FTO Inhibits Insulin Secretion and Promotes NF-κB Activation through Positively Regulating ROS Production in Pancreatic β cells

Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility

(2014) B. Guigas et al.   DIABETIC MEDICINE

Changes in Gene Expression Associated with FTO Overexpression in Mice

(2014) Myrte Merkestein et al.   PLoS One

Long-Term IKK2/NF- B Signaling in Pancreatic  -Cells Induces Immune-Mediated Diabetes

(2013) H. H. Salem et al.   DIABETES

Relation of the rs9939609 gene variant in FTO with metabolic syndrome in obese female patients

(2013) Daniel Antonio de Luis et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Meta-analysis identifies common variants associated with body mass index in east Asians

(2012) Wanqing Wen et al.   NATURE GENETICS

CACNA1E Variants Affect Beta Cell Function in Patients with Newly Diagnosed Type 2 Diabetes. The Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 3

(2012) Maddalena Trombetta et al.   PLoS One

Pharmacological Modulation of Dopamine Receptor D2-Mediated Transmission Alters the Metabolic Phenotype of Diet Induced Obese and Diet Resistant C57Bl6 Mice

(2011) J. E. de Leeuw van Weenen et al.   Experimental Diabetes Research

Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS)

(2010) Susanne Tan et al.   BMC Medical Genetics

Conditional expression of theFTOgene product in rat INS-1 cells reveals its rapid turnover and a role in the profile of glucose-induced insulin secretion

(2010) Mark A. Russell et al.   CLINICAL SCIENCE

FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction

(2010) A. Bravard et al.   DIABETES

Overexpression of Fto leads to increased food intake and results in obesity

(2010) Chris Church et al.   NATURE GENETICS

The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice

(2010) Xue Gao et al.   PLoS One

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene

(2009) Chris Church et al.   PLoS Genetics

Regulation of Fto/Ftm gene expression in mice and humans

(2008) George Stratigopoulos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians

(2008) C. S. Yajnik et al.   DIABETOLOGIA

Cytosolic Protein Tyrosine Phosphatase-ε Is a Negative Regulator of Insulin Signaling in Skeletal Muscle

(2007) Shlomit Aga-Mizrachi et al.   ENDOCRINOLOGY