grinding. The emission wavelength returned to the original state after further heavy grinding. Under isotropic compression, the emitter exhibited a large bathochromic-shifted and weakened fluorescence. In addition, in the film state, the emission color of the emitter changed from green to blue as the temperature increased.
ACS MATERIALS LETTERS
(2023)
Article
Materials Science, Multidisciplinary
Yuxiang Dai, Haichao Liu, Ting Geng, Ruijie Duan, Xiaoming Li, Yongli Liu, Wengang Liu, Ben-Guo He, Laizhi Sui, Kai Wang, Bo Zou, Bing Yang, Yang Qi
Summary: The wide application of excimer materials in the OLED field is mainly driven by the regulation of their stacking structure. This study designed three anthracene derivative molecules with sterically hindered substituents and prepared crystals with different aggregating structures to investigate the relationship between their structures and properties. The study found that under high pressures, these anthracene groups exhibit enhanced fluorescence during the formation of excimers, while the ones that have already formed excimers under ambient conditions show a wider red-shift range. The piezochromic fluorescence behavior observed indicates that regulating the aggregation mode of anthracene groups can meet different application requirements and guide the expansion of excimer materials' usage.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)