Article
Multidisciplinary Sciences
Mariana Borsa, Niculo Barandun, Fabienne Graebnitz, Isabel Barnstorf, Nicolas S. Baumann, Katharina Pallmer, Samira Baumann, Dominique Stark, Miroslav Balaz, Nathalie Oetiker, Franziska Wagen, Christian Wolfrum, Anna Katharina Simon, Nicole Joller, Yves Barral, Roman Spoerri, Annette Oxenius
Summary: Impaired asymmetric cell division in CD8(+) T cells during aging can be rescued by transient mTOR inhibition, restoring expansion and memory potential of cellular progenies. Virtual memory T cells (T-VM cells) in aged individuals display unique proliferation and metabolic profiles, retaining the ability to divide asymmetrically and having increased memory potential.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Casimiro Luca Gigliotti, Elena Boggio, Francesco Favero, Danny Incarnato, Claudio Santoro, Salvatore Oliviero, Jose Maria Rojo, Silvia Zucchelli, Francesca Persichetti, Gianluca Baldanzi, Umberto Dianzani, Davide Cora
Summary: ICOS and CD28 costimulatory signals play distinct roles in the activation of naive T cells by modulating different sets of immunological and immunometabolic genes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Muhammad Daud, Prasad Dasari, Marion Adelfinger, Daniela Langenhorst, Jasmin Lother, Dragana Slavkovic-Lukic, Carsten Berges, Michaela Kruhm, Annette Galler, Cathrin Schleussner, Christian H. Luther, Karl Alberter, Anton Althammer, Haroon Shaikh, Niklas Pallmann, Jochen Bodem, Mohammed El-Mowafy, Andreas Beilhack, Marcus Dittrich, Max S. Topp, Peter F. Zipfel, Niklas Beyersdorf
Summary: To gain a better understanding of life-threatening fungal infections caused by Candida albicans, our study conducted in silico screening to identify protein interactions between the fungus and the host. We discovered that the human CD4 binds to the C. albicans protein enolase 1 (Eno1), which affects the immune response and cytokine secretion. This interaction modulates CD4(+) T-cell responses, favoring the fungus.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Hematology
Dalia E. Gaddis, Lindsey E. Padgett, Runpei Wu, Anh Nguyen, Chantel McSkimming, Huy Q. Dinh, Daniel J. Araujo, Angela M. Taylor, Coleen A. McNamara, Catherine C. Hedrick
Summary: The study found dysregulated expression of metabolism genes in CD4 T cells from atherosclerotic mice, and impaired glucose uptake, proliferation, and activation in these cells. Furthermore, a reduction in naive CD4 T cells and their proliferative capacity was observed in subjects with high cardiovascular disease, highlighting the dysfunction in CD4 T-cell metabolism and immune responses during atherosclerosis. Targeting metabolic pathways within naive CD4 T cells could offer novel therapeutic approaches for improving CD4 T-cell responses against atheroprogression.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Cell Biology
David A. Lewis, Tony Ly
Summary: CD8(+) T cells are crucial in immunity and immuno-oncology, as they undergo complex cellular growth, cell cycle entry, and differentiation to produce antigen-specific cytotoxic T lymphocytes. Some activated T cells will differentiate into memory T cells which are essential in adaptive immunity. This review explores the control of cell cycle entry in CD8(+) T cells and the interaction between these mechanisms and pathways regulating immunological phenotypes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Muhammad Munir Iqbal, Michael Serralha, Parwinder Kaur, David Martino
Summary: T-cell activation induces specific gene expression programs that regulate energy generation, biosynthesis, cell cycle progression, and cell differentiation. This study used omni ATAC-seq method to characterize chromatin changes induced by T-cell activation. The research identified thousands of chromatin accessibility peaks associated with T-cell activation, with significant changes in gene expression related to cell cycle regulation, metabolism, and inflammatory response pathways.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Aditi Sood, Marie-Eve Lebel, Mengqi Dong, Marilaine Fournier, Suzanne J. Vobecky, Elie Haddad, Jean-Sebastien Delisle, Judith N. Mandl, Nienke Vrisekoop, Heather J. Melichar
Summary: Studies show that CD5 levels correlate with TCR signal strength in human naive CD4(+) T cells, marking functional heterogeneity and dominance of CD5(hi) T cells in the memory compartment. Differences in gene expression and cytokine production between CD5(lo) and CD5(hi) naive human CD4(+) T cells are in line with observations in mice, suggesting potential for improving adoptive cell therapies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Allison M. Meadows, Kim Han, Komudi Singh, Antonio Murgia, Ben D. McNally, James A. West, Rebecca D. Huffstutler, Tiffany M. Powell-Wiley, Yvonne Baumer, Julian L. Griffin, Michael N. Sack
Summary: Caloric deprivation interventions such as intermittent fasting and caloric restriction have positive effects on metabolic and inflammatory diseases. When subjected to a 24-hour fast, both innate and adaptive immune cell responsiveness is reduced, and this effect can be transferred through serum. Metabolomic and lipidomic analysis of serum extracted after a 24-hour fast and re-feeding revealed metabolite-sensing GPCRs as crucial mediators of fasting-mediated immune modulation. The elevated levels of N-arachidonylglycine (NAGly), a putative GPR18 ligand, during fasting attenuate CD4(+)T cell responsiveness and reduce inflammatory cytokines levels in obese subjects, suggesting its role in regulating nutrient-level dependent inflammation associated with metabolic disease.
Article
Biology
Drew Wilfahrt, Rachael L. Philips, Jyoti Lama, Monika Kizerwetter, Michael Jeremy Shapiro, Shaylene A. McCue, Madeleine M. Kennedy, Matthew J. Rajcula, Hu Zeng, Virginia Smith Shapiro
Summary: The absence of HDAC3 in CD4(+) T cells results in increased cholesterol efflux during activation, which in turn affects cell proliferative capacity.
Article
Immunology
Haoxiao Chang, Hengri Cong, Huabing Wang, Li Du, De-Cai Tian, Yuetao Ma, Yun Xu, Yupeng Wang, Linlin Yin, Xinghu Zhang
Summary: This study revealed alterations in naive CD4 T cell homeostasis and unique characteristics of the thymus in NMOSD patients, providing new insights into the immunological mechanisms underlying severe disease in NMOSD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Wenjing Yang, Han Liu, Leiqi Xu, Tianming Yu, Xiaojing Zhao, Suxia Yao, Qihong Zhao, Sean Barnes, Steven M. Cohn, Sara M. Dann, Hongjie Zhang, Xiuli Zuo, Yanqing Li, Yingzi Cong
Summary: This study demonstrates the role of GPR120 in regulating intestinal CD4(+) T cell production of IL10 to inhibit colitis development, indicating GPR120 as a potential therapeutic target for treating inflammatory bowel diseases.
Article
Multidisciplinary Sciences
Fabienne Mazerolles, Frederic Rieux-Laucat
Summary: The expression of co-signalling receptors on T cells plays a crucial role in regulating T cell responses, and an imbalance between activating and inhibitory signals may lead to autoimmunity. Research showed that activated TEFFs and TREGs express different co-signalling receptors, and the expression of PD-L1 on activated TEFFs is correlated with their proliferation.
Article
Immunology
Patrick M. McTernan, Danielle E. Levitt, David A. Welsh, Liz Simon, Robert W. Siggins, Patricia E. Molina
Summary: This study found that ethanol disrupts CD4(+) T cell differentiation, increasing pro-inflammatory cells and decreasing immunosuppressive cells, as well as affecting CD4(+) T cell immunometabolism and impairing mitochondrial repair processes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Nail Benallegue, Hania Kebir, Richa Kapoor, Alexis Crockett, Cen Li, Lara Cheslow, Mohamed S. Abdel-Hakeem, James Gesualdi, Miles C. Miller, E. John Wherry, Molly E. Church, M. Andres Blanco, Jorge Alvarez
Summary: The study reveals the previously unrecognized role of the endogenous hedgehog signaling pathway in regulating pathogenic inflammation within the central nervous system. By targeting CD4 T cells and modulating the production of inflammatory cytokines, the hedgehog pathway shows potential as a therapeutic strategy to limit the progression of ongoing neuroinflammation. Systemic administration of a hedgehog agonist after disease onset effectively halts disease progression and reduces neuroinflammation and associated neuropathology.
Article
Immunology
Aimin Gong, Long Mi, Fangzhi Wei, Yanping Zhuang, Yitian Song, Chengdan Pan, Xuan Zhang, Guiling Lin, Zhiquan Wu, Ying Liu
Summary: From the experimental study, it was found that the expression of miR-137 was downregulated and the expression of AMPK was upregulated in CD4+ T cells of systemic lupus erythematosus (SLE) patients. Further experiments demonstrated that miR-137 inhibited the pyroptosis of CD4+ T cells in SLE patients through modulating the AMPK pathway. These findings suggest the important role of miR-137 in the diagnosis and treatment of SLE.
JOURNAL OF IMMUNOLOGY RESEARCH
(2023)
Article
Cell Biology
Lukas Krasny, Philip Bland, Jessica Burns, Nadia Carvalho Lima, Peter T. Harrison, Laura Pacini, Mark L. Elms, Jian Ning, Victor Garcia Martinez, Yi-Ru Yu, Sophie E. Acton, Ping-Chih Ho, Fernando Calvo, Amanda Swain, Beatrice A. Howard, Rachael C. Natrajan, Paul H. Huang
DISEASE MODELS & MECHANISMS
(2020)
Article
Oncology
Lidia M. Fernandez-Sevilla, Jaris Valencia, Miguel A. Flores-Villalobos, Africa Gonzalez-Murillo, Rosa Sacedon, Eva Jimenez, Manuel Ramirez, Alberto Varas, Angeles Vicente
JOURNAL OF PATHOLOGY
(2020)
Article
Immunology
Alberto Vazquez, Lidia M. Fernandez-Sevilla, Eva Jimenez, David Perez-Cabrera, Rosa Yanez, Jose Luis Subiza, Alberto Varas, Jaris Valencia, Angeles Vicente
FRONTIERS IN IMMUNOLOGY
(2020)
Letter
Hematology
Lidia M. Fernandez-Sevilla, German Belenguer, Beatriz Marti-Prado, Paula Ortiz-Sanchez, Manuel Ramirez, Alberto Varas, Isabel Farinas, Angeles Vicente
Article
Biochemistry & Molecular Biology
Marta Gomez-Ferrer, Elena Amaro-Prellezo, Akaitz Dorronsoro, Rafael Sanchez-Sanchez, Angeles Vicente, Jesus Cosin-Roger, Maria Dolores Barrachina, Maria Carmen Baquero, Jaris Valencia, Pilar Sepulveda
Summary: The EVs derived from MSCs, particularly the EVMSC-T-HIF(C), demonstrate potent immunomodulatory activity with the ability to repolarize macrophages, suppress inflammatory responses, and promote healing in colitis models. These findings suggest the therapeutic potential of EVMSC-T-HIF(C) in treating immune-mediated inflammatory diseases like Crohn's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Alejandra Bernardini, Marta Duenas, Maria Cruz Martin-Soberon, Carolina Rubio, Cristian Suarez-Cabrera, Raquel Ruiz-Palomares, Ester Munera-Maravilla, Sara Lazaro, Iris Lodewijk, Daniel Rueda, David Gomez-Sanchez, Teresa Alonso-Gordoa, Javier Puente, Alvaro Pinto, Pilar Gonzalez-Peramato, Carlos Aguado, Mercedes Herrera, Flora Lopez, Victor M. G. Martinez, Lucia Morales, Daniel Castellano, Jesus M. Paramio, Guillermo de Velasco
Summary: Metastatic urothelial carcinoma is a difficult-to-cure disease with limited treatment options. Vinflunine has shown some improvement in overall survival and is still used for patients who are refractory to chemotherapy and immunotherapy. However, there is a lack of biomarkers to identify responding patients and alternative therapies after treatment failure.
Article
Oncology
Carolina Rubio, Jose Avendano-Ortiz, Raquel Ruiz-Palomares, Viktoriya Karaivanova, Omaira Alberquilla, Rebeca Sanchez-Dominguez, Jose Carlos Casalvilla-Duenas, Karla Montalban-Hernandez, Iris Lodewijk, Marta Rodriguez-Izquierdo, Ester Munera-Maravilla, Sandra P. Nunes, Cristian Suarez-Cabrera, Miriam Perez-Crespo, Victor G. Martinez, Lucia Morales, Mercedes Perez-Escavy, Miguel Alonso-Sanchez, Roberto Lozano-Rodriguez, Francisco J. Cueto, Luis A. Aguirre, Felix Guerrero-Ramos, Jesus M. Paramio, Eduardo Lopez-Collazo, Marta Duenas
Summary: The aim of this study was to assess the effect of butyrate derivatives in treating bladder cancer (BC) and modifying the tumor microenvironment. Treatment with butyrate derivatives increased PD-L1 surface expression and reduced pluripotency molecular markers in a hybrid BC-macrophage cell population, providing a better chance of immunotherapy success for BC patients.
Article
Hematology
Lidia M. Fernandez-Sevilla, Jaris Valencia, Paula Ortiz-Sanchez, Alberto Fraile-Ramos, Pilar Zuluaga, Eva Jimenez, Rosa Sacedon, Maria V. Martinez-Sanchez, Janez Jazbec, Marusa Debeljak, Birthe Fedders, Martin Stanulla, Denis Schewe, Gunnar Cario, Alfredo Minguela, Manuel Ramrez, Alberto Varas, Angeles Vicente
Summary: A retrospective study found that BMP4 expression levels in leukemic cells could serve as a new biomarker for prognosis in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). High BMP4 expression was associated with higher relapse rates and worse survival outcomes. Furthermore, BMP4 may be a potential therapeutic target for blocking leukemic central nervous system disease.
Letter
Dermatology
Rosa Sacedon, M. Carmen de Arriba, Lucia Martinez-Santamaria, Rocio Maseda, Sara Herraiz-Gil, Eva Jimenez, Isabel Rosales, Lucia Quintana, Nuria Illera, Marta Garcia, Nora Butta, Ihosvany Fernandez-Bello, Su M. Lwin, Miguel Fernandez-Arquero, Carlos Leon, John A. Mcgrath, M. Angeles Vicente, Marcela del Rio, Raul de Lucas, Silvia Sanchez-Ramon, Maria Jose Escamez
BRITISH JOURNAL OF DERMATOLOGY
(2023)