Article
Radiology, Nuclear Medicine & Medical Imaging
Roya Afshari, Francesco Santini, Rahel Heule, Craig H. Meyer, Josef Pfeuffer, Oliver Bieri
Summary: The purpose of this study is to introduce a 1-minute whole-brain spiral MTR method with intrinsic B-1-field correction for assessment of diffuse pathological changes in the brain. This method offers fast scanning and reduced confounding factors for high reproducibility, showing excellent prospects for clinical studies exploring magnetization-transfer effects based on MTR histogram analysis. The proposed B-1-correction scheme improves the reproducibility of MTR histograms and accentuates MTR differences in gray and white matter in the brain.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Clinical Neurology
J. Kollmer, T. Kessler, G. Sam, J. M. Hayes, S. I. Lentz, S. Heiland, M. Bendszus, W. Wick, M. Weiler
Summary: This study quantified peripheral nerve lesions in SMA type 3 patients using magnetization transfer ratio (MTR) of the sciatic nerve and found that MTR can serve as a novel biomarker for evaluating nerve changes. Results showed that MTR and CSA of the sciatic nerve differed significantly between patients and healthy controls, with MTR correlating with clinical scores and CMAPs.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Phillip Zhe Sun
Summary: Our study demonstrates that the generalized QUASS analysis enhances pH MRI contrast and improves quantification of the underlying CEST contrast mechanism, promising for further in vivo applications.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chongxue Bie, Peter C. M. van Zijl, Deng Mao, Nirbhay N. Yadav
Summary: This study presents a new approach to improve the application of ultrafast Z-spectroscopy (UFZ) in the human body, making it more stable and accurate. By applying saturation gradients and readout gradients in the slice direction and phase encoding in the in-plane directions, high-resolution Z-spectra can be obtained. The results show that this method allows for better quantification and mapping of saturation transfer effects, opening up new possibilities for brain imaging.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Neurosciences
Fanny Munsch, Gopal Varma, Manuel Taso, Olivier Girard, Arnaud Guidon, Guillaume Duhamel, David C. Alsop
Summary: The study implemented a 3D ihMT acquisition and analysis to characterize cortical gray matter myeloarchitecture, finding qualitative agreement between cortical ihMTsat and dual MTsat maps with previous work and cortical T(1)w map, but with important regional differences. The research demonstrated that ihMTsat shows unique contrast between cortical regions.
Article
Engineering, Biomedical
Fulin Wei, Xueyuan Xu, Tianyuan Jia, Daoqiang Zhang, Xia Wu
Summary: Individual differences present a challenge in motor imagery (MI) decoding. Multi-source transfer learning (MSTL) is a promising approach to reduce these differences. In this study, we propose a method called multi-source transfer joint matching (MSTJM) and weighted MSTJM (wMSTJM) to align data distribution between subject pairs and improve MI-BCI accuracy. Our framework outperformed state-of-the-art methods by at least 4.24% and 2.62%. This has potential implications for practical applications of MI-BCI.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Neurosciences
Valentin H. Prevost, Andrew Yung, Sarah R. Morris, Irene M. Vavasour, Zahra Samadi-Bahrami, G. R. Wayne Moore, Cornelia Laule, Alex Mackay, Piotr Kozlowski
Summary: The temperature has different effects on unfiltered and filtered ihMT, with MWF decreasing and filtered ihMTR increasing at higher temperatures. The recommendations suggest controlled temperatures close to 37 degrees C for filtered ihMT acquisitions, while ex vivo myelin water imaging should be performed at room temperature.
Article
Chemistry, Analytical
Fan Jia, Zijing Zhang, Yuan Zhao
Summary: Ghost imaging is a technique that improves the signal-to-noise ratio and resolution by using the correlation between reference and signal arms to obtain intensity images of targets. This paper proposes a new scheme for obtaining velocity images of moving targets using the slice difference method. The experimental results show good agreement with the theoretical analysis, and a velocity image with 64 x 64 resolution is obtained. This scheme fulfils an urgent need for the detection of moving targets and has potential applications in target attitude perception and security monitoring.
Article
Radiology, Nuclear Medicine & Medical Imaging
Blake Benyard, Ravi Prakash Reddy Nanga, Neil E. E. Wilson, Deepa Thakuri, Paul S. S. Jacobs, Anshuman Swain, Dushyant Kumar, Ravinder Reddy
Summary: This study aims to determine the reproducibility of NOE magnetization transfer ratio (NOEMTR) and isolated or relayed NOE (rNOE) in NOE MRI of the healthy human brain at 7 Tesla (T). The study found that both NOEMTR and rNOE metrics have excellent reproducibility in the healthy human brain at 7 T.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Medicine, General & Internal
Deep B. Gandhi, Mina Al Saeedi, James D. Krier, Kai Jiang, James F. Glockner, Lilach O. Lerman
Summary: Renal fibrosis is a significant marker for the progression of chronic kidney disease, and renal biopsy is currently the reference standard for detecting it. Magnetization transfer imaging (MTI) can estimate renal fibrosis, but its reliability may vary with scanning conditions. This study demonstrated that MTI is highly reproducible at 1.5T and 3T MRI and sensitive in detecting changes in fibrotic kidneys compared to normal ones in the RAS porcine model at 3T.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Monika Gloor, Michaela Andelova, Laura Gaetano, Athina Papadopoulou, Federico Burguet Villena, Till Sprenger, Ernst-Wilhelm Radue, Ludwig Kappos, Oliver Bieri, Meritxell Garcia
Summary: This study analyzed the potential of magnetization transfer imaging (MTI) and diffusion tensor imaging (DTI) for the detection and evolution of new multiple sclerosis (MS) lesions. The results showed that MTI provides more information than DTI and can detect tissue changes 2 to 4 months prior to their appearance on MRI.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucas Soustelle, Thomas Troalen, Andreea Hertanu, Samira Mchinda, Jean-Philippe Ranjeva, Maxime Guye, Gopal Varma, David C. Alsop, Guillaume Duhamel, Olivier M. Girard
Summary: Concentrating RF saturation energy in ihMT-GRE sequences mitigates the sensitivity of ihMTR to B1+ variations, allowing for clinical-ready ihMT imaging at 3 T. Under optimal conditions, 73% of WM voxels presented delta(ihMTR) below 10%. Reproducibility analysis showed minimal systematic bias and high correlation between test and retest experiments.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Optics
Xi Zhang, Suhas P. Veetil, Yan Kong, Xiaoliang He, Zhilong Jiang, Shouyu Wang, Cheng Liu
Summary: A transmission K-domain transform method is proposed for multi-slice imaging using a light sheet and a high pass filter. The method computes the image of the illuminated sample volume at each scanning location using a 2D K-domain transform algorithm, allowing for sequential scanning of the sample through the light sheet. The method offers advantages for short wavelength applications where reflection is absent and reduces the need for rotation and mechanical precision.
OPTICS COMMUNICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vira Grynko, Yurii Shepelytskyi, Tao Li, Ayman Hassan, Karl Granberg, Mitchell S. Albert
Summary: This study demonstrated the feasibility of performing multi-slice human brain MRI using HP Xe-129, showing similar SNR values and signal distribution in axial and sagittal orientations. Anatomical features such as ventricles were also observed in both orientations, indicating the potential of HP Xe-129 multi-slice MRI for improving brain imaging techniques.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nan Meng, Xuejia Wang, Jing Sun, Zhun Huang, Zhen Yang, Jie Shang, Yan Bai, Wei Wei, Dongming Han, Hui Han, Kaiyu Wang, Fengmin Shao, Meiyun Wang
Summary: Both DKI- and APTWI-related parameters have potential as imaging markers in estimating the histological features of EC, while DKI shows better performance than APTWI in this study.
EUROPEAN RADIOLOGY
(2021)
Article
Biophysics
Ki Hwan Kim, Sunghun Seo, Won-Joon Do, Huan Minh Luu, Sung-Hong Park
Summary: The proposed new sampling strategy showed superior performance in various types of MRI imaging, regardless of sampling pattern or datasets, particularly in multicontrast MR imaging and multiple PC-bSSFP imaging.
NMR IN BIOMEDICINE
(2022)
Article
Oncology
Gyu Sang Yoo, Huan Minh Luu, Heejung Kim, Won Park, Hongryull Pyo, Youngyih Han, Ju Young Park, Sung-Hong Park
Summary: The study compares the qualities of synthetic computed tomography (sCT) generated by various deep-learning methods in volumetric modulated arc therapy (VMAT) planning for prostate cancer. The results show that sCT generated from the RgGAN demonstrates the best performance in dosimetric conservation D-98% and D-95% compared to other methodologies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Muhammad Asaduddin, Hong Gee Roh, Hyun Jeong Kim, Eung Yeop Kim, Sung-Hong Park
Summary: This study successfully extracted perfusion maps using deep learning methods from a single dose of contrast agent. Testing showed that U-net with multiple decoders and enhanced encoders performed the best, demonstrating strong agreement between the generated perfusion maps and the ground truth.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Clinical Neurology
Na Rae Kim, Seong-Ik Kim, Jin Woo Park, Chul-Kee Park, Chun Kee Chung, Seung-Hong Choi, Hongseok Yun, Sung-Hye Park
Summary: In this study, two cases of rare angiomatoid fibrous histiocytomas (AFH) were reported, one in the brain parenchyma and the other in the spinal cord. Molecular investigations revealed that both cases harbored FET:CREB fusion. A comprehensive review of 40 cases of central nervous system AFHs/myxoid mesenchymal tumors showed that they predominantly occurred in children and young adults, were dura-based, and were associated with EWSR1 rearrangements.
Article
Clinical Neurology
H. Chung, H. Seo, S. H. Choi, C. -k. Park, T. M. Kim, S. -h. Park, J. K. Won, J. H. Lee, S. -t. Lee, J. Y. Lee, I. Hwang, K. M. Kang, T. J. Yun
Summary: This study developed a machine learning-based model to identify preoperative multiparametric MR imaging markers associated with prognosis in glioblastoma patients. The model found that nonenhancing T2 high-signal-intensity lesions with the relatively low normalized CBV, low volume transfer constant values, and the lowest ADC values could serve as useful prognostic imaging markers for predicting survival outcomes in patients with glioblastoma.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Otorhinolaryngology
In Gul Kim, Yanru Wu, Su A. Park, Ji Suk Choi, Seong Keun Kwon, Seung Hong Choi, Kyeong Cheon Jung, Jung-Woog Shin, Eun-Jae Chung
Summary: This study evaluated the potential of a double-layered polymeric scaffold and a custom-designed mesenchymal stem cell-based bioreactor system for esophageal tissue engineering. The results showed that electrospun polyurethane scaffolds cultured in a custom bioreactor can be a promising approach for esophageal reconstruction.
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2023)
Article
Clinical Neurology
Ye Yoon Suh, Kwanghoon Lee, Yu-Mi Shim, Ji Hoon Phi, Chul-Kee Park, Seung-Ki Kim, Seung Hong Choi, Hongseok Yun, Sung-Hye Park
Summary: The MYB/MYBL1::QKI fusion activates the oncogene MYB and deletes the tumor suppressor gene QKI. Previously, this fusion was only reported in angiocentric glioma (AG) and diffuse low-grade glioma. This study compares two tumors with the MYB/MYBL1::QKI fusion: a diffuse pediatric-type high-grade glioma (DPedHGG) in an 11-year-old boy and an AG in a 46-year-old woman. Characterization using immunohistochemistry, next-generation sequencing, and methylation profiling reveals their molecular characteristics and supports the presence of MYB/MYBL1 alterations in higher-grade gliomas.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bomin Kim, Geun Young Lee, Sung-Hong Park
Summary: This study proposed a deep learning model for MR-only ONFH staging, which reduces the additional cost and radiation exposure from the acquisition of CT images. By integrating information from MR images of five different protocols using attention fusion, and using self-supervised learning, the model showed improved performance in ARCO staging. The proposed method has the potential to be used in the diagnosis of other diseases that require staging from multiple MR protocols.
Article
Oncology
Beomseok Sohn, Kisung Park, Sung Soo Ahn, Yae Won Park, Seung Hong Choi, Seok-Gu Kang, Se Hoon Kim, Jong Hee Chang, Seung-Koo Lee
Summary: A radiomics model based on dynamic contrast-enhanced (DCE) MRI was developed and validated to predict epidermal growth factor receptor (EGFR) amplification in patients with glioblastoma, isocitrate dehydrogenase (IDH) wildtype.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Review
Clinical Neurology
Hyunhee Kim, Kwanghoon Lee, Ji Hoon Phi, Sun Ha Paek, Hongseok Yun, Seung Hong Choi, Sung-Hye Park
Summary: This study presents the clinicopathological and molecular genetic characteristics of a neuroepithelial tumor (NET) with EWSR1::PATZ1 fusion, which has recently been discovered in rare central nervous system tumors and soft tissue sarcomas. Two cases of this fusion were identified, with the pediatric case showing a high-grade tumor and longer survival compared to conventional glioblastoma. The TERT promoter mutation may serve as an indicator of high-grade behavior in PATZ1 fusion NET.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Article
Biophysics
Jun-Hee Kim, Jae-Geun Im, Sung-Hong Park
Summary: This study proposes a new approach to studying the alteration of cerebrospinal fluid (CSF) dynamics in traumatic brain injury (TBI) patients. The findings suggest that the decreased CSF pulsation after TBI could lead to the accumulation of toxic substances in the brain and have an adverse effect on brain function.
NMR IN BIOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Eunhyeong Lee, Eun-Ah Lee, Eunji Kong, Haemin Chon, Melissa Llaiqui-Condori, Cheon Ho Park, Beom Yong Park, Nu Ri Kang, Jin-San Yoo, Hyun-Soo Lee, Hyung-Seok Kim, Sung-Hong Park, Seung-Won Choi, Dietmar Vestweber, Jeong Ho Lee, Pilhan Kim, Weon Sup Lee, Injune Kim
Summary: An antibody targeting key signalling pathways has been developed to prevent abnormal blood vessels in brain tumors, thus improving drug delivery into tumor tissues. This study reveals a potential strategy for improving glioblastoma treatment through multiple vascular mechanisms.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Beomseok Sohn, Kisung Park, Sung Soo Ahn, Yae Won Park, Seung Hong Choi, Seok-Gu Kang, Se Hoon Kim, Jong Hee Chang, Seung-Koo Lee
Summary: The study developed and validated a radiomics model based on dynamic contrast-enhanced (DCE) MRI to predict EGFR amplification in glioblastoma patients. The radiomics model using the K-trans map showed higher accuracy than conventional MRI in predicting EGFR amplification.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Huan Minh Luu, Sung-Hong Park
Summary: This paper presents the author's contribution to the brain tumor segmentation challenge in 2021, with modifications to the nn-UNet model resulting in first place in the final ranking for unseen test data, achieving high dice scores for different tumor regions.
BRAINLESION: GLIOMA, MULTIPLE SCLEROSIS, STROKE AND TRAUMATIC BRAIN INJURIES, BRAINLES 2021, PT II
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Jaa-Yeon Lee, Min A. Yoon, Choong Guen Chee, Jae Hwan Cho, Jin Hoon Park, Sung-Hong Park
Summary: The research aims to accelerate MRI for metal artifact correction in patients with degenerative spine diseases using multi-contrast deep neural networks. It proposes a method to reduce the scan time by generating high SEMAC factor data from low SEMAC factor data. The developed networks provide great performance for correcting metal artifacts with potentially reduced scan time and reasonable quality.
MACHINE LEARNING FOR MEDICAL IMAGE RECONSTRUCTION (MLMIR 2022)
(2022)
