Review
Biochemistry & Molecular Biology
Eva M. Verdugo-Sivianes, Amancio Carnero
Summary: SPINOPHILIN (SPN) is a multifunctional protein involved in regulating protein-protein interactions and the dephosphorylation of pRB, which plays a role in cell cycle progression. SPN has been identified as a tumor suppressor gene, and mutations in the SPN protein have been associated with human tumors. Furthermore, an oncogenic mutation, A566V, has been shown to promote tumorigenesis by increasing the CSC pool in breast tumors. Loss or mutation of SPN may contribute to tumor progression by enhancing CSC populations and malignant behavior.
Article
Microbiology
Carmen Stecher, Sanja Marinkov, Lucia Mayr-Harting, Ana Katic, Marie-Theres Kastner, Franz J. J. Rieder-Rommer, Xionghao Lin, Sergei Nekhai, Christoph Steininger
Summary: In this study, the researchers found that inhibition of PP1 using 1E7-03 severely impaired HCMV replication and viral protein translation, potentially through preventing AMP-activated protein kinase dephosphorylation. This revealed an important mechanism of PP1 for lytic HCMV infection.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Song Song, Bomsoo Cho, Alexis T. Weiner, Silas Boye Nissen, Irene Ojeda Naharros, Pablo Sanchez Bosch, Kaye Suyama, Yanhui Hu, Li He, Tanya Svinkina, Namrata D. Udeshi, Steven A. Carr, Norbert Perrimon, Jeffrey D. Axelrod
Summary: This study identified proteins involved in regulating planar cell polarity (PCP) using mass spectrometry-based proteomics. It was found that the catalytic subunit of protein phosphatase 1 (Pp1-87B) and the regulatory subunit PNUTS are involved in regulating PCP. The results suggest that cycling between phosphorylated and unphosphorylated forms of core PCP components may regulate cell polarity.
Article
Biochemistry & Molecular Biology
Aline Freville, Benedicte Gnangnon, Annie Z. Tremp, Caroline De Witte, Katia Cailliau, Alain Martoriati, El Moukthar Aliouat, Priyanka Fernandes, Cerina Chhuon, Olivier Silvie, Sabrina Marion, Ida Chiara Guerrera, Johannes T. Dessens, Christine Pierrot, Jamal Khalife
Summary: This study reveals the regulation mechanism of key enzyme PP1 in Plasmodium development, including the formation of PbLRR1 complex and its inhibition on PP1 phosphatase activity. Depletion of PbLRR1 negatively affects oocyst development and controls the phosphorylation status of multiple proteins through interaction with new partners.
Article
Immunology
QinLei Gu, Kenneth S. Tung, Ulrike M. Lorenz
Summary: To achieve a healthy and functional immune system, there is a delicate balance between the activation of Tcon cells and the suppression by Treg cells. SHP-1 plays a role in modulating this balance by regulating Tcon cell resistance to Treg-mediated suppression. However, the role of SHP-1 in Treg function is still not fully understood.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Adrienn Markovics, Sydney Lupo, Niyati Patel, Katalin Mikecz, D. Rick Sumner, Ryan D. Ross
Summary: This study found that Shp1 overexpression leads to increased bone mass and improved mechanical properties in mice, but only in 28-day-old mice. Female SHP1-Tg mice showed higher trabecular bone volume, trabecular number, and connectivity density compared to wildtype mice.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Obstetrics & Gynecology
Joana Vieira Silva, Maria Joao Freitas, Joana Santiago, Sarah Jones, Sofia Guimaraes, Srinivasan Vijayaraghavan, Steven Publicover, Giorgio Colombo, John Howl, Margarida Fardilha
Summary: By designing bioportides with targeting PP1 disrupting function, the sperm vitality and motility were significantly affected, providing a new research approach for predicting male fertility indicators.
FERTILITY AND STERILITY
(2021)
Article
Biochemistry & Molecular Biology
Zoltan Konya, Istvan Tamas, Balint Becsi, Beata Lontay, Maria Raics, Istvan Timari, Katalin E. Kover, Ferenc Erdodi
Summary: This study demonstrates that a phosphorylated peptide derived from the inhibitory region of MYPT1 interacts with and inhibits the PP1c and MP holoenzyme. These findings provide insights into the cellular functions of PP1 and may have therapeutic implications for signaling-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yi-Yong Wang, Bin Gao, Yong Yang, Shao-Bin Jia, Xue-Ping Ma, Ming-Hao Zhang, Li-Juan Wang, Ai-Qun Ma, Qin-Ning Zhang
Summary: This study aimed to explore the regulatory mechanism of histone deacetylase 3 (HDAC3) and DNA methyltransferase 1 (DNMT1)/Src homology domain 2-containing tyrosine phosphatase-1 (SHP-1) axis in heart failure (HF). The study found that HDAC3 modified DNMT1 through deacetylation to suppress SHP-1 expression, which in turn led to the development of cardiomyocyte hypertrophy-induced HF. This provides potential therapeutic targets for HF treatment.
Article
Biochemistry & Molecular Biology
Laurent Schmied, Thuy T. Luu, Jonas N. Sondergaard, Sophia H. Hald, Stephan Meinke, Dara K. Mohammad, Sunitha B. Singh, Corinna Mayer, Giovanna Perinetti Casoni, Michael Chrobok, Heinrich Schlums, Giorgia Rota, Hieu M. Truong, Lisa S. Westerberg, Greta Guarda, Evren Alici, Arnika K. Wagner, Nadir Kadri, Yenan T. Bryceson, Mezida B. Saeed, Petter Hoglund
Summary: Natural killer (NK) cells recognize infected cells and tumors. The function of NK cells depends on balanced signaling from activating and inhibitory receptors. The subcellular localization of tyrosine phosphatase SHP-1 determines NK cell tolerance and education. Education of NK cells leads to reduced synapse accumulation of SHP-1 and augmented signaling from activating receptors.
Article
Biochemistry & Molecular Biology
Miriam Fontanillo, Malgorzata Trebacz, Christopher D. Reinkemeier, Daniela Aviles Huerta, Ulrike Uhrig, Peter Sehr, Maja Kohn
Summary: This study presents the sequence optimization of a 23mer PDP to a 5mer peptide, providing a lead structure for targeting PP1 in therapy or for its use in phosphatase-recruiting chimeras in the future.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Hyeong Jun Kim, Hoyoung Jung, Soyeon Kim, Jeong Kon Seo, Jung-Min Kee
Summary: Despite the recent discovery of numerous phosphohistidine sites, their functions remain largely unknown. PHPT1 is a protein phosphatase that regulates important cellular processes, but the lack of inhibitors has hindered further research and therapeutic development.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Immunology
Lei Shi, Zhen Bian, Koby Kidder, Hongwei Liang, Yuan Liu
Summary: Macrophage functional plasticity is crucial in responding to proinflammatory stimuli. SIRP alpha serves as a key negative regulator of proinflammatory macrophage polarization by activating SHP-1 and inhibiting Akt2, leading to decreased proinflammatory cytokine production and Ag presentation machinery expression.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell & Tissue Engineering
Hyeri Park, Jin Seok, Jun Hyeong You, Jae Yeon Kim, Ja-Yun Lim, Gi Jin Kim
Summary: This study investigated the therapeutic mechanism of PD-MSCs overexpressing PRL-1 in ovarian dysfunction and vascular remodeling. The results showed that PRL-1 enhanced ovarian function through the PDGF signaling pathway, providing new insights for more efficient therapies in degenerative medicine.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Yunmeng Bian, Li Yuan, Xiaoqian Yang, Lichun Weng, Yanli Zhang, He Bai, Jinhong Chen
Summary: The study revealed the crucial role of the SHP-1-STAT3 pathway in the pathogenesis of endometriosis. SMURF1 activated the STAT3 pathway by ubiquitylating and degrading SHP-1, thereby promoting cell proliferation and invasion.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Hematology
Peisong Ma, Kristy Ou, Andrew J. Sinnamon, Hong Jiang, David P. Siderovski, Lawrence F. Brass
Article
Hematology
Peisong Ma, Aleksandra Cierniewska, Rachel Signarvic, Marcin Cieslak, Hong Kong, Andrew J. Sinnamon, Richard R. Neubig, Debra K. Newman, Timothy J. Stalker, Lawrence F. Brass
Editorial Material
Hematology
Lawrence F. Brass, Peisong Ma
Correction
Cell Biology
Peisong Ma, Shannon L. Beck, Ronald W. Raab, Robert L. McKown, George L. Coffman, Atsushi Utani, William J. Chirico, Alan C. Rapraeger, Gordon W. Laurie
JOURNAL OF CELL BIOLOGY
(2011)
Review
Hematology
L. F. Brass, K. M. Wannemacher, P. Ma, T. J. Stalker
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2011)
Review
Biochemistry & Molecular Biology
Xi Chen, Xuefei Zhao, Matthew Cooper, Peisong Ma
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Hematology
Stephanie A. Renna, Xuefei Zhao, Satya P. Kunapuli, Peisong Ma, Michael Holinstat, Matthew B. Boxer, David J. Maloney, James V. Michael, Steven E. Mckenzie
Summary: This study investigated the cooperativity of PARs (protease-activated receptors) and Fc & gamma;RIIA in HIT using human and mouse model systems. It was found that pharmacological inhibition of 12-LOX can decrease platelet procoagulant phenotype and reduce thrombocytopenia and thrombosis in a mouse model of HIT.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Hematology
Xi Chen, Shuchi Gupta, Matthew Cooper, Daniel DeHelian, Xuefei Zhao, Meghna U. Naik, Jeremy G. T. Wurtzel, Timothy J. Stalker, Lawrence E. Goldfinger, Jeffrey Benovic, Lawrence F. Brass, Steven E. McKenzie, Ulhas P. Naik, Peisong Ma
Meeting Abstract
Hematology
Xi Chen, Shuchi Gupta, Matthew Cooper, Daniel Dehelian, Lawrence F. Brass, Peisong Ma
Article
Hematology
Peisong Ma, Shuchi Gupta, Sara Sampietro, Daniel DeHelian, Valerie Tutwiler, Alan Tang, Timothy J. Stalker, Lawrence F. Brass
Meeting Abstract
Hematology
Peisong Ma, Daniel DeHelian, Shuchi Gupta, Lawrence Brass
AMERICAN JOURNAL OF HEMATOLOGY
(2016)
Meeting Abstract
Hematology
P. Ma, A. Sinnamon, K. Ou, L. Brass
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2015)
Meeting Abstract
Hematology
P. Ma, A. Cierniewska, R. Signarvic, A. Sinnamon, M. Cieslak, T. Stalker, R. Neubig, L. Brass
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2011)
Meeting Abstract
Hematology
L. F. Brass, K. M. Wannemacher, P. Ma, T. J. Stalker
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2011)