Expanding our Understanding of Sequence-Function Relationships of Type II Polyketide Biosynthetic Gene Clusters: Bioinformatics-Guided Identification of Frankiamicin A from Frankia sp. EAN1pec

Arixanthomycins A–C: Phylogeny-Guided Discovery of Biologically Active eDNA-Derived Pentangular Polyphenols

(2014) Hahk-Soo Kang et al.   ACS Chemical Biology

Recent advances in genome-based polyketide discovery

(2014) Eric JN Helfrich et al.   CURRENT OPINION IN BIOTECHNOLOGY

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

(2014) Kazuya Yamanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks

(2014) Suwen Zhao et al.   eLife

Emerging trends in the discovery of natural product antibacterials

(2013) Cristian G Bologa et al.   CURRENT OPINION IN PHARMACOLOGY

Exploring Natural Product Chemistry and Biology with Multicomponent Reactions. 5. Discovery of a Novel Tubulin-Targeting Scaffold Derived from the Rigidin Family of Marine Alkaloids

(2013) Liliya V. Frolova et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Structure–Function Linkage Database

(2013) Eyal Akiva et al.   NUCLEIC ACIDS RESEARCH

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

PKMiner: a database for exploring type II polyketide synthases

(2012) Jinki Kim et al.   BMC MICROBIOLOGY

Unveiling the Post-PKS Redox Tailoring Steps in Biosynthesis of the Type II Polyketide Antitumor Antibiotic Xantholipin

(2012) Weike Zhang et al.   CHEMISTRY & BIOLOGY

Environmental DNA-Encoded Antibiotics Fasamycins A and B Inhibit FabF in Type II Fatty Acid Biosynthesis

(2012) Zhiyang Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Significant Natural Product Biosynthetic Potential of Actinorhizal Symbionts of the Genus Frankia, as Revealed by Comparative Genomic and Proteomic Analyses

(2011) Daniel W. Udwary et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A key cytochrome P450 hydroxylase in pradimicin biosynthesis

(2011) Kandy L. Napan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antibiotics as Signal Molecules

(2011) Diego Romero et al.   CHEMICAL REVIEWS

Selective Overproduction of the Proteasome Inhibitor Salinosporamide A via Precursor Pathway Regulation

(2011) Anna Lechner et al.   CHEMISTRY & BIOLOGY

Role and regulation of bacterial LuxR-like regulators

(2011) Jing Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Biology ofFrankiasp. Strains in the Post-Genome Era

(2011) David R. Benson et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Interactive Tree Of Life v2: online annotation and display of phylogenetic trees made easy

(2011) I. Letunic et al.   NUCLEIC ACIDS RESEARCH

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Cofactor-Independent Monooxygenase SnoaB fromStreptomyces nogalater: Implications for the Reaction Mechanism

(2010) Thadee Grocholski et al.   BIOCHEMISTRY

Isolation of the lysolipin gene cluster of Streptomyces tendae Tü 4042

(2010) Patricio Lopez et al.   GENE

Cloning of the biosynthetic gene cluster for naphthoxanthene antibiotic FD-594 from Streptomyces sp. TA-0256

(2010) Fumitaka Kudo et al.   JOURNAL OF ANTIBIOTICS

Induced Biosynthesis of Cryptic Polyketide Metabolites in a Burkholderia thailandensis Quorum Sensing Mutant

(2010) Keishi Ishida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cloning, Sequencing, Heterologous Expression, and Mechanistic Analysis of A-74528 Biosynthesis

(2010) Kathia Zaleta-Rivera et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Natural Products Version 2.0: Connecting Genes to Molecules

(2010) Christopher T. Walsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New insights into the formation of fungal aromatic polyketides

(2010) Jason M. Crawford et al.   NATURE REVIEWS MICROBIOLOGY

FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments

(2010) Morgan N. Price et al.   PLoS One

Automated genome mining for natural products

(2009) Michael HT Li et al.   BMC BIOINFORMATICS

Investigation of Tailoring Modifications in Pradimicin Biosynthesis

(2009) Jixun Zhan et al.   CHEMBIOCHEM

TLN-05220, TLN-05223, new Echinosporamicin-type antibiotics and proposed revision of the structure of bravomicins

(2009) Arjun H Banskota et al.   JOURNAL OF ANTIBIOTICS

CLUSEAN: A computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters

(2009) T. Weber et al.   JOURNAL OF BIOTECHNOLOGY

Triggering cryptic natural product biosynthesis in microorganisms

(2009) Kirstin Scherlach et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synergistic Actions of a Monooxygenase and Cyclases in Aromatic Polyketide Biosynthesis

(2008) Jixun Zhan et al.   CHEMBIOCHEM

Orchestration of Discoid Polyketide Cyclization in the Resistomycin Pathway

(2008) Kathrin Fritzsche et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure and functional analysis of tetracenomycin ARO/CYC: Implications for cyclization specificity of aromatic polyketides

(2008) B. D. Ames et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA