Article
Nutrition & Dietetics
Siyuan Lv, Rui Qin, Yangqian Jiang, Hong Lv, Qun Lu, Shiyao Tao, Lei Huang, Cong Liu, Xin Xu, Qingru Wang, Mei Li, Zhi Li, Ye Ding, Ci Song, Tao Jiang, Hongxia Ma, Guangfu Jin, Yankai Xia, Zhixu Wang, Shanshan Geng, Jiangbo Du, Yuan Lin, Zhibin Hu
Summary: This study investigated the associations between maternal dietary patterns during different gestational periods and infant's neurodevelopment at 1 year of age. The results showed that adherence to the 'Aquatic products, Fresh vegetables and Homonemeae' dietary pattern in the second trimester and the 'Aquatic products and Homonemeae' pattern in the third trimester was associated with decreased risk of developmental delays in cognitive, gross motor, and receptive communication skills in infants.
Article
Environmental Sciences
Xin Xu, Shiyao Tao, Lei Huang, Jiangbo Du, Cong Liu, Yangqian Jiang, Tao Jiang, Hong Lv, Qun Lu, Qingxia Meng, Xiaoyan Wang, Rui Qin, Hongxia Ma, Guangfu Jin, Yankai Xia, Haidong Kan, Yuan Lin, Rong Shen, Zhibin Hu
Summary: This study conducted a prospective birth cohort study in Jiangsu, China, and found that prenatal exposure to PM2.5, particularly with high sulfate concentration, was associated with non-optimal gross motor development in infants at 1 year old.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Medicine, General & Internal
Caroline A. Crowther, Pat Ashwood, Philippa F. Middleton, Andrew McPhee, Thach Tran, Jane E. Harding
Summary: Administering intravenous magnesium sulfate to pregnant women before 30 weeks' gestation reduces the risk of death and cerebral palsy in their children. However, the effects at later gestational ages are unclear.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Acoustics
I Papastefanou, V Thanopoulou, S. Dimopoulou, A. Syngelaki, R. Akolekar, K. H. Nicolaides
Summary: This study developed a competing-risks model for predicting SGA neonates by incorporating sonographically estimated fetal weight (EFW) and biomarkers of impaired placentation at 36 weeks' gestation. The performance of the new model was compared with that of the traditional EFW < 10th percentile cut-off. The new model showed better predictive performance, especially when there was a longer time interval between assessment and delivery.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Nutrition & Dietetics
Rosa M. Garcia-Garcia, Maria Arias-Alvarez, Pilar Millan, Maria Rodriguez, Ana Sanchez-Rodriguez, Pedro L. Lorenzo, Pilar G. Rebollar
Summary: The study found that maternal food restriction followed by re-feeding in early and mid-pregnancy in a rabbit model can establish a compensatory energy status in dams and alleviate potential long-term consequences in growth and metabolism in offspring, even if fetal metabolism was altered. Although fetal metabolism was affected, offspring in the juvenile period showed a similar pattern of growth and serum metabolic parameters, except for slightly increased serum aminotransferases levels associated with higher liver fibrosis.
Article
Multidisciplinary Sciences
Stefanie Elisabeth Damhuis, Hester Dorien Kamphof, Anita C. J. Ravelli, Sanne Jehanne Gordijn, Wessel J. Ganzevoort
Summary: This study aimed to evaluate the burden of hypoxia-related adverse perinatal outcomes among (near) term births, reflected in an association with birth weight centiles as a proxy for placental function. The study found that the incidence of hypoxia-related outcomes was highest in fetuses with lowest birth weight centiles but can be identified throughout the entire spectrum. Additional diagnostic modalities that indicate placental dysfunction at (near) term gestation are urgently needed.
Article
Endocrinology & Metabolism
Brian Akhaphong, Brigid Gregg, Doga Kumusoglu, Seokwon Jo, Kanakadurga Singer, Joshua Scheys, Jennifer DelProposto, Carey Lumeng, Ernesto Bernal-Mizrachi, Emilyn U. Alejandro
Summary: Maternal high-fat diet before and during pregnancy may predispose female offspring to insulin resistance in adulthood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Clive J. J. Petry, Laurentya Olga, Ieuan A. A. Hughes, Ken K. K. Ong
Summary: Maternal iron supplementation during pregnancy may have an impact on newborn size and adiposity, but these effects disappear during infancy. However, there is some evidence to suggest that iron supplementation during pregnancy may have long-term effects on blood pressure in mid-childhood.
Article
Food Science & Technology
Qiutong Zheng, Na Li, Yingying Zhang, Jingyang Li, Eryun Zhang, Zhice Xu
Summary: This study demonstrates that perinatal high-fat diets can affect fetal/neonate development and lead to cardiovascular pathogenesis. The activation of aldosterone receptors stimulates calcium influx through L-type calcium channels in vascular myocytes, which ultimately results in vasoconstriction.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Multidisciplinary Sciences
Benjamin P. Larkin, Sonia Saad, Sarah J. Glastras, Long T. Nguyen, Miao Hou, Hui Chen, Rosy Wang, Carol A. Pollock
Summary: The study found that administration of low-dose Hydralazine to pregnant mice can reduce the occurrence of CKD in offspring of obese mothers by lowering global DNA methylation levels and renal fibrotic markers. This supports the use of low-dose Hydralazine as a demethylating agent to prevent CKD arising in offspring due to maternal HFD consumption.
Article
Immunology
Chien-Wen Su, Chih-Yu Chen, Tangyou Mao, Ning Chen, Nicholas Steudel, Lefei Jiao, Jinggang Lan, Alessio Fasano, W. Allan Walker, Hai Ning Shi
Summary: This study aimed to determine the impact of maternal immunity and microbial factors on the induction and development of obesity in offspring. The results showed that maternal infection with helminths and the resulting changes in gut microbiota composition significantly reduced offspring obesity. Furthermore, supplementation of short-chain fatty acids to the pups of uninfected mothers protected against high-fat diet-induced weight gain.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Susumu Muroya, Konosuke Otomaru, Kazunaga Oshima, Ichiro Oshima, Koichi Ojima, Takafumi Gotoh
Summary: This study investigated the impact of maternal undernutrition (MUN) on epigenetic modifications of hepatic genes in Japanese Black fetal calves during gestation. The study found that MUN led to hypomethylation of promoters and gene bodies in the fetal liver, affecting genes involved in various pathways related to metabolism and function. Gene expression analysis revealed that MUN influenced the expression of genes involved in energy, cholesterol, and mitochondrial metabolism. Overall, MUN altered gene methylation patterns in the fetal liver, highlighting the importance of maternal nutrition for proper gene regulation during development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
James Bogie, Michael Fleming, Breda Cullen, Daniel Mackay, Jill P. Pell
Summary: The study combined directed acyclic graphs with mediation analysis to unravel the impact mechanism of poverty on the education, employment, or training status of offspring, identifying maternal smoking and school absence as the main mediators. It suggests modifiable factors that can be targeted for intervention.
Article
Multidisciplinary Sciences
Matthias C. Schabel, Victoria H. J. Roberts, Karen J. Gibbins, Monica Rincon, Jessica E. Gaffney, Aaron D. Streblow, Adam M. Wright, Jamie O. Lo, Byung Park, Christopher D. Kroenke, Kathryn Szczotka, Nathan R. Blue, Jessica M. Page, Kathy Harvey, Michael W. Varner, Robert M. Silver, Antonio E. Frias
Summary: This study investigates the association between placental T2* measured by blood oxygen-level dependent magnetic resonance imaging (BOLD-MRI) and adverse pregnancy outcomes. The results show that the evolution of placental T2* across gestation follows a sigmoid model and is significantly associated with adverse outcomes.
Article
Nutrition & Dietetics
Jiaqi Cui, Lin Song, Rui Wang, Shuyuan Hu, Zhao Yang, Zengtie Zhang, Bo Sun, Wei Cui
Summary: This study suggests that maternal metformin during gestation and lactation has the potential to overcome the negative effects of perinatal exposure to a high-fat diet in offspring. This is achieved by altering myogenesis, mitochondrial biogenesis, and dynamics through the AMPK/mTOR pathways in skeletal muscle.
Article
Endocrinology & Metabolism
Roberta Dalle Molle, Euclides Jose de Mendonca Filho, Luciano Minuzzi, Tania Diniz Machado, Roberta Sena Reis, Danitsa Marcos Rodrigues, Amanda Brondani Mucellini, Alexandre Rosa Franco, Augusto Buchweitz, Rudineia Toazza, Andressa Bortoluzzi, Giovanni Abrahao Salum, Sonia Boscenco, Michael J. Meaney, Robert D. Levitan, Gisele Gus Manfro, Patricia Pelufo Silveira
Summary: Prenatal growth impairment leads to an increased preference for palatable foods and a higher risk for developing chronic diseases. This study found altered feeding behavior and resting-state connectivity in areas related to reward, self-control, and value determination in individuals with prenatal growth impairment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Patricia Maidana Miguel, Loise Peres Bronauth, Bruna Ferrary Deniz, Heloisa Deola Confortim, Bruna Chaves de Oliveira, Roberta Dalle Molle, Patricia Pelufo Silveira, Lenir Orlandi Pereira
Summary: This study investigated addictive-like behaviors in adult animals subjected to neonatal hypoxia-ischemia (HI) and treated with or without methylphenidate (MPH). The results showed that HI animals had dysregulated feeding intake, which was reversed by MPH treatment. However, MPH stimulated higher intake of the palatable diet, especially in animals subjected to HI. Increased ethanol intake was observed in HI animals, but MPH administration alleviated this behavior. Interestingly, MPH treatment in control animals induced an increase in ethanol consumption.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Neurosciences
Patricia Maidana Miguel, Michael J. Meaney, Patricia Pelufo Silveira
Summary: Executive functions (EFs) are responsible for cognitive control of emotions and behaviors, as well as information processing for learning and memory. Impairments in EFs, including attention, working memory, flexibility, and self-regulation, are associated with various psychopathologies throughout life. EF development starts in early childhood and continues into early adulthood, with vulnerability to environmental influences. Genetic factors also contribute to interindividual variation in EFs, and recent studies have explored the relationship between early-life adversity, genetics, and EF development.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Pediatrics
Euclides Jose de Mendonca Filho, Irina Pokhvisneva, Christina Maria Maalouf, Carine Parent, Shanna B. Mliner, Natalie Slopen, David R. Williams, Nicole R. Bush, William Thomas Boyce, Pat Levitt, Charles A. Nelson, Megan R. Gunnar, Michael J. Meaney, Jack P. Shonkoff, Patricia Pelufo Silveira
Summary: This study explores the associations between various early-life adversities and biomarkers of inflammatory and HPA responses. The results show that higher socioeconomic disadvantage is associated with higher levels of TNF-alpha, IL-1 beta, and DHEA, while lower family functioning is associated with higher cortisol and cortisone levels. There is also an interaction between socioeconomic disadvantage and family dysfunction on cortisol levels. These findings are partially replicated in a second sample.
PEDIATRIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Kimia Shafighi, Sylvia Villeneuve, Pedro Rosa Neto, AmanPreet Badhwar, Judes Poirier, Vaibhav Sharma, Yasser Iturria Medina, Patricia P. Silveira, Laurette Dube, David Glahn, Danilo Bzdok
Summary: Alzheimer's disease and related dementias pose a significant public health burden that will continue to increase due to longer life expectancy. Recent clinical evidence indicates that social isolation may accelerate the onset of dementia. Through the analysis of large population cohorts, we have identified strong associations between individuals' social capital, loneliness, and lack of social support with the risk of Alzheimer's disease and related dementias. The quality and quantity of daily social interactions are deeply connected to key risk factors, highlighting the importance of social lifestyle determinants as potential targets for preventive clinical action.
Article
Family Studies
Victoria F. Keeton, Janice F. Bell, Christiana Drake, Erik O. Fernandez y Garcia, Matthew Pantell, Danielle Hessler, Holly Wing, Patricia P. Silveira, Kieran J. O' Donnell, Euclides Jose de Mendonca Filho, Michael J. Meaney, Laura M. Gottlieb
Summary: Latinx families may face higher rates of emotional dysfunction due to economic hardship and complex social influences. The impact of unmet social needs and maternal stress on the emotional health of Latinx children from low-income families is not well understood. This study found that high perceived maternal stress and high hair cortisol concentration (HCC) in mothers were associated with increased risk of child emotional dysfunction.
JOURNAL OF CHILD AND FAMILY STUDIES
(2023)
Article
Biochemistry & Molecular Biology
Patricia Pelufo Silveira, Irina Pokhvisneva, David M. Howard, Michael J. Meaney
Summary: Sex differences play a significant role in the prevalence and treatment response of major depression. This study conducted a genome-wide association analysis and identified sex-specific markers and pathways associated with broad depression. The findings highlight the importance of sex-dependent genetic pathways in clinical depression and comorbid health conditions.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Patricia Pelufo Silveira, Michael J. Meaney
Summary: We explore how integrating datasets from different species can help us understand the impact of gene-environment interactions on mental disorders. We discuss various levels of gene expression regulation and the corresponding data available in humans. We also highlight the importance of multilevel integration of diverse types of data in improving vulnerability detection and informing preventive and therapeutic interventions.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Pediatrics
Angela M. Jaramillo-Ospina, Gabriel T. Roman, Danitsa M. Rodrigues, Sachin Patel, Irina Pokhvisneva, Valentina G. Chakr, Robert D. Levitan, Michael J. Meaney, Patricia P. Silveira
Summary: This study examined the relationship between the genetic background associated with increased production of omega-3 PUFA and eating behaviors in infants with intrauterine growth restriction (IUGR). The findings suggest that a higher genetic score for omega-3 PUFA is associated with a decreased risk of eating behavior alterations in infants born IUGR, while a higher genetic score for the omega-6/omega-3 PUFA ratio increases the risk of eating behavior alterations.
PEDIATRIC RESEARCH
(2023)
Article
Neurosciences
Sondos Ayyash, Aleeza Sunderji, Heather D. Gallant, Alexander Hall, Andrew D. Davis, Irina Pokhvisneva, Michael J. Meaney, Patricia Pelufo Silveira, Roberto B. Sassi, Geoffrey B. Hall
Summary: This study investigates the impact of poor maternal mental health and socioeconomic context during the perinatal period on network connectivity in middle childhood using an anatomically weighted functional connectivity (awFC) approach. The results indicate that maternal adversity during the perinatal period can affect offspring's resting-state network connectivity during middle childhood, particularly in the ventral attention network. These findings highlight the importance of considering both structural and functional imaging data in studying network maturation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Aashita Batra, Santiago Cuesta, Marcio Bonesso Alves, Jose Maria Restrepo, Michel Giroux, Daniela Pereira Laureano, Amanda Brondani Mucellini Lovato, Patricia Maidana Miguel, Tania Diniz Machado, Roberta Dalle Molle, Cecilia Flores, Patricia Pelufo Silveira
Summary: Fetal restriction affects insulin sensitivity and may impact the development of the dopamine system and related behaviors. The Netrin-1/DCC system is involved in the maturation of the DA circuitry. This study found that FR downregulates Netrin-1 levels at birth and affects Dcc expression in response to insulin in adult rodents, possibly through miR-218 regulation.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Neurosciences
Tianyuan Lu, Patricia Pelufo Silveira, Celia M. T. Greenwood
Summary: This study found that both genetic and early life risk factors are important in the development and progression of adult depression. By analyzing genome-wide association studies, a polygenic risk score for depression was developed, which was moderately associated with early life risk factors. However, the polygenic risk score had a stronger association with depression phenotypes compared to most early life risk factors.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Neurosciences
Jose M. Restrepo-Lozano, Cecilia Flores, Patricia P. Silveira
Summary: The possibility of establishing a metric of individual genetic risk for a particular disease or trait has sparked interest in the scientific community. Current approaches for calculating genetic risk to specific psychiatric conditions involve aggregating estimates from genome-wide association studies into polygenic risk scores. Novel approaches are considering functional molecular phenotypes and prior knowledge of biological processes to improve understanding and diagnosis of psychopathology.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2023)
Meeting Abstract
Neurosciences
Patricia Pelufo Silveira
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Neurosciences
Jose Maria Restrepo, Irina Pokhvisneva, Zihan Wang, Sachin Patel, Michael J. Meaney, Patricia P. Silveira, Cecilia Flores
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)