Article
Physiology
Hongli Zeng, Xiangsheng Cai, Zhenyang Qiu, Yuchan Liang, Lu Huang
Summary: The study aimed to investigate the effects of quinoa on glucose and lipid metabolism, and the prognosis in people with impaired glucose tolerance. The results showed that adding quinoa to staple food intake significantly reduced postprandial blood glucose, improved lipid metabolism and insulin resistance, and delayed the progression of diabetes in people with impaired glucose tolerance.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Elena Succurro, Maria Adelaide Marini, Alessia Riccio, Teresa Vanessa Fiorentino, Maria Perticone, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti
Summary: This study found that deteriorated glucose homeostasis in women is associated with greater fat accumulation and worsening insulin sensitivity compared to men.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Motonori Sato, Yoshifumi Tamura, Takashi Nakagata, Yuki Someya, Hideyoshi Kaga, Nozomu Yamasaki, Mai Kiya, Satoshi Kadowaki, Daisuke Sugimoto, Hiroaki Satoh, Ryuzo Kawamori, Hirotaka Watada
Summary: The prevalence of impaired glucose tolerance (IGT) was higher in young underweight Japanese women compared to normal weight women, with those with IGT showing impaired early-phase insulin secretion, lower fitness levels, and reduced whole-body and adipose tissue insulin sensitivity levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Public, Environmental & Occupational Health
Xin Zhang, Yankun Yue, Shaobo Liu, Xiangfeng Cong, Wenjuan Wang, Jianhong Li
Summary: This study investigates the relationship between BMI and the risk of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) in Chinese adults. The results show that obesity is an important risk factor for IGT and IFG in China, and the risk of IGT increases during the overweight stage.
Article
Endocrinology & Metabolism
Kathryn J. Potter, Quitterie Reynaud, Valerie Boudreau, Florence Racine, Francois Tremblay, Annick Lavoie, Maite Carricart, Genevieve Mailhot, Isabelle Durieu, Peter A. Senior, Remi Rabasa-Lhoret
Summary: Patients meeting both criteria of indeterminate glycemia and impaired glucose tolerance have an increased risk of developing diabetes, suggesting the need for closer monitoring.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Hsuan-Wen Chou, Hao-Chang Hung, Ching-Han Lin, An-Chi Lin, Ye-Fong Du, Kai-Pi Cheng, Chung-Hao Li, Chih-Jen Chang, Hung-Tsung Wu, Horng-Yih Ou
Summary: The study revealed a negative association between Hhip concentrations and BMI, with overweight and obese individuals having lower Hhip levels. Overweight and obesity were independently associated with lower Hhip concentrations, suggesting Hhip may play a role in linking obesity and diabetes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Vittorio Picchio, Giulio Ferrero, Claudia Cozzolino, Barbara Pardini, Erica Floris, Sonia Tarallo, Xhulio Dhori, Cristina Nocella, Lorenzo Loffredo, Giuseppe Biondi-Zoccai, Roberto Carnevale, Giacomo Frati, Isotta Chimenti, Francesca Pagano
Summary: This study defines for the first time the miRNA profile in the serum of chronic exclusive heat-not-burn cigarette smokers and suggests a significant impact of heat-not-burn cigarettes on circulating miRNAs.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Procolo Di Bonito, Giuliana Valerio, Maria R. Licenziati, Giuseppina Campana, Emanuele M. del Giudice, Anna Di Sessa, Anita Morandi, Claudio Maffeis, Claudio Chiesa, Lucia Pacifico, Marco G. Baroni, Melania Manco
Summary: The study revealed a significant association between uric acid levels and markers of prediabetes, insulin resistance, and insulin sensitivity in overweight/obese youth. Higher uric acid levels were correlated with elevated markers of impaired glucose metabolism, particularly post-challenge conditions.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
Daniel C. Parker, Ma Wan, Kurt Lohman, Li Hou, Anh Tram Nguyen, Jingzhong Ding, Alain Bertoni, Steve Shea, Gregory L. Burke, David R. Jacobs, Wendy Post, David Corcoran, Ina Hoeschele, John S. Parks, Yongmei Liu
Summary: miRNAs play a role in the occurrence and development of type 2 diabetes (T2D) and are also associated with lipid levels.
Article
Food Science & Technology
Yutaka Inoue, Lianne Cormanes, Kana Yoshimura, Aiko Sano, Yumiko Hori, Ryuichiro Suzuki, Ikuo Kanamoto
Summary: This study investigated the impact of consuming apples on postprandial blood glucose and insulin levels in individuals with normal versus impaired glucose tolerance. The findings suggest that consuming an apple before a meal can help regulate blood glucose and insulin levels in both normal individuals and those with impaired glucose tolerance.
Article
Endocrinology & Metabolism
Alessia Dattilo, Giovanni Ceccarini, Gaia Scabia, Silvia Magno, Lara Quintino, Caterina Pelosini, Guido Salvetti, Roberto Cusano, Matteo Massidda, Lucia Montanelli, Donatella Gilio, Gianluca Gatti, Alessandro Giacomina, Mario Costa, Ferruccio Santini, Margherita Maffei
Summary: Lipodystrophy (LD) is a rare group of disorders characterized by the loss of white adipose tissue (WAT) and metabolic disturbances. This study found that cmiRs-320 may serve as novel biomarkers for LD, with cmiR-320a-3p abundance inversely associated with indicators of WAT function, and downregulation of cmiR-320d predicting altered liver function and increased inflammation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Wei Jia, Dong-Liang Fang, Xin-Yi Shi, Tao Lu, Chun Yang, Yan Gao
Summary: Inducible beige adipocytes may have beneficial effects on improving impaired glucose metabolism and enhancing energy expenditure, even in the absence of interscapular brown adipose tissue (iBAT). Data shows that beige adipocytes could partly contribute to the improvement of impaired glucose metabolism and enhancing glucose uptake in iBAT-removal animal models. Additionally, inducible beige adipocytes may have different mechanisms to improve glucose metabolism and enhance energy expenditure when iBAT is lacking.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Endocrinology & Metabolism
Ariadni Spyroglou, Laura Handgriff, Lisa Mueller, Paul Schwarzlmueller, Mirko Parasiliti-Caprino, Carmina Teresa Fuss, Hana Remde, Anna Hirsch, Samuel Matthew O'Toole, Moe Thuzar, Luigi Petramala, Claudio Letizia, Elisa Deflorenne, Laurence Amar, Rok Vrckovnik, Tomaz Kocjan, Catherine D. Zhang, Dingfeng Li, Sumitabh Singh, Takuyuki Katabami, Takashi Yoneda, Masanori Murakami, Norio Wada, Nobuya Inagaki, Marcus Quinkler, Ezio Ghigo, Mauro Maccario, Michael Stowasser, William M. Drake, Martin Fassnacht, Irina Bancos, Martin Reincke, Mitsuhide Naruse, Felix Beuschlein
Summary: APA patients have higher plasma aldosterone levels, while female patients with IHA show worse metabolic parameters linked to abnormal cortisol levels. Female patients may experience deterioration in lipid profile after adrenalectomy.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Babu Kavitha, Sampathkumar Ranganathan, Sundaramoorthy Gopi, Umashankar Vetrivel, Nagarajan Hemavathy, Viswanathan Mohan, Venkatesan Radha
Summary: Functional protein analyses and structural prediction were conducted to determine the molecular basis for 14 HNF1A gene variants in 20 patients with monogenic diabetes. 4 variants were classified as pathogenic, 6 as likely pathogenic, 3 as variants of uncertain significance, and 1 as benign. Patients with pathogenic/likely pathogenic variants were able to switch from insulin to sulfonylureas (SU) for treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Microbiology
Isabel Huber-Ruano, Enrique Calvo, Jordi Mayneris-Perxachs, M-Mar Rodriguez-Pena, Victoria Ceperuelo-Mallafre, Lidia Cedo, Catalina Nunez-Roa, Joan Miro-Blanch, Maria Arnoriaga-Rodriguez, Aurelie Balvay, Claire Maudet, Pablo Garcia-Roves, Oscar Yanes, Sylvie Rabot, Ghjuvan Micaelu Grimaud, Annachiara De Prisco, Angela Amoruso, Jose Manuel Fernandez-Real, Joan Vendrell, Sonia Fernandez-Veledo
Summary: The study reveals that gut microbiota is a significant source of elevated succinate in obese individuals. Therapeutic treatments with selected bacteria can reduce circulating succinate levels in obese mice, and Odoribacter laneus shows promise as a probiotic to deplete succinate and improve glucose tolerance.
Article
Endocrinology & Metabolism
Sureshkumar Pichakacheri, Venkatesan Radha, Viswanathan Mohan, Sidharth S. Kumar, Aishwarya Suresh Babu
Summary: Maternally inherited diabetes and deafness (MIDD) is a rare form of diabetes caused by a mutation in mitochondrial DNA, leading to impaired mitochondrial function. It is often misdiagnosed as type 1 or type 2 diabetes, which can have negative long-term effects. Early differentiation and correct treatment are crucial.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2023)
Article
Pharmacology & Pharmacy
Raman Puri, Vimal Mehta, P. Barton Duell, S. K. Wangnoo, Ashu Rastogi, V. Mohan, Abdul Hamid Zargar, Sanjay Kalra, Abhay Kumar Sahoo, S. S. Iyengar, Jamal Yusuf, Saibal Mukhopadhyay, Mani Kant Singla, Altamash Shaikh, Sunil Kohli, Sandeep Mathur, Sachin Jain, S. N. Narasingan, Vipul Gupta, Rajeev Agarwala, Vinod Mittal, Amit Varma, Jayant Kumar Panda, Sadanand Shetty, Madhur Yadav, A. Muruganathan, Pradeep Dabla, K. K. Pareek, P. C. Manoria, Rashmi Nanda, G. B. Sattur, A. K. Pancholia, Nathan D. Wong
Summary: According to the National Lipid Association's report in 2022, an estimated 74 million people in India had diabetes in 2021, mostly type 2 diabetes. Over 50% of diabetes patients were undiagnosed, and over 90% had dyslipidemia associated with accelerated development of atherosclerotic cardiovascular disease (ASCVD). Indian individuals with diabetes have distinct characteristics compared to Western populations, including earlier onset, higher prevalence of metabolic syndrome features, more prevalent ASCVD risk factors, and a more aggressive course of ASCVD complications. In response to the unique features of diabetes and diabetic dyslipidemia in Indian individuals, the Lipid Association of India developed an expert consensus statement to guide the management of diabetic dyslipidemia in this high-risk population. The recommendations were based on a series of 165 webinars conducted by the Lipid Association of India from May 2020 to July 2021, involving 155 experts in endocrinology and cardiology and an additional 2880 physicians.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Health Care Sciences & Services
Kara Suvada, Mohammed K. Ali, Lydia Chwastiak, Subramani Poongothai, Karl M. F. Emmert-Fees, Ranjit Mohan Anjana, Rajesh Sagar, Radha Shankar, Gumpeny R. Sridhar, Madhu Kasuri, Aravind R. Sosale, Bhavana Sosale, Deepa Rao, Nikhil Tandon, K. M. Venkat Narayan, Viswanathan Mohan, Shivani A. Patel
Summary: This study investigated the effects of collaborative care on patients with depression and diabetes over a period of 36 months. The results showed that there were no differences in improvements in multiple or single risk factors at 36 months between the collaborative care and usual care groups. However, patients who had achieved improvements in depressive symptoms and glucose levels at 12 months were more likely to maintain these improvements at 36 months.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Rajagopal Gayathri, Kuzhandhaivelu Abirami, Natarajan Kalpana, Valangaiman Sriram Manasa, Vasudevan Sudha, Shanmugam Shobana, Raman Ganesh Jeevan, Vasudevan Kavitha, Karthikeyan Parkavi, Ranjit Mohan Anjana, Ranjit Unnikrishnan, Kuppan Gokulakrishnan, D. Annette Beatrice, Kamala Krishnaswamy, Rajendra Pradeepa, Richard D. Mattes, Jordi Salas-Salvado, Walter Willett, Viswanathan Mohan
Summary: This study suggests that daily consumption of almonds can increase the intake of mono unsaturated fatty acids, reduce carbohydrate calories, decrease insulin resistance, improve insulin sensitivity, and lower serum cholesterol in overweight Asian Indian adults.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Charlotte Steenblock, Nicole Toepfner, Felix Beuschlein, Nikolaos Perakakis, Ranjit Mohan Anjana, Viswanathan Mohan, Nitish R. Mahapatra, Stefan R. Bornstein
Summary: The SARS-CoV-2 virus can infect various tissues including endocrine organs, leading to organ damage or dysfunction. The main receptor ACE2 is expressed in cells of the endocrine system, and the virus has been found in post-mortem samples from COVID-19 patients. The exact mechanisms are not fully understood and further research is needed. Additionally, endocrine diseases may impact the severity of COVID-19, highlighting the importance of reducing their prevalence or improving treatment in the future.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Garudam Raveendiran Aarthi, Thaharullah Shah Mehreen Begum, Suzana Al Moosawi, Dian Kusuma, Harish Ranjani, Rajendra Paradeepa, Venkatasubramanian Padma, Viswanathan Mohan, Ranjit Mohan Anjana, Daniela Fecht
Summary: Our study systematically reviewed the literature on the associations between built environment characteristics and type 2 diabetes (T2D) in Asia. The findings showed that several built environment attributes, such as urban green space, walkability, food environment, and air pollution, were significantly related to T2D in Asia. Additionally, particulate matter, nitrogen dioxide, and sulfur dioxide were strongly associated with T2D risk. This highlights the importance of considering the built environment in relation to T2D prevention and public health planning.
Article
Medicine, General & Internal
Aastha Aggarwal, Ranganathan Rama, Preet K. Dhillon, Mohan Deepa, Dimple Kondal, Naveen Kaushik, Dipika Bumb, Ravi Mehrotra, Betsy A. Kohler, Viswanathan Mohan, Theresa W. Gillespie, Alpa Patel, Swaminathan Rajaraman, Dorairaj Prabhakaran, Kevin C. Ward, Michael Goodman
Summary: To test a systematic alternative approach, a population-based cohort in Chennai, India was linked with a local population-based cancer registry, and the study found a high level of agreement between self-reported diagnoses and registry-based diagnoses. These findings provide important insights for future cancer surveillance and research in low-income and middle-income countries.
Article
Endocrinology & Metabolism
Ramasamy Aarthy, Kathryn Aston-Mourney, Anandakumar Amutha, Antonina Mikocka-Walus, Ranjit Mohan Anjana, Ranjit Unnikrishnan, Saravanan Jebarani, Ulagamathesan Venkatesan, Sundaramoorthy Gopi, Venkatesan Radha, Viswanathan Mohan
Summary: This study investigates the prevalence, clinical features, and complications of MODY in a tertiary diabetes center in South India and compares them with T1D and T2D. The results show a high prevalence of retinopathy and nephropathy in MODY patients, highlighting the importance of early diagnosis and better diabetes control for individuals with MODY.
PRIMARY CARE DIABETES
(2023)
Editorial Material
Endocrinology & Metabolism
Michael Bergman, Martin Buysschaert, Antonio Ceriello, Akhtar Hussain, Viswanathan Mohan, Giorgio Sesti, Jaakko Tuomilehto
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Stephen Twigg, Soo Lim, Seung-Hyun Yoo, Liming Chen, Yuqian Bao, Alice Kong, Ester Yeoh, Siew Pheng Chan, Jeremyjones Robles, Viswanathan Mohan, Neale Cohen, Margaret McGill, Linong Ji
Summary: Diabetes is highly prevalent worldwide and in the APAC region, and glucose monitoring is crucial for optimizing diabetes management. The APAC Diabetes Care Advisory Board conducted a survey and expert panel meeting to explore glucose monitoring patterns, patient profiles, benefits, challenges, and potential solutions in the region. The results will guide the formulation of APAC-specific consensus guidelines for continuous glucose monitoring in people with diabetes.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Neurosciences
Athira Anirudhan, George Chandy Mattethra, Khalid J. Alzahrani, Hamsa Jameel Banjer, Fuad M. Alzahrani, Ibrahim F. Halawani, Shankargouda Patil, Ashutosh Sharma, Prabu Paramasivam, Shiek S. S. J. Ahmed
Summary: Pesticides kill neurons, but the mechanism leading to selective dopaminergic loss in Parkinson's disease (PD) is unknown. Understanding the pesticide's effect on dopaminergic neurons (DA) can help to screen and treat PD. Through molecular docking, protein networks, regulatory pathways, and prioritization of key pesticide-regulating proteins, the study reveals the mechanisms of eleven crucial pesticides and their impact on gene expression in pesticide-exposed PD patients.
Review
Multidisciplinary Sciences
Venkatesan Radha, Sekar Kanthimathi, Anandakumar Amutha, Balaji Bhavadharini, Ranjit Mohan Anjana, Ranjit Unnikrishnan, Viswanathan Mohan
Summary: Monogenic diabetes refers to single gene disorders that cause impairment of insulin secretion and result in diabetes. This study focused on the prevalence of two common forms of monogenic diabetes, maturity onset of diabetes of the young (MODY) and neonatal diabetes mellitus (NDM), in South Asians. The aim was to identify the number of reported cases of monogenic diabetes in South Asian countries.
JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE
(2023)
Review
Multidisciplinary Sciences
Viswanathan Mohan, Kuzhandhaivelu Abirami, Valangaiman Sriram Manasa, Anandakumar Amutha, Balaji Bhavadharini, Rinky Rajput, Nagarajan Lakshmipriya, Chowdary Sruthi, Ranjit Mohan Anjana, Ranjit Unnikrishnan, Sudha Vasudevan, Kamala Krishnaswamy
Summary: A systematic review and meta-analysis found that total and fermented dairy products, especially plain yogurt, are inversely associated with new onset type 2 diabetes, while milk, cheese, and other dairy products have a neutral effect. Subgroup analysis by ethnicity showed that total dairy products and milk have protective effects on diabetes in Asian populations, while fermented dairy products are protective in Western populations. The analysis by age demonstrated that the consumption of high-fat dairy products predisposes younger adults to type 2 diabetes.
JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE
(2023)
Article
Geriatrics & Gerontology
Patricio Lopez-Jaramillo, Diego Gomez-Arbelaez, Daniel Martinez-Bello, Marc Evans M. Abat, Khalid F. Alhabib, Alvaro Avezum, Olga Barbarash, Jephat Chifamba, Maria L. Diaz, Sadi Gulec, Noorhassim Ismail, Romaina Iqbal, Roya Kelishadi, Rasha Khatib, Fernando Lanas, Naomi S. Levitt, Yang Li, Viswanathan Mohan, Prem K. Mony, Paul Poirier, Annika Rosengren, Biju Soman, Chuangshi Wang, Yang Wang, Karen Yeates, Rita Yusuf, Afzalhussein Yusufali, Katarzyna Zatonska, Sumathy Rangarajan, Salim Yusuf
Summary: The TyG index is associated with cardiovascular diseases and mortality, especially in Asia. It is significantly related to the risk of cardiovascular diseases, myocardial infarction, stroke, and type 2 diabetes, indicating that insulin resistance plays a promoting role in the development of these diseases.
LANCET HEALTHY LONGEVITY
(2023)
Article
Endocrinology & Metabolism
Viswanathan Mohan, Ganesan Uma Sankari, Anandakumar Amutha, Ranjit Mohan Anjana, Saravanan Jeba Rani, Ranjit Unnikrishnan, Ulagamathesan Venkatesan, Coimbatore Subramanian Shanthi Rani
Summary: This study aimed to compare the clinical and biochemical profile, as well as the prevalence of complications, between childhood/adolescent-onset and adult-onset type 1 diabetes (T1D) at a diabetes center in south India. The data of 5,578 individuals diagnosed with T1D and treated at the center between 1991 and 2021 were analyzed. The results showed that individuals with adult-onset T1D had a higher prevalence of microvascular complications than those with childhood/adolescent-onset T1D, and GAD-negative individuals in the adult-onset group had a higher percentage of retinopathy and chronic kidney disease.
ACTA DIABETOLOGICA
(2023)