miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways

Acetylation of FoxO1 Activates Bim Expression to Induce Apoptosis in Response to Histone Deacetylase Inhibitor Depsipeptide Treatment

(2015) Yang Yang et al.   NEOPLASIA

PI3K/AKT signaling pathway and cancer: an updated review

(2014) Miriam Martini et al.   ANNALS OF MEDICINE

Th2 Lymphoproliferative Disorder of LatY136F Mutant Mice Unfolds Independently of TCR-MHC Engagement and Is Insensitive to the Action of Foxp3+ Regulatory T Cells

(2014) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice

(2013) E. Zonari et al.   BLOOD

PAK1 Mediates Resistance to PI3K Inhibition in Lymphomas

(2013) K. Walsh et al.   CLINICAL CANCER RESEARCH

mTOR and lymphocyte metabolism

(2013) Hu Zeng et al.   CURRENT OPINION IN IMMUNOLOGY

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein

(2013) Marco J Herold et al.   EMBO REPORTS

MicroRNA-155 Is Required for Effector CD8+ T Cell Responses to Virus Infection and Cancer

(2013) Jan C. Dudda et al.   IMMUNITY

MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer

(2013) Esmerina Tili et al.   IMMUNOLOGICAL REVIEWS

Role of miR-155 in the regulation of lymphocyte immune function and disease

(2013) Nabila Seddiki et al.   IMMUNOLOGY

miRNA Signature of Mouse Helper T Cell Hyper-Proliferation

(2013) Connie L. Sommers et al.   PLoS One

Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects

(2013) J. E. Allen et al.   Science Translational Medicine

Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells

(2013) Robert L. Kortum et al.   TRENDS IN IMMUNOLOGY

The Paradox of Akt-mTOR Interactions

(2013) Lakshmipathi Vadlakonda et al.   Frontiers in Oncology

Reprogramming Tumor-Associated Dendritic Cells In Vivo Using miRNA Mimetics Triggers Protective Immunity against Ovarian Cancer

(2012) J. R. Cubillos-Ruiz et al.   CANCER RESEARCH

Regulation of the MIR155 host gene in physiological and pathological processes

(2012) Terry S. Elton et al.   GENE

Oncogenic MicroRNA-155 Down-regulates Tumor SuppressorCDC73and Promotes Oral Squamous Cell Carcinoma Cell Proliferation

(2012) Mohammad Iqbal Rather et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PP242 Mammalian Target of Rapamycin (mTOR) Inhibitor Activates Extracellular Signal-regulated Kinase (ERK) in Multiple Myeloma Cells via a Target of Rapamycin Complex 1 (TORC1)/ Eukaryotic Translation Initiation Factor 4E (eIF-4E)/RAF Pathway and Activation Is a Mechanism of Resistance

(2012) Bao Hoang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells

(2012) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Phospholipase C- 1-Independent, RasGRP1-ERK-Dependent Pathway Drives Lymphoproliferative Disease in Linker for Activation of T Cells-Y136F Mutant Mice

(2012) R. L. Kortum et al.   JOURNAL OF IMMUNOLOGY

The Importance of the Erk Pathway in the Development of Linker for Activation of T Cells-Mediated Autoimmunity

(2012) D. M. Fuller et al.   JOURNAL OF IMMUNOLOGY

LAT-Independent Erk Activation via Bam32-PLC-γ1-Pak1 Complexes: GTPase-Independent Pak1 Activation

(2012) Alexandre K. Rouquette-Jazdanian et al.   MOLECULAR CELL

Mutant p53 drives invasion in breast tumors through up-regulation of miR-155

(2012) P M Neilsen et al.   ONCOGENE

Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma

(2012) I. A. Babar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

(2011) Guri Tzivion et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

(2011) P N Kelly et al.   CELL DEATH AND DIFFERENTIATION

Increased Expression of the Pro-apoptotic Protein BIM, a Mechanism for cAMP/Protein Kinase A (PKA)-induced Apoptosis of Immature T Cells

(2011) Alexander C. Zambon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compensatory Pathways Induced by MEK Inhibition Are Effective Drug Targets for Combination Therapy against Castration-Resistant Prostate Cancer

(2011) D. Gioeli et al.   MOLECULAR CANCER THERAPEUTICS

miR-155, a Modulator of FOXO3a Protein Expression, Is Underexpressed and Cannot Be Upregulated by Stimulation of HOZOT, a Line of Multifunctional Treg

(2011) Mayuko Yamamoto et al.   PLoS One

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

(2011) C. C. Ong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-155Regulates Cell Survival, Growth, and Chemosensitivity by TargetingFOXO3ain Breast Cancer

(2010) William Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The LAT Story: A Tale of Cooperativity, Coordination, and Choreography

(2010) L. Balagopalan et al.   Cold Spring Harbor Perspectives in Biology

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions

(2009) G Chinnadurai et al.   ONCOGENE

Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice

(2009) M. Miyaji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inositol phosphatase SHIP1 is a primary target of miR-155

(2009) R. M. O'Connell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

(2008) J. R. Bayascas et al.   MOLECULAR AND CELLULAR BIOLOGY