Hemozoin Induces Hepatic Inflammation in Mice and Is Differentially Associated with Liver Pathology Depending on the Plasmodium Strain

Coinfection with Nonlethal Murine Malaria Parasites Suppresses Pathogenesis Caused by Plasmodium berghei NK65

(2014) M. Niikura et al.   JOURNAL OF IMMUNOLOGY

Hemozoin Induces Lung Inflammation and Correlates with Malaria-Associated Acute Respiratory Distress Syndrome

(2013) Katrien Deroost et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Involvement of p38 MAPK in haemozoin-dependent MMP-9 enhancement in human monocytes

(2013) Amina Khadjavi et al.   CELL BIOCHEMISTRY AND FUNCTION

Sequestration and histopathology inPlasmodium chabaudimalaria are influenced by the immune response in an organ-specific manner

(2013) Thibaut Brugat et al.   CELLULAR MICROBIOLOGY

Cross-species malaria immunity induced by chemically attenuated parasites

(2013) Michael F. Good et al.   JOURNAL OF CLINICAL INVESTIGATION

The hemozoin conundrum: is malaria pigment immune-activating, inhibiting, or simply a bystander?

(2013) Márcia Boura et al.   TRENDS IN PARASITOLOGY

Improved methods for haemozoin quantification in tissues yield organ-and parasite-specific information in malaria-infected mice

(2012) Katrien Deroost et al.   MALARIA JOURNAL

Activation of nuclear factor kappa B in peripheral blood mononuclear cells from malaria patients

(2012) Chuchard Punsawad et al.   MALARIA JOURNAL

Haemozoin Induces Early Cytokine-Mediated Lysozyme Release from Human Monocytes through p38 MAPK- and NF-kappaB- Dependent Mechanisms

(2012) Manuela Polimeni et al.   PLoS One

IL-22 Protects Against Liver Pathology and Lethality of an Experimental Blood-Stage Malaria Infection

(2012) Béatris Mastelic et al.   Frontiers in Immunology

Host fibrinogen stably bound to hemozoin rapidly activates monocytes via TLR-4 and CD11b/CD18-integrin: a new paradigm of hemozoin action

(2011) V. Barrera et al.   BLOOD

Digestive vacuoles of Plasmodium falciparum are selectively phagocytosed by and impair killing function of polymorphonuclear leukocytes

(2011) P. Dasari et al.   BLOOD

Liver pathology in Malawian children with fatal encephalopathy

(2011) Richard Whitten et al.   HUMAN PATHOLOGY

Insufficiently Defined Genetic Background Confounds Phenotypes in Transgenic Studies As Exemplified by Malaria Infection in Tlr9 Knockout Mice

(2011) Nathalie Geurts et al.   PLoS One

New Inflammation-Related Biomarkers during Malaria Infection

(2011) Fikregabrail Aberra Kassa et al.   PLoS One

Immunopathology and Dexamethasone Therapy in a New Model for Malaria-associated Acute Respiratory Distress Syndrome

(2010) Philippe E. Van den Steen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immunogenicity of Whole-Parasite Vaccines against Plasmodium falciparum Involves Malarial Hemozoin and Host TLR9

(2010) Cevayir Coban et al.   Cell Host & Microbe

Role of the NF-κB transcription pathway in the haemozoin- and 15-HETE-mediated activation of matrix metalloproteinase-9 in human adherent monocytes

(2010) Mauro Prato et al.   CELLULAR MICROBIOLOGY

Essential Role for IL-27 Receptor Signaling in Prevention of Th1-Mediated Immunopathology during Malaria Infection

(2010) E. G. Findlay et al.   JOURNAL OF IMMUNOLOGY

Protein-DNA Complex Is the Exclusive Malaria Parasite Component That Activates Dendritic Cells and Triggers Innate Immune Responses

(2010) X. Wu et al.   JOURNAL OF IMMUNOLOGY

Innate inflammatory response to the malarial pigment hemozoin

(2010) Marina T. Shio et al.   MICROBES AND INFECTION

The Liver as a Lymphoid Organ

(2009) Ian Nicholas Crispe   Annual Review of Immunology

Pure Hemozoin Is Inflammatory In Vivo and Activates the NALP3 Inflammasome via Release of Uric Acid

(2009) J. W. Griffith et al.   JOURNAL OF IMMUNOLOGY

Synthetic Plasmodium-Like Hemozoin Activates the Immune Response: A Morphology - Function Study

(2009) Maritza Jaramillo et al.   PLoS One

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

(2009) Catherine Dostert et al.   PLoS One

Heme oxygenase-1 affords protection against noncerebral forms of severe malaria

(2009) E. Seixas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

(2009) Marina Tiemi Shio et al.   PLoS Pathogens

CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-γ-induced chemokines

(2008) Philippe E. Van den Steen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY