Article
Endocrinology & Metabolism
Ye Young Kim, Hagoon Jang, Gung Lee, Yong Geun Jeon, Jee Hyung Sohn, Ji Seul Han, Won Taek Lee, Jeu Park, Jin Young Huh, Hahn Nahmgoong, Sang Mun Han, Jeesoo Kim, Minwoo Pak, Sun Kim, Jong-Seo Kim, Jae Bum Kim
Summary: This study demonstrated that the reduction of hepatic CRY1 protein in diabetic mice is stimulated by FBXL3-dependent proteasomal degradation and GSK3 beta-induced CRY1 phosphorylation. Tight regulation of hepatic CRY1 protein stability is crucial for maintaining systemic glucose homeostasis.
Article
Biochemistry & Molecular Biology
Raffaella Mastrocola, Federica Dal Bello, Alessia S. Cento, Katrien Gaens, Debora Collotta, Manuela Aragno, Claudio Medana, Massimo Collino, Kristiaan Wouters, Casper G. Schalkwijk
Summary: High levels of sphingolipid intermediates ceramide and sphingosine-1-phosphate are suggested to be involved in the development of insulin resistance. Accumulation of advanced glycation endproducts (AGEs) in the liver may alter sphingolipids metabolism, leading to insulin resistance. Modulating sphingolipids metabolism through preventing AGEs accumulation could potentially reduce the development of insulin resistance.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Endocrinology & Metabolism
Sambit Roy, Aierken Abudu, Irving Salinas, Niharika Sinha, Holly Cline-Fedewa, Alexandra M. Yaw, Wenjie Qi, Todd A. Lydic, Diana L. Takahashi, Jon D. Hennebold, Hanne M. Hoffmann, Jianrong Wang, Aritro Sen
Summary: This study shows that chronic high androgen levels cause hepatic steatosis in a PCOS mouse model, and this phenotype can be rescued through hepatocyte-specific androgen receptor (AR)-knockout. The study also reveals that androgens can disrupt the hepatic timing system and affect the expression of metabolic genes and circadian genes.
Article
Biochemistry & Molecular Biology
Andreas Giannisis, Kalicharan Patra, Anna K. Edlund, Lur Agirrezabala Nieto, Joan Benedicto-Gras, Simon Moussaud, Andres de la Rosa, Daniel Twohig, Tore Bengtsson, Yuan Fu, Guojun Bu, Greg Bial, Lander Foquet, Christina Hammarstedt, Stephen Strom, Kristina Kannisto, Jacob Raber, Ewa Ellis, Henrietta M. Nielsen
Summary: Liver-generated plasma apoE, although it does not enter the brain, is correlated with the risk and biomarker levels of Alzheimer's disease (AD). Carriers of APOE ε4, the strongest genetic risk factor for AD, show lower plasma apoE and altered brain integrity even in mid-life. This study investigates the role of liver-derived apoE in promoting neurodegeneration and emphasizes the potential importance of the liver in the APOE ε4-associated risk of neurodegenerative disease.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Zirui Huang, Yun Liu, Xiaoyan Liu, Kewen Chen, Wenyu Xiong, Yuyang Qiu, Xiaoyu He, Bin Liu, Feng Zeng
Summary: This study evaluated the effects of oral administration of a Sanghuangporus vaninii mixture (SVM) on type 2 diabetes mice. The results showed that SVM intervention could improve body weight, glucose/lipid metabolism, and levels of inflammatory factors in the pancreas and jejunum. Furthermore, SVM intervention altered the intestinal microbiota, regulated various metabolic pathways, and had significant correlations with glucose/lipid metabolism-related indicators. These findings suggest that SVM could potentially ameliorate type 2 diabetes and its complications by modulating the structure, abundance, and function of intestinal microbiota.
Article
Gastroenterology & Hepatology
Sebastian Larion, Caleb A. Padgett, Joshua T. Butcher, James D. Mintz, David J. Fulton, David W. Stepp
Summary: Nonalcoholic fatty liver disease (NAFLD) is related to the disruption of the liver's biological clock, and nobiletin can improve NAFLD by restoring the biological clock. The study suggests that nobiletin reduces hepatic lipid accumulation and alleviates steatosis in obesity.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Cell Biology
Jan-Frieder Harmsen, Michel van Weeghel, Rex Parsons, Georges E. Janssens, Jakob Wefers, Dirk van Moorsel, Jan Hansen, Joris Hoeks, Matthijs K. C. Hesselink, Riekelt H. Houtkooper, Patrick Schrauwen
Summary: This study investigates the 24-hour muscle metabolome in young, healthy men and older, metabolically compromised men. The results show that metabolites involved in glycolysis and hexosamine biosynthesis are increased in the metabolically compromised men, while metabolites related to glutamine-alpha-ketoglutarate, ketone, and redox metabolism are decreased. The findings suggest a plasticity of the skeletal muscle metabolome over the 24-hour period and significant differences between healthy and metabolically compromised individuals.
Review
Biochemistry & Molecular Biology
Nicolas J. Pillon, Ruth J. F. Loos, Sally M. Marshall, Juleen R. Zierath
Summary: This review focuses on the influence of genetic and environmental factors on metabolism and highlights the importance of personalized strategies for prevention, management, and care to improve health outcomes and reduce the impact of metabolic diseases.
Article
Biochemistry & Molecular Biology
Andras Franko, Martin Irmler, Cornelia Prehn, Silke S. Heinzmann, Philippe Schmitt-Kopplin, Jerzy Adamski, Johannes Beckers, Juergen-Christoph von Kleist-Retzow, Rudolf Wiesner, Hans-Ulrich Haring, Martin Heni, Andreas L. Birkenfeld, Martin Hrabe de Angelis
Summary: The study found that bezafibrate improved glucose metabolism in diabetic mice by decreasing inflammatory pathways and increasing insulin signaling and lipid pathways. This resulted in ameliorated glucotoxicity and reduced insulin resistance in the mice.
Article
Endocrinology & Metabolism
Brittany L. Moyce Gruber, Laura K. Cole, Bo Xiang, Mario A. Fonseca, Julianne Klein, Grant M. Hatch, Christine A. Doucette, Vernon W. Dolinsky
Summary: Adiponectin deficiency contributes to the development of fatty liver during pregnancy and is associated with GDM. Adiponectin knockout mice developed hepatic steatosis and exhibited glucose and pyruvate intolerance during pregnancy.
Review
Endocrinology & Metabolism
Sitara Niranjan, Brett E. E. Phillips, Nick Giannoukakis
Summary: Diabetes mellitus is a metabolic disease characterized by hyperglycemia. It is becoming a common condition associated with liver disease in the US. The mechanism by which diabetes drives liver disease is a hot topic of discussion and research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Brendan M. Gabriel, Jonathon A. B. Smith, Laura Sardon-Puig, Xiping Zhang, Astrid L. Basse, Rhianna C. Laker, Hui Gao, Zhengye Liu, Lucile Dollet, Jonas T. Treebak, Antonio Zorzano, Zhiguang Huo, Mikael Ryden, Johanna T. Lanner, Karyn A. Esser, Romain Barres, Nicolas J. Pillon, Anna Krook, Juleen R. Zierath
Summary: Disruption of circadian rhythms in diabetes affects the cycling of core-clock genes and the expression of inner-mitochondrial genes associated with insulin sensitivity. Treatments restoring mitochondrial function and rhythmic gene expression may help address metabolic dysfunction in diabetes. Bidirectional communication between mitochondrial function and rhythmic gene expression is disturbed in diabetes.
Article
Biochemistry & Molecular Biology
Jianpeng Li, Siqiang Jia, Chao Yuan, Bin Yu, Zheng Zhang, Meng Zhao, Pengfei Liu, Xia Li, Bo Cui
Summary: The study focused on the protective mechanism of Jerusalem artichoke inulin against abnormal hepatic lipid metabolism and gut microbiota dysfunction in diabetic mice. It was found that consuming Jerusalem artichoke inulin significantly improved the biochemical and physiological parameters related to type 2 diabetes mellitus. Additionally, supplementation with Jerusalem artichoke inulin also improved abnormal hepatic lipid metabolism and enriched certain beneficial bacteria in the gut microbiota.
Article
Medicine, Research & Experimental
Yuanchao Ye, Marwa Abu El Haija, Reine Obeid, Hussein Herz, Liping Tian, Benjamin Linden, Yi Chu, Deng Fu Guo, Daniel C. . Levine, Jonathan Cedernaes, Kamal Rahmouni, Joseph Bass, Mohamad Mokadem
Summary: Roux-en-Y gastric bypass (RYGB) has a weight-independent effect on glucose homeostasis and transiently reduces food intake. RYGB reprograms the peripheral clock within the liver early after surgery to alter diurnal eating behavior and regulate hepatic glucose flux. The central clock in the suprachiasmatic nucleus is not affected by RYGB.
Article
Biochemistry & Molecular Biology
Zunli Ke, Si Tan, Haiyang Li, Shanshan Jiang, Yuping Li, Rui Chen, Mingxia Li
Summary: Nonalcoholic liver disease (NAFLD) is a liver condition associated with excessive fat deposition and is closely related to obesity or metabolic syndrome. Oxidative stress plays an important role in the progression of NAFLD, and reducing oxidative stress may improve the condition. Tangeretin, a natural compound with antioxidant and hepatoprotective properties, has shown promise in ameliorating NAFLD. This study found that tangeretin supplementation slowed down NAFLD progression by improving metabolic indexes, reducing hepatic oxidative stress, and reducing fat accumulation in the liver. The study also identified the Nrf2 pathway as a potential mechanism through which tangeretin exerts its effects. These findings suggest that tangeretin could be used as a dietary therapy for obesity-related NAFLD or metabolic syndrome.
Article
Construction & Building Technology
Yiming Zhu, Junyan Yi, Meng Xu, Zhuo Chen, Shih-Hsien Yang, Decheng Feng
Summary: The study explored the use of bio-oil as a substitute for petroleum asphalt in resin asphalt materials, achieving excellent high and low temperature performance. This substitution has the potential to promote the production of greener and more sustainable infrastructure materials.
INTERNATIONAL JOURNAL OF PAVEMENT ENGINEERING
(2021)
Article
Construction & Building Technology
Sainan Xie, Junyan Yi, Hengting Wang, Shih-Hsien Yang, Meng Xu, Decheng Feng
Summary: This paper studies the influence of geometric structure cutting on transverse crack treatment using the discrete elements method (DEM). Suitable strategies for geometric structure cutting are proposed. By establishing a two-dimensional DEM model of asphalt mixture and conducting laboratory tests, the reliability of the modeling method and the microscopic parameters are verified. The mechanical response of transverse crack treatment under different geometric structures is analyzed, and it is concluded that a quadrangular groove with a depth of no less than 6 cm and a width of 60 cm is recommended for severe transverse crack treatment.
INTERNATIONAL JOURNAL OF PAVEMENT ENGINEERING
(2022)
Article
Education & Educational Research
Jo Shan Fu, Shih-Hsien Yang, Hui-Chin Yeh
Summary: The study found that using Toontastic to create digital stories significantly improves students' fluency and language use in speaking, but there was no significant correlation between student engagement and fluency, language use. Topic familiarity and scaffolding embedded within DST were identified as the main methods through which Toontastic supported students in improving speaking competence and learning engagement.
JOURNAL OF RESEARCH ON TECHNOLOGY IN EDUCATION
(2022)
Article
Construction & Building Technology
Hery Awan Susanto, Shih-Hsien Yang, Chien-Ting Kao, Chien-Wei Huang
Summary: This study evaluated the rutting behavior of asphalt pavements through laboratory simulations and analyzed the correlation between different simulation tests to determine the conversion factor. The results showed that the different simulation tests at different temperatures provided similar rutting performance, and the effectiveness of the conversion factor decreased with increasing rutting damage.
INTERNATIONAL JOURNAL OF PAVEMENT RESEARCH AND TECHNOLOGY
(2022)
Article
Construction & Building Technology
Hery Awan Susanto, Shih-Hsien Yang, Mai Anh Duc
Summary: Studies have shown that the incorporation of geogrid in flexible pavements can effectively improve their rutting performance and extend their service life.
INTERNATIONAL JOURNAL OF PAVEMENT RESEARCH AND TECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Chueh-Yu Lin, Minh Tam Ly, Shih Hsien Yang, Shang-Chih Lai, Tung-Wu Chang, I-Hsin Lin, Yin-Jeh Tzeng
Summary: The study demonstrated that Tanshinone IIA has potential antitumor activities, especially in A549 cancer cells, by inducing both apoptosis and necroptosis simultaneously.
NATURAL PRODUCT COMMUNICATIONS
(2021)
Article
Green & Sustainable Science & Technology
Nam Hoai Tran, Shih-Hsien Yang, Calista Y. Tsai, Nien Chia Yang, Chih-Ming Chang
Summary: This study aims to develop transportation livability-related indicators (TLIs) for Taiwan's urban road system and identify critical barriers to TLI application. Two approaches, top-down and bottom-up, were integrated to derive four TLIs and 21 corresponding requirements, and to investigate nine potential barriers to indicator adoption.
Article
Engineering, Multidisciplinary
Chia-Chang Hu, Shih-Hsien Yang, Chi-Jen Wang, Wei-Chen Lin
Summary: The study explores a hybrid precoding architecture for mmWave MIMO systems, which reduces hardware complexity and energy consumption while improving transmission energy efficiency. The SI-based OSA hybrid precoding shows excellent performance in ASR maximization.
JOURNAL OF THE CHINESE INSTITUTE OF ENGINEERS
(2022)
Article
Education & Educational Research
Hui-Chin Yeh, Shih-hsien Yang, Jo Shan Fu, Yen-Chen Shih
Summary: This research focuses on promoting college students' critical thinking through reflective writing. The results show that students significantly improve their critical thinking and exhibit four prevalent changes. Self-worth and volunteerism, as well as patience and gratefulness, stand out among these changes.
HIGHER EDUCATION RESEARCH & DEVELOPMENT
(2023)
Article
Construction & Building Technology
Didi Yuda Wiranata, Shih-Hsien Yang, Cagla Meral Akgul, Ho Yu Hsien, Muhammad Zilzaludin Putra Nugraha
Summary: Coal fly ash (CFA) and coal bottom ash (CBA) pose a significant challenge for solid waste management in power plants and local authorities. This study explored the mechanical properties and structural design parameters of coal ash as pavement base materials, revealing the influence of coal ash on secondary curing and improved long-term performance. The findings demonstrate that coal ash as a pavement base offers enhanced concrete durability and reduced carbon footprint emissions.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Article
Environmental Sciences
Shih-Hsien Yang, Qi-Xing Chang, Chung-Chao Liang, Jia-Ching Chen
Summary: Using a low-cost exercise toolkit in a structured group-based health promotion program can effectively improve physical performances, balance, and walking ability of community-dwelling older adults.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Chemistry, Multidisciplinary
Ciao-Fen Chen, Shih-Hsien Yang, Che-Yi Lin, Mu-Pai Lee, Meng-Yu Tsai, Feng-Shou Yang, Yuan-Ming Chang, Mengjiao Li, Ko-Chun Lee, Keiji Ueno, Yumeng Shi, Chen-Hsin Lien, Wen-Wei Wu, Po-Wen Chiu, Wenwu Li, Shun-Tsung Lo, Yen-Fu Lin
Summary: In this study, Van der Waals (vdW) heterostructures are used to integrate O-2-ultrasensitive MoTe2 and O-2-insensitive SnS2, allowing for the reversible operation of multifunctional transistors through polarity control. This research provides guidance for the application development of 2D materials and demonstrates the potential of reversible multifunctional devices.
Article
Chemistry, Multidisciplinary
Hailu Yang, Qun Chen, Huifang Liu, Haoran Chang, Shih-Hsien Yang, Linbing Wang, Pengfei Liu
Summary: This paper proposes a distributed vibration reduction and energy harvesting method for bridges based on the vibration control method and energy harvesting principle. The analytical solutions of the induced electromotive force, output power, and magnetic damping were deduced through an electromagnetic theory analysis. A new method of joint simulation and modeling analysis of vibration and energy output was proposed. The feasibility and vibration reduction effect of the designed method were verified.
APPLIED SCIENCES-BASEL
(2023)
Article
Construction & Building Technology
Firmansyah Rachman, Shih-Hsien Yang, Hanna Chintya, Yin-Hong Chen, Hoai-Nam Tran
Summary: The research aims to investigate the effectiveness of lignin bio-additives derived from black liquor paper pulp as asphalt antioxidants. Two lignin bio-additives, H-L and S-L, were developed by acidifying black liquor with hydrochloric and sulfuric acid. The laboratory aging procedures used in this study included the Rolling Thin Film Oven and the Ultraviolet Chamber methods. The results showed that S-L demonstrated superior antioxidant performance compared to H-L, with the lowest reduction in |G*c|, the lowest decrease in fatigue life, and the lowest increment in asphaltene proportion.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Ko-Chun Lee, Shun-Yong Huang, Meng-Yu Tsai, Shih-Hsien Yang, Che-Yi Lin, Mengjiao Li, Yuan-Ming Chang, Kenji Watanabe, Takashi Taniguchi, Ying-Chih Lai, Shu-Ping Lin, Po-Wen Chiu, Yen-Fu Lin
Summary: A van der Waals stacking field-effect transistor (VS-FET) inspired by an FET with a floating gate structure was proposed and experimentally demonstrated to mimic the important characteristics of mechanoreceptors, showing feasibility in artificial humanoid systems.