Review
Pharmacology & Pharmacy
Ka Hong Wong, Donglin Yang, Shanshan Chen, Chengwei He, Meiwan Chen
Summary: Dihydroartemisinin (DHA) has demonstrated great anticancer effects and has the potential to become an antineoplastic agent. However, its therapeutic efficacy is compromised by its inherent disadvantages. Nanoscale drug delivery systems (NDDSs) have been introduced to overcome these drawbacks and maximize the therapeutic efficacy of DHA in cancer therapy.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Koushik Debnath, Suman Pal, Nikhil R. Jana
Summary: Nanoparticles play a significant role in biomedical applications, where their ability to enter cells, target subcellular compartments, and control intracellular processes depends on appropriate design of size and surface chemistry. There have been great advancements in understanding the principles of cellular uptake of foreign materials, with size-dependent endocytotic uptake being a key factor in nanoparticle interaction with cells.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Review
Medicine, Research & Experimental
Mehrdad Hashemi, Rezvaneh Aparviz, Marzie Beickzade, Mahshid Deldar Abad Paskeh, Simin Khorsand Kheirabad, Zeinab Khazaei Koohpar, Amir Moravej, Hossein Dehghani, Hamidreza Saebfar, Mohammad Arad Zandieh, Shokooh Salimimoghadam, Mohsen Rashidi, Afshin Taheriazam, Maliheh Entezari, Saeed Samarghandian
Summary: This review explores the potential applications of small interfering RNA (siRNA) and short hairpin RNA (shRNA) in the treatment of gastric cancer. It highlights the ability of siRNA to reduce the proliferation and invasion of gastric cancer cells and induce chemosensitivity. However, the unmodified siRNA faces challenges in translational potential. The role of nanostructures in facilitating siRNA delivery to gastric cancer cells and suppressing tumor progression is emphasized. The translation of these findings into clinical trials holds promise for advancing the treatment of gastric cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Chemistry, Multidisciplinary
Muse Ji, Hongbing Liu, Jingxin Gou, Tian Yin, Haibing He, Yu Zhang, Xing Tang
Summary: Chemodynamic therapy (CDT), based on the Fenton reaction, utilizes metal ions to react with excess hydrogen peroxide in tumor microenvironments and generate highly cytotoxic hydroxyl radicals to kill cancer cells. In recent years, nanoscale metal-organic frameworks (nMOFs) have emerged as promising agents for CDT and combination therapy. This review summarizes the latest advances in the design of nMOFs as nanomedicine for CDT or combination therapy and discusses future development and challenges in this field.
Article
Engineering, Biomedical
Jianming Zhao, Jirong Shi, Xiangdan Meng, Chenchen Gong, Peng Wu, Zhou Yang, Haifeng Dong
Summary: Stimuli-responsive nanoplatforms have great potential for delivering drugs to kill cancer cells with high accuracy and minimal invasiveness. In this study, ROS-responsive nanoscale coordination polymers were designed, and the release of drugs was enhanced under ultrasound stimulation. The nanoplatform achieved the synergistic effect of sonodynamic therapy and chemotherapy, and showed good targeting ability to cancer cells.
ACTA BIOMATERIALIA
(2022)
Review
Nanoscience & Nanotechnology
Shuncheng Yao, Zhirong Liu, Linlin Li
Summary: Covalent organic frameworks (COFs) are porous and crystalline materials with diverse characteristics, making them excellent candidate materials for biomedical applications such as drug delivery, diagnostic imaging, and disease therapy. The components, dimensions, and guest molecule loading into COFs have a great influence on their performance in various applications, requiring further investigation.
NANO-MICRO LETTERS
(2021)
Article
Nanoscience & Nanotechnology
Qian Wang, Yuxuan Ma, Zhangwei Lu, Hanyang Yu, Zhe Li
Summary: DNA nanostructures are used as drug delivery systems to achieve synergistic therapeutic effects in chemoimmunotherapy, showing excellent biocompatibility and superior treatment efficacy.
ACS APPLIED NANO MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Yang Liu, Pengfei Lei, Xuewei Liao, Chen Wang
Summary: This review article summarizes recent advances in nanoscale metal-organic frameworks (nMOFs) as nanoplatforms for drug delivery and cancer therapy. Different techniques using nMOFs are systematically summarized, and their advantages in biomedical applications are highlighted.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2022)
Review
Chemistry, Applied
Milad Ashrafizadeh, Masoud Delfi, Farid Hashemi, Amirhossein Zabolian, Hossein Saleki, Morteza Bagherian, Negar Azami, Mahdi Vasheghani Farahani, Seyed Omid Sharifzadeh, Soodeh Hamzehlou, Kiavash Hushmandi, Pooyan Makvandi, Ali Zarrabi, Michael R. Hamblin, Rajender S. Varma
Summary: Gene therapy using siRNA faces challenges, but chitosan nanoparticles as carriers show promise in overcoming siRNA issues and demonstrating potential in cancer therapy.
CARBOHYDRATE POLYMERS
(2021)
Article
Oncology
Asmita Deka Dey, Ashkan Bigham, Yasaman Esmaeili, Milad Ashrafizadeh, Farnaz Dabbagh Moghaddam, Shing Cheng Tan, Satar Yousefiasl, Saurav Sharma, Aziz Maleki, Navid Rabiee, Alan Prem Kumar, Vijay Kumar Thakur, Gorka Orive, Esmaeel Sharifi, Arun Kumar, Pooyan Makvandi
Summary: Chemotherapy is the primary treatment for cancer, but it lacks safety and effectiveness. Targeted nanotechnology treatment shows promise in delivering therapeutic agents to tumor cells without affecting normal cells. Dendrimers, as promising nanocarriers, have received considerable attention in cancer therapy studies. This review discusses the progress, challenges, and functionalities of dendrimers in cancer therapy, along with their role in cell entry and various modifications for drug and gene delivery. Biosafety concerns and issues hindering clinical applications are also discussed.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Weihua Chen, Zhen Sun, Lehui Lu
Summary: This review highlights the main drawbacks of current anticancer drugs and the urgency to improve targeting efficacy. It summarizes current targeting strategies and offers guidelines for structure optimization to obtain effective targeting drugs. Additionally, it presents viewpoints on crucial problems and potential challenges in future research on targeted cancer therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Mohamed Alaa Mohamed, Ajay Singh, Paras N. Prasad, Chong Cheng
Summary: Delivery of chemotherapeutics to cancer cells using polymeric micelles is a promising strategy for cancer treatment. However, the limited stability of micelles, premature drug release, and off-target effect hinder their utilization as effective drug delivery systems. In this study, pH-sensitive crosslinked polymeric micelles were designed to address these challenges and showed remarkable promise as smart drug delivery systems for cancer therapy.
Article
Polymer Science
Jia Liu, Yiyang Cong, Yawen Zeng, Yiming He, Ying Luo, Weifei Lu, Haixing Xu, Yihua Yin, Hao Hong, Wenjin Xu
Summary: Nanoscale metal-organic frameworks (nMOFs) have shown potential as drug delivery carriers due to their porous structure. In this study, nano-sized MIL-101(Fe)-N-3 was prepared and loaded with the anticancer drug doxorubicin (DOX). Surface modification of MIL-101(Fe)-N-3 with a synthetic polymer layer improved dispersion, avoided sudden drug release, and increased biocompatibility. The addition of the F3 peptide enabled active targeting of tumor tissues. This novel drug delivery system has the potential to reduce systemic toxicity and improve the efficacy of cancer treatment.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Review
Materials Science, Multidisciplinary
Xiaodi Zhang, Seyoung Koo, Ji Hyeon Kim, Xiangang Huang, Na Kong, Liqun Zhang, Jun Zhou, Jiajia Xue, Mitchel B. Harris, Wei Tao, Jong Seung Kim
Summary: This review aims to summarize various types of recently developed nanotherapeutic platforms, present different material strategies for treating bone diseases, and enhance treatment efficacy through a combination of multifunctional systems.
Article
Chemistry, Multidisciplinary
Daniel A. Richards, Michael R. Thomas, Peter A. Szijj, James Foote, Yiyun Chen, Joao C. F. Nogueira, Vijay Chudasama, Molly M. Stevens
Summary: Novel methods for introducing chemical and biological functionality to the surface of gold nanoparticles have been developed to increase their utility in various applications. The strong interaction between chemically functionalised bovine serum albumin and citrate-capped gold nanoparticles allows for versatile introduction of functionality. This approach has been shown to be generalisable and effective in enhancing the affinity of gold nanoparticles for target molecules in diagnostic tests.
Review
Nanoscience & Nanotechnology
Niranjan Chatterjee, Piyush Kumar, Krishan Kumar, Santosh K. Misra
Summary: Carbon nanoparticles (CNPs) have been widely used in biology for sensing, imaging, and therapy due to their biocompatibility and unique properties. This article discusses the correlations between synthesis, characterization, and utilization of CNPs, and explores their applications in various biological activities. The insights gained from this study can lead to the development of new CNPs with improved applications and evaluation methods, ultimately benefiting human needs in the future.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Review
Environmental Sciences
A. Ojha, S. Jaiswal, P. Thakur, S. K. Mishra
Summary: Accumulation of heavy metals increases toxic contaminants in soil and the environment, posing significant threats to ecosystems. Bioremediation, using microorganisms to lower/remove toxicity, is an important, cost-effective solution. Alternative methods like nanobioremediation, vermiremediation, and genetically modified microbes have also shown promise.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Aishwarya Naik, Krishan Kumar, Niranjan Chatterjee, Santosh K. Misra
Summary: A biocompatible and fluorescently trackable nanosystem, FeNCP, was developed to modulate the GSH pool in cancer cells and enhance the cytotoxic effects of Dox. The combination treatment of FeNCP and Dox showed higher cytotoxicity towards cancer cells compared to normal cells. This nanosystem has the potential for optical detection of GSH and imaging-assisted surgery, in addition to advancing anticancer chemotherapy.
ACS APPLIED BIO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Niranjan Chatterjee, Santosh Kumar Misra
Summary: A novel biomaterial, MusCAMLR, has been developed to repair mechanically damaged skeletal muscles, which can have a significant impact on the health and lifestyle of athletes, mountaineers, and security personnel. This musculoresponsive polymer-carbon composite establishes a mechanical interaction with muscle cells and supports myotube regeneration, restoring the structural integrity and biochemical parameters of damaged muscles within a short period of 72 hours. In summary, this study demonstrates the potential of smartly passivated nanocarbon in generating an advanced biomaterial system for therapeutic applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Parikshit Moitra, Maria Iftesum, David Skrodzki, Priyanka Paul, Elnaz Sheikh, Jennifer Lynn Gray, Ketan Dighe, Zach Sheffield, Manas Ranjan Gartia, Dipanjan Pan
Summary: Liquid interfaces are used to organize nanometer-scale biomaterials with plasmonic properties for molecular diagnostics. A multifunctional material is designed using hierarchical assembly of hafnium disulfide nanoplatelets and gold nanoparticles. The self-assembling pattern of the nanocomposites changes in the presence of the target analyte, altering their plasmonic response. This study provides a better understanding of the genomic organization of monkeypox virus (MPXV) and develops a selective molecular detection method for MPXV within a few minutes.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Electrical & Electronic
Alka Mishra, Surekha Bhusnur, Santosh Mishra
Summary: In the last 20 years, most human deaths have been caused by heart failure. ECG is an important clinical test for diagnosing dangerous cardiac electrical disturbances. Generating an artificial ECG signal that reflects the characteristics of a real ECG signal is challenging due to noise and artifacts. This paper presents a method of modeling an ECG signal and classifies it using different techniques. The tree algorithm shows the best performance in classifying abnormal and normal sinus rhythms, eliminating the need for pre-processing and traditional feature extraction techniques.
CIRCUITS SYSTEMS AND SIGNAL PROCESSING
(2023)
Article
Nanoscience & Nanotechnology
Maha Alafeef, David Skrodzki, Parikshit Moitra, Nivetha Gunaseelan, Dipanjan Pan
Summary: In response to the COVID-19 pandemic, a rapid electrochemical test has been developed to detect SARS-CoV-2 without the need for RNA extraction or amplification. The test uses a binding-induced folding principle and has shown high sensitivity with a detection limit of 2.5 copies/mu L. By targeting the N-gene of the virus, the test accurately identifies the presence of SARS-CoV-2 genetic material.
ACS APPLIED BIO MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Indrajit Srivastava, Parikshit Moitra, Kurtis M. Brent, Kevin Wang, Subhendu Pandit, Esra Altun, Dipanjan Pan
Summary: This research developed a fluorescent probe that can detect normoxic and hypoxic environments, which is important in detecting early tumor progression.
Review
Chemistry, Multidisciplinary
Maha Alafeef, Indrajit Srivastava, Teresa Aditya, Dipanjan Pan
Summary: Carbon dots (CDs) are a new type of carbon-based nanomaterial that have excellent biophysical properties and are being considered as alternatives to traditional quantum dots and organic dyes in various applications.
Article
Chemistry, Multidisciplinary
Ketan Dighe, Parikshit Moitra, Nivetha Gunaseelan, Maha Alafeef, Tor Jensen, Carla Rafferty, Dipanjan Pan
Summary: Novel single-stranded DNA probes targeting Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are designed and attached to gold nanoparticles (AuNPs) to create an absorbance-based assay. The assay shows high sensitivity and specificity in detecting CT and NG DNA in clinical samples, and can be adapted for point-of-care (POC) use on a lateral flow platform without the need for complicated DNA extraction and purification steps.
Article
Nanoscience & Nanotechnology
Maha Alafeef, David Skrodzki, Parikshit Moitra, Nivetha Gunaseelan, Dipanjan Pan
Summary: Since the outbreak of the COVID-19 pandemic, millions of confirmed cases and deaths have been reported globally. To slow down and ultimately stop the spread of COVID-19, a rapid on-site test for diagnosing positive cases of the disease is essential. In this study, we developed an electrochemical test using the binding-induced folding principle to detect SARS-CoV-2 without the need for RNA extraction or nucleic acid amplification. The test demonstrated high sensitivity and was validated using clinical samples, showing an accuracy, sensitivity, and specificity of 98.4%, 98.2%, and 98.5%, respectively.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Santosh K. Misra, Mao Ye, Parikshit Moitra, Ketan Dighe, Abhinav Sharma, Enrique A. Daza, Aaron S. Schwartz-Duval, Fatemeh Ostadhossein, Dipanjan Pan
Summary: In this study, we propose an environmentally friendly technology using a graphene-based carbon allotrope surface to remediate genetic materials in hospital waste. Extensive characterization has shown that this approach has great potential in large-scale hospital waste disposal.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Zach Sheffield, Maha Alafeef, Parikshit Moitra, Priyanka Ray, Dipanjan Pan
Summary: This study reports a method for highly specific molecular aggregation using carbon dots and complementary antisense oligonucleotide sequences in the presence of SARS-CoV-2 RNA. The sensor can differentiate between different coronaviruses and has high detection sensitivity.
Review
Nanoscience & Nanotechnology
Priyanka Ray, Parikshit Moitra, Dipanjan Pan
Summary: This article discusses the recent progress in the research of carbon dots in the field of nanobiotechnology, focusing on their chemical composition, varieties, and comparison with graphene quantum dots. It provides detailed information on synthetic routes for carbon dots fabrication and their emerging applications in theranostics, as well as outlining the major roadblocks for the translation of carbon dots from research laboratories to clinics. The article aims to update the latest results in this rapidly developing field and inspire novel research in the domain.
