Article
Biochemistry & Molecular Biology
Mohamed A. Lebda, Rabab E. Mostafa, Nabil M. Taha, Eman M. Abd El-Maksoud, Hossam G. Tohamy, Soad K. Al Jaouni, Ali H. El-Far, Mohamed S. Elfeky
Summary: The study found that myrrh oil and extract significantly improved ethanol-induced oxidative damage in gastric ulcers, with the extract showing better effects in protection and treatment compared to the oil.
Article
Medicine, Research & Experimental
Sevil Arabaci Tamer, Selin Akbulut, Irem Peker Eyuboglu, Omer Erdogan, Ozge Cevik, Mustafa Akkiprik, Dilek Akakin, Berrak C. Yegen
Summary: The present study demonstrated that peripherally administered NPW has gastroprotective effects by regulating gastric blood flow, suppressing oxidant damage and inflammation, and modulating COX-induced gastroprotection. The expression of NPW is closely related to the occurrence and development of stress-induced ulcers.
Article
Pharmacology & Pharmacy
Ahmed A. J. Jabbar, Ramzi A. Mothana, Mahmood Ameen Abdulla, Fuad Othman Abdullah, Khaled Abdul-Aziz Ahmed, Rawaz Rizgar Hussen, Mohammed F. Hawwal, Omer I. Fantoukh, Sidgi Hasson
Summary: Prangos pabularia has been traditionally used as a medicinal herb for treating gastric ulcers. This study found that root extracts of Prangos pabularia have gastro-protective effects and can reduce ethanol-induced gastric lacerations. The extracts also modulate oxidative stress and inflammation, which may contribute to their therapeutic effects.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Ranran Wang, Fengjun Sun, Chunyao Ren, Liyan Zhai, Rongrong Xiong, Yi Yang, Weiqing Yang, Ruokun Yi, Chong Li, Xin Zhao
Summary: The study showed that Hunan insect tea polyphenols (HITPs) had preventive and therapeutic effects on gastric injury induced by HCl/ethanol in mice, with antioxidant properties and the ability to modulate gene expression in gastric tissues. High concentrations of HITPs were more effective in protecting against gastric injury than low concentrations, and the compounds also contained cryptochlorogenic acid, (-)-epicatechin gallate, and isochlorogenic acid C through HPLC analysis.
Article
Medicine, Research & Experimental
Chaoyi Zhou, Jing Chen, Kechun Liu, Kannan Maharajan, Yun Zhang, Linhua Hou, Jianheng Li, Ma Mi, Qing Xia
Summary: Gastric ulcer (GU) is a common digestive system disease in humans and is associated with inflammation. Isoalantolactone (IAL), a sesquiterpene lactone isolated from Radix Inulae, has been found to have anti-inflammatory potential. However, the pharmacological effects of IAL on GU and its mechanism of action are still unclear. In this study, the anti-inflammatory potential of IAL on GU was investigated through in vitro and in vivo experiments. The key targets and pathways involved in the anti-GU effects of IAL were also identified using network pharmacology and molecular docking studies.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Chemical
Ahmed Aj Jabbar, Fuad O. Abdullah, Kamaran Abdoulrahman, Yaseen Galali, Ibrahim Abdel Aziz Ibrahim, Abdullah R. Alzahrani, Rawaz Rizgar Hassan
Summary: This study investigates the gastroprotective effects of P. decaisnei on ethanol-induced ulcers, showing its potential as a protective and therapeutic agent for gastric ulcers and stomach lesions.
Article
Engineering, Chemical
Suhayla H. Shareef, Morteta H. Al-Medhtiy, Ibrahim Abdel Aziz Ibrahim, Abdullah R. Alzahrani, Ahmed Aj Jabbar, Yaseen Galali, Nabaz Fisal Shakir Agha, Peshawa Y. Aziz, Muthanna A. Thabit, Derin N. F. Agha, Nur Ain Salehen, Zeena M. Ameen, Mahmood A. Abdulla
Summary: This study demonstrated the gastroprotective effect of p-Cymene on acute gastric mucosal lesions induced by ethanol, attributed to its ability to increase mucus secretion, regulate endogenous enzymes, and reduce inflammatory responses in the stomach.
Article
Nutrition & Dietetics
Sineenart Sanpinit, Piriya Chonsut, Chuchard Punsawad, Palika Wetchakul
Summary: This study investigated the gastroprotective effects of Phy-Blica-D against gastric ulcers in rats and explored the underlying mechanism. The results showed that Phy-Blica-D reduced oxidative stress and stimulated antioxidant enzymes, thus protecting the gastric tissue from ethanol-induced acute ulcers.
Article
Chemistry, Medicinal
Amira Tarek Salaheldin, Mohamed Refaat Shehata, Hader I. Sakr, Tarek Atia, Ayman Saber Mohamed
Summary: Peptic ulcer is a common disease with a significant impact on the general population. Ovothiol A, derived from sea urchin eggs, exhibits special antioxidant activity. Studies on rats showed that Ovothiol A reduced gastric acid secretion, decreased ulcer index and oxidative damage, and increased antioxidant levels, thereby promoting the healing of gastric ulcers.
Article
Biochemistry & Molecular Biology
Meltem Kolgazi, Sumeyye Cilingir, Ozgur Yilmaz, Merve Gemici, Hasan Yazar, Samed Ozer, Merve Acikel-Elmas, Serap Arbak, Guldal Gulec Suyen
Summary: The study found that caffeic acid can ameliorate ethanol-induced gastric mucosal damage, with the nitric oxide pathway contributing to this effect but a lack of evidence for the muscarinic cholinergic system's contribution.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Wenfang Xia, Zhou Pan, Huanming Zhang, Qingshan Zhou, Yu Liu
Summary: This study investigates the role of estrogen-related receptor alpha (ERRα) in sepsis-induced acute lung injury (ALI). The results show that overexpression of ERRα can ameliorate LPS-induced endothelial hyperpermeability, apoptosis, and inhibit autophagy, while knockdown of ERRα exacerbates these effects. Administration of an ERRα agonist can alleviate pathological damage, increase the levels of junctional proteins, and decrease apoptosis-related protein expression. Promoting ERRα expression enhances autophagy and reduces sepsis-induced ALI. ERRα is essential for maintaining the integrity of adherens junctions by regulating the balance between autophagy and apoptosis.
MOLECULAR MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Chen Wang, Chang-Ning Ma, Xiao-Long Liu, Quan Sun, Qian Zhang, Ying-Ying Lin, Cheng-Yu Yan, Da-Gang Hu
Summary: Apples have the potential to be a natural protective agent against acute alcoholic liver injury due to their antioxidant and anti-inflammatory properties. This study evaluated the protective effect of apples on liver injury in rats induced by ethanol consumption. Results showed that apple consumption reduced liver lipid peroxidation, improved liver histopathology, increased antioxidant enzyme activity, and decreased inflammatory cytokine levels in the liver.
APPLIED SCIENCES-BASEL
(2023)
Article
Integrative & Complementary Medicine
Hee-seon Park, Chang-Seob Seo, Eun Bok Baek, Jin-hyung Rho, Young-Suk Won, Hyo-jung Kwun
Summary: In this study, it was found that pretreatment with myricetin effectively reduced alcohol-induced gastric ulcers and injury in rats by decreasing oxidative damage, increasing PGE(2) production, and inhibiting NF-kappa B activation. Myricetin may be considered as an alternative treatment for gastric injury caused by alcohol consumption.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Hina Imran, Tehmina Sohail, Shazia Syed, Shazia Syed
Summary: The ethanolic crude extract of dried ripe fruit of Aegle marmelos showed significant protective effects against ethanol-induced gastric injury in rats, reducing ulcer area, increasing protection rate and gastric content.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Ibrahim Abdel Aziz Ibrahim, Abbas I. Hussein, Mahmoud S. Muter, Abdulalah T. Mohammed, Morteta H. Al-Medhtiy, Suhayla Hamad Shareef, Peshawa Yunis Aziz, Nabaz Fisal Shakir Agha, Mahmood Ameen Abdulla
Summary: The study confirms that silver nanoparticles can protect the gastric mucosa from ethanol-induced damage. They exert their effects through antioxidant activity, increased mucus secretion, and modulation of relevant protein expression.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Mohamed A. Abdelgawad, Syed Nasir Abbas Bukhari, Arafa Musa, Mohammed Elmowafy, AbdElAziz A. Nayl, Ahmed H. El-Ghorab, Mohamed Sadek Abdel-Bakky, Hany A. Omar, Nasser Hadal Alotaibi, Hossam M. Hassan, Mohammed M. Ghoneim, Rania B. Bakr
Summary: New phthalazone tethered 1,2,3-triazole derivatives 12-21 were synthesized through Cu(I)-catalyzed click reactions. The synthesized compounds were confirmed by spectroscopic tools and elemental analysis. The antiproliferative efficacy of compounds 12-21 against cancer cell lines was evaluated, and compound 16 showed potent activity and selectivity. In silico molecular docking confirmed stable protein-ligand interactions for the effective derivatives.
BIOORGANIC CHEMISTRY
(2023)
Article
Immunology
Emad H. M. Hassanein, Wafaa R. Mohamed, Rasha M. Hussein, El-Shaimaa A. Arafa
Summary: Edaravone (ED) was found to have protective effects against methotrexate (MTX)-induced testicular damage by reducing oxidative stress, inflammation, and apoptosis. It also regulated the Akt/p53 signaling pathway and improved steroidogenesis. These findings highlight the potential of ED as a treatment for MTX-induced testicular damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Salma A. Al-Shamma, Dana M. Zaher, Fatema Hersi, Nour N. Abu Jayab, Hany A. Omar
Summary: Modern cancer chemotherapy has been limited by the resistance of cancer cells to therapy. One crucial factor in chemotherapy resistance is the overexpression of ALDH, which detoxifies toxic aldehydes and prevents the formation of reactive oxygen species. This review discusses the mechanisms of chemotherapy resistance promoted by ALDH and highlights its role in cancer stemness, metastasis, metabolism, and cell death. Targeting ALDH in combination with other treatments may be a potential therapeutic strategy to overcome resistance in various cancers.
Article
Chemistry, Medicinal
Hany H. Arab, Ali Khames, Shuruq E. Alsufyani, Azza A. K. El-Sheikh, Amany M. Gad
Summary: The study investigated the neuroprotective potential of magnesium sulfate in a rat model of chronic-restraint stress (CRS)-induced depression-like behavioral disturbance and the underlying molecular mechanisms. The results demonstrated that magnesium sulfate attenuated the depression-like behavioral outcomes and histopathological changes in the brain by dampening inflammation, ER stress, and the associated PERK/GRP78/CHOP pathway. These findings suggest the promising neuroprotective/antidepressant actions of magnesium sulfate in CRS.
Article
Chemistry, Medicinal
Hany H. Arab, Ali Khames, Mostafa K. Mohammad, Shuruq E. Alsufyani, Ahmed M. Ashour, Azza A. K. El-Sheikh, Hany W. Darwish, Amany M. Gad
Summary: This study demonstrates the potential antidepressant effect of meloxicam in a chronic restraint stress model. Meloxicam improved depression-like behavior, neurohistopathological changes, and decreased neurotransmitter levels. These effects may be mediated through inhibition of the COX-2/NOX1/NOX4 pathway and activation of the Nrf2/HO-1 antioxidant pathway.
Article
Chemistry, Medicinal
Maha M. Abdel-Fattah, Emad H. M. Hassanein, Ahmed M. Sayed, Shuruq E. Alsufyani, Azza A. K. El-Sheikh, Hany H. Arab, Wafaa R. Mohamed
Summary: The current study aimed to investigate the ameliorative effect of rebamipide in a rat model of acetic acid-evoked ulcerative colitis and the molecular mechanisms involved. The findings demonstrated that rebamipide significantly improved colonic injury by combating inflammation and oxidative stress, which may be mediated by regulating the SIRT1/FoxO3a/Nrf2 and PI3K/AKT pathways.
Article
Pharmacology & Pharmacy
Mohammed H. Elkomy, Fatma I. Abo El-Ela, Randa Mohammed Zaki, Omar A. Alsaidan, Mohammed Elmowafy, Ameeduzzafar Zafar, Khaled Shalaby, Mohamed A. Abdelgawad, Hany A. Omar, Rania Salama, Hussein M. Eid
Summary: This study developed and optimized a drug-loaded thermosensitive gel for intranasal administration to combat depression. The results demonstrated that compared to other formulations, this thermosensitive gel significantly improved behavioral performance and alleviated neural tissue changes in depressed rats. Further research is needed to determine its effectiveness in humans.
Article
Chemistry, Medicinal
Hany H. Arab, Ebtehal Mohammad Fikry, Shuruq E. Alsufyani, Ahmed M. Ashour, Azza A. K. El-Sheikh, Hany W. Darwish, Abdullah M. Al-Hossaini, Muhammed A. Saad, Muhammad Y. Al-Shorbagy, Ahmed H. Eid
Summary: The study demonstrated that dapagliflozin has a positive effect on Cd-induced testicular dysfunction by improving testicular weight, serum testosterone, and sperm count/motility, and reducing sperm abnormalities. It also showed antioxidative, anti-apoptotic, and pro-autophagic effects to mitigate testicular impairment and spermatogenesis disruption caused by Cd. Therefore, dapagliflozin could be a potential therapeutic tool for the management of Cd-induced testicular dysfunction.
Article
Chemistry, Medicinal
Hany H. Arab, Ahmed H. Eid, Shuruq E. Alsufyani, Ahmed M. Ashour, Azza A. K. El-Sheikh, Hany W. Darwish, Gehan S. Georgy
Summary: This study investigated the potential neuroprotective effect of linagliptin against cadmium-induced cognitive deficits in rats. The results showed that linagliptin improved learning and memory impairment caused by cadmium and reduced hippocampal neurodegeneration. Additionally, linagliptin regulated the signaling pathways in the hippocampus by inhibiting DPP-4 and increasing GLP-1 levels, resulting in a neuroprotective impact.
Article
Chemistry, Medicinal
Maaly A. Abd Elmaaboud, Remon S. Estfanous, Aliaa Atef, Ahmed M. Kabel, Khalid A. Alnemari, Tamer M. Naguib, Shuruq E. Alsufyani, Hany W. Darwish, Hany H. Arab
Summary: In this study, the potential ameliorative effects of dapagliflozin and/or hesperidin on lipopolysaccharide-induced Alzheimer's disease (AD) were investigated. The results showed that both dapagliflozin and hesperidin improved the biochemical parameters, behavioral tests, and histopathological parameters in a rat model of AD. These favorable effects were significantly enhanced when the two agents were used in combination.
Article
Chemistry, Medicinal
Hany H. Arab, Ahmed H. Eid, Rania Yahia, Shuruq E. Alsufyani, Ahmed M. Ashour, Azza A. K. El-Sheikh, Hany W. Darwish, Muhammed A. Saad, Muhammad Y. Al-Shorbagy, Marwa A. Masoud
Summary: The study found that topiramate has the potential to combat cadmium neurotoxicity and improve cognitive deficits. Topiramate is able to alleviate hippocampal oxidative damage, apoptosis, and autophagy induced by cadmium through multiple mechanisms, as well as increase hippocampal glutamate content and enhance acetylcholine and GABA neurotransmitters. These findings suggest that topiramate may be useful in mitigating cadmium-induced cognitive deficits.
Article
Chemistry, Multidisciplinary
Marwa Alsulaimany, Khaled El-Adl, Ahmed K. B. Aljohani, Hussam Y. Alharbi, Omar M. Alatawi, Majed S. Aljohani, Ahmed El-morsy, Sara A. Almadani, Abdulrahman A. Alsimaree, Samir A. Salama, Doaa E. Keshek, Abeer A. Mohamed
Summary: Fifteen new 1-alkyl-6-iodoquinazoline derivatives were designed and synthesized, and their anticancer activities were evaluated against multiple cancer cell lines. Compound 9c showed the highest activity and exhibited excellent dual inhibition of EGFR and VEGFR-2.
Article
Chemistry, Multidisciplinary
Kurls E. Anwer, Sanadelaslam S. A. El-Hddad, Nour E. A. Abd El-Sattar, Ahmed El-morsy, Fathalla Khedr, Samy Mohamady, Doaa E. Keshek, Samir A. Salama, Khaled El-Adl, Noura S. Hanafy
Summary: Novel azobenzene scaffold-joined heterocyclic isoxazole, pyrazole, triazole, and/or triazine derivatives were synthesized and tested for their growth inhibition effects on A549, MCF-7, HCT-116, and HepG2 cancer cells. The compounds showed dual targeting effects on VEGFR-2 and EGFR(T790M) enzymes. Molecular design and MD modeling revealed the binding mode of the compounds with the active sites. The compounds demonstrated significant inhibitory effects, particularly compound 14, which showed the highest activity on A549 cells.
Article
Pharmacology & Pharmacy
Hanan S. Anbar, Nisha Yarifbhai Vahora, Hajra laghman Shah, Mariyam Mohammed Azam, Tamanna Islam, Fatima Hersi, Hany A. Omar, Wolfgang Dohle, Barry V. L. Potter, Mohammed I. El-Gamal
Summary: This study investigated the therapeutic potential of three drug candidates for the treatment of PCOS. The drug candidates showed promising effects on ovarian and uterine weight, lipid profile, hormone levels, and signaling pathways.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ateyatallah Aljuhani, Hany E. A. Ahmed, Saleh K. Ihmaid, Abdelsattar M. Omar, Sultan S. Althagfan, Yaser M. Alahmadi, Iqrar Ahmad, Harun Patel, Sahar Ahmed, Mohannad A. Almikhlafi, Ahmed M. El-Agrody, Mohamed F. Zayed, Safaa Abdulrahman Turkistani, Shorouk H. Abulkhair, Mohammed Almaghrabi, Samir A. Salama, Ahmed A. Al-Karmalawy, Hamada S. Abulkhair
Summary: A novel set of compounds was designed and evaluated for their antiviral activity against COVID-19 using in vitro assays and molecular docking simulations. The majority of these compounds showed potent antiviral activity with minimal cytotoxicity. Compounds 25 and 29 exhibited promising inhibitory activity and were stable in molecular dynamic simulations. These results suggest that compounds 25 and 29 are potential drug candidates for the treatment of SARS-CoV-2.
