Article
Gastroenterology & Hepatology
Tracey G. Simon, Bjorn Roelstraete, Hannes Hagstrom, Johan Sundstroem, Jonas F. Ludvigsson
Summary: This study demonstrated that patients with biopsy-proven NAFLD have a significantly higher risk of major adverse cardiovascular events, including ischemic heart disease, stroke, congestive heart failure, and cardiovascular mortality, compared to matched population controls. The risk of such events increases progressively with worsening NAFLD severity.
Article
Cardiac & Cardiovascular Systems
Ben Li, Raj Verma, Derek Beaton, Hani Tamim, Mohamad A. Hussain, Jamal J. Hoballah, Douglas S. Lee, Duminda N. Wijeysundera, Charles de Mestral, Muhammad Mamdani, Mohammed Al-Omran
Summary: Machine learning models accurately predicted 30-day outcomes following carotid endarterectomy (CEA) using preoperative data and performed better than existing tools. They have potential for important utility in guiding risk-mitigation strategies to improve outcomes for patients being considered for CEA.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Rheumatology
Tsai-Hung Yen, Yun-Wen Chen, Tsu-Yi Hsieh, Yi-Ming Chen, Wen-Nan Huang, Yi-Hsing Chen, Hsin-Hua Chen
Summary: This study aimed to assess the incidence and risk factors of major adverse cardiovascular events (MACEs) in patients with systemic sclerosis (SSc). A nationwide cohort study was conducted in Taiwan, including 1379 SSc patients and 2758 non-SSc individuals. The study found that SSc was associated with increased risk of myocardial infarction and peripheral arterial occlusion disease, but not of ischaemic stroke. Age, gender, residential area, valvular heart disease, rheumatoid arthritis, and the use of clopidogrel and aspirin were identified as independent risk factors for MACEs in SSc patients. The findings of this study are clinically significant in understanding the risk factors for MACEs in SSc patients.
Article
Cardiac & Cardiovascular Systems
Patricia Andersen, Kristian Kragholm, Christian Torp-Pedersen, Svend Eggert Jensen, Rubina Attar
Summary: This study investigated the cardiovascular outcomes following myocardial infarction (MI) in patients with peripheral artery disease (PAD). The results showed that compared to patients without PAD, those with PAD had higher 1-year risks of major adverse cardiovascular events (MACE), all-cause mortality, reinfarction, stroke, heart failure, cardiovascular mortality, and bleeding.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Tianyu Xia, Bo Li, Wei Zhang, Zhe Wang, Xiaofeng Ye, Mi Zhou, Haiqing Li, Jiapei Qiu, Yunpeng Zhu, Qiang Zhao
Summary: Our study aimed to identify the independent risk factors for major adverse cardiovascular events (MACE-4) after coronary artery bypass grafting using radial artery grafts (RA-CABG). We found that prior myocardial infarction and radial artery graft to the left anterior descending artery (non-left internal mammary artery to LAD) were independent predictors of MACE-4 after RA-CABG.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Dermatology
Jeanette Halskou Haugaard, Lene Dreyer, Mathias Bo Ottosen, Gunnar Gislason, Kristian Kofoed, Alexander Egeberg
Summary: The use of hydroxychloroquine may reduce the risk of cardiovascular events in patients with LE, especially in those with SLE and CLE.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Clinical Neurology
Axel Nordenskjold, Pelin Guney, Anna M. Nordenskjold
Summary: This study found that ECT treatment in hospitalized patients with depression did not significantly increase the short-term risk of cardiovascular events, and instead, was associated with a reduced risk of MACE within 1 year compared to those not undergoing ECT treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Rheumatology
Laura Pina Vegas, Philippe Le Corvoisier, Laetitia Penso, Muriel Paul, Emilie Sbidian, Pascal Claudepierre
Summary: An analysis of a large database revealed that PsA patients starting IL-12/23 and IL-17 had a higher risk of MACEs compared to those starting TNF inhibitors, while the risk with apremilast was relatively low.
Article
Multidisciplinary Sciences
Po-Chang Wang, Tien-Hsing Chen, Chang-Min Chung, Mei-Yen Chen, Jung-Jung Chang, Yu-Sheng Lin, Pao-Hsien Chu, Yun-Shing Peng, Ming-Shyan Lin
Summary: This retrospective cohort study aimed to assess the impact of previous deep vein thrombosis on major adverse limb events and major adverse cardiovascular events in patients with type 2 diabetes. The results showed that the presence of DVT was associated with an increased risk of MALEs, major amputation, and systemic thromboembolism, leading to a higher mortality rate in T2DM patients.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Mihui Kim, Yong Sook Yang, Young-Guk Ko, Mona Choi
Summary: This study aimed to investigate the associated factors of major adverse events in peripheral artery disease (PAD) patients after endovascular revascularization. The results showed that patients with diabetes mellitus and non-regular exercise had a shorter major adverse events-free survival, and the risk of major adverse events increased for patients with critical limb ischemia or chronic kidney disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ramy Mando, Muhammad Waheed, Adrian Michel, Patrick Karabon, Alexandra Halalau
Summary: Type II diabetes mellitus is a proinflammatory process and a known risk factor for major adverse cardiac events (MACE). This study found that prediabetes is also a risk factor for MACE, while normalization of HbA1c values may decrease the adjusted risk for MACE, highlighting the importance of managing prediabetes to prevent cardiovascular events.
ANNALS OF MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Mikkel Hojlund, Christina Blanner Wagner, Rikke Wesselhoeft, Kjeld Andersen, Anders Fink-Jensen, Jesper Hallas
Summary: This study found that low-dose chlorprothixene use is associated with increased risk of diabetes and cardiovascular adverse events compared with low-dose quetiapine use.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ninghao Huang, Zhenhuang Zhuang, Zimin Song, Wenxiu Wang, Yueying Li, Yimin Zhao, Wendi Xiao, Xue Dong, Jinzhu Jia, Zhonghua Liu, Caren E. Smith, Tao Huang
Summary: The study constructed a modified Healthy Aging Index (mHAI) to quantify the association between physiological aging and vascular events. The mHAI was found to be significantly correlated with major cardiovascular events, with systolic blood pressure being the most significant factor. A healthy lifestyle was shown to attenuate the associations between mHAI and vascular events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Zhongxing Cai, Haoyu Wang, Sheng Yuan, Dong Yin, Weihua Song, Kefei Dou
Summary: In patients with coronary artery ectasia, a high plasma big Endothelin-1 level is associated with an increased risk of major adverse cardiovascular events (MACE), improving risk stratification.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Psychiatry
Mikkel Hojlund, Kjeld Andersen, Martin T. Ernst, Christoph U. Correll, Jesper Hallas
Summary: This study found that the use of low-dose quetiapine is associated with an increased risk of major adverse cardiovascular events, especially in women and the elderly. Compared to Z-drug hypnotics and selective serotonin reuptake inhibitors, the use of low-dose quetiapine is also associated with an increased risk of major adverse cardiovascular events.