Article
Ophthalmology
Eugene A. Lowry, Steven L. Mansberger, Stuart K. Gardiner, Hongli Yang, Facundo Sanchez, Juan Reynaud, Shaban Demirel, Claude F. Burgoyne, Brad Fortune
Summary: The frequency and severity of optic nerve head prelaminar schisis were found to be greater in glaucoma and glaucoma suspect eyes compared to healthy control eyes, and were associated with markers of glaucoma severity.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Mi Sun Sung, Hyung Nam Jin, Sang Woo Park
Summary: The study found that the presence of optic nerve head (ONH) prelaminar schisis in eyes with advanced glaucoma is associated with specific characteristics of the lamina cribrosa and macular thickness. In patients with these features, macular measurements are better predictors of functional status than peripapillary or ONH measurements.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Casey J. Keuthan, Julie A. Schaub, Meihan Wei, Weixiang Fang, Sarah Quillen, Elizabeth Kimball, Thomas V. Johnson, Hongkai Ji, Donald J. Zack, Harry A. Quigley
Summary: The level of intraocular pressure (IOP) is a major risk factor for glaucomatous optic neuropathy. This study found that the unmyelinated optic nerve region is differentially susceptible to IOP-induced damage compared to the myelinated region. Gene expression patterns in the unmyelinated optic nerve showed significant differences compared to the myelinated optic nerve and retina. Changes in gene expression induced by optic nerve injury were more extensive in the myelinated region than the unmyelinated region.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Ophthalmology
Anthony Arnold
Summary: The vascular supply of the optic nerve head is complex and remains unclear. Over the past 50 years, conflicting theories have evolved due to different research techniques used to study the contributions of various blood vessels.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Immunology
Wenwen Lai, Jie Huang, Wangyi Fang, Saiyue Deng, Yi Xie, Wei Wang, Tong Qiao, Gezhi Xu, Xiaowei Wang, Fengfei Ding
Summary: This study investigates the role of optic nerve head (ONH) in defense against vitreous inflammation. The researchers found that while the retina showed signs of inflammation, the posterior optic nerve and the optic nerve head showed no signs of inflammation or infiltration of inflammatory cells. The study also found that the astrocytes in the ONH changed their spatial orientation in response to inflammation. The findings suggest that glial responses in the ONH may serve as a barrier to inflammation for the central nervous system.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Ophthalmology
Jing Zhao, Graydon Gonsalvez, Manuela Bartoli, Barbara A. Mysona, Sylvia B. Smith, Kathryn E. Bollinger
Summary: The study evaluated the ability of S1R to modulate reactivity responses of optic nerve head astrocytes (ONHAs) and found that S1R activation enhanced ONHA reactivity characteristics, which may have important implications for the survival of retinal ganglion cells.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Mona Safizadeh, Amirreza Shaabani, Alireza Kamalipour, Masoud Aghsaei Fard, Kaileen Yeh, Mehdi Yaseri, Nikoo Hamzeh, Nassim Khatibi, Harsha Laxmana Rao, Robert Weinreb, Sasan Moghimi
Summary: OCTA can be used to detect reduced capillary density in fellow eyes of PXG patients, enabling earlier detection of glaucomatous loss in pseudoexfoliation disease and enhancing disease management.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ji-Ah Kim, Eun Ji Lee, Tae-Woo Kim, Hee Kyung Yang, Jeong-Min Hwang
Summary: The microvasculature of the optic nerve head and peripapillary tissues in eyes with normal-tension glaucoma (NTG) and nonarteritic anterior ischemic optic neuropathy (NAION) was compared using optical coherence tomography angiography (OCTA). Despite similar levels of retinal nerve fiber layer loss and vessel density decreases in the peripapillary retina, there were differences in vessel densities in the optic nerve head between NTG and NAION eyes, suggesting distinct mechanisms of vascular impairment and optic nerve head damage in each condition.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Liam K. Fisher, Xiaofei Wang, Tin A. Tun, Hsi-Wei Chung, Dan Milea, Michael J. A. Girard
Summary: The study assessed gaze evoked deformations of the optic nerve head in thyroid eye disease (TED) using computational modeling and optical coherence tomography (OCT). The results showed that TED can cause increased gaze-evoked deformations of the ONH.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Cell Biology
Andrea E. Dillinger, Gregor R. Weber, Matthias Mayer, Magdalena Schneider, Corinna Goeppner, Andreas Ohlmann, Mikhail Shamonin, Gareth J. Monkman, Rudolf Fuchshofer
Summary: Primary open-angle glaucoma is a neurodegenerative disease that is associated with structural changes in the optic nerve head and extracellular matrix. The molecular factors involved in this remodeling process, particularly TGF-beta 2 and CCN2/CTGF, play important roles in the pathogenesis of the disease. Understanding the function of CCN2/CTGF in normal and pathological conditions could provide insights into the development of new therapeutic approaches for glaucoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Emma K. Geiduschek, Colleen M. Mcdowell
Summary: Glaucoma is a progressive disease that leads to irreversible blindness. Understanding the cellular mechanisms behind optic nerve head damage during disease progression can help identify new drug targets and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Thanadet Chuangsuwanich, Tin A. Tun, Fabian A. Braeu, Xiaofei Wang, Zhi Yun Chin, Satish K. Panda, Martin Buist, Dan Milea, Nicholas Strouthidis, Shamira Perera, Monisha Esther Nongpiur, Tin Aung, Michael J. A. Girard
Summary: This study aimed to assess the strains in optic nerve head (ONH) induced by intraocular pressure (IOP) and gaze in subjects with high-tension glaucoma (HTG) and normal-tension glaucoma (NTG). The results showed that NTG subjects experienced higher strains due to gaze, while HTG subjects experienced higher strain due to IOP elevation, and these differences were most pronounced in the lamina cribrosa (LC) tissue.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Oncology
Ibrahim Ozdemir, Huseyin Murat Bulut, Suecattin Ilker Kocamis
Summary: This study suggests that oral isotretinoin therapy may lead to significant thickening of the retinal nerve fiber layer in patients with small optic disc area.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Ophthalmology
Kristina Hess, Kristin Raming, Peter Charbel Issa, Philipp Herrmann, Frank G. Holz, Maximilian Pfau
Summary: This study revealed a significant association between aging and ONHD with GCL thinning in patients with PXE, but not with the number of anti-VEGF injections.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Rebecca Gade Johannesen, Lea Lykkebirk, Morten Jorgensen, Lasse Malmqvist, Steffen Hamann
Summary: In ODD-AION, the location of the ODD within the optic nerve head is important, while the size of the ODD is not. ODD-AION and nODD-AION patients have different vascular risk factors and anatomical characteristics, establishing ODD and potentially PHOMS as independent risk factors for developing NA-AION.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Reyes Gamez-Belmonte, Mireia Tena-Garitaonaindia, Cristina Hernandez-Chirlaque, Samir Cordova, Diego Ceacero-Heras, Fermin Sanchez de Medina, Olga Martinez-Augustin
Summary: The study showed that TNAP haplodeficient mice can develop hepatosteatosis similar to that induced by a MCD diet when fed a control diet, but without weight loss, increased ALT levels, or hypoglycemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Maria Victoria Rodriguez-Benitez, Reyes Gamez-Belmonte, Mercedes Gil-Campos, Cristina Hernandez-Chirlaque, Paula R. Bouzas, Fermin Sanchez de Medina, Olga Martinez-Augustin
Summary: This study investigated the inflammatory status of preterm children, showing increased neutrophil markers and decreased AP in meconium, as well as elevated levels of some proinflammatory cytokines and growth factors in plasma, correlating with birth weight and gestational age. Preterm infants also exhibited neutropenia and decreased adiponectin, leptin, haematocrit, and hemoglobin, with some parameters correlating positively with GA and BW, while others showed negative correlations. Postnatal morbidity in preterm children was associated with increased MPO and MIP-1 alpha.
FRONTIERS IN PEDIATRICS
(2021)
Article
Nanoscience & Nanotechnology
Rafael Contreras-Montoya, Maria Arredondo-Amador, Guillermo Escolano-Casado, Mari C. Manas-Torres, Mercedes Gonzalez, Mayte Conejero-Muriel, Vaibhav Bhatia, Juan J. Diaz-Mochon, Olga Martinez-Augustin, Fermin Sanchez de Medina, Modesto T. Lopez-Lopez, Francisco Conejero-Lara, Jose A. Gavira, Luis Alvarez de Cienfuegos
Summary: Protein therapeutics play a crucial role in medicine by treating various pathologies, but their stability and in vivo half-life can be limited. This study introduces a method to increase the stability of proteins and modulate their release profile, demonstrated with thermally stable insulin composite crystals intended for diabetic treatment. The novel composite crystals show promising results in terms of stability and dissolution rate, paving the way for more stable protein pharmaceuticals.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Maria Arredondo-Amador, Carlos J. Aranda, Borja Ocon, Raquel Gonzalez, Olga Martinez-Augustin, Fermin Sanchez de Medina
Summary: The study found that in a colitis model, intestinal epithelial glucocorticoid receptor knockout mice performed better in reducing disease activity, preventing weight loss, and limiting tissue damage compared to WT mice. Budesonide treatment had limited anti-inflammatory effects on mice, but resulted in weight loss. Knockout of the receptor also provided protection in a protracted colitis protocol.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Cristina Hernandez-Chirlaque, Carlos J. Aranda, Borja Ocon, Javier Polo, Olga Martinez-Augustin, Fermin Sanchez de Medina
Summary: This study demonstrates that two porcine protein concentrates can alter immune cell function, modulate cytokine secretion in intestinal epithelial cells and spleen cells, with varying effects on TNF, GRO alpha, MCP-1, and IL-10. The mechanisms underlying these immunomodulatory effects involve MyD88/NF-kappa B-dependent pathways and are independent of IL-10 production or the stimulation of NF-kB, MAPKs, AKT, or RAGE.
Article
Gastroenterology & Hepatology
Maria Arredondo-Amador, Raquel Gonzalez, Carlos J. Aranda, Olga Martinez-Augustin, Fermin Sanchez de Medina
Summary: Research shows that knockout mice with epithelial-specific deletion of NR3C1 are protected against experimental colitis but have a higher tumor load in colitis-associated cancer, with signs of increased neoplastic transformation and tumor-associated inflammation.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Emma Muinos Lopez, Kevin Leclerc, Malissa Ramsukh, Paulo El Parente, Karan Patel, Carlos J. Aranda, Anna M. Josephson, Lindsey H. Remark, David J. Kirby, Daniel B. Buchalter, Tarik Hadi, Sophie M. Morgani, Bhama Ramkhelawon, Philipp Leucht
Summary: Tissue injury triggers immune cell mobilization, but during aging, this process becomes dysregulated, leading to harmful inflammatory response. Toll-like receptor signaling appears to be responsible for the abnormal immune cell recruitment in aging animals. By targeting Myd88, a key regulator in TLR signaling, the impaired fracture healing caused by aging can be reversed, offering a potential therapeutic target for bone regeneration.
Editorial Material
Allergy
Ruben Fernandez-Santamaria, Jose Antonio Canas, Carlos J. Aranda
Article
Allergy
Daniel Lozano-Ojalvo, Scott R. Tyler, Carlos J. Aranda, Julie Wang, Scott Sicherer, Hugh A. Sampson, Robert A. Wood, A. Wesley Burks, Stacie M. Jones, Donald Y. M. Leung, Maria Curotto de Lafaille, M. Cecilia Berin
Summary: This study observed that oral immunotherapy can increase the frequency of Tregs in individuals with lasting clinical tolerance. It also found that the release of IL-2 from Th2 effector cells can induce delayed and persistent activation of Tregs, which could be significant for improving current oral immunotherapy approaches.
Article
Allergy
Carlos J. Aranda, Edgar Gonzalez-Kozlova, Sean P. Saunders, Weslley Fernandes-Braga, Miyo Ota, Sriram Narayanan, Jin-Shu He, Ester Del Duca, Bose Swaroop, Sacha Gnjatic, Gail Shattner, Joan Reibman, Nicholas A. Soter, Emma Guttman-Yassky, Maria A. Curotto de Lafaille
Summary: This study identified a population of IgG memory B cells in individuals with atopic diseases that expressed genes regulated by IL-4/IL-13. These cells may serve as precursors of pathogenic IgE plasma cells. The frequency of CD23(+)IL4R(+)IgG(+) memory B cells correlated with levels of circulating IgE and B cells from atopic individuals generated more IgE(+) cells in vitro.
Review
Chemistry, Multidisciplinary
Marta Espada-Sanchez, Rocio Saenz de Santa Maria, Maria del Carmen Martin-Astorga, Clara Lebron-Martin, Maria Jesus Delgado, Ibon Eguiluz-Gracia, Carmen Rondon, Cristobalina Mayorga, Maria Jose Torres, Carlos Jose Aranda, Jose Antonio Canas
Summary: Respiratory diseases, such as asthma and allergic rhinitis, are common airway conditions that cause breathing difficulties and have high mortality rates. They share similar physiological and immunological mechanisms, and early diagnosis and effective treatment are crucial for patient health and quality of life. In recent years, efforts have been made to improve treatments using biological agents and specific allergen immunotherapy, as well as developing more precise diagnostic tools. This review compiles important information for managing asthma and allergic rhinitis, including classical and innovative treatment approaches and diagnostic techniques.
APPLIED SCIENCES-BASEL
(2023)
Letter
Allergy
Jose Antonio Cespedes, Clara Lebron-Martin, Reyes Garcia-Oton, Maria Jesus Delgado, Maria del Carmen Martin-Astorga, Natalia Perez-Sanchez, Francisca Gomez, Maria Jose Torres, Jose Antonio Canas, Carlos Jose Aranda, Cristobalina Mayorga
Editorial Material
Otorhinolaryngology
Francisca Palomares, Almudena Testera-Montes, Carlos Jose Aranda, Carmen Alba-Linero, Rocio Saenz de Santa Maria-Garcia, Guillermo Bentabol-Ramos, Cristobalina Mayorga, Maria Jose Torres, Carmen Rondon, Ibon Eguiluz-Gracia
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)