Article
Oncology
Huiling Wang, Xiaonan Sheng, Tingting Yan, Yaqian Xu, Yaohui Wang, Yanping Lin, Jie Zhang, Yumei Ye, Shuguang Xu, Liheng Zhou, Wenjin Yin, Jinsong Lu
Summary: This study aimed to investigate the relationship between peripheral immune cell subsets and pathological complete response (pCR) in breast cancer patients. Analysis of patient data from two clinical trials revealed that the percentages of peripheral immune cell subsets were associated with pCR, suggesting their potential as biomarkers for predicting neoadjuvant chemotherapy efficacy.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Ecology
Zizhuo Wang, Rourou Xiao, Jia Huang, Xu Qin, Dianxing Hu, Ensong Guo, Chen Liu, Funian Lu, Lixin You, Chaoyang Sun, Gang Chen
Summary: The study revealed a close relationship between the vaginal microbiota of cervical cancer patients and their responsiveness to platinum-based chemotherapy, with higher alpha diversity in nonresponders compared to responders and the enrichment of the Bacteroides genus in nonresponders.
Article
Immunology
Jinjin Wang, Wenjuan Wang, Anxin Wang, Xiaoli Zhang, Liheng Bian, Yang Du, Jingjing Lu, Xingquan Zhao
Summary: This study aimed to determine the association between admission lymphocyte to monocyte ratio (LMR) values and clinical outcomes in patients with spontaneous intracerebral hemorrhage (ICH). The study found that higher LMR was associated with lower risks, poorer short-term outcomes, higher mortality rates, and lower risk of in-hospital infections in patients with ICH.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Oncology
Feiqiong Gao, Jianlai Hu, Jiawei Zhang, Yang Xu
Summary: Low LMR in peripheral blood is associated with poor prognosis in lymphoma patients, including HL, NHL, and its subtypes. Additionally, low LMR is related to higher LDH, advanced tumor staging, and IPI score.
Article
Oncology
Haruhiko Yamazaki, Kiminori Sugino, Ryohei Katoh, Kenichi Matsuzu, Chie Masaki, Junko Akaishi, Kiyomi Yamada Hames, Chisato Tomoda, Akifumi Suzuki, Keiko Ohkuwa, Wataru Kitagawa, Mitsuji Nagahama, Yasushi Rino, Koichi Ito
Summary: This study investigated the outcomes and prognostic factors in anaplastic thyroid carcinoma (ATC) patients treated with paclitaxel as neoadjuvant therapy. The results showed that prognostic index (PI) >= 2, response to paclitaxel, resection, and radiotherapy were independent prognostic factors for overall survival (OS) in ATC patients. There were no significant predictive factors for response to paclitaxel in baseline characteristics.
Article
Oncology
Yan Zhang, Yuanfei Shi, Huafei Shen, Lihong Shou, Qiu Fang, Xiaolong Zheng, Mingyu Zhu, Xin Huang, Jiansong Huang, Li Li, De Zhou, Lixia Zhu, Jingjing Zhu, Xiujin Ye, Jie Jin, Wanzhuo Xie
Summary: Peripheral T-cell lymphoma (PTCL) is an aggressive group of lymphoproliferative tumors with poor prognosis. A retrospective study of 347 PTCL patients revealed that low lymphocyte-monocyte ratio (LMR) and platelet-monocyte ratio (PMR) were independently associated with shorter survival. A new Peripheral Blood Score (PBS) model was established to identify high-risk PTCL patients based on LMR and PMR, providing a simple and cost-effective screening tool.
CANCER CELL INTERNATIONAL
(2021)
Article
Emergency Medicine
Yin-Chou Hsu, Yong-Ye Yang, I-Ting Tsai
Summary: The study found that the lymphocyte-to-monocyte ratio (LMR) in peripheral blood can serve as a predictive marker for mortality risk in cirrhotic patients with septic shock. Compared with other indicators, LMR demonstrated superior predictive ability in mortality prediction.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Immunology
Yujian He, Xiaoyan Huang, Jingwen Zhang, Jinlan Liao, Huie Huang, Yan He, Min Gao, Yumei Liao, Zibo Xiong
Summary: This study found that lower peripheral blood lymphocyte counts are associated with an increased risk of treatment failure in patients with peritoneal dialysis-associated peritonitis (PDAP).
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Kristi Kruger, Laxmi Silwal-Pandit, Elisabeth Wik, Oddbjorn Straume, Ingunn M. Stefansson, Elin Borgen, Oystein Garred, Bjorn Naume, Olav Engebraaten, Lars A. Akslen
Summary: High baseline microvessel density (MVD) significantly predicted response to bevacizumab treatment, while high proliferative microvessel density (pMVD), glomeruloid microvascular proliferation (GMP), and the angiogenesis signature score did not predict pathologic complete response (pCR) but were associated with aggressive tumor features.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Emre Ozoran, Ibrahim Halil Ozata, Derya Salim Uymaz, Nail Omarov, Emre Bozkurt, Tutku Tufekci, Salih Nafiz Karahan, Buelent Gurbuz, Fatih Selcukbiricik, Yasemin Bolukbasi, Orhun cig Taskin, Bengi Gurses, Ahmet Rencuzogullari, Dursun Bugra, Emre Balik
Summary: This study compared the efficacy of total neoadjuvant therapy (TNT) and standard neoadjuvant chemoradiotherapy (SNCRT) in locally advanced rectal cancer patients. The study results showed that the TNT group had significantly higher rates of pathological and sustained clinical complete response compared to the SNCRT group. However, these outcomes did not translate into a survival advantage.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Cell Biology
Shota Sasagawa, Hiroaki Kato, Koji Nagaoka, Changbo Sun, Motohiro Imano, Takao Sato, Todd A. Johnson, Masashi Fujita, Kazuhiro Maejima, Yuki Okawa, Kazuhiro Kakimi, Takushi Yasuda, Hidewaki Nakagawa
Summary: This study developed a machine-learning model to predict the response of esophageal squamous cell carcinoma (ESCC) to neoadjuvant chemotherapy (NAC) using whole-genome sequencing and RNA sequencing analysis. The study found that neutrophil infiltration and specific gene copy-number alterations are closely associated with NAC response.
CELL REPORTS MEDICINE
(2022)
Article
Oncology
Jiayi Zhang, Yanfen Cui, Kaikai Wei, Zhenhui Li, Dandan Li, Ruirui Song, Jialiang Ren, Xin Gao, Xiaotang Yang
Summary: This study developed a model using deep learning algorithm and computed tomography (CT) images to predict neoadjuvant chemotherapy (NACT) resistance in patients with locally advanced gastric cancer (LAGC). The model showed promising performance in both internal and external validation cohorts, outperforming the clinical model.
Article
Nutrition & Dietetics
Li Chen, Yihang Qi, Xiangyi Kong, Zhaohui Su, Zhongzhao Wang, Xiangyu Wang, Yaying Du, Yi Fang, Xingrui Li, Jing Wang
Summary: The study found that NRI can independently predict disease-free survival (DFS) and overall survival (OS) in breast cancer patients, with high NRI value patients having significantly longer survival times. Patients with high NRI scores also had longer survival times in both early-stage and advanced breast cancer. Additionally, high NRI scores were associated with longer survival times in different molecular subtypes.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Meng-Di Wang, Fang-Fang Duan, Xin Hua, Lu Cao, Wen Xia, Jia-Yi Chen
Summary: This study explores the association between a novel nutrition marker called lymphocyte x albumin (LA) and disease-free survival (DFS) in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). The study finds that a predictive model incorporating LA and other variables offers a more precise assessment of DFS. This model could serve as a valuable tool for personalized prognostic predictions.
Article
Oncology
Chongyuan Sun, Penghui Niu, Xiaojie Zhang, Lulu Zhao, Wanqing Wang, Xiaoyi Luan, Xue Han, Yingtai Chen, Dongbing Zhao
Summary: This study aimed to compare the effect of clinical and pathological response on the prognosis of patients with gastric cancer. The results showed that concurrent clinical and pathological response might predict a favorable prognosis of patients with gastric cancer after neoadjuvant therapy.