Article
Pharmacology & Pharmacy
Daniele Romani Miksza, Giuliana Regina Biazi, Isabele Goncalves Frasson, Winny Beatriz de Souza Galia, Laura Socio Ferraz, Brenda Francisconi Diaz, Mirian Ayumi Kurauti, Carine Marmentini, Cecilia Edna Mareze-Costa, Sidney Barnabe Peres, Priscila Cassolla, Gisele Lopes Bertolini, Roberto Barbosa Bazotte, Helenir Medri de Souza
Summary: This study investigated the effects of insulin and pioglitazone on cancer cachexia. The results showed that the combined treatment with insulin and pioglitazone was more effective in preventing cachexia in rats, through a synergistic mechanism linked to improved insulin sensitivity.
PHARMACOLOGICAL REPORTS
(2023)
Article
Geriatrics & Gerontology
Jorne Ubachs, Janine Ziemons, Zita Soons, Romy Aarnoutse, David P. J. Dijk, John Penders, Ardy Helvoort, Marjolein L. Smidt, Roy F. P. M. Kruitwagen, Lieke Baade-Corpelijn, Steven W. M. Olde Damink, Sander S. Rensen
Summary: Cancer cachexia is a condition characterized by negative energy balance, muscle and adipose tissue wasting, insulin resistance, and systemic inflammation. This study found altered gut microbiota composition and decreased SCFA levels in cachectic cancer patients. Additionally, inflammatory parameters were found to be correlated with certain bacterial abundances.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Geriatrics & Gerontology
Silvia Catanese, Carl Friedrich Beuchel, Teresa Sawall, Florian Lordick, Rommy Brauer, Markus Scholz, Uta Ceglarek, Ulrich T. Hacker
Summary: Cancer patients undergoing systemic treatment showed significant alterations in amino acid levels and acylcarnitine patterns, which could be predictive for weight loss. Baseline acylcarnitine analysis was valuable in studying energy metabolism related to cancer cachexia. Pathway analyses indicated the involvement of serine/glycine and tryptophan pathways in this condition.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Psychology, Multidisciplinary
Gabriela Nazar, Carlos-Maria Alcover, Fabian Lanuza, Ana Maria Labrana, Karina Ramirez-Alarcon, Claudia Troncoso-Pantoja, Ana Maria Leiva, Carlos Celis-Morales, Fanny Petermann-Rocha
Summary: This study aimed to examine the agreement between BMI-based nutritional status and perceived nutritional status and explore the association between weight perception accuracy and weight control practices in the Chilean adult population. The results showed fair agreement between BMI-based and perceived nutritional status in the total sample, with higher accuracy in women, younger respondents, and those with higher education and income. Individuals with overweight or obesity tended to underestimate their nutritional status. Weight loss behaviors were more related to perceived nutritional status rather than BMI-based status in all groups.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Medicine, Research & Experimental
Lauri O. Byerley, Hsiao-Man Chang, Brittany Lorenzen, Jessie Guidry, W. Elaine Hardman
Summary: This study investigated the effect of walnuts on a transplantable carcinoma rat model and found that walnuts did not slow or prevent tumor growth. Additionally, consuming walnuts did not alter the weight and fat mass loss or metabolic dysregulation in the TB model.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Nicolien C. de Clercq, Tom van den Ende, Andrei Prodan, Robert Hemke, Mark Davids, Helle K. Pedersen, Henrik B. Nielsen, A. K. Groen, Willem M. de Vos, Hanneke W. M. van Laarhoven, Max Nieuwdorp
Summary: A study on fecal microbiota transplantation in cachectic patients with gastroesophageal cancer showed that allogenic FMT did not improve cachexia, but led to better disease control rate, overall survival, and progression-free survival. Patients in the allogenic group also experienced significant changes in fecal microbiota composition after FMT. This suggests a potential benefit of FMT in improving treatment response and survival in advanced gastroesophageal cancer patients.
CLINICAL CANCER RESEARCH
(2021)
Article
Nutrition & Dietetics
Magdalena Dettlaff-Dunowska, Michal Brzezinski, Agnieszka Zagierska, Anna Borkowska, Maciej Zagierski, Agnieszka Szlagatys-Sidorkiewicz
Summary: The problem of overweight and obesity is increasing in the population and is associated with metabolic disorders and increased risk of death. This study assessed the changes in body composition and physical fitness in children participating in a weight-loss program and found a possible relationship between changes in body composition and improvements in fitness. Both BIA and DXA methods were equally useful for measuring body composition.
Article
Nutrition & Dietetics
Madoka Tokuyama, Jun Seino, Keishoku Sakuraba, Yoshio Suzuki
Summary: The study found that low energy availability occurred during a rugby summer camp, and serum iron levels and TSAT may be better predictors of LEA.
Article
Endocrinology & Metabolism
Alic Bellicha, Marleen A. van Baak, Francesca Battista, Kristine Beaulieu, John E. Blundell, Luca Busetto, Eliana V. Carraca, Dror Dicker, Jorge Encantado, Andrea Ermolao, Nathalie Farpour-Lambert, Adriyan Pramono, Euan Woodward, Jean-Michel Oppert
Summary: This overview summarizes the positive effects of exercise training on weight loss and body composition changes in overweight or obese adults, showing significant reductions in fat and visceral fat. Resistance training can help reduce muscle mass loss during weight loss. However, exercise did not show significant effects on weight maintenance.
Article
Biophysics
Marie Matos, Eric J. Perreault, Daniel Ludvig
Summary: Ankle sprains are common musculoskeletal injuries with a significant percentage developing into chronic ankle instability. This study found that weight-bearing affects frontal plane ankle impedance, with ankle stiffness increasing proportionally with weight due to both increased loading on the joint and muscle activation. Additionally, men typically exhibited greater stiffness than women in the majority of weight-bearing range.
JOURNAL OF BIOMECHANICS
(2021)
Article
Nutrition & Dietetics
Sunil K. Saini, Arashdeep Singh, Manisha Saini, Marta Gonzalez-Freire, Christiaan Leeuwenburgh, Stephen D. Anton
Summary: Time-restricted eating (TRE), a form of intermittent fasting, has been shown to provide health benefits by influencing the expression of circulatory miRNAs. This study aimed to examine the effects of a 4-week TRE regimen on global circulatory miRNA in older overweight participants. The results demonstrated that TRE downregulated miRNA, which could inhibit cell growth pathways and activate cell survival pathways, potentially promoting healthy aging.
Review
Endocrinology & Metabolism
Pablo Ranea-Robles, Jens Lund, Christoffer Clemmensen
Summary: Experimental overfeeding is a powerful method to study the defense mechanisms against weight gain and investigate the relationship between energy balance and obesity development, as well as the pathogenesis of metabolic liver diseases and the links with infection biology.
MOLECULAR METABOLISM
(2022)
Article
Peripheral Vascular Disease
Nermin Ahmed, Alana Kassis, Jena Malone, Jodie Yang, Esraa Zamzami, An-Hsuan Lin, Scott M. Gordon, Ming C. Gong, Michael Bardo, Carolina Dalmasso, Analia S. Loria
Summary: This study examined the offspring of pregnant rats exposed to morphine and found that they had an increased risk of cardiovascular disease in adulthood, as well as dysregulation of the endogenous opioid system. Specifically, the offspring showed impaired physical growth, elevated blood pressure, vascular dysfunction, and metabolic abnormalities. These findings suggest that morphine exposure during pregnancy can have negative effects on the cardiovascular development of the offspring.
Article
Biochemistry & Molecular Biology
Liang Tang, Wenxin Cao, Tingting Zhao, Kang Yu, Lijun Sun, Jianzhong Guo, Xiushan Fan, Dean Ta
Summary: Weight-bearing exercise can effectively prevent skeletal muscle atrophy induced by estrogen deficiency in rats by activating Akt, upregulating mTOR, and downregulating MSTN and its receptor ActRIIB and FoxO1 expressions, respectively.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Geriatrics & Gerontology
Hailun Xie, Guotian Ruan, Lishuang Wei, Heyang Zhang, Yizhong Ge, Shiqi Lin, Mengmeng Song, Qi Zhang, Xi Zhang, Ziwen Wang, Chenan Liu, Jinyu Shi, Xiaoyue Liu, Ming Yang, Xin Zheng, Yue Chen, Xiaowei Zhang, Li Deng, Hanping Shi
Summary: The modified weight loss grading system (mWLGS) was developed and validated in Chinese cancer patients, showing better prognostic differentiation for predicting the prognosis, especially in lung and gastrointestinal cancers. High-grade mWLGS was associated with poor quality of life and adverse 90-day outcomes.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Hematology
Lucas Kuehne, Jessica Kaufeld, Linus A. Voelker, Ralph Wendt, Ulf Schoenermarck, Holger Haegele, Thomas Osterholt, Dennis A. Eichenauer, Markus Bieringer, Anke Bergwelt-Baildon, Michael Fischereder, Veronika Buxhofer-Ausch, Jan Menne, Paul T. Brinkkoetter, Paul Knoebl
Summary: This study analyzed the risks and benefits of an alternate-day dosing regimen of caplacizumab in 25 iTTP patients. The results showed that alternate-day dosing appeared feasible and led to persisting normal platelet counts in most patients. However, some patients experienced exacerbations or relapses that required daily administration of caplacizumab.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Transplantation
Kathrin Eller, Paul Knoebl, Sevcan A. Bakkaloglu, Jan J. Menne, Paul T. Brinkkoetter, Leonie Grandt, Ursula Thiem, Paul Coppo, Marie Scully, Maria C. Haller
Summary: Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease, and the clinical practice guidelines published by ISTH in 2020 have been endorsed and emphasized by the European Renal Best Practice Working Group.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Nutrition & Dietetics
Gabriela Salim de Castro, Marcia Fabia Andrade, Flaydson Clayton Silva Pinto, Jaline Zandonato Faiad, Marilia Seelaender
Summary: This systematic review and meta-analysis evaluated the effects of n-3 fatty acid supplementation on body weight and inflammatory markers in cancer cachexia patients. The results showed that n-3 had no significant effect on interleukin-6, C-reactive protein, and albumin levels. However, due to the limited number of studies and small sample size, no robust conclusions could be drawn regarding the effects on body weight. More research is needed to further evaluate the role of n-3 supplementation in cancer cachexia.
FRONTIERS IN NUTRITION
(2022)
Review
Nutrition & Dietetics
Flaydson Clayton Silva Pinto, Marcia Fabia Andrade, Guilherme Henrique Gatti da Silva, Jaline Zandonato Faiad, Ana Paula Noronha Barrere, Renata de Castro Goncalves, Gabriela Salim de Castro, Marilia Seelaender
Summary: This systematic review analyzed the studies on skeletal muscle mass in patients with COVID-19 and found an association between skeletal muscle quality and disease severity. The meta-analysis revealed lower skeletal muscle density and handgrip strength in patients with severe disease. Muscle function assessment can serve as a valuable prognostic tool for COVID-19.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, General & Internal
Marion Wiegele, Daniel Laxar, Eva Schaden, Andreas Baierl, Mathias Maleczek, Paul Knoebl, Martina Hermann, Alexander Hermann, Christian Zauner, Johannes Gratz
Summary: This study retrospectively analyzed the use of subcutaneous enoxaparin for systemic anticoagulation in COVID-19 patients undergoing extracorporeal membrane oxygenation. The results showed that enoxaparin was associated with lower rates of thromboembolic and hemorrhagic events compared to unfractionated heparin. The findings suggest that subcutaneous enoxaparin may be a successful alternative for anticoagulation in these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Hematology
Olga Oleshko, Sonja Werwitzke, Annika Klingberg, Torsten Witte, Hermann Eichler, Robert Klamroth, Katharina Holstein, Christina Hart, Christian Pfrepper, Paul Knoebl, Richard Greil, Peter Neumeister, Birgit M. Reipert, Andreas Tiede
Summary: The root cause of autoantibody formation against FVIII in AHA is unclear. A diverse pattern of autoantibodies is associated with AHA, suggesting a more general breakdown of immune tolerance might be involved in its pathology.
Article
Hematology
Marie Scully, Javier de la Rubia, Katerina Pavenski, Ara Metjian, Paul Knoebl, Flora Peyvandi, Spero Cataland, Paul Coppo, Johanna A. Kremer Hovinga, Jessica Minkue Mi Edou, Rui De Passos Sousa, Filip Callewaert, Sriya Gunawardena, Julie Lin
Summary: Long-term follow-up supports the safety and efficacy of caplacizumab for iTTP and its repeated use for recurrences.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Irene Graf, Georg Greiner, Rodrig Marculescu, Karoline Gleixner, Susanne Herndlhofer, Gabriele Stefanzl, Paul Knoebl, Ulrich Jaeger, Alexander Hauswirth, Ilse Schwarzinger, Renate Thalhammer, Michael Kundi, Gregor Hoermann, Gerlinde Mitterbauer-Hohendanner, Peter Valent, Wolfgang R. Sperr
Summary: Patient-related factors, including N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, age, and the 2009 European LeukemiaNet (ELN-2009) classification, independently predict outcomes in acute myeloid leukemia (AML) patients receiving induction chemotherapy. Elevated NT-proBNP levels are associated with increased risk of induction failure, early death, and reduced overall survival (OS) in AML patients. These findings highlight the importance of considering cardiac disorders and NT-proBNP as prognostic factors in AML treatment.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Georg Gelbenegger, Ludwig Traby, Nina Rahimi, Paul Knoebl
Summary: This study presents a treatment approach for a 75-year-old male with severe Covid-19, acquired haemophilia A, and severe muscle bleeding. The treatment includes haemostatic therapy and immunosuppression. Different reagents are used to measure the activity of coagulation factor VIII, and recombinant human activated FVII and emicizumab are administered for haemostatic control. Steroids and rituximab are used for immunosuppression. The treatment is effective with no thromboembolic events.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Viviana Moresi, Alessandra Renzini, Giorgia Cavioli, Marilia Seelaender, Dario Coletti, Giuseppe Gigli, Alessia Cedola
Summary: Neurogenic muscle atrophy is a condition associated with diseases and aging, leading to reduced interaction between motoneurons and skeletal fibers. Current therapeutic approaches provide no concrete resolution. Nutritional support could play a relevant part in mitigating neurogenic muscle atrophy.
Article
Hematology
Andreas Tiede, Christina Hart, Paul Knoebl, Richard Greil, Johannes Oldenburg, Ulrich J. Sachs, Wolfgang Miesbach, Christian Pfrepper, Karolin Trautmann-Grill, Katharina Holstein, Jan Pilch, Patrick Moehnle, Christoph Schindler, Carmen Weigt, Dorothea Schipp, Marcus May, Christiane Dobbelstein, Fabius J. Pelzer, Sonja Werwitzke, Robert Klamroth
Summary: The study investigated the use of emicizumab, a factor VIIIa mimetic antibody, in preventing bleeding and deferring immunosuppression in patients with acquired haemophilia A. The results showed that emicizumab was effective in preventing bleeding and allowed patients to defer immunosuppression during the treatment period, indicating potential treatment advantages.
LANCET HAEMATOLOGY
(2023)
Article
Hematology
Linus A. Voelker, Jessica Kaufeld, Gesa Balduin, Lena Merkel, Lucas Kuehne, Dennis A. Eichenauer, Thomas Osterholt, Holger Haegele, Martin Kann, Franziska Grundmann, Benedikt Kolbrink, Kevin Schulte, Anja Gaeckler, Andreas Kribben, Kristina Boss, Sebastian A. Potthoff, Lars C. Rump, Tilman Schmidt, Anja S. Muehlfeld, Karsten Schulmann, Matthias Hermann, Jens Gaedeke, Kristin Sauerland, Joern Bramstedt, Ulrich P. Hinkel, Wolfgang Miesbach, Frederic Bauer, Timm H. Westhoff, Heike Bruck, Veronika Buxhofer-Ausch, Tobias J. Mueller, Ralph Wendt, Ana Harth, Adrian Schreiber, Evelyn Seelow, Markus Toelle, Christopher Gohlisch, Markus Bieringer, Gesa Geuther, Wolfram J. Jabs, Michael Fischereder, Anke von Bergwelt-Baildon, Ulf Schoenermarck, Paul Knoebl, Jan Menne, Paul T. Brinkkoetter
Summary: This study retrospectively reviewed the use of von Willebrand factor-directed nanobody caplacizumab in the treatment of immune thrombotic thrombocytopenic purpura (iTTP). The results showed that caplacizumab was efficacious when used in the early stages of iTTP and until partial ADAMTS13-activity remission, leading to a reduction in mortality and hospital stay.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Christian Pfrepper, Robert Klamroth, Johannes Oldenburg, Katharina Holstein, Hermann Eichler, Christina Hart, Patrick Moehnle, Kristina Schilling, Karolin Trautmann-Grill, Mohammed Alrifai, Cihan Ay, Wolfgang Miesbach, Paul Knoebl, Andreas Tiede
Summary: This study provides clinical practice recommendations on the use of emicizumab in acquired hemophilia A (AHA). The results show that emicizumab is effective for bleed prophylaxis and should be considered from the time of diagnosis. A fast-loading regimen of 6 mg/kg on day 1 and 3 mg/kg on day 2 should be used if rapid bleeding prophylaxis is required. Maintenance doses of 1.5 mg/kg once weekly should be given. Immunosuppression should be offered to eligible patients on emicizumab. Emicizumab should be discontinued when remission of AHA is achieved.
Article
Hematology
Erika Tarasco, Anne Sophie von Krogh, Radomira Hrdlickova, Thomas R. Braschler, Teresa Iwaniec, Paul N. Knoebl, Eriko Hamada, Oleg Pikovsky, Stefan Farese, Odit Gutwein, Petr Kessler, Nina H. Schultz, Charis von Auer, Jerzy Windyga, Kenneth Friedman, Ingrid Hrachovinova, James N. George, Masanori Matsumoto, Reinhard Schneppenheim, Bernhard Laemmle, Johanna Anna Kremer Hovinga
Summary: This study investigated the association between COVID-19, SARS-CoV-2 vaccination, and acute episodes in patients with hereditary TTP. The results showed that the risk of acute episodes triggered by COVID-19 seems to be higher than that following vaccination. However, it is safe for patients with hereditary TTP to receive SARS-CoV-2 vaccination.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Meeting Abstract
Hematology
W. Miesbach, P. Knoebl, R. Santoro, J. Chen, N. Kemenyash, K. A. Badejo, C. Percy, A. H. Schmaier, R. Klamroth