Article
Chemistry, Medicinal
Qingfei Yu, Peng Qu, Vidya Devanathadesikan Seshadri, Xiaogang Wang
Summary: The study showed that escin treatment significantly improved kidney function and reduced inflammation levels in a rat model of hyperoxaluria-induced nephropathy, suggesting its potential as a therapeutic approach.
PHARMACOGNOSY MAGAZINE
(2022)
Article
Environmental Sciences
Mai M. Eissa, Mohamed M. Ahmed, Mabrouk A. Abd Eldaim, Ahmed A. Mousa, Ahmed F. Elkirdasy, Mostafa A. Mohamed, Sahar H. Orabi
Summary: Chlorella vulgaris extract ameliorates sodium nitrite-induced hepatotoxicity in rats by modulating inflammation, oxidative stress, and hepatic tissue function and architecture.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Physiology
Pei-Li Chou, Yin-Shian Chen, Shiu-Dong Chung, Sam-Chi Lin, Chiang-Ting Chien
Summary: The study showed that sodium thiosulfate (STS) could significantly reduce hypertension, oxidative stress, fibrosis, and apoptosis formation in rats with renovascular hypertension (RVHT), as well as decrease urinary protein levels.
KIDNEY & BLOOD PRESSURE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Seiko Yamakoshi, Takahiro Nakamura, Lusi Xu, Masahiro Kohzuki, Osamu Ito
Summary: Exercise training can protect renal function in patients with chronic kidney disease by reducing the generation of reactive oxygen species.
Article
Environmental Sciences
Rania Samir, Ekrami A. Hassan, Abdullah A. Saber, David S. A. Haneen, Eman M. Saleh
Summary: This study investigated the cardioprotective effects of thermally treated sodium alginate (TTSA) in treating doxorubicin-induced cardiotoxicity. The results showed that TTSA improved cardiac dysfunction and alleviated doxorubicin-induced myocardial apoptosis. Furthermore, TTSA exhibited antioxidant properties and rebalanced the redox state of cardiomyocytes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Yungang Shan, Deqing Chen, Bo Hu, Guangtao Xu, Wanlu Li, Ye Jin, Xiuhui Jin, Xin Jin, Limin Jin
Summary: The study demonstrated that allicin exerts a protective effect against renal ischemia/reperfusion injury in rats by regulating apoptosis, oxidative stress, and inflammatory response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Babak Gholamine, Gholamreza Houshmand, Azam Hosseinzadeh, Mojtaba Kalantar, Saeed Mehrzadi, Mehdi Goudarzi
Summary: The study found that gallic acid can protect against sodium arsenite-induced kidney and liver toxicity, likely through scavenging reactive free radicals and increasing intracellular antioxidant capacity.
DRUG AND CHEMICAL TOXICOLOGY
(2021)
Article
Transplantation
Neslihan Tezcan, Zarife Nigar Ozdemir-Kumral, Naziye Ozkan Yenal, Ozlem T. Cilingir-Kaya, Aysin Tulunay Virlan, Dilek Ozbeyli, Sule Cetinel, Berrak C. Yegen, Mehmet Koc
Summary: The study demonstrates that NES-1 has renoprotective effects and can ameliorate renal fibrosis induced by unilateral ureteral obstruction. The mechanism may involve inhibition of neutrophil infiltration, reduction of oxidative stress, and inflammation. These findings suggest that NES-1 may play a regulatory role in protecting the kidneys against obstruction-induced renal injury.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Cell Biology
Yikun Wu, Hua Shi, Yuangao Xu, Jun Pei, Shang Song, Wei Chen, Shuxiong Xu
Summary: Renal ischemia-reperfusion (I/R) injury is a common cause of chronic kidney disease (CKD) and has significant negative impacts on patients and society. Ebselen, an organic selenide, has shown to attenuate I/R injury in various organs, but its effect and mechanism in renal I/R injury remain unclear. In this study, a rat model of renal I/R injury was established to investigate the protective effect of ebselen and the underlying mechanism. It was found that ebselen pretreatment reduced renal dysfunction and tissue damage caused by renal I/R, enhanced autophagy, and inhibited oxidative stress. Additionally, ebselen pretreatment activated the Nrf2 signaling pathway. The protective effect of ebselen was suppressed by an autophagy inhibitor. In conclusion, ebselen could improve renal I/R injury by enhancing autophagy, activating the Nrf2 signaling pathway, and reducing oxidative stress.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Fatma H. Shaker, Marwa O. El-Derany, Sara A. Wahdan, Ebtehal El-Demerdash, Hala O. El-Mesallamy
Summary: The study demonstrated that BBR has a significant neuroprotective effect against DOX-induced cognitive impairment, improving behavioral defects and reversing histopathological abnormalities. Mechanistically, BBR modulated neuroinflammation, anti-oxidative defense, and synaptic plasticity, highlighting its potential as a therapeutic agent for cognitive decline in cancer survivors undergoing DOX-based chemotherapy.
Article
Environmental Sciences
Ashwani Kumar Sharma, Japneet Kaur, Tajpreet Kaur, Balbir Singh, Harlokesh Narayan Yadav, Devendra Pathak, Amrit Pal Singh
Summary: Arsenic exposure causes renal damage and oxidative stress in rats, which can be attenuated by bosentan treatment. Bosentan also restores renal eNOS expression and mitigates arsenic-induced hepatic changes in rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Peripheral Vascular Disease
Takahiro Miura, Akihiro Sakuyama, Lusi Xu, Jiahe Qiu, Asako Namai-Takahashi, Yoshiko Ogawa, Masahiro Kohzuki, Osamu Ito
Summary: This study aimed to investigate the mechanisms behind the antihypertensive and renal protective effects of the xanthine oxidoreductase inhibitor febuxostat. The results showed that febuxostat attenuated high salt diet-induced hypertension and renal damage in Dahl salt-sensitive rats by reducing renal oxidative stress. The antihypertensive effect of febuxostat may be partly mediated by its diuretic and natriuretic actions.
JOURNAL OF HYPERTENSION
(2022)
Article
Biochemistry & Molecular Biology
Sariya Meephat, Patoomporn Prasatthong, Prapassorn Potue, Sarawoot Bunbupha, Poungrat Pakdeechote, Putcharawipa Maneesai
Summary: Diosmetin demonstrated a reduction in blood pressure and alleviation of vascular abnormalities in experimentally hypertensive rats by exerting antioxidant and anti-inflammatory effects, and modulating the expression of Nrf2/HO1 and p-JNK/NF-kappa B proteins.
Article
Behavioral Sciences
Enam Alhagh Charkhat Gorgich, Houman Parsaie, Sazin Yarmand, Farzaneh Baharvand, Maryam Sarbishegi
Summary: The study demonstrated that long-term administration of metformin can reduce age-associated oxidative stress, improve cognitive function, increase the survival of hippocampal neurons, and enhance passive avoidance memory. This suggests that metformin intake modulates oxidant/antioxidant mechanisms to prevent hippocampal neuron loss caused by age-dependent oxidative stress while enhancing memory.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Toru Miyoshi, Kazufumi Nakamura, Naofumi Amioka, Omer F. Hatipoglu, Tomoko Yonezawa, Yukihiro Saito, Masashi Yoshida, Satoshi Akagi, Hiroshi Ito
Summary: LCZ696 ameliorated DOX-induced cardiotoxicity in rat hearts in vivo and in vitro, possibly by mediating a decrease in oxidative stress.
SCIENTIFIC REPORTS
(2022)
Review
Rheumatology
Yehya Al-Adwi, Johanna Westra, Harry van Goor, Janette K. Burgess, Christopher P. Denton, Douwe J. Mulder
Summary: SSc is a multiphase autoimmune disease characterized by vasculopathy, inflammation, and fibrosis. Macrophages play a crucial role in the pathogenesis of SSc, as they can initiate chronic inflammation and secrete fibrotic factors.
Article
Psychiatry
Jenny Borkent, Magdalini Ioannou, Tessa S. Folkertsma, Klaas J. Wardenaar, Bartholomeus C. M. Haarman, Harry van Goor, Iris E. C. Sommer, Arno R. Bourgonje
Summary: Recent research has shown that levels of serum free thiols (R-SH) are reduced in patients with recently diagnosed schizophrenia spectrum disorders (SSD) compared to healthy controls (HC), and are negatively correlated with the inflammatory marker CRP and age. Further studies are needed to investigate the role of R-SH in SSD.
PSYCHIATRY RESEARCH
(2023)
Article
Immunology
Isabella M. Atzeni, Yehya Al-Adwi, Berber Doornbos van der Meer, Caroline Roozendaal, Alja Stel, Harry van Goor, C. Tji Gan, Michael Dickinson, Wim Timens, Andries J. Smit, Johanna Westra, Douwe J. Mulder
Summary: This study investigated the levels of soluble RAGE (sRAGE) and its ligand HMGB1 in SSc and their abilities to predict SSc-related pulmonary complications. The results showed that high baseline sRAGE levels may serve as a prospective biomarker for patients with SSc at high risk to develop new onset of PAH, and high sRAGE levels could predict lower survival rates due to PAH in patients with SSc.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Arno R. Bourgonje, Damian Kloska, Anna Grochot-Przeczek, Martin Feelisch, Antonio Cuadrado, Harry van Goor
Summary: Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are closely associated with inflammation and overproduction of reactive oxygen species (ROS). The variability in disease activity and response to therapy poses challenges to diagnosis and patient care. The use of redox metabolomics approaches and integration of clinical-omics can help identify disrupted redox signaling pathways and develop personalized redox medicine approaches for IBD treatment.
Article
Biochemistry & Molecular Biology
Arno R. Bourgonje, Amaal E. Abdulle, Martin F. Bourgonje, Lyanne M. Kieneker, Sacha la Bastide-van Gemert, Sanne J. Gordijn, Clara Hidden, Tom Nilsen, Ron T. Gansevoort, Douwe J. Mulder, Robin P. F. Dullaart, Martin H. de Borst, Stephan J. L. Bakker, Harry van Goor
Summary: Circulating levels of NGAL are associated with acute kidney injury, severity and progression of CKD. This study investigated NGAL as a potential biomarker for new-onset CKD and found that higher plasma NGAL concentrations are associated with an increased risk of developing CKD in the general population, mainly driven by renal function decline.
Article
Biochemistry & Molecular Biology
Yehya Al-Adwi, Isabella M. M. Atzeni, Berber van der Meer, Amaal Eman Abdulle, Anniek M. M. van Roon, Alja Stel, Harry van Goor, Andries J. Smit, Johanna Westra, Douwe J. J. Mulder
Summary: Raynaud's Phenomenon (RP), an early sign of systemic sclerosis (SSc), leads to increased oxidative stress. HMGB1 released after oxidative stress can signal through RAGE. We found that RP attacks promote the release of HMGB1 in SSc patients and induce upregulation of IFN-induced genes. HMGB1 stimulates IP-10 expression in dermal fibroblasts, suggesting a link between RP attacks, HMGB1 release, and IFN-induced proteins in SSc.
Article
Biochemistry & Molecular Biology
Martin F. F. Bourgonje, Amaal E. E. Abdulle, Lyanne M. M. Kieneker, Sacha la Bastide-van Gemert, Stephan J. L. Bakker, Ron T. T. Gansevoort, Sanne J. J. Gordijn, Harry van Goor, Arno R. R. Bourgonje
Summary: Oxidative stress is important in cardiovascular disease, and current biomarkers are insufficient for predicting cardiovascular events. This study assessed the utility of redox-related biomarkers in predicting cardiovascular events and all-cause mortality in a population-based cohort. The levels of homocysteine, gamma-GT, HDL cholesterol, bilirubin, and protein-adjusted free thiol were analyzed, and lower levels of protein-adjusted R-SH were associated with an increased risk of cardiovascular events and all-cause mortality in men. The study highlights the value of R-SH levels in cardiovascular risk assessment and the importance of other oxidative stress-related biomarkers.
Article
Biochemistry & Molecular Biology
Hanno Maassen, Leonie H. Venema, Marc G. Weiss, Tobias M. Huijink, H. Sijbrand Hofker, Anna K. Keller, Tom E. Mollnes, Marco Eijken, Soren E. Pischke, Bente Jespersen, Harry van Goor, Henri G. D. Leuvenink
Summary: Kidney extraction time has a detrimental effect on post-transplantation outcome. This study aimed to improve the flush-out and decrease ischemic injury by adding hydrogen sulphide (H2S) to the flush medium. The addition of H2S during flush out and static cold storage resulted in a reduction in pro-inflammatory cytokines without affecting renal function or injury markers.
Article
Cardiac & Cardiovascular Systems
Arno R. Bourgonje, Margery A. Connelly, Harry van Goor, Peter R. van Dijk, Robin P. F. Dullaart
Summary: This study found that the total lipoprotein particle concentrations of both LDL and HDL are positively associated with an increased risk of developing microvascular complications in patients with established T2D. The protective role of HDL on the development of microvascular complications may be lost in established T2D.
CARDIOVASCULAR DIABETOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sem Geertsema, Arno R. Bourgonje, Raphael R. Fagundes, Ranko Gacesa, Rinse K. Weersma, Harry van Goor, Giovanni E. Mann, Gerard Dijkstra, Klaas N. Faber
Summary: Oxidative stress is an important mechanism in inflammatory bowel disease. The NRF2/Keap1 pathway regulates cellular responses to oxidative stress and has been implicated in the development of inflammatory bowel disease. Activation of the NRF2/Keap1 pathway enhances antioxidant responses and may potentially improve clinical outcomes for inflammatory bowel disease.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Arno R. Bourgonje, Margery A. Connelly, Harry van Goor, Peter R. van Dijk, Robin P. F. Dullaart
Summary: This study found that higher plasma citrate levels are associated with an increased risk of cardiovascular (CV) mortality in patients with type 2 diabetes (T2D), particularly in males. These findings suggest that citrate may play an important role in the pathogenesis of T2D-related vascular complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Arno R. Bourgonje, Amarens van der Vaart, Eke G. Gruppen, Harry van Goor, Stephan J. L. Bakker, Margery A. Connelly, Peter R. van Dijk, Robin P. F. Dullaart
Summary: In this study, the association between plasma GlycA and the development of microvascular complications in patients with established type 2 diabetes (T2D) was investigated. It was found that higher levels of GlycA were associated with an increased risk of developing microvascular complications in T2D patients. This suggests that GlycA may serve as a useful biomarker for predicting diabetic complications.
Article
Biochemistry & Molecular Biology
Yang Luo, Laurent Chatre, Shaden Melhem, Zayana M. Al-Dahmani, Natalie Z. M. Homer, Anneke Miedema, Leo E. Deelman, Matthew R. Groves, Martin Feelisch, Nicholas M. Morton, Amalia Dolga, Harry van Goor
Summary: This study reveals that TST deficiency leads to disturbances in the reactive species interactome in the brain cortex, resulting in altered ROS and RSS (specifically, polysulfide) generation, as well as mitochondrial OXPHOS remodeling. These changes are associated with abnormal Nrf2-Keap1 expression and thiol-dependent antioxidant function. Tst-/- mice exhibit lower antioxidant capacity compared to wildtype controls when challenged with the redox-active herbicide paraquat.
Article
Medicine, General & Internal
Yehya Al-Adwi, Isabella Maria Atzeni, Berber Doornbos-van der Meer, Marcel John van der Leij, Rita Delphine Maiko Varkevisser, Alja Stel, Wim Timens, Christiaan Tji Gan, Harry van Goor, Johanna Westra, Douwe Johannes Mulder
Summary: This study assessed the use of CXCL10 as a predictive biomarker for new onset of SSc-ILD. The findings showed that serum CXCL10 levels were higher in SSc-ILD patients compared to SSc patients without ILD. Survival analysis indicated that baseline CXCL10 levels >78.5 pg/ml had a 2.74-fold increased risk of developing new onset of ILD.
Review
Biochemistry & Molecular Biology
R. Loveikyte, A. R. Bourgonje, H. van Goor, G. Dijkstra, A. E. van der Meulen-de Jong
Summary: This article discusses the effects of anemia and iron deficiency on patients with Inflammatory Bowel Disease (IBD), emphasizing the importance of treatment. Current data are limited and inconsistent, and further research is necessary to determine the impact of anemia and iron therapy on the redox status and intestinal microbiota.
