Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration

Identification of rare protein disulfide isomerase gene variants in amyotrophic lateral sclerosis patients

(2015) Paloma Gonzalez-Perez et al.   GENE

Polymorphisms in protein disulfide isomerase are associated with sporadic amyotrophic lateral sclerosis in the Chinese Han population

(2015) Qin Yang et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Proteostasis control by the unfolded protein response

(2015) Claudio Hetz et al.   NATURE CELL BIOLOGY

Calreticulin levels determine onset of early muscle denervation by fast motoneurons of ALS model mice

(2015) Nathalie Bernard-Marissal et al.   NEUROBIOLOGY OF DISEASE

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

(2015) I. Das et al.   SCIENCE

Calcium Release from Intra-Axonal Endoplasmic Reticulum Leads to Axon Degeneration through Mitochondrial Dysfunction

(2014) R. Villegas et al.   JOURNAL OF NEUROSCIENCE

The Parkinsonian mimetic, 6-OHDA, impairs axonal transport in dopaminergic axons

(2014) Xi Lu et al.   Molecular Neurodegeneration

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

(2014) Claudio Hetz et al.   NATURE REVIEWS NEUROSCIENCE

Late-Onset of Spinal Neurodegeneration in Knock-In Mice Expressing a Mutant BiP

(2014) Hisayo Jin et al.   PLoS One

Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1

(2014) P. Valdes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensing nerve injury at the axonal ER: Activated Luman/CREB3 serves as a novel axonally synthesized retrograde regeneration signal

(2014) Zhengxin Ying et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-nitrosylating protein disulphide isomerase mediates α-synuclein aggregation caused by methamphetamine exposure in PC12 cells

(2014) Xiao-Fang Wu et al.   TOXICOLOGY LETTERS

Molecular chaperones and proteostasis regulation during redox imbalance

(2014) Katerina Niforou et al.   Redox Biology

ERp29 deficiency affects sensitivity to apoptosis via impairment of the ATF6–CHOP pathway of stress response

(2013) Irina Hirsch et al.   APOPTOSIS

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

(2013) Karen Castillo et al.   Autophagy

Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice

(2013) K. Kim et al.   BLOOD

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen

(2013) Maud Plantinga et al.   IMMUNITY

Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice

(2013) Maurizio D’Antonio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An ERcentric view of Parkinson's disease

(2013) Gabriela Mercado et al.   TRENDS IN MOLECULAR MEDICINE

BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α

(2012) Diego A Rodriguez et al.   EMBO JOURNAL

Protein disulfide isomerases in neurodegeneration: From disease mechanisms to biomedical applications

(2012) Catherine I. Andreu et al.   FEBS LETTERS

Endoplasmic reticulum dysfunction in neurological disease

(2012) Benoit D Roussel et al.   LANCET NEUROLOGY

Glucose Regulated Protein 78 Diminishes α-Synuclein Neurotoxicity in a Rat Model of Parkinson Disease

(2012) Marina S Gorbatyuk et al.   MOLECULAR THERAPY

ATF6alpha Promotes Astroglial Activation and Neuronal Survival in a Chronic Mouse Model of Parkinson’s Disease

(2012) Koji Hashida et al.   PLoS One

Mitochondria as a central sensor for axonal degenerative stimuli

(2012) Felipe A. Court et al.   TRENDS IN NEUROSCIENCES

Activation of the unfolded protein response enhances motor recovery after spinal cord injury

(2012) V Valenzuela et al.   Cell Death & Disease

Specialization of endoplasmic reticulum chaperones for the folding and function of myelin glycoproteins P0 and PMP22

(2011) Joanna Jung et al.   FASEB JOURNAL

The Unfolded Protein Response Is a Major Mechanism by Which LRP1 Regulates Schwann Cell Survival after Injury

(2011) E. Mantuano et al.   JOURNAL OF NEUROSCIENCE

Protein disulfide isomerases contribute differentially to the endoplasmic reticulum–associated degradation of apolipoprotein B and other substrates

(2011) Sarah Grubb et al.   MOLECULAR BIOLOGY OF THE CELL

Valproate reduces CHOP levels and preserves oligodendrocytes and axons after spinal cord injury

(2011) C. Penas et al.   NEUROSCIENCE

Neurotoxin-based models of Parkinson's disease

(2011) J. Bové et al.   NEUROSCIENCE

The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

(2011) Claudio Hetz et al.   PHYSIOLOGICAL REVIEWS

Amyotrophic Lateral Sclerosis Multiprotein Biomarkers in Peripheral Blood Mononuclear Cells

(2011) Giovanni Nardo et al.   PLoS One

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Participation of lectin chaperones and thiol oxidoreductases in protein folding within the endoplasmic reticulum

(2010) Lori A Rutkevich et al.   CURRENT OPINION IN CELL BIOLOGY

Calnexin Deficiency Leads to Dysmyelination

(2010) Allison Kraus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Endoplasmic Reticulum Stress Sensor, ATF6α, Protects against Neurotoxin-induced Dopaminergic Neuronal Death

(2010) Naohiro Egawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intestinal Cell Calcium Uptake and the Targeted Knockout of the 1,25D3-MARRS (Membrane-associated, Rapid Response Steroid-binding) Receptor/PDIA3/Erp57

(2010) Ilka Nemere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

(2010) Benjamin G Hoffstrom et al.   Nature Chemical Biology

Protein quality control in the ER: The recognition of misfolded proteins

(2010) Pekka Määttänen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland

(2009) Akira Hosoda et al.   BIOCHEMICAL JOURNAL

Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis

(2009) Adam K. Walker et al.   BRAIN

Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2−/− mice

(2009) Fang Zhao et al.   DEVELOPMENTAL BIOLOGY

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

(2009) C. Hetz et al.   GENES & DEVELOPMENT

ERp57 Modulates STAT3 Signaling from the Lumen of the Endoplasmic Reticulum

(2009) Helen Coe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dramatic Reduction of PrPC Level and Glycosylation in Peripheral Nerves following PrP Knock-Out from Schwann Cells Does Not Prevent Transmissible Spongiform Encephalopathy Neuroinvasion

(2009) B. M. Bradford et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic reticulum stress in disorders of myelinating cells

(2009) Wensheng Lin et al.   NATURE NEUROSCIENCE

The protein disulfide isomerase AGR2 is essential for production of intestinal mucus

(2009) S.-W. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Requirement of Myeloid Cells for Axon Regeneration

(2008) B. Barrette et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

(2008) Julie D. Atkin et al.   NEUROBIOLOGY OF DISEASE

Ablation of the UPR-Mediator CHOP Restores Motor Function and Reduces Demyelination in Charcot-Marie-Tooth 1B Mice

(2008) Maria Pennuto et al.   NEURON

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE