Article
Psychiatry
Reem M. A. Shafi, Paul A. Nakonezny, Keith A. Miller, Jinal Desai, Ammar G. Almorsy, Anna N. Ligezka, Brooke A. Morath, Magdalena Romanowicz, Paul E. Croarkin
Summary: The study found that social media use significantly affects the physiological response of adolescents with depression, but has minimal impact on healthy control adolescents; although there were minor changes in depressive symptoms in all participants after 20 minutes of SMU, these changes were not clinically meaningful; in addition, SMU did not significantly alter self-esteem measures among participants.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Mayura Veerana, Eun Ha Choi, Gyungsoon Park
Summary: The study demonstrated that plasma treatment significantly increased spore germination and alpha-amylase activity in A. oryzae, likely by elevating levels of ORP and NOX. Genomic sequencing analysis showed minimal variations in the DNA sequence post plasma treatment, suggesting potential mechanisms for enhancing enzyme activity.
APPLIED SCIENCES-BASEL
(2021)
Article
Multidisciplinary Sciences
Sandip Varkey George, Yoram K. Kunkels, Sanne Booij, Marieke Wichers
Summary: In this study, lower complexity levels were observed in the physical activity patterns of depressed individuals compared to non-depressed controls, indicating shorter durations of recurrent physical activity periods and less diversity in the duration of these periods. Additionally, diagnosing depression was found to be better predicted by these activity patterns than mean activity levels or measures of circadian rhythm stability.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Nicolai M. Doliba, Andrea V. Rozo, Jeffrey Roman, Wei Qin, Daniel Traum, Long Gao, Jinping Liu, Elisabetta Manduchi, Chengyang Liu, Maria L. Golson, Golnaz Vahedi, Ali Naji, Franz M. Matschinsky, Mark A. Atkinson, Alvin C. Powers, Marcela Brissova, Klaus H. Kaestner, Doris A. Stoffers
Summary: This study found that alpha cell dysfunction exists during the early stages of GADA(+) state, even when alpha cell mass is still normal. This has important implications for understanding the role of early alpha cell dysfunction in the progression of T1D.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biology
Manuel Strach, Felicitas Koch, Svenja Fiedler, Klaus Liebeton, Peter L. Graumann
Summary: Research on the secretion of alpha-amylase AmyE in Bacillus strains revealed that the protein may be released through a combination of active transport across the cell membrane and slow, passive diffusion through the cell wall. The existence of secretion zones during the transition to and within the stationary phase indicates a dynamic process of protein secretion in Gram-positive bacteria.
Article
Endocrinology & Metabolism
Maurizio Sicorello, Andreas B. Neubauer, Martin Stoffel, Friederike Koehler, Andreas Voss, Beate Ditzen
Summary: The study shows a strong relationship between subjective stress and momentary physiological stress indicators, while the mismatch between demands and resources has no impact on physiological indicators. Additionally, the study confirms theoretical predictions regarding stress appraisal and the imbalance between demands and resources.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Psychology, Multidisciplinary
Vittorio Pasquali, Cristina Mihaela Ghiciuc, Valeria Castellani, Gian Vittorio Caprara, Guido Alessandri, Raffaele D'Amelio, Vincenzo Ziparo, Fabio Scarinci, Francesca Romana Patacchioli
Summary: This study examined the association between positivity (POS) and salivary cortisol and alpha-amylase (alpha-Amy) production in healthy male volunteers. The findings showed distinct patterns of salivary cortisol and alpha-Amy production between individuals with high POS and low POS. Further research is needed to confirm whether these differences are linked to a better quality of life in individuals with higher levels of positivity.
JOURNAL OF HAPPINESS STUDIES
(2021)
Article
Psychology, Clinical
Shauna G. Simon, Larry D. Jamner, Amy L. Dent, Douglas A. Granger, Jenna L. Riis
Summary: This study examined the impact of chronic cannabis use on the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) reactivity and regulation. The results showed that, compared to non-users, cannabis users exhibited blunted cortisol reactivity and greater reduction in sAA concentrations when faced with stress. This suggests that chronic cannabis users may have a weakened response to acute psychosocial stress and better SNS recovery.
ADDICTIVE BEHAVIORS
(2023)
Article
Psychology, Clinical
Kerry L. Kinney, Uma Rao, Brooklynn Bailey, Natalie Hellman, Chris Kelly, Nicholas W. McAfee, Matthew C. Morris
Summary: This study examined the relationship between PTSD diagnosis and symptom severity, depressive symptoms, childhood trauma, and diurnal neuroendocrine secretion in women who recently experienced interpersonal trauma. The results showed that lower waking cortisol levels in trauma survivors predicted the development of PTSD, and higher childhood trauma exposure was associated with flattened diurnal cortisol and alpha-amylase slopes as well as higher waking alpha-amylase levels.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Leyla A. Erozenci, Sander R. Piersma, Thang V. Pham, Irene V. Bijnsdorp, Connie R. Jimenez
Summary: The study evaluated the stability of urinary EV proteomes in healthy individuals over a 6-month period, finding high consistency and stability with 90% of proteins detected in more than 1 individual at all timepoints. Unsupervised analysis revealed person-specific protein profiles, while the core EV-protein-interaction network showed involvement in various biological processes. Gender-specific expression patterns were also observed in the urinary EV proteome.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Clinical
Chungah Kim, Gabriel John Dusing, Andrew Nielsen, Frank P. MacMaster, Katherine Rittenbach, Sara Allin, Patricia O'Campo, Tarra L. Penney, Hayley A. Hamilton, Maritt Kirst, Antony Chum
Summary: Recreational cannabis policies in Canada did not increase the risk of cannabis-related emergency department visits among individuals with depression. However, individuals with depression still had a higher risk of these visits compared to those without depression.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Biological
M. Cima, N. A. Nicolson
Summary: This study explored morning cortisol levels and stress responses in psychopathic offenders, non-psychopathic offenders, and non-offender controls. The researchers found that psychopathic offenders exhibited significantly lower cortisol levels during a stress task compared to controls, while non-psychopathic offenders showed a similar but non-significant trend. However, there were no significant differences in cortisol response slopes among the three groups.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Larissa Steigmann, Shogo Maekawa, Frederic Kauffmann, Jacob Reiss, Ashley Cornett, James Sugai, Julian Venegas, Xudong Fan, Yuying Xie, William V. Giannobile, Rodica Pop-Busui, Isabelle M. A. Lombaert
Summary: The objective of this pilot clinical study was to identify salivary biomarkers associated with periodontal disease and diabetic autonomic dysfunction. The study found that selected salivary biomarkers, such as IgA, combined with a periodontal examination, can offer a non-invasive method to assess the risk for developing diabetic neuropathy.
SCIENTIFIC REPORTS
(2022)
Review
Endocrinology & Metabolism
Georgia Pitsava, Andrea G. Maria, Fabio R. Faucz
Summary: This review provides an overview of disorders associated with the adrenal cortex, the genetic factors implicated in these disorders, and their molecular implications. It highlights the advancements in genomic data analysis over the past decade, which have improved the diagnosis and treatment of adrenal cortical diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anahit Mkrtchian, Jennifer W. Evans, Christoph Kraus, Peixiong Yuan, Bashkim Kadriu, Allison C. Nugent, Jonathan P. Roiser, Carlos A. Zarate
Summary: Ketamine improved motivational symptoms in patients with treatment-resistant major depressive disorder by normalizing fronto-striatal connectivity, while disrupting this connectivity in healthy volunteers, regardless of inflammatory processes.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychiatry
Johanna T. W. Wigman, Sara van der Tuin, David van den Berg, Merel K. Muller, Sanne H. Booij
Summary: This study provides an in-depth characterization of individuals at different levels of risk for psychosis. The results show that psychopathology increases across different clinical stages, while well-being and functioning differ between non-clinical and clinical populations. Risk and protective factors vary between those with and without substantial psychotic experiences. Subgroup 4 reports particularly high levels of daily positive and negative psychotic experiences.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Editorial Material
Psychology, Developmental
Annelieke M. Roest, Ymkje Anna de Vries, Albert W. Wienen, Peter de Jonge
Summary: Mental disorders starting in childhood can have severe consequences throughout an individual's lifespan. While effective short-term treatments exist for common mental disorders in young people, little is known about their long-term effects. This editorial perspective examines the long-term effectiveness and safety of treatments for attention deficit hyperactivity disorder, behavior disorders, and anxiety and depressive disorders in children aged 6 to 12 years, and discusses methodological difficulties and risk-benefit ratio of these treatments.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Psychology, Experimental
Anne M. Reitsema, Bertus F. Jeronimus, Elisabeth H. Bos, Peter de Jonge, Pontus Leander
Summary: This study examined the hedonic adaptation trajectories of positive and negative affect in different age groups during the first wave of the COVID-19 pandemic. The results showed that these trajectories were largely similar across age groups, suggesting that age differences in emotional well-being are limited to mean-level differences rather than emotion dynamics. However, there were substantial individual differences in emotional adaptation. The emotional recovery trajectories were virtually similar across age groups, valence, and arousal levels in 33 countries.
Article
Psychology, Experimental
Anne Margit Reitsema, Bertus F. Jeronimus, Marijn van Dijk, Eva Ceulemans, Eeske van Roekel, Peter Kuppens, Peter de Jonge
Summary: This study explores the dynamic features of emotions in adolescents and identifies different emotion and dynamic modes. These emotion dynamic profiles capture meaningful interpersonal differences in adolescents' emotional experiences and change. Future research should focus on irritability and positive affect.
Article
Medical Laboratory Technology
Bas Sleumer, Jordan Zwerwer, Martijn van Faassen, Michel J. Vos, Rainer Bischoff, Ido P. Kema, Nico C. van de Merbel
Summary: A LC-MS/MS method was developed to quantify sex hormone binding globulin (SHBG) in serum and plasma without an immunocapture step. The method demonstrated good correlation with the Abbott Alinity immunoassay, and improved lab-to-lab consistency of results.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Neurosciences
Anne B. Foreman, Jana V. van Vliet-Ostaptchouk, Martijn van Faassen, Ido P. Kema, Bruce H. R. Wolffenbuttel, Pieter J. J. Sauer, Arend F. Bos, Sietske A. Berghuis
Summary: This study aimed to determine the effects of exposure to substances that affect neurobehaviour on attention and concentration during adolescence. The results showed that girls had higher concentrations of parabens than boys, and methylparaben and ethylparaben concentrations were associated with attention and hyperactivity. However, propylparaben concentrations were associated with poorer attention. Bisphenol concentrations were not associated with attention and concentration.
Article
Multidisciplinary Sciences
Nantia Othonos, Riccardo Pofi, Anastasia Arvaniti, Sarah White, Ilaria Bonaventura, Nikolaos Nikolaou, Ahmad Moolla, Thomas Marjot, Roland H. Stimson, Andre P. van Beek, Martijn van Faassen, Andrea M. Isidori, Elizabeth Bateman, Ross Sadler, Fredrik Karpe, Paul M. Stewart, Craig Webster, Joanne Duffy, Richard Eastell, Fatma Gossiel, Thomas Cornfield, Leanne Hodson, K. Jane Escott, Andrew Whittaker, Ufuk Kirik, Ruth L. Coleman, Charles A. B. Scott, Joanne E. Milton, Olorunsola Agbaje, Rury R. Holman, Jeremy W. Tomlinson
Summary: The study suggests that inhibiting 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) with AZD4017 could mitigate the adverse effects of glucocorticoids while preserving their anti-inflammatory actions. Co-treatment of AZD4017 with prednisolone shows potential in limiting the adverse effects of glucocorticoids.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Yuqi Wang, Bernd Riedstra, Bonnie de Vries, Martijn van Faassen, Alle Pranger, Ido Kema, Ton Groothuis
Summary: Mothers can influence offspring phenotypes by transferring non-genetic information to the young, providing them with a flexible tool to adjust their developmental trajectory in fluctuating environments. This study investigated the plasticity of embryonic metabolism of maternal androgens in Rock pigeons, finding that embryos have certain plasticity in response to maternal androgen levels depending on maternal signals.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Celien Tigchelaar, Willemien D. D. Muller, Sawal D. D. Atmosoerodjo, Klaas J. J. Wardenaar, Ido P. P. Kema, Anthony R. R. Absalom, Martijn van Faassen
Summary: A study on neurologically healthy patients undergoing spinal anesthesia found that there is a concentration gradient for most of the investigated biomarkers between the ventricles and the lumbar region. The results contribute to the understanding of neurobiology and emphasize the importance of standardized procedures for cerebrospinal fluid handling for comparison between studies.
FLUIDS AND BARRIERS OF THE CNS
(2023)
Article
Chemistry, Medicinal
Annelies Heylen, Yannick Vermeiren, Ido P. Kema, Martijn van Faassen, Claude van der Ley, Debby Van Dam, Peter P. De Deyn
Summary: Despite distinct clinical profiles, ALS and FTD patients share pathological features, with a substantial percentage of patients displaying a mixed disease phenotype. Kynurenine metabolism plays a role in dementia-associated neuroinflammation and has been linked to both diseases. Kynurenine pathway metabolite levels were significantly lower in ALS patients compared to FTD, EOAD, and control subjects in multiple brain regions. This suggests that the contribution of kynurenine metabolism in neuroinflammation is lower in ALS than in FTD or EOAD, possibly due to differences in age of onset.
Editorial Material
Psychology, Developmental
Annelieke M. Roest, Ymkje Anna de Vries, Albert W. Wienen, Peter de Jonge
Summary: In their response, Dekkers et al. argue that treatment is the best option for children with mental disorders due to 'sound evidence' of its effectiveness in both short and long-term. While we agree that there is evidence for short-term effectiveness and certain treatments have shown some long-term effects, such as behavioral parent training for behavioral disorders, we strongly disagree that there is solid evidence for long-term effectiveness overall.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Review
Psychology, Social
Jannis Kreienkamp, Laura F. Bringmann, Raili F. Engler, Peter de Jonge, Kai Epstude
Summary: One of the key challenges in researching psychological acculturation is the diversity in theories and measures, which makes it difficult to compare past literature and hinder theoretical integration. To address this, the authors propose utilizing the four basic aspects of human experiences (wanting, feeling, thinking, and doing) as a conceptual framework. They use this framework to assess past theoretical, psychometric, and empirical literature, finding that it allows for examination and comparison of past conceptualizations and provides novel insights for future research and interventions.
PERSONALITY AND SOCIAL PSYCHOLOGY REVIEW
(2023)
Article
Psychology, Multidisciplinary
Anne M. van Valkengoed, Linda Steg, Peter de Jonge
Summary: Climate anxiety refers to persistent, difficult-to-control apprehensiveness and worry about climate change. Emotion researchers can contribute by better understanding its prevalence, indicators, causes, and consequences. They can provide integrative and functional theories, explain the reasons behind climate anxiety, theorize how it motivates climate action, and develop coping strategies based on emotion regulation theory.
Article
Psychiatry
Maruschka N. Sluiter, Elisabeth H. Bos, Jeannette M. Doornenbal, Peter de Jonge, Laura Batstra
Summary: This preliminary study investigated the effect of a group parent training program without child-bound classifications on children with attention-deficit/hyperactivity disorder. The results showed that the intervention group had significantly lower scores on parental stress and communication problems compared with the control group. However, there were no significant differences in attention and hyperactivity problems, oppositional defiant problems, and responsivity.
JOURNAL OF PSYCHIATRIC PRACTICE
(2023)
Article
Psychology, Social
Jannis Kreienkamp, Maximilian Agostini, Laura F. Bringmann, Peter de Jonge, Kai Epstude
Summary: This article presents evidence that the fulfillment of situational needs during real-life intergroup contacts significantly predicts perceived interaction quality and positive outgroup attitudes. Methodologically, it supports the emerging practice of capturing real-life interactions using intensive longitudinal data. Theoretically, it highlights motivational fulfillment as a flexible and effective mechanism for understanding positive intergroup contact.
PERSONALITY AND SOCIAL PSYCHOLOGY BULLETIN
(2023)