A Functional Approach Reveals a Genetic and Physical Interaction between Ribonucleotide Reductase and CHK1 in Mammalian Cells

The identification of novel 5′-amino gemcitabine analogs as potent RRM1 inhibitors

(2014) Marc A. Labroli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response

(2014) Yu-Fen Lin et al.   NUCLEIC ACIDS RESEARCH

Targeting ribonucleotide reductase for cancer therapy

(2013) Jimin Shao et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A Kinome Screen Identifies Checkpoint Kinase 1 (CHK1) as a Sensitizer for RRM1-Dependent Gemcitabine Efficacy

(2013) Jun Zhou et al.   PLoS One

Replication stress activates DNA polymerase alpha-associated Chk1

(2011) Lorena Taricani et al.   CELL CYCLE

Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified via High Content Screening

(2011) T. J. Guzi et al.   MOLECULAR CANCER THERAPEUTICS

Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase

(2010) H. Niida et al.   GENES & DEVELOPMENT

Features of Potentially Predictive Biomarkers of Chemotherapeutic Efficacy in Small Cell Lung Cancer

(2010) Alberto A. Chiappori et al.   Journal of Thoracic Oncology

DDB1 Targets Chk1 to the Cul4 E3 Ligase Complex in Normal Cycling Cells and in Cells Experiencing Replication Stress

(2009) V. Leung-Pineda et al.   CANCER RESEARCH