Na+/H+ Exchanger Isoform 1 Induced Cardiomyocyte Hypertrophy Involves Activation of p90 Ribosomal S6 Kinase

Sgk1-Dependent Stimulation of Cardiac Na+/H+Exchanger Nhe1 by Dexamethasone

(2013) Jakob Voelkl et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

H+-activated Na+ influx in the ventricular myocyte couples Ca2+-signalling to intracellular pH

(2013) Carolina D. Garciarena et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

p90RSKs mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes

(2013) Ze Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Interference with ERKThr188 phosphorylation impairs pathological but not physiological cardiac hypertrophy

(2013) C. Ruppert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sgk1 sensitivity of Na+/H+ exchanger activity and cardiac remodeling following pressure overload

(2012) Jakob Voelkl et al.   BASIC RESEARCH IN CARDIOLOGY

p90 Ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to Gq-protein-coupled receptor stimuli, endothelin-1 and α1-adrenergic receptor agonists

(2012) Emre Amirak et al.   BIOCHEMICAL JOURNAL

p90RSK Targets the ERK5-CHIP Ubiquitin E3 Ligase Activity in Diabetic Hearts and Promotes Cardiac Apoptosis and Dysfunction

(2012) Nhat-Tu Le et al.   CIRCULATION RESEARCH

Identification of a Potent Sodium Hydrogen Exchanger Isoform 1 (NHE1) Inhibitor with a Suitable Profile for Chronic Dosing and Demonstrated Cardioprotective Effects in a Preclinical Model of Myocardial Infarction in the Rat

(2012) John D. Huber et al.   JOURNAL OF MEDICINAL CHEMISTRY

NHE-1 participates in isoproterenol-induced downregulation of SERCA2a and development of cardiac remodeling in rat hearts

(2011) Munetaka Shibata et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Activated NHE1 is required to induce early cardiac hypertrophy in mice

(2011) Fatima Mraiche et al.   BASIC RESEARCH IN CARDIOLOGY

Involvement of ERK–RSK cascade in phenylephrine-induced phosphorylation of GATA4

(2011) Tao Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cell signaling pathways for the regulation of GATA4 transcription factor: Implications for cell growth and apoptosis

(2011) Yuichiro J. Suzuki   CELLULAR SIGNALLING

Elevated expression of activated Na+/H+ exchanger protein induces hypertrophy in isolated rat neonatal ventricular cardiomyocytes

(2011) Fatima Mraiche et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Elevated myocardial Na+/H+ exchanger isoform 1 activity elicits gene expression that leads to cardiac hypertrophy

(2010) Jin Xue et al.   PHYSIOLOGICAL GENOMICS

Phenylephrine and sustained acidosis activate the neonatal rat cardiomyocyte Na+/H+ exchanger through phosphorylation of amino acids Ser770 and Ser771

(2009) Ersilia Coccaro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sodium–hydrogen exchange inhibition attenuates glycoside-induced hypertrophy in rat ventricular myocytes

(2009) Xiaohong Tracey Gan et al.   CARDIOVASCULAR RESEARCH

Differential regulation of NHE1 phosphorylation and glucose uptake by inhibitors of the ERK pathway and p90RSK in 3T3-L1 adipocytes

(2009) Shuai Chen et al.   CELLULAR SIGNALLING

Reactive Oxygen Species-Induced Activation of p90 Ribosomal S6 Kinase Prolongs Cardiac Repolarization Through Inhibiting Outward K + Channel Activity

(2008) Zhibo Lu et al.   CIRCULATION RESEARCH

Activation of Na + /H + Exchanger 1 Is Sufficient to Generate Ca 2+ Signals That Induce Cardiac Hypertrophy and Heart Failure

(2008) Tomoe Y. Nakamura et al.   CIRCULATION RESEARCH

Targeting Na+/H+ exchanger regulation for cardiac protection: a RSKy approach?

(2008) M AVKIRAN et al.   CURRENT OPINION IN PHARMACOLOGY

Regulation of the Na+/H+exchanger in the healthy and diseased myocardium

(2008) Larry Fliegel   EXPERT OPINION ON THERAPEUTIC TARGETS

The RSK family of kinases: emerging roles in cellular signalling

(2008) Rana Anjum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY