Article
Biochemistry & Molecular Biology
Woo Kyung Ryu, Sekyung Oh, Jun Hyeok Lim, Seung Jae Lee, Hyun-Tae Shin, Jeong-Seon Ryu
Summary: Recent research suggests that changes in ctDNA levels are correlated with TB changes, and the detection of ctDNA can be used to predict new metastases, rapid tumor growth, and poor survival in NSCLC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Ning Li, Bao-Xiao Wang, Jian Li, Yang Shao, Ming-Tian Li, Jian-Jun Li, Peng-Peng Kuang, Zui Liu, Tian-Yu Sun, Hui-Qi Wu, Wei Ou, Si-Yu Wang
Summary: This study found that monitoring ctDNA before and after surgery in operable non-small cell lung cancer patients is associated with inferior recurrence-free survival and overall survival. Serial ctDNA detection can identify disease recurrence earlier than routine radiologic imaging. ctDNA analysis can detect minimal residual disease in resectable lung cancer patients, facilitating early intervention.
Article
Medicine, Research & Experimental
Win Lwin Thuya, Li Ren Kong, Nicholas L. Syn, Ling -Wen Ding, Esther Sok Hwee Cheow, Regina Tong Xin Wong, Tingting Wang, Robby Miguel Wen-Jing Goh, Hongyan Song, Migara K. Jayasinghe, Minh T. N. Le, Jian Cheng Hu, Wei-Peng Yong, Soo-Chin Lee, Andrea Li-Ann Wong, Gautam Sethi, Huynh The Hung, Paul Chi-Lui Ho, Jean-Paul Thiery, Siu Kwan Sze, Tiannan Guo, Ross A. Soo, Henry Yang, Yaw Chyn Lim, Lingzhi Wang, Boon-Cher Goh
Summary: This study reveals that the cargo protein FAM3C carried by tumor-released extracellular vesicles (EVs) can enhance the growth and metastatic potential of lung cancer cells. FAM3C interacts with RalA protein to activate the Src/Stat3 signaling pathway, promoting oncogenicity. This finding provides a new target for lung cancer therapy.
Article
Oncology
Anna Sandstrom Gerdtsson, Mattis Knulst, Johan Botling, Artur Mezheyeuski, Patrick Micke, Sara Ek
Summary: The immune microenvironment of NSCLC is heterogeneous, hindering the prediction of response to immune checkpoint inhibitors. Mapping the expression of 49 proteins in 33 NSCLC tumors revealed key differences in phenotype and function associated with the spatial context of immune infiltration. Tumor-infiltrating leukocytes (TIL) displayed high levels of immune suppressive markers, while stromal leukocytes (SL) expressed higher levels of T-cell activation marker CD27. Tertiary lymphoid structures (TLS) showed less variation in expression profile and higher levels of lymphocyte markers, dendritic cells, and antigen presentation.
Article
Immunology
Yi Wang, Yuxi Zhang, Haoyi Sun, Jilan Chen, Hui Yang, Zhanqiong Zhong, Xiaoqian Xiao, Yanping Li, Yibei Tang, Haolan Lu, Xinzhi Tang, Mengyang Zhang, Wenjun Wu, Shiyi Zhou, Jiahui Yang
Summary: Over the last decade, immuno-oncologic drugs, particularly CD3-engaging bispecific antibodies (biAbs), have seen rapid development. However, there are still significant challenges in their clinical development for solid tumors, especially non-small cell lung cancer (NSCLC). In this study, a ROR1 x CD3 biAb, called R11 x v9 biAb, was investigated for its tumor-inhibiting role in NSCLC. The biAb demonstrated specific binding to T cells and tumor cells, dose-dependent cytotoxicity against various ROR1+ NSCLC cell lines, and promoted immune responses in tumor tissues. The antitumor activity of R11 x v9 biAb was confirmed in mouse models of ROR1+ NSCLC without observed side effects, supporting further preclinical and clinical studies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jacqueline Aparecida Torres, Angelo Borsarelli Carvalho Brito, Virgilio Souza e Silva, Iara Monique Messias, Alexcia Camila Braun, Anna Paula Carreta Ruano, Marcilei E. C. Buim, Dirce Maria Carraro, Ludmilla Thome Domingos Chinen
Summary: Circulating tumor cells (CTCs) and/or circulating tumor microemboli (CTM) from non-small cell lung cancer (NSCLC) patients could serve as a non-invasive tool for prognosis, acting as liquid biopsy. This study found that CTCs/CTMs from NSCLC patients expressed immune evasion markers TGF beta RI/CD47, and the presence of CTMs CD47+ was associated with poor progression-free survival (PFS).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Peng-Peng Kuang, Ning Li, Zui Liu, Tian-Yu Sun, Shu-Quan Wang, Jia Hu, Wei Ou, Si-Yu Wang
Summary: ctDNA analysis can help identify the risk of recurrence in NSCLC patients and guide treatment strategies. Detection of ctDNA in plasma is consistent with that in tumor tissue. Postoperative and post-chemotherapy ctDNA is a promising prognostic marker for NSCLC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Argyro Roumeliotou, Evangelia Pantazaka, Anastasia Xagara, Foteinos-Ioannis Dimitrakopoulos, Angelos Koutras, Athina Christopoulou, Theodoros Kourelis, Nada H. Aljarba, Saad Alkahtani, Filippos Koinis, Athanasios Kotsakis, Galatea Kallergi
Summary: Studies have shown that JUNB and CXCR4 play important roles in tumor progression and metastasis in various cancer types, including lung cancer. In this study, the expression of JUNB and CXCR4 in circulating tumor cells (CTCs) of lung cancer patients was investigated, and their clinical significance was determined. The results showed that both JUNB and CXCR4 were overexpressed in CTCs from lung cancer patients and were associated with worse survival, indicating that they could be important prognostic biomarkers for lung cancer.
Review
Oncology
Alvaro Marcos Rubio, Celine Everaert, Eufra Van Damme, Katleen De Preter, Karim Vermaelen
Summary: The use of immune checkpoint inhibitors (ICIs) has significantly impacted the treatment of non-small cell lung cancer (NSCLC), but reliable predictive biomarkers are still lacking. Comprehensive analysis of peripheral blood immune cell subsets can provide important information for guiding immunotherapy decision-making.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Cell Biology
Alexia Monastirioti, Chara Papadaki, Konstantinos Rounis, Despoina Kalapanida, Dimitrios Mavroudis, Sofia Agelaki
Summary: The study revealed that high expression of miR-202 in non-small cell lung cancer patients is associated with disease progression, shorter progression-free survival, and overall survival. In subgroup analysis, miR-202 and miR-26a expression had different impacts on overall survival in squamous and non-squamous subgroups. These findings suggest that circulating miRNAs may serve as potential biomarkers in NSCLC patients.
Article
Oncology
Noriyoshi Sawabata, Takeshi Kawaguchi, Takashi Watanabe, Daiki Yohikawa, Noriko Ouji-Sageshima, Toshihiro Ito
Summary: This study assessed the implications of solid patterns of non-small cell lung cancer (NSCLC) on computed tomography (CT) and the existence of preoperative clustered circulating tumor cells (CTCs) as a predictor of poor prognosis. The results showed that the pure solid pattern of NSCLC on CT indicated the presence of preoperative clustered CTCs, which were independent predictors of poor recurrence-free survival.
Article
Chemistry, Multidisciplinary
Yoon-Tae Kang, Zeqi Niu, Thomas Hadlock, Emma Purcell, Ting-Wen Lo, Mina Zeinali, Sarah Owen, Venkateshwar G. Keshamouni, Rishindra Reddy, Nithya Ramnath, Sunitha Nagrath
Summary: NK cells and their derived exosomes play a crucial role in cancer immunotherapy, as they exhibit high stability and lower immunogenicity, providing possibilities for personalized treatments. A novel microfluidic system for collecting patient-specific NK cells and NK-exosomes on chips offers potential applications in cancer therapies.
Review
Oncology
Justyna Raczkowska, Agnieszka Bielska, Adam Kretowski, Magdalena Niemira
Summary: Non-small cell lung cancer (NSCLC) is a malignant condition resistant to advanced-stage treatment and the leading cause of cancer death worldwide. Current diagnostic methods cannot detect the disease at an early stage or predict its development. Micro RNAs (miRNAs) show significant differences in NSCLC tissues and can be easily detected in biofluids without invasive collection techniques. Many studies support the importance of miRNAs as a promising biomarker for detecting and predicting NSCLC. This review discusses the role of biofluid miRNAs as a diagnostic tool in NSCLC and highlights future areas of interest.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Jialiang Yang, Yan Hui, Yanxiang Zhang, Minghui Zhang, Binbin Ji, Geng Tian, Yangqiang Guo, Min Tang, Lianxing Li, Bella Guo, Tonghui Ma
Summary: Liquid biopsy, particularly circulating tumor DNA (ctDNA) testing, shows promise in diagnosing, prioritizing treatment plans, detecting residual disease, and monitoring treatment response in NSCLC patients. Studies have indicated that ctDNA testing is critical in guiding therapies for NSCLC patients, predicting clinical outcomes, monitoring response to therapies, and detecting cancer recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Cloud P. Paweletz, Grace A. Heavey, Yanan Kuang, Emily Durlacher, Thian Kheoh, Richard C. Chao, Alexander I. Spira, Konstantinos Leventakos, Melissa L. Johnson, Sai-Hong Ignatius Ou, Gregory J. Riely, Kenna Anderes, Wenjing Yang, James G. Christensen, Pasi A. Janne
Summary: This study reports on early ctDNA changes of KRAS G12C in lung cancer patients and suggests that ctDNA changes can be used as a potential measure for early prediction of clinical response.
CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shuanglin Gu, Li Lv, Xue Lin, Xingyu Li, Juncheng Dai, Jianqiong Zhang, Ren Kong, Wei Xie, Jian Li
Summary: This study identified important mutation sites in HBV and evaluated their impact using molecular dynamics simulation. The findings provide insights for immunotherapy.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Genetics & Heredity
Pei Ji, Jiang Chang, Xiaoyu Wei, Xueyao Song, Hua Yuan, Linnan Gong, Yuancheng Li, Dongsheng Ding, Erbao Zhang, Caiwang Yan, Meng Zhu, Xiaoping Miao, Chen Wu, Guangfu Jin, Zhibin Hu, Hongbing Shen, Hongxia Ma
Summary: This study identified three novel genetic variants associated with SCCHN risk. Functional analysis revealed that one variant could modulate TCF19 expression by regulating the binding affinity of SREBF1 to the promoter of TCF19. These findings suggest that TCF19 may serve as a susceptibility gene for SCCHN.
JOURNAL OF MEDICAL GENETICS
(2022)
Review
Infectious Diseases
Yongyue Wei, Liangmin Wei, Yihan Liu, Lihong Huang, Sipeng Shen, Ruyang Zhang, Jiajin Chen, Yang Zhao, Hongbing Shen, Feng Chen
Summary: This study estimated the median and dispersion of the SARS-CoV-2 incubation period more precisely. The incubation period for asymptomatic transmissions was significantly longer. Additionally, for every 10-year increase in age, there was an average 16% increment in the length of the median incubation period.
Article
Oncology
Mengmeng Ji, Lingbin Du, Zhimin Ma, Junxing Xie, Yanqian Huang, Xiaoxia Wei, Xiangxiang Jiang, Jing Xu, Rong Yin, Yuzhuo Wang, Juncheng Dai, Guangfu Jin, Lin Xu, Chen Zhu, Zhibin Hu, Hongxia Ma, Meng Zhu, Hongbing Shen
Summary: Elevated CRP levels are associated with a 22% increased risk of lung cancer, with positive associations observed in small cell lung cancer, lung adenocarcinoma, and lung squamous cell carcinoma. However, no genetical association between circulating CRP levels and lung cancer risk was found. Adding CRP to the risk model of lung cancer can improve the model's performance in current smokers.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Critical Care Medicine
Ni Li, Fengwei Tan, Wanqing Chen, Min Dai, Fei Wang, Sipeng Shen, Wei Tang, Jiang Li, Yiwen Yu, Wei Cao, Yongjie Xu, Chao Qin, Liang Zhao, Meng Zhu, Lanwei Guo, Zheng Wu, Zhuoyu Yang, Yadi Zheng, Hongda Chen, Yunyong Liu, Donghua Wei, Dong Dong, Ji Cao, Shaokai Zhang, Shipeng Yan, Ning Wang, Lingbin Du, Hongbing Shen, Ning Wu, Jie He
Summary: This study evaluated the effectiveness of one-off low-dose CT (LDCT) screening for the early detection of lung cancer in China. The results showed that one-off LDCT screening significantly reduced lung cancer mortality and all-cause mortality, indicating its potential in countries with limited medical resources.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Infectious Diseases
Guoping Du, Chao Li, Yangyang Liu, Fulai Tu, Ruizhe Yang, Rui Li, Hongbing Shen, Wei Li
Summary: This study investigated the knowledge, attitudes, and practices regarding tuberculosis among freshmen in Jiangsu colleges and universities. The overall awareness rate of core knowledge met national requirements, but the overall awareness rate was low. Strengthening health education on tuberculosis is recommended for individuals with identified risk factors.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Oncology
Fanghui Zhao, Archana Jastorff, Ying Hong, Shangying Hu, Wen Chen, Xiaoqian Xu, Yejiang Zhu, Jiahong Zhu, Xun Zhang, Wenhua Zhang, Dacheng Xu, Dali Wang, Rong Tang, Yonghong Sun, Yiping Shen, Qinjing Pan, Jian Yin, Daokuan Liu, Bin Liu, Naveen Karkada, Chunmei Jiang, Jianfeng Cui, Feng Chen, Jun Bi, Yuqing Bao, Xin Zhou, Cyrille Cartier, Yuemei Hu, Dorota Borys
Summary: The AS04-HPV-16/18 vaccine demonstrated acceptable safety and long-term protection in Chinese women aged 26 years or above, with a good efficacy against HPV-16/18 infections and cytological lesions.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ping Li, Mingjia Yang, Dong Hang, Yongyue Wei, Hongling Di, Hongbing Shen, Zhihong Liu
Summary: Current smoking, high TG, and high SBP were the top three risk factors contributing to CKD burden in China. Increased BMI, DBP, plasma glucose, and decreased HDL-C were also associated with the increase in CKD burden.
JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Oncology
Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu, Mengting Sun, Xue Wu, Yang Shao, Qianghu Wang, Juncheng Dai, Mantang Qiu, Jinke Wang, Qin Zhang, Lin Xu, Hongbing Shen, Rong Yin
Summary: This study demonstrates that circulating tumor DNA can be used as a marker for monitoring minimal residual disease in early-to-mid-stage non-small cell lung cancer patients, and can predict the recurrence of high-risk patients.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Oncology
Na Qin, Cheng Wang, Congcong Chen, Liu Yang, Su Liu, Jun Xiang, Yuan Xie, Shuang Liang, Jun Zhou, Xianfeng Xu, Xiaoyu Zhao, Meng Zhu, Guangfu Jin, Hongxia Ma, Juncheng Dai, Zhibin Hu, Hongbing Shen
Summary: Detection of mCAs can serve as a new indicator for lung cancer risk, and it may be combined with PRS for personalized risk stratification of lung cancer.
Article
Oncology
Xu Zhang, Na Qin, Jingyi Fan, Chang Zhang, Qi Sun, Yayun Gu, Meng Zhu, Erbao Zhang, Juncheng Dai, Guangfu Jin, Hongxia Ma, Zhibin Hu, Hongbing Shen
Summary: This study identified the causal variant rs3769823 in chromosome 2q33.1 and explored its biological functions in non-small cell lung cancer (NSCLC). The variant was found to inhibit the proliferation and metastasis of lung cancer cells and was involved in the apoptosis pathway.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Oncology
Jian Yin, Neal D. Freedman, Yiwei Liu, Sanford M. M. Dawsey, Huan Yang, Philip R. R. Taylor, Liangyu Yin, Bin Liu, Jianfeng Cui, Jinhu Fan, Wen Chen, Youlin Qiao, Christian C. C. Abnet
Summary: This study found that serum insulin and HOMA-IR may be risk factors for the development of primary liver cancer (PLC) or chronic liver disease (CLD) death. In HBV-positive patients, glucose was also associated with an increased risk of these diseases.
BRITISH JOURNAL OF CANCER
(2023)
Article
Virology
Jian Yin, Siying Peng, Xinyue Li, Changning Zhang, Fangfang Hu, Wen Chen, Youlin Qiao
Summary: In this study, a novel GP5+/6+-PCR-based reverse dot blot hybridization assay (Yaneng-23) was compared with the widely used SPF10-PCR-based line probe assay (LiPA-25) for human papillomavirus (HPV) genotyping. It was found that Yaneng-23 was more sensitive than LiPA-25 for certain HPV types and the two assays showed good agreement. The conclusion is that Yaneng-23 can be used for HPV detection and genotyping in cervical samples for epidemiological and vaccine studies worldwide.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Jian Yin, Siying Peng, Changning Zhang, Xinyue Li, Fangfang Hu, Wen Chen, Youlin Qiao
Summary: The performance of LiPA-25 and Hybribio-23 in HPV detection and genotyping was compared. The results showed that the two methods had similar outcomes, suggesting that Hybribio-23 can be used for HPV detection and genotyping in epidemiological and vaccine studies worldwide.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Yujing Liu, Tingyuan Li, Ruochun Guo, Tingting Chen, Sumeng Wang, Dingkun Wu, Jing Li, Zhihua Liu, Yuqian Zhao, Jian Yin, Junjie Qin, Li Sun, Wen Chen
Summary: This study aimed to demonstrate the association between vaginal microbiota and high-risk human papillomavirus (HR-HPV) infection in women with and without bacterial vaginosis (BV). The findings showed that HR-HPV infection alters the composition and diversity of vaginal microbiota, and BV further reinforces this trend. Certain microbial genera are associated with multiple HPV infections, specific HPV genotypes, and cervical intraepithelial neoplasia (CIN) status.
JOURNAL OF MEDICAL VIROLOGY
(2023)