Article
Clinical Neurology
David Stevens, Chris Barr, Katherine Bassett, Aaron Oh, Stephen R. Lord, Maria Crotty, Kelsey Bickley, Sutapa Mukherjee, Andrew Vakulin
Summary: This study examined the effect of continuous positive airway pressure (CPAP) on fall risk markers in people over 65yrs diagnosed with obstructive sleep apnoea (OSA). The results showed that CPAP significantly reduced fall risk and improved visual contrast sensitivity and lower limb proprioception.
Review
Respiratory System
Ama Johal, Mona M. Hamoda, Fernanda R. Almeida, Marie Marklund, Harishri Tallamraju
Summary: There is increasing recognition of the importance of dental sleep medicine and oral appliance therapy (OAT) in managing obstructive sleep apnoea (OSA). This review focuses on understanding the mode of action of OAT, exploring its anatomical and physiological impact, clinical guidelines, device design features, patient predictors, and the impact on health outcomes.
EUROPEAN RESPIRATORY REVIEW
(2023)
Review
Medicine, General & Internal
Frederico T. Barbosa, Michele P. Silva, Luis Eduardo S. Fontes, Daniela Pachito, Tamara Melnik, Rachel Riera
Summary: The study evaluated the effectiveness and acceptability of CPAP therapy for improving erectile dysfunction in OSAS patients. Uncertainty was found in the comparison of CPAP with no CPAP, while sildenafil may slightly improve erectile function at 12 weeks compared to CPAP.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Review
Clinical Neurology
Michelle A. Miller, Francesco P. Cappuccio
Summary: This study reviewed the relationship between OSA and COVID-19 outcomes, finding that risk factors associated with OSA are also linked to poor COVID-19 outcomes. Plausible mechanisms suggest OSA may independently increase the risk of death from COVID-19. The study also highlights the major impact of COVID-19 on the diagnosis and treatment of OSA.
SLEEP MEDICINE REVIEWS
(2021)
Review
Cardiac & Cardiovascular Systems
Susan Redline, Ali Azarbarzin, Yuksel Peker
Summary: In this Review, the authors summarize the shared risk factors and causal links between obstructive sleep apnoea (OSA) and cardiovascular disease (CVD), as well as the emerging knowledge on the heterogeneity of OSA. They also explore the potential role of new biomarkers for cardiovascular risk stratification in patients with OSA.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ryutaro Shirahama, Takeshi Tanigawa, Yoshifumi Ida, Kento Fukuhisa, Rika Tanaka, Kiyohide Tomooka, Fan-Yun Lan, Ai Ikeda, Hiroo Wada, Stefanos N. Kales
Summary: The study found that good long-term adherence to CPAP therapy was associated with lower diastolic blood pressure without significant weight loss.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Michael S. H. Chou, Natasha C. H. Ting, Nicole El-Turk, Zinta Harrington, Claudia C. Dobler
Summary: This study found that patients using CPAP for OSA experience significant treatment burden, including healthcare tasks, consequences of healthcare tasks, exacerbating and alleviating factors of treatment burden. Patients commonly reported burden from attending healthcare appointments, treatment cost, lifestyle changes, treatment side effects and general discomfort.
Review
Biochemistry & Molecular Biology
Abdulmohsen Alterki, Mohamed Abu-Farha, Eman Al Shawaf, Fahd Al-Mulla, Jehad Abubaker
Summary: Obstructive sleep apnoea (OSA) is a prevalent but underdiagnosed disorder that disrupts the circadian rhythm and is characterized by frequent interruptions in breathing during sleep, leading to systemic consequences. OSA is a well-recognized risk factor for cardiovascular and cerebrovascular diseases, and it is also linked to obesity. The pathogenesis of both OSA and obesity involve oxidative stress, inflammation, and metabolic dysregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Respiratory System
Adel Bachour, Leif Back, Petra Pietarinen
Summary: In this study, 15 patients treated with Hypoglossal Neurostimulation therapy (HGNS) were analyzed for changes in AHI and ODI4 parameters. The results showed no significant changes in AHI and ODI4 after HGNS therapy. More extensive multicentre randomized controlled trials are needed before considering widespread international use of HGNS.
CLINICAL RESPIRATORY JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Miuni Athauda Arachchige, Joerg Steier
Summary: Obstructive Sleep Apnoea (OSA) is a common condition that can have a significant impact on physical and mental health, including an increased risk of cardiovascular diseases. Continuous Positive Airway Pressure (CPAP) therapy is the recommended treatment for moderate to severe OSA, but long-term adherence remains a challenge. There are alternative non-CPAP treatments available, such as lifestyle changes, surgical options, and nerve stimulation. When choosing long-term therapies, symptom control, patient-related outcomes, and long-term cardiovascular health should be prioritized.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biology
Konstantinos Chaidas, Kallirroi Lamprou, Amberley Munnings, John R. Stradling, Annabel H. Nickol
Summary: This study aimed to investigate the association between CPAP usage and nasal symptoms in patients with obstructive sleep apnoea. The findings suggested that runny nose was a predictive factor for poorer CPAP adherence and worsened after three months of high-CPAP usage.
Article
Ophthalmology
Meltem Guzin Altinel, Hasim Uslu, Ayse Yagmur Kanra, Orhan Dalkilic
Summary: The study evaluated the effect of OSAS and CPAP therapy on choroidal structural changes and CVI in patients with OSAS. OSAS was associated with stromal edema in the choroid, which improved after 12 months of CPAP therapy. CVI can be an important parameter for monitoring patients with OSAS.
Article
Obstetrics & Gynecology
Peter G. Middleton
Summary: This review provides a summary of the interactions between pregnancy and breathing during sleep, and highlights the changes in respiratory function that can increase the incidence and severity of sleep-disordered breathing. The increased risk of snoring and obstructive sleep apnea hypopnea syndrome during pregnancy is discussed, and the potential impact of increasing obesity rates on sleep-disordered breathing in pregnant women is considered.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Article
Respiratory System
Jean-Benoit Martinot, Nhat-Nam Le-Dong, Atul Malhotra, Jean-Louis Pepin
Summary: Respiratory effort is a main feature of obstructive sleep apnoea (OSA), and is associated with sympathetic overactivity. This study found that the percentage of total sleep time spent with increased respiratory effort (REMOV,%TST), measured by mandibular jaw movements, can predict the prevalence of hypertension in adults with OSA.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Medicine, General & Internal
Chien-Chia Huang, Pei-Wen Wu, Chi-Cheng Chuang, Cheng-Chi Lee, Yun-Shien Lee, Po-Hung Chang, Chia-Hsiang Fu, Chi-Che Huang, Ta-Jen Lee
Summary: This study aimed to investigate sleep quality and the presence of obstructive sleep apnoea (OSA) in empty nose syndrome (ENS) patients. The study found a high prevalence of OSA and significant sleep impairment in ENS patients. The severity of OSA was associated with obesity levels and ENS symptom severity. The severity of ENS symptoms was negatively correlated with nasal resistance and positively correlated with the frequency of arousals and daytime sleepiness.
Article
Cardiac & Cardiovascular Systems
Antonio J. Vallejo-Vaz, Sarah Bray, Guillermo Villa, Julia Brandts, Gaia Kiru, Jennifer Murphy, Maciej Banach, Stefano De Servi, Dan Gaita, Ioanna Gouni-Berthold, G. Kees Hovingh, Jacek J. Jozwiak, J. Wouter Jukema, Robert Gabor Kiss, Serge Kownator, Helle K. Iversen, Vincent Maher, Luis Masana, Alexander Parkhomenko, Andre Peeters, Piers Clifford, Katarina Raslova, Peter Siostrzonek, Stefano Romeo, Dimitrios Tousoulis, Charalambos Vlachopoulos, Michal Vrablik, Alberico L. Catapano, Neil R. Poulter, Kausik K. Ray
Summary: In patients with atherosclerotic cardiovascular disease (ASCVD), achieving European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) LDL-C goals may result in an additional 2% absolute risk reduction (ARR) over 10 years compared to the American College of Cardiology/American Heart Association (ACC/AHA) approach.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Neurosciences
Eduardo Molina-Holgado, Pedro F. Esteban, Angel Arevalo-Martin, Rafael Moreno-Luna, Francisco Molina-Holgado, Daniel Garcia-Ovejero
Summary: Oligodendrocytes in the central nervous system synthesize myelin and have the ability to regulate their functions through interactions with other cells and sensing the environment. They respond to various signals, including the endocannabinoid signaling, which has therapeutic potential for promoting remyelination in central nervous system pathologies.
Review
Gastroenterology & Hepatology
Javier Ampuero, Rocio Gallego-Duran, Douglas Maya-Miles, Rocio Montero, Sheila Gato, Angela Rojas, Antonio Gil, Rocio Munoz, Manuel Romero-Gomez
Summary: This meta-analysis evaluates the histological response of NAFLD clinical trials and finds suboptimal results, especially in liver fibrosis, despite robust preclinical drug development. The therapy shows higher efficacy in achieving NASH resolution and fibrosis improvement, while preventing NASH and fibrosis worsening. Longer duration of trials, lower proportion of diabetic population, and targeting specific mechanisms contribute to better outcomes.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Angela Rojas, Antonio Gil-Gomez, Patricia de la Cruz-Ojeda, Rocio Munoz-Hernandez, Yolanda Sanchez-Torrijos, Rocio Gallego-Duran, Raquel Millan, Maria Carmen Rico, Rocio Montero-Vallejo, Sheila Gato-Zambrano, Douglas Maya-Miles, M. Teresa Ferrer, Jordi Muntane, Maria Jose Robles-Frias, Javier Ampuero, Francisco J. Padillo, Manuel Romero-Gomez
Summary: This study explored the role of lncRNA-H19 as a biomarker for liver cancer, and the results showed that lncRNA-H19 could be upregulated in liver cancer stem cells, liver tissue, and plasma of HCC patients, and decreased after therapeutic response, which suggests its potential as a new biomarker for HCC.
LIVER INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Lucia Beltran-Camacho, Sara Eslava-Alcon, Marta Rojas-Torres, Daniel Sanchez-Morillo, Ma Pilar Martinez-Nicolas, Victoria Martin-Bermejo, Ines Garcia de la Torre, Esther Berrocoso, Juan Antonio Moreno, Rafael Moreno-Luna, Ma Carmen Duran-Ruiz
Summary: This study evaluated the impact of serum from asymptomatic COVID-19 individuals on circulating angiogenic cells (CACs) using a proteomics-based quantitative approach. The results confirmed that SARS-CoV-2 infection in asymptomatic individuals caused protein level changes related to coagulation and inflammatory processes. Additionally, certain proteins were up-regulated only in CACs treated with serum from asymptomatic patients during the highest peak of infection. These findings provide insight into the effects of SARS-CoV-2 infection and the development of potential treatment methods.
MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Rocio Gallego-Duran, Javier Ampuero, Helena Pastor-Ramirez, Leticia Alvarez-Amor, Jose Antonio del Campo, Douglas Maya-Miles, Rocio Montero-Vallejo, Antonio Cardenas-Garcia, Ma Jesus Pareja, Sheila Gato-Zambrano, Raquel Millan, Maria del Carmen Rico, Amparo Luque-Sierra, Antonio Gil-Gomez, Angela Rojas, Rocio Munoz-Hernandez, Maria Garcia-Lozano, Rocio Aller, Raul J. Andrade, Carmelo Garcia-Monzon, Fausto Andreola, Francisco Martin, Rajiv Jalan, Manuel Romero-Gomez
Summary: This study aimed to evaluate changes in urea cycle enzymes in NAFLD patients and animal models, and found that liver fibrosis and steatosis were associated with a reduction in both gene and protein expression patterns of mitochondrial urea cycle enzymes.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Mario Martinez-Torija, Pedro F. Esteban, Francisco Javier Espino-Rodriguez, Beatriz Paniagua-Torija, Eduardo Molina-Holgado, Silvia Ceruelo, Gemma Barroso-Garcia, Alba G. Arandilla, Luis F. Lopez-Almodovar, Angel Arevalo-Martin, Juan Antonio Moreno, Daniel Garcia-Ovejero, M. Carmen Duran-Ruiz, Rafael Moreno-Luna
Summary: The risk of complications following surgical procedures is significantly increased in patients with SARS-CoV-2 infection. This study found that SCI patients with a COVID-19-positive diagnosis showed worse recovery and severe postoperative complications. Proteomic analysis revealed several upregulated proteins in the adipose tissue surrounding the ulcers. Among them, CKMT2 and CKM stood out and increased after the COVID-19 diagnosis. These proteins were largely found in MGCs within the adipose tissue. The presence of CKMT2, CKM, and MGCs may serve as predictive biomarkers of postsurgical complications in post-COVID patients.
Article
Biochemistry & Molecular Biology
Ismael Sanchez-Gomar, Josefa Benitez-Camacho, Cristina Cejudo-Bastante, Lourdes Casas, Rafael Moreno-Luna, Casimiro Mantell, Ma Carmen Duran-Ruiz
Summary: The study evaluated the potential of mango leaves, olive leaves, and red grape pomace extracts rich in polyphenols to promote ECFC reparative effects. It was found that ethanolic extracts at low concentrations improved angiogenic capacities of ECFCs and reduced proliferation, apoptosis, and the inflammatory response of these cells.
Article
Cell & Tissue Engineering
Marta Rojas-Torres, Ismael Sanchez-Gomar, Antonio Rosal-Vela, Lucia Beltran-Camacho, Sara Eslava-Alcon, Jose Angel Alonso-Pineiro, Javier Martin-Ramirez, Rafael Moreno-Luna, Ma Carmen Duran-Ruiz
Summary: Before translating ECFCs into clinical treatment, it is necessary to perform biodistribution assays to ensure biosafety and determine the distribution of cells. This study optimized a cell-tracking assay using DiR labeling and qPCR analysis, and found that intramuscularly administered ECFCs mainly remained in the ischemic tissues, while intravenously injected cells were found in multiple organs.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Antonio Gil-Gomez, Angela Rojas, Maria R. Garcia-Lozano, Rocio Munoz-Hernandez, Rocio Gallego-Duran, Douglas Maya-Miles, Rocio Montero-Vallejo, Sheila Gato, Javier Gallego, Ruben Frances, German Soriano, Javier Ampuero, Manuel Romero-Gomez
Summary: In patients with cirrhosis carrying the HSD17B13 gene variant rs72613567:TA, there is an increased risk of hepatic decompensation and death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Veronica Alfaro-Lara, Rocio Munoz-Hernandez, Luis Gimenez-Miranda, Luis Beltran-Romero, Francisco Javier Castell-Montsalve, Pablo Stiefel
Summary: This study explored the relationship between pancreatic fat content and insulin resistance, beta-cell function, endothelial dysfunction, and platelet or endothelial cell destruction in essential hypertension. The results showed that pancreatic fat content was related to endothelial cell destruction, but not to platelet microparticles count. Pancreatic fat content is superior to liver fat in studying beta-cell functionality and insulin resistance.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
Article
Multidisciplinary Sciences
Antonia Gasch-Illescas, Marta Calle-Serrano, Antonio J. Vallejo-Vaz, Juan M. Praena-Fernandez, Jose A. Guerrero, Enrique J. Calderon, Marina Pollan, Francisco J. Medrano
Summary: We examined the impacts of the first wave of COVID-19 on non-COVID hospital admissions and mortality. The study found a decrease in non-COVID hospitalizations and an increase in non-COVID mortality during the first wave compared to pre-pandemic years. Older age, male gender, longer hospital stays, and increased disease severity were associated with non-COVID hospitalizations during the first wave. Hospitalization during the first wave was an independent risk factor for non-COVID mortality, highlighting the negative impact of the pandemic on hospitalized patients.
SCIENTIFIC REPORTS
(2023)
Article
Health Care Sciences & Services
Julia Brandts, Sarah Bray, Guillermo Villa, Alberico L. Catapano, Neil R. Poulter, Antonio J. Vallejo-Vaz, Kausik K. Ray, DA VINCI Study Grp
Summary: This study simulated the impact of the stepwise implementation of the 2019 ESC/EAS treatment algorithm on LDL-C goal attainment and found that most high-risk cardiovascular disease patients require a PCSK9 inhibitor to achieve their targets and further reduce cardiovascular risk.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Review
Health Care Sciences & Services
Christophe A. T. Stevens, Alexander R. M. Lyons, Kanika Dharmayat, Alireza Mahani, Kausik K. Ray, Antonio J. Vallejo-Vaz, Mansour T. A. Sharabiani
Summary: Electronic health records provide opportunities for machine learning techniques to identify undiagnosed individuals with diseases and improve medical screening and case finding. Ensemble machine learning models, especially those with complex combination strategies and heterogeneous classifiers, often outperform other models in this context. However, there is a lack of comprehensive reporting on the methodologies used in clinical research involving machine learning.
Article
Biochemistry & Molecular Biology
Lucia Beltran-Camacho, Santosh D. Bhosale, Daniel Sanchez-Morillo, Ismael Sanchez-Gomar, Marta Rojas-Torres, Sara Eslava-Alcon, Mario Martinez-Torija, M. Angeles Ruiz de Infante, M. Dolores Nieto-Martin, Manuel A. Rodriguez-Iglesias, Juan A. Moreno, Esther Berrocoso, Martin R. Larsen, Rafael Moreno-Luna, M. Carmen Duran-Ruiz
Summary: SARS-CoV-2 infection affects the cardiovascular system, causing vascular damage and thromboembolic events. Endothelial dysfunction is an early response to COVID-19, which may lead to cardiovascular complications and long-term sequelae. However, the molecular mechanisms involved in these processes remain poorly understood.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
