Article
Multidisciplinary Sciences
Katy Diallo, Numa Simons, Souraya Sayegh, Michel Baron, Yannick Degboe, Jean-Frederic Boyer, Andrey Kruglov, Sergei Nedospasov, Julien Novarino, Meryem Aloulou, Nicolas Fazilleau, Arnaud Constantin, Alain Cantagrel, Jean-Luc Davignon, Benjamin Rauwel
Summary: The study shows that the binding of anti-TNF biologics to tmTNF can reduce the severity of arthritis by increasing the expression of anti-inflammatory markers and decreasing inflammation. This suggests a complementary explanation for the effects of anti-TNF biologics in treating inflammatory diseases and opens the door to studies on new arginase-1-dependent therapeutic targets.
Article
Biochemistry & Molecular Biology
Sri Jayanti, Rita Moretti, Claudio Tiribelli, Silvia Gazzin
Summary: This study investigated the neuroprotective effect of low concentrations of UCB in a PD model and found that UCB could effectively protect against the loss of dopaminergic neurons, with inflammation being the key factor in this protection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yunseon Yang, Jae-Jin Song, Yu Ree Choi, Seong-Hoon Kim, Min-Jong Seok, Noviana Wulansari, Wahyu Handoko Wibowo Darsono, Oh-Chan Kwon, Mi-Yoon Chang, Sang Myun Park, Sang-Hun Lee
Summary: Astrocytes have therapeutic potential in alleviating α-synuclein pathology in Parkinson's disease by regulating neuronal α-syn proteostasis and correcting inflammatory environments.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Yunqian Guan, Ren Wang, Xiaobo Li, Haiqiang Zou, Wenxiu Yu, Zhaohui Liang, Lei Li, Ling Chen, Liping Zhou, Zhiguo Chen
Summary: The study found that astrocytes, not microglia, were the main source of TNF-alpha expression in the infarct area of rats after ischemia. MSC transplantation was shown to suppress TNF-alpha expression by astrocytes.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
A. de Rus Jacquet, M. Alpaugh, H. L. Denis, J. L. Tancredi, M. Boutin, J. Decaestecker, C. Beauparlant, L. Herrmann, M. Saint-Pierre, M. Parent, A. Droit, S. Breton, F. Cicchetti
Summary: Astrocyte dysfunction and inflammation contribute to blood-brain barrier (BBB) compromise in Parkinson's disease (PD). This study demonstrates that astrocytes derived from female PD patients with LRRK2 G2019S mutation are pro-inflammatory and impair BBB formation. MEK1/2 signaling inhibition attenuates the inflammatory profile and rescues BBB formation in mutant astrocytes. Vascular changes are observed in the postmortem substantia nigra of both male and female PD patients.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Tianyou Wang, Yingqi Sun, Ulf Dettmer
Summary: Parkinson's disease is characterized by the loss of dopaminergic neurons. This review highlights the roles of astrocytes in PD and how their properties can be utilized to increase neuron survivability. Astrocytes normally have protective functions but can become dysfunctional and contribute to neurotoxicity in PD. Restoring healthy astrocyte function and maximizing their beneficial effects represent promising therapeutic approaches.
Review
Medicine, Research & Experimental
Farid Ghorbaninezhad, Patrizia Leone, Hajar Alemohammad, Basira Najafzadeh, Niloufar Nourbakhsh, Marcella Prete, Eleonora Malerba, Hossein Saeedi, Neda Tabrizi, Vito Racanelli, Behzad Baradaran
Summary: This study reviews the dual role of tumor necrosis factor-alpha (TNF-alpha) in systemic lupus erythematosus (SLE), as well as the efficacy and safety of anti-TNF-alpha therapies in SLE.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Review
Neurosciences
Sean J. Miller, Cameron E. Campbell, Helen A. Jimenez-Corea, Guan-Hui Wu, Robert Logan
Summary: Parkinson's disease is a common neurodegenerative disease without a cure. While research often focuses on neurons, this review highlights the important role of neuroglia in the disease. Factors such as oxidative stress and neuroinflammation are discussed, along with the potential therapeutic avenue of senolytics for PD.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Uzma Saleem, Sundas Hira, Fareeha Anwar, Muhammad Ajmal Shah, Samia Bashir, Roua S. Baty, Reem H. Badr, Renald Blundell, Gaber El-Saber Batiha, Bashir Ahmad
Summary: The study found that the methanolic extract of Viola odorata exhibited memory-enhancing activity in LPS-treated mice, showing potential therapeutic effects on Alzheimer's disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Lukas Henning, Henrike Antony, Annika Breuer, Julia Mueller, Gerald Seifert, Etienne Audinat, Parmveer Singh, Frederic Brosseron, Michael T. Heneka, Christian Steinhaeuser, Peter Bedner
Summary: In the mouse model of temporal lobe epilepsy, reactive microglia are shown to be the primary producers of tumor necrosis factor alpha (TNFα), which contributes to astrocyte dysfunction and the severity of seizures.
Article
Cell Biology
Diana Szucs, Vanda Miklos, Tamas Monostori, Melinda Guba, Aniko Kun-Varga, Szilard Poliska, Erika Kis, Balazs Bende, Lajos Kemeny, Zoltan Vereb
Summary: Adipose-derived mesenchymal stem cells are used in regenerative medicine for burns and ulcers treatment. Inflammatory microenvironment can induce different biological pathways in these cells as shown by gene expression analysis. The secretion of cytokines and wound healing assay further support the accelerated wound healing potential of these cells under inflammation conditions.
Review
Biochemistry & Molecular Biology
Stephanie Vrijsen, Marine Houdou, Ana Cascalho, Jan Eggermont, Peter Vangheluwe
Summary: The polyamines putrescine, spermidine, and spermine play a vital role in mammalian cells and are tightly regulated by various mechanisms. This article discusses the balance between the neuroprotective and neurotoxic effects of polyamines in Parkinson's disease (PD). Polyamine levels decline with aging and are altered in PD patients, and recent studies suggest a disrupted polyamine homeostasis as a driving factor in PD. Polyamines influence PD pathogenesis, such as alpha-synuclein aggregation, and affect PD-related processes like autophagy, heavy metal toxicity, oxidative stress, neuroinflammation, and lysosomal/mitochondrial dysfunction. The article also highlights outstanding research questions regarding the role of polyamines in PD, their potential as biomarkers, and possible therapeutic strategies targeting polyamine homeostasis.
ANNUAL REVIEW OF BIOCHEMISTRY
(2023)
Article
Pathology
Chandra S. Bathula, Jian Chen, Rahul Kumar, Perry J. Blackshear, Yogesh Saini, Sonika Patial
Summary: The study reveals that inactivation of ZFP36L1 can protect the liver from alcohol-induced hepatic steatosis, injury, and inflammation, possibly by stabilizing Fgf21 mRNA. Modulation of ZFP36L1 may be beneficial in the prevention and treatment of alcoholic liver disease.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Andy Ruiz, Yadira Palacios, Irene Garcia, Leslie Chavez-Galan
Summary: Tumor necrosis factor (TNF) is a key cytokine regulating inflammatory responses and plays a crucial role in granuloma formation during mycobacterial infections. The interactions between soluble and transmembrane TNF with their receptors influence effector mechanisms, providing insights into potential therapeutic strategies against mycobacterial infections. Understanding the structural and activation pathways of TNF and its receptors can offer valuable knowledge for developing more efficient therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Choong Hyun Lee, Ji Hyeon Ahn, Bai Hui Chen, Dae Won Kim, Hyejin Sim, Tae-Kyeong Lee, Joon Ha Park, Moo-Ho Won, Soo Young Choi
Summary: This study compared the time-dependent changes in TNF-alpha and TNF-R1 protein expression levels in the hippocampal subfield CA1 between adult and young gerbils following cerebral ischemia, finding different expression patterns between the two age groups. The higher levels of TNF-alpha in young gerbils compared with adult gerbils may be related to age-dependent differences in neuronal death induced by ischemia.
MOLECULAR MEDICINE REPORTS
(2021)
