Article
Medicine, General & Internal
Hassen Kared, Amin Alirezaylavasani, Katrine Persgard Lund, Adity Chopra, Lisa Tietze, Taissa de Matos Kasahara, Guro Lovik Goll, Gunnveig Grodeland, Mari Kaarbo, Anna Varberg Reisaeter, Markus Hovd, Kristian Heldal, John Torgils Vaage, Fridtjof Lund-Johansen, Karsten Midtvedt, Anders Asberg, Ludvig A. Munthe
Summary: Kidney transplant recipients (KTR) have poor response to COVID-19 vaccination, but boosting vaccination can induce Spike-specific immunity. After 3 doses of vaccine, most KTR developed Spike-specific T cell responses but had reduced Spike-binding B cells. Breakthrough infections led to increased Spike-specific T cells, non-Spike T and B cell responses, and systemic inflammation. Late seroconversion occurred after 5-6 doses, but some KTR still had no detectable immunity even after multiple vaccine doses.
Article
Medicine, General & Internal
Wiwat Chancharoenthana, Asada Leelahavanichkul, Wassawon Ariyanon, Somratai Vadcharavivad, Weerapong Phumratanaprapin
Summary: In this retrospective study of kidney transplant recipients with recurrent IgA nephropathy, the combination of rituximab and standard therapy effectively reduced proteinuria and maintained renal allograft function. Patients treated with rituximab showed less severe renal allograft pathology despite strong IgA deposition. Further mechanistic studies with longer follow-up periods are recommended.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Thomas Bachelet, Jonathan Visentin, Philippine Davis, Benjamin Taton, Gwendaline Guidicelli, Hannah Kaminski, Pierre Merville, Lionel Couzi
Summary: The study suggests that in kidney transplant recipients, receiving induction therapy with rituximab in addition to ATG does not result in a higher incidence of post-transplant malignancies compared to those who only receive ATG. Risk factors for post-transplant malignancies include male gender, age, history of cancer, and use of azathioprine.
CLINICAL TRANSPLANTATION
(2021)
Article
Virology
Naohiro Aida, Taihei Ito, Kei Kurihara, Izumi Hiratsuka, Megumi Shibata, Atsushi Suzuki, Midori Hasegawa, Takashi Kenmochi
Summary: Kidney transplant recipients on immunosuppressive therapy are at high risk for COVID-19. This study investigated the effect of B cell depletion therapy on COVID-19 in 30 kidney transplant recipients. Results showed that patients receiving B cell depletion therapy had higher progression rates and lower survival rates compared to those without the therapy, suggesting an increased risk of COVID-19 in kidney transplant recipients due to long-term effects of B cell depletion therapy.
Article
Immunology
Martina Fabris, Ginevra De Marchi, Rossana Domenis, Federica Caponnetto, Silvia Guella, Chiara Dal Secco, Nicola Cabas, Salvatore De Vita, Antonio Paolo Beltrami, Francesco Curcio, Luca Quartuccio
Summary: This study evaluated the immune response to SARS-CoV-2 mRNA vaccination in patients with complex or rare systemic autoimmune diseases who were previously treated with or under continuous treatment with B-cell-targeted therapies. The results showed that even in the absence of circulating B cells, virus-specific cellular immunity can be induced, indicating that B-cell-targeted therapies do not preclude SARS-CoV-2 vaccination.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Urology & Nephrology
Christian Morath, Matthias Schaier, Eman Ibrahim, Lei Wang, Christian Kleist, Gerhard Opelz, Caner Suesal, Gerald Ponath, Mostafa Aly, Cristiam M. Alvarez, Florian Kaelble, Claudius Speer, Louise Benning, Christian Nusshag, Luiza Pego da Silva, Claudia Sommerer, Angela Hueckelhoven-Krauss, David Czock, Arianeb Mehrabi, Constantin Schwab, Ruediger Waldherr, Paul Schnitzler, Uta Merle, Thuong Hien Tran, Sabine Scherer, Georg A. Boehmig, Carsten Mueller-Tidow, Jochen Reiser, Martin Zeier, Michael Schmitt, Peter Terness, Anita Schmitt, Volker Daniel
Summary: This study shows that using donor-derived modified immune cells (MICs)-PBMCs for specific immunosuppression treatment before kidney transplantation can result in an increase in CD19(+)CD24(hi)CD38(hi) transitional B lymphocytes by up to 68-fold compared to transplanted controls.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Surgery
Hernani M. Neto, Helio Tedesco Silva Junior, Jose M. Pestana, Renato D. Foresto, Wilson F. Aguiar
Summary: This study suggests that ligating the native ureter without ipsilateral nephrectomy during pyeloureterostomy is associated with a low incidence of clinically indicated ipsilateral native nephrectomy. Caution and awareness should be emphasized in patients with a history of ADPKD and neurogenic augmented bladders.
TRANSPLANT INTERNATIONAL
(2022)
Article
Immunology
Lauren E. Higdon, Ayah A. Ahmad, Steven Schaffert, Kenneth B. Margulies, Jonathan S. Maltzman
Summary: This study investigated the impact of CMV infection on the differentiation, functionality, and expansion of CD4 T cells in transplant recipients in the first year post-transplant. The findings suggest that the CD4 response to CMV is dominated by cytotoxicity and remains stable in the first year after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Piotr K. Krajewski, Kinga Tyczynska, Klaudia Bardowska, Piotr Olczyk, Magdalena Krajewska, Jacek C. Szepietowski
Summary: Itch is a common symptom of chronic dermatoses and can be associated with systemic disorders. This study found that itch is a significant burden in renal transplant recipients (RTR), with higher prevalence of anxiety and depression among those experiencing itch. The severity of itch was positively correlated with anxiety, depression, and stigmatization. The results highlight the importance of addressing itch relief in a holistic approach to RTR patients.
Article
Immunology
Praveen Chandrashekhar, Anupma Kaul, Dharmendra Bhaduaria, Narayan Prasad, Manas Behera, Ravi Kushwaha, Manas Patel, Monika Yachha, Aneesh Srivastava
Summary: This study found that the use of Rituximab is not significantly associated with a higher incidence of tuberculosis (TB) in renal transplant patients. The only factor associated with a greater incidence of TB was a higher number of rejection episodes. Treatment of humoral rejections with plasmapheresis in the post-transplant period was also associated with a significantly higher incidence of TB.
TRANSPLANT INFECTIOUS DISEASE
(2022)
Article
Medicine, General & Internal
Piotr K. Krajewski, Piotr Olczyk, Magdalena Krajewska, Wojciech Krajewski, Jacek C. Szepietowski
Summary: This study analyzed data from 197 renal transplant patients and found that approximately one-third experienced itch during hemodialysis, but the majority saw complete resolution of itch after successful transplantation. Additionally, over half of the renal transplant recipients did not experience itch during dialysis.
FRONTIERS IN MEDICINE
(2021)
Article
Surgery
Kevin Lu, Kun-Yuan Chiu
Summary: This study conducted a longitudinal cohort study on renal transplant recipients and found that the occurrence of malignancies after kidney transplantation showed an M-shaped twin peak trend, mainly focusing on urological and digestive tract malignancies. The research results suggest the need for specific customized cancer surveillance strategies to optimize post-transplant care.
CLINICAL TRANSPLANTATION
(2023)
Article
Clinical Neurology
Amandine Mathias, Vasiliki Pantazou, Sylvain Perriot, Mathieu Canales, Samuel Jones, Larise Oberholster, Michael Moulin, Craig Fenwick, Raphael Bernard-Valnet, Marie Theaudin, Caroline Pot, Renaud A. Du Pasquier
Summary: This study aims to investigate the impact of ocrelizumab (OCRE) on immune cell subsets in patients with multiple sclerosis (pwMS). The results showed that OCRE not only depletes B cells, but also reduces memory CD8(+) T cells, which may increase the risk of infections. Therefore, clinicians should pay special attention to the increased infection risk when switching pwMS from other disease-modifying therapies (DMTs) to OCRE.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Review
Medicine, General & Internal
Elena Treppo, Marco Binutti, Roberto Agarinis, Salvatore De Vita, Luca Quartuccio
Summary: Antineutrophil cytoplasmatic antibody-associated vasculitis is a rare autoimmune disease that can be effectively treated with RTX, which has shown to be both effective and safe in inducing and maintaining remission. Optimizing RTX-based treatment strategies is a key focus of current AAV research.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Urology & Nephrology
Yu Ho Lee, Yuki Sato, Mitsuru Saito, Shingo Fukuma, Masaya Saito, Shigenori Yamamoto, Atsushi Komatsuda, Nobuhiro Fujiyama, Shigeru Satoh, Sang-Ho Lee, Peter Boor, Tomonori Habuchi, Juergen Floege, Motoko Yanagita
Summary: Tertiary lymphoid tissues (TLTs) are commonly found in transplanted kidneys and advanced TLTs are associated with graft dysfunction.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Judith Tommel, Andrea W. M. Evers, Henk W. van Hamersvelt, Rien Jordens, Sandra van Dijk, Luuk B. Hilbrands, Marc M. H. Hermans, Daan A. M. J. Hollander, Jos J. van de Kerkhof, Marc A. G. J. ten Dam, Henriet van Middendorp
Summary: The study aimed to identify dialysis patients' most prominent problems and calculate disease-specific norms for questionnaires measuring these problems. Results showed that fatigue was the most prominent problem, and patient priorities and functioning domains differed based on patient characteristics.
SEMINARS IN DIALYSIS
(2023)
Article
Immunology
Jan Stephan F. Sanders, A. Lianne Messchendorp, Rory D. de Vries, Carla C. Baan, Debbie van Baarle, Rob van Binnendijk, Dimitri A. Diavatopoulos, Daryl Geers, Katharina S. Schmitz, Corine H. GeurtsvanKessel, Gerco den Hartog, Marcia M. L. Kho, Marion P. G. Koopmans, Renate G. van der Molen, Ester B. M. Remmerswaal, Nynke Rots, Ron T. Gansevoort, Frederike J. Bemelman, Luuk B. Hilbrands, Marlies E. J. Reinders
Summary: The immune response to COVID-19 vaccination is inferior in kidney transplant recipients and to a lesser extent in patients on dialysis or with chronic kidney disease. The antibody levels and T-cell responses significantly decrease after 6 months of vaccination, and neutralization of the Omicron variant is barely detectable.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Marcia M. L. Kho, A. Lianne Messchendorp, Sophie C. Froelke, Celine Imhof, Vera J. C. H. Koomen, S. Reshwan K. Malahe, Priya Vart, Daryl Geers, Rory D. de Vries, Corine H. Geurtsvan Kessel, Carla C. Baan, Renate G. van der Molen, Dimitri A. Diavatopoulos, Ester B. M. Remmerswaal, Debbie van Baarle, Rob van Binnendijk, Gerco den Hartog, Aiko P. J. de Vries, Ron T. Gansevoort, Frederike J. Bemelman, Marlies E. J. Reinders, Jan-Stephan F. Sanders, Luuk B. Hilbrands
Summary: This study aimed to compare three alternative strategies for improving the COVID-19 vaccine response in kidney transplant recipients: double vaccine dose, heterologous vaccination, and temporary discontinuation of mycophenolate mofetil or mycophenolic acid. The results showed that repeated vaccination increased SARS-CoV-2-specific antibodies in kidney transplant recipients, but higher dose, heterologous vaccine, or discontinuation of immunosuppressants did not further enhance the response.
LANCET INFECTIOUS DISEASES
(2023)
Article
Transplantation
Mehmet Sukru Sever, Raymond Vanholder, Gabriel Oniscu, Daniel Abramowicz, Wim Van Biesen, Umberto Maggiore, Bruno Watschinger, Christophe Mariat, Jadranka Buturovic-Ponikvar, Marta Crespo, Geir Mjoen, Peter Heering, Licia Peruzzi, Ilaria Gandolfini, Rachel Hellemans, Luuk Hilbrands
Summary: This study reviewed transplantation practice during the COVID-19 pandemic and provided guidance for transplantation strategies in future disasters. It suggests continuing transplantation programs with appropriate operational circumstances and implementing preventative measures to minimize risks. Patient education and adherence to ethical rules are also important.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Psychiatry
Cinderella K. Cardol, Henriet van Middendorp, Elise Dusseldorp, Paul J. M. van der Boog, Luuk B. Hilbrands, Gerjan Navis, Yvo W. J. Sijpkens, Andrea W. M. Evers, Sandra van Dijk, E GOAL Study Grp
Summary: This study evaluated the effectiveness of a personalized electronic health care pathway for patients with chronic kidney disease. The results showed that while psychological distress did not decrease, personalized outcomes significantly improved after the intervention and were maintained at follow-up.
PSYCHOSOMATIC MEDICINE
(2023)
Article
Urology & Nephrology
Pim Bouwmans, A. Lianne Messchendorp, Celine Imhof, Jan-Stephan F. Sanders, Luuk B. Hilbrands, Marlies E. J. Reinders, Priya Vart, Frederike J. Bemelman, Alferso C. Abrahams, Rene M. A. van den Dorpel, Marc A. G. J. Ten Dam, Aiko P. J. de Vries, Theo Rispens, Maurice Steenhuis, Ron T. Gansevoort, Marc H. Hemmelder, R. E. C. O. V. A. C. Collaborators RECOVAC Collaborators
Summary: Patients with chronic kidney disease or kidney replacement therapy have lower antibody levels after SARS-CoV-2 vaccination compared with healthy controls. The study found that immunosuppressive treatment and vaccine type had an impact on antibody levels after three vaccinations. Patients with CKD and dialysis patients with immunosuppressive treatment had lower antibody levels after two and three vaccinations.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Marlies Noordzij, Bjorn Meijers, Ron T. Gansevoort, Adrian Covic, Raphael Duivenvoorden, Luuk B. Hilbrands, Marc H. Hemmelder, Kitty J. Jager, Geir Mjoen, Ionut Nistor, Ekaterina Parshina, Giuseppina Pessolano, Serhan Tuglular, Priya Vart, Luca Zanoli, Casper F. M. Franssen, ERACODA collaborators
Summary: This study analyzed the infection prevention and control strategies implemented by dialysis centers in Europe during the first wave of the COVID-19 pandemic. The results showed that most centers implemented measures such as fever screening, hand disinfection, and mask-wearing to prevent the spread of the virus. There were variations between centers and national guidelines in terms of recommended distances between dialysis chairs and isolation practices.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Surgery
S. Reshwan K. Malahe, Yvette den Hartog, Wim J. R. Rietdijk, Debbie van Baarle, Ronella de Kuiper, Derek Reijerkerk, Alicia M. Ras, Daryl Geers, Dimitri A. Diavatopoulos, A. Lianne Messchendorp, Renate G. van der Molen, Ester B. M. Remmerswaal, Frederike J. Bemelman, Ron T. Gansevoort, Luuk B. Hilbrands, Jan-Stephan Sanders, Corine H. Geurtsvankessel, Marcia M. L. Kho, Rory D. de Vries, Marlies E. J. Reinders, Carla C. Baan
Summary: This study found that IL-21, an important regulatory factor in B cell-mediated immune response, plays a role in patients with kidney disease and kidney transplant recipients. Kidney transplant recipients showed lower levels of SARS-CoV-2-specific IL-21 producing T cells and IgG antibody levels compared to controls. The T-cell IL-21 response was positively correlated with the B cell response and IgG antibody levels. Additionally, the SARS-CoV-2-specific B cell response was shown to be dependent on IL-21.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Peripheral Vascular Disease
Laura E. J. Peeters, Dennis. A. Hesselink, Melvin Lafeber, David Severs, Martijn W. F. van den Hoogen, Michelle A. H. Sonneveld, Christian R. B. Ramakers, Soma Bahmany, Teun van Gelder, Birgit C. P. Koch, Jorie Versmissen
Summary: The study aimed to determine the prevalence of nonadherence to antihypertensive drugs (AHDs) among patients visiting the nephrology and vascular outpatient clinics. Adherence was assessed by measuring drug concentrations in blood, and the overall adherence rate to AHDs was 78.2%. Furthermore, patients after kidney transplant had a higher adherence rate of 85.7%.
JOURNAL OF HYPERTENSION
(2023)
Article
Immunology
Yvette den Hartog, S. Reshwan K. Malahe, Wim J. R. Rietdijk, Marjolein Dieterich, Lennert Gommers, Daryl Geers, Susanne Bogers, Debbie A. van Baarle, Dimitri Diavatopoulos, A. Lianne G. Messchendorp, Renate van der Molen, Ester B. M. J. Remmerswaal, Frederike T. Bemelman, Ron B. Gansevoort, Luuk Hilbrands, Jan-Stephan H. Sanders, Corine GeurtsvanKessel, Marcia M. L. Kho, Marlies E. J. D. Reinders, Rory C. de Vries, Carla Baan
Summary: Cytokines secreted by memory T cells play a role in the immune response against SARS-CoV-2, and their expression patterns are associated with vaccine-induced immunity. A balanced production of cytokines by memory T cells is related to seroconversion and the production of antibodies.
Article
Immunology
Janeri Froberg, Vera J. C. H. Koomen, Christa E. van der Gaast-de Jongh, Ria Philipsen, Corine H. Geurtsvankessel, Rory D. de Vries, Marije C. Baas, Renate G. van der Molen, Marien de Jonge, Luuk B. Hilbrands, Martijn A. Huynen, Dimitri A. Diavatopoulos, RECOVAC Consortium
Summary: This study found that mucosal IgA concentrations were significantly higher postinfection compared to postvaccination, while vaccination induced higher IgG concentrations. However, the ACE2-inhibiting activity did not differ between the two cohorts. Binding inhibition post-infection was driven by both IgA and IgG, while post-vaccination binding inhibition was mainly driven by IgG.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Editorial Material
Transplantation
Luuk B. Hilbrands
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Surgery
Kim Bunthof, Khalid Saboerali, Jacqueline Van De Wetering, Azam Nurmohamed, Frederike Bemelman, Arjan Van Zuilen, Jan Van Den Brand, Marije Baas, Luuk Hilbrands
Summary: This study aimed to validate a previously established prediction model for graft intolerance syndrome in an independent cohort. The validation cohort consisted of patients with late kidney graft failure between 2008 and 2018. The original model, which included donor age, graft survival, and number of acute rejections, performed poorly in the validation cohort. However, after retraining the model using recipient age at graft failure instead of donor age, it showed moderate performance in both the development and validation cohorts.
TRANSPLANT INTERNATIONAL
(2023)
Meeting Abstract
Peripheral Vascular Disease
Laura E. J. Peeters, Dennis A. Hesselink, Brenda C. M. de Winter, Melvin Lafeber, David Severs, Martijn W. F. van den Hoogen, Michelle A. H. Sonneveld, Chris R. B. Ramakers, Soma Bahmany, Teun van Gelder, Birgit C. P. Koch, Jorie Versmissen
JOURNAL OF HYPERTENSION
(2023)
Article
Urology & Nephrology
Manna A. Alma, Sijrike F. van der Mei, Sandra Brouwer, Luuk B. Hilbrands, Paul J. M. van der Boog, Herma Uiterwijk, Femke Waanders, Maaike Hengst, Ron T. Gansevoort, Annemieke Visser
Summary: Kidney failure negatively impacts employment opportunities. Employed patients with chronic kidney disease face difficulties in work functioning, requiring adjustments or work disability benefits. Pre-emptive transplantation and good physical health contribute to sustained employment.
JOURNAL OF NEPHROLOGY
(2023)