Article
Pathology
Xiaoling Lu, Meitong Liu, Yuxiao Liao, Chao Huang, Longlong Chai, Yuchen Jin, Qiantao Xiong, Bifeng Chen
Summary: The meta-analysis revealed a significant association between SNPs rs2295080, rs17036508, and rs1034528 in the mTOR gene and cancer risk, while target genetic polymorphisms in the mLST8 gene or RPTOR gene may not be associated with cancer risk. Further large-scale and well-designed studies in different ethnic populations are needed to confirm or strengthen these findings.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Oncology
Ke Zhu, Aiqun Xu, Wanli Xia, Pulin Li, Binbin Zhang, Huihui Jiang, Sijing Zhou, Ran Wang
Summary: The NAT2 slow + intermediate phenotype is significantly associated with an increased risk of lung cancer, while the NAT2 rapid phenotype is associated with a reduced risk of lung cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Genetics & Heredity
Lin Zhao, Xiang-Xiongyi Yin, Jun Qin, Wei Wang, Xiao-Feng He
Summary: Based on a comprehensive analysis of a large number of studies, this meta-analysis found no significant association between TP53 codons 72, IVS3 16 bp, and IVS6+62A > G polymorphisms and breast cancer risk. The previous results suggesting an association may be false-positive results due to confounding factors.
FRONTIERS IN GENETICS
(2022)
Review
Obstetrics & Gynecology
Yuxi Li, Lanlan Fang, Yang Yan, Zhen Wang, Ze Wu, Qiongqiong Jia, Jung-Chien Cheng, Ying-Pu Sun
Summary: The presence of a polymorphism of eight or more SHBG (TAAAA)n may be a predictive factor for the risk of PCOS, as it is associated with PCOS risk and low serum SHBG concentrations in women with PCOS. Other SHBG gene polymorphisms were not significantly associated with either PCOS risk or serum SHBG concentrations.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Medicine, General & Internal
Miao Zeng, Yiping Liu, Yunquan Xie
Summary: The study investigated the association between ALDH2 polymorphisms and the risk of developing diabetes mellitus in hypertensive patients. The results showed that the G/A and A/A genotypes of ALDH2 were significantly more prevalent in patients with diabetes, suggesting an increased risk of diabetes in hypertensive patients with these genotypes.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Genetics & Heredity
Xu Han, Lai Zheng, Yi-Yang Mu, Hong-Zhuo Li, Xiao-Feng He
Summary: The meta-analysis investigated the association between OPG gene polymorphisms and osteoporosis risk, finding a significant correlation in certain subgroups but overall pointing to false-positive results. This suggests that previous studies may not have accurately assessed the true association between OPG gene variants and osteoporosis risk.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Chuankun Zhou, Shutao Gao, Xi Yuan, Zixing Shu, Song Li, Xuying Sun, Jun Xiao, Hui Liu
Summary: CTLA-4 gene polymorphisms may be associated with the risk of Rheumatoid arthritis (RA), with rs3087243 and rs231775 polymorphisms showing significant associations, while rs5742909 polymorphism is not associated with RA risk. Meta-analysis confirms the relationship between CTLA-4 gene polymorphisms and RA risk in different populations.
Review
Medicine, General & Internal
Jinnian Liu, Jian Zheng, Yu Guo, Xia Sheng, Yongjian Yin, Shengqiang Qian, Bin Xu, Wei Xiong, Xiangrui Yin
Summary: The study suggests a significant association between APE1 gene polymorphisms (rs1760944 and rs1130409) and prostate cancer risk. Specifically, rs1760944 may be a protective factor while rs1130409 could be a risk factor for prostate cancer. The polymorphisms of APE1 genes could potentially be used for risk assessment in prostate cancer.
Review
Dermatology
Zhi Xiang, Zhimin Hao, Pangen Cul, Lin Lin, Min Chen, Pro Min Chen
Summary: The IL-17F rs763780 T/C polymorphism is significantly associated with the risk of psoriasis in Asian populations.
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
(2022)
Article
Medicine, General & Internal
Shilin Xue, Wenya Shen, Jianning Cai, Jinhai Jia, Dan Zhao, Shan Zhang, Xiujun Zhao, Ning Ma, Wenjuan Wang, Bingshuang Wang, Xiaolin Zhang, Xuehui Liu
Summary: This meta-analysis aimed to examine the association between rs735482 polymorphism and cancer risk. The results showed that there is no significant association between rs735482 polymorphism and susceptibility to various cancers overall. However, stratified analysis by ethnicity indicated that rs735482 is associated with an increased risk of cancer in the Chinese population and a decreased risk in the Italian population.
Article
Multidisciplinary Sciences
Qiuchen Jin, Fangjun Teng, Zhigang Cheng
Summary: Functional polymorphisms of IL-1 alpha (C-889T), IL-1 beta (C+3954T, C-511T) and the composite genotype of IL-1 can serve as predictive markers for peri-implant disease, while the TNF alpha G-308A polymorphism is not associated with peri-implant disease.
Review
Medicine, General & Internal
Kexin Wang, Zhen Jiao, Hongxiang Chen, Xiaowan Liu, Jing Lu, Xuli Liu, Jinming Li, Lin Wang
Summary: The meta-analysis reveals a significant negative association between rs1800872 polymorphism in interleukin-10 and risk of cervical cancer, indicating a protective effect of the AC/AA + AC variant in the development of cervical cancer.
Article
Cell Biology
Xue-Feng Li, Guang-Bin Jiang, Shi-Yan Cheng, Ya-Feng Song, Cai Deng, Yu-Ming Niu, Jun-Wei Cai
Summary: The meta-analysis on the association between PPAR-gamma 2 gene polymorphisms and diabetic retinopathy risk did not find a significant relationship between the two factors. Subgroup analyses also failed to reveal any significant associations.
Article
Endocrinology & Metabolism
Chenchen Yang, Can Shi
Summary: This meta-analysis aimed to study the correlation between four polymorphisms in the matrix metalloproteinase (MMP) gene and risk of cervical cancer. The results showed that MMP-7 rs11568818 G/A and MMP-3 rs3025058 5A/6A were significantly associated with cervical cancer susceptibility.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Multidisciplinary Sciences
Mohamad Ayub Khan Sharzehan, Hilary Sito, Noraidatulakma Abdullah, Athanasios Alexiou, Marios Papadakis, Rahman Jamal, Shing Cheng Tan
Summary: This meta-analysis found a significant association between CYP2E1 rs2031920 and CRC risk, while rs3813867 and rs6413432 were not associated.
SCIENTIFIC REPORTS
(2022)