Article
Public, Environmental & Occupational Health
Yilin Yoshida, Zhipeng Chen, Vivian A. Fonseca, Franck Mauvais-Jarvis
Summary: In women, prediabetes and undiagnosed T2D are associated with a greater risk of cardiovascular disease. Sex-specific guidelines are needed for T2D screening and treatment.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Juliana Portes, Beatriz Bullon, Isabel Gallardo, Patricia Fernandez-Riejos, Jose Luis Quiles, Francesca Giampieri, Pedro Bullon
Summary: The prevalence of undiagnosed diabetes and prediabetes in elderly patients attending a dental clinic was high and underestimated. Risk factors such as periodontitis, overweight, high blood pressure, and low adherence to the Mediterranean diet were observed in these patients.
JOURNAL OF DENTISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Marie Hauguel-Moreau, Helene Hergault, Laure Cazabat, Marion Pepin, Alain Beauchet, Vincent Aidan, Mounir Ouadahi, Loic Josseran, Mirella Hage, Christophe Rodon, Olivier Dubourg, Ziad Massy, Nicolas Mansencal
Summary: The study aimed to assess the prevalence and long-term change of prediabetes and unknown diabetes in a large middle-aged urban population. The results showed a high prevalence of prediabetes and unknown diabetes, but a decrease over a 12-year period. This highlights the importance of screening and cardiovascular prevention campaigns.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Kevin L. Joiner, Mackenzie P. Adams, Kathryn A. Lee, Gretchen Piatt, Matthew A. Davis
Summary: The study aimed to examine the differences in perceived risk for diabetes by race and ethnicity among U.S. adults with undiagnosed prediabetes. The study found that the perceived risk for diabetes did not change significantly in any racial and ethnic groups. Non-Hispanic Black and Hispanic populations had a lower perceived risk for diabetes compared to Non-Hispanic White population.
PREVENTIVE MEDICINE
(2022)
Article
Endocrinology & Metabolism
Anwar Mohammad, Ali H. Ziyab, Talal Mohammad
Summary: This study aimed to estimate the prevalence of prediabetes and undiagnosed type 2 diabetes mellitus among Kuwaiti adults, and found that there are variations in prevalence across sex, age, and BMI. Early identification and management of affected individuals are crucial to reduce the public health burden.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Public, Environmental & Occupational Health
Yilin Yoshida, Jia Wang, Yuanhao Zu, Vivian A. Fonseca, Franck Mauvais-Jarvis
Summary: The prevalence of prediabetes and undiagnosed diabetes has increased among premenopausal women in the past two decades, and they face a significant cardiovascular risk burden associated with these conditions. Improvement in cardiovascular risk screening and patient education should be prioritized for young and early middle-aged adults, particularly women.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Eilane Souza Marques dos Santos, Roberta de Oliveira Maximo, Fabiola Bof de Andrade, Cesar de Oliveira, Maria Fernanda Lima-Costa, Tiago da Silva Alexandre
Summary: This study analyzed differences in the prevalence of prediabetes, undiagnosed diabetes, and diagnosed diabetes, as well as associated factors, among older adults in Brazil and England. The prevalence of diabetes was higher in the Brazilian sample, with different associated factors found in the two samples, which may be related to differences in nutritional transition, access to healthcare services, and the use of such services.
PUBLIC HEALTH NUTRITION
(2021)
Article
Endocrinology & Metabolism
Michael Fang, Dan Wang, Josef Coresh, Elizabeth Selvin
Summary: This study aims to update the trends in undiagnosed diabetes using definitions consistent with clinical practice, and finds a substantial decline in the proportion of undiagnosed diabetes cases.
Article
Medicine, General & Internal
Natalia Drobek, Pawel Sowa, Piotr Jankowski, Maciej Haberka, Zbigniew Gasior, Dariusz Kosior, Danuta Czarnecka, Andrzej Pajak, Karolina Szostak-Janiak, Agnieszka Krzykwa, Malgorzata Setny, Pawel Koziel, Marlena Paniczko, Jacek Jamiolkowski, Irina Kowalska, Karol Kaminski
Summary: This study aimed to evaluate the prevalence of undiagnosed diabetes and prediabetes in patients with chronic coronary syndromes (CCS) and identify factors associated with dysglycemia. Results showed a 5.1% newly diagnosed diabetes rate and 72.3% prediabetes rate among study participants. Body mass index and high-density lipoprotein cholesterol were identified as important factors in assessing the risk of dysglycemia development after hospital discharge.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Carolina Giraldez-Garcia, Lucia Cea-Soriano, Romana Albaladejo, Josep Franch-Nadal, Manel Mata-Cases, Javier Diez-Espino, Sara Artola, Rosario Serrano, Enrique Regidor
Summary: Healthy lifestyle interventions and drug therapies are crucial for normal glucose regulation in prediabetes, but the specific role of these factors in reversion to normal glycemia remains unclear.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Sigrun Henjum, Victoria Telle Hjellset, Eivind Andersen, Merete Oyaland Flaaten, Marianne S. Morseth
Summary: The aim of this study was to create a risk score for identifying subjects with undiagnosed prediabetes or T2D among Saharawi refugees in Algeria and compare its performance to the Finnish diabetes risk score (FINDRISC). The risk score included age, body mass index (BMI), and waist circumference. The sensitivity and specificity of the risk score were higher than FINDRISC, making it a helpful tool for screening prediabetes or T2D patients.
Article
Multidisciplinary Sciences
Farhad Moradpour, Satar Rezaei, Bakhtiar Piroozi, Ghobad Moradi, Yousef Moradi, Negar Piri, Azad Shokri
Summary: The study aimed to estimate the prevalence of prediabetes and diabetes mellitus (DM), and its association with socioeconomic inequality. The study found high prevalence of prediabetes and DM, and low levels of glycemic control. Age, body mass index (BMI), smoking, family history of diabetes, and comorbidity were identified as independent risk factors for DM. Age group, family history of diabetes, and education level were associated with diabetes awareness and glycemic control. Lower socioeconomic status was associated with higher prevalence of prediabetes and DM. The findings highlight the importance of awareness, treatment, and glycemic control strategies in diabetes prevention and management.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Elena Succurro, Maria Adelaide Marini, Teresa Vanessa Fiorentino, Maria Perticone, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti
Summary: This study aimed to investigate the prevalence of NAFLD in adults with one or more cardio-metabolic risk factors and analyze the impact of sex on NAFLD prevalence. The results showed that women with prediabetes and type 2 diabetes have a higher risk of NAFLD compared to men, and the deterioration of metabolic risk factors is more severe in women.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Public, Environmental & Occupational Health
P. Brunetti, L. Baldessin, S. Pagliacci
Summary: This cohort study conducted a large-scale screening campaign in Italy and identified a certain proportion of individuals with undiagnosed diabetes and prediabetes. The results highlight the importance of population screening and the key role of pharmacists in screening activities and education promotion.
JOURNAL OF PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Jane Tucker, Joanne Salas, Scott Secrest, Jeffrey F. Scherrer
Summary: This study found that erectile dysfunction (ED) is associated with prediabetes and type 2 diabetes (T2D), suggesting that ED may be a risk factor for these conditions. The findings suggest that ED could serve as a marker and early screening tool for diabetes.
PREVENTIVE MEDICINE
(2023)
Editorial Material
Multidisciplinary Sciences
Annette Peters
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Environmental Sciences
Basant Pradhan, Rohan Jayaratne, Helen Thompson, Giorgio Buonanno, Mandana Mazaheri, Mawutorli Nyarku, Weiwei Lin, Marcelo Luiz Pereira, Josef Cyrys, Annette Peters, Lidia Morawska
Summary: Epidemiological studies often use a single monitoring site in urban areas to investigate the association between particle exposure and health effects. However, for ultrafine particles (PNC), the central site cannot consistently represent personal exposure, as they are affected by different sources.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Clinical Neurology
Mingming Wang, Claudia Flexeder, Anna Kilanowski, Sara Kress, Gunda Herberth, Tamara Schikowski, Annette Peters, Marie Standl
Summary: This study aimed to assess the association of changes in sleep behaviors from adolescence to young adulthood with the risk of overweight/obesity, and the reverse relationship. The results showed that only insufficient sleep during young adulthood was associated with an increased risk of overweight/obesity, while long-term sleep difficulties from adolescence to young adulthood were associated with young adult overweight/obesity. Conversely, long-term overweight/obesity from adolescence to young adulthood was associated with insufficient sleep and sleep difficulties in young adulthood.
Article
Cardiac & Cardiovascular Systems
Mengya Shi, Siyu Han, Kristin Klier, Gisela Fobo, Corinna Montrone, Shixiang Yu, Makoto Harada, Ann-Kristin Henning, Nele Friedrich, Martin Bahls, Marcus Doerr, Matthias Nauck, Henry Voelzke, Georg Homuth, Hans J. Grabe, Cornelia Prehn, Jerzy Adamski, Karsten Suhre, Wolfgang Rathmann, Andreas Ruepp, Johannes Hertel, Annette Peters, Rui Wang-Sattler
Summary: This research aimed to identify candidate metabolite biomarkers of Metabolic Syndrome (MetS) and its associated risk factors. The study identified 56 specific metabolites related to MetS, with 13 of them being positively associated and 43 being negatively associated. The majority of these metabolites were associated with low HDL-C and hypertension. Additionally, one lipid metabolite, lysoPC a C18:2, was negatively associated with MetS and its five components. The study also revealed impaired metabolism of branched-chain and aromatic amino acids, as well as accelerated Glycine catabolism through metabolic networks.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Julia Hoffmann, Sabine Hanss, Monika Kraus, Jens Schaller, Christian Schaefer, Dana Stahl, Stefan D. Anker, Gabriele Anton, Thomas Bahls, Stefan Blankenberg, Arne Blumentritt, Leif-Hendrik Boldt, Steffen Cordes, Steffen Desch, Wolfram Doehner, Marcus Doerr, Frank Edelmann, Ingo Eitel, Matthias Endres, Stefan Engelhardt, Jeanette Erdmann, Katharina Eulenburg, Volkmar Falk, Stephan B. Felix, Derk Frank, Thomas Franke, Norbert Frey, Tim Friede, Lars Geidel, Lisa Germans, Ulrich Grabmaier, Martin Halle, Joerg Hausleiter, Vera Jakobi, Ahmad-Fawad Jebran, Alexander Jobs, Stefan Kaeaeb, Mahir Karakas, Hugo A. Katus, Alexandra Klatt, Christoph Knosalla, Joachim Krebser, Ulf Landmesser, Mahsa Lee, Kristin Lehnert, Stephanie Lesser, Katrin Leyh, Roberto Lorbeer, Stephanie Mach-Kolb, Benjamin Meder, Eike Nagel, Christian H. Nolte, Abdul S. Parwani, Astrid Petersmann, Miriam Puls, Henriette Rau, Maximilian Reiser, Otto Rienhoff, Tabea Scharfe, Mario Schattschneider, Heiko Scheel, Renate B. Schnabel, Andreas Schuster, Boris Schmitt, Tim Seidler, Moritz Seiffert, Barbara-Elisabeth Staehli, Adriane Stas, Thomas J. Stocker, Lukas von Stuelpnagel, Holger Thiele, Rolf Wachter, Reza Wakili, Tanja Weis, Kerstin Weitmann, Heinz-Erich Wichmann, Philipp Wild, Tanja Zeller, Wolfgang Hoffmann, Elisabeth Maria Zeisberg, Wolfram-Hubertus Zimmermann, Dagmar Krefting, Titus Kuehne, Annette Peters, Gerd Hasenfuss, Steffen Massberg, Thomas Sommer, Stefanie Dimmeler, Thomas Eschenhagen, Matthias Nauck
Summary: The German Centre for Cardiovascular Research (DZHK) aims to conduct early and guideline-relevant studies to develop new therapies and diagnostics for people with cardiovascular disease. The DZHK designed a research platform to standardize data and sample collections across all studies and ensure compliance with legal regulations and FAIR principles. The platform includes web-based and central units for data management, as well as a Public Open Data strategy to enable interdisciplinary use of data and samples.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Hong Luo, Alina Bauer, Jana Nano, Agnese Petrera, Wolfgang Rathmann, Christian Herder, Stefanie M. Hauck, Benjamin B. Sun, Annika Hoyer, Annette Peters, Barbara Thorand
Summary: This study aimed to investigate the role of plasma proteins in glucose metabolism and type 2 diabetes development. The study identified several novel proteins associated with glucose metabolism abnormalities and type 2 diabetes, as well as confirming previously reported proteins. These findings highlight the importance of proteins in the pathogenesis of type 2 diabetes and suggest potential targets for diabetes treatment and prevention.
Article
Environmental Sciences
Nikolaos Nikolaou, Marco Dallavalle, Massimo Stafoggia, Laurens M. Bouwer, Annette Peters, Kai Chen, Kathrin Wolf, Alexandra Schneider
Summary: This study aims to improve the spatiotemporal coverage of near-surface air temperature in Germany using multi-stage modeling. The models achieved high accuracy and low errors in estimating nationwide temperature at high resolution. The results have important implications for temperature-based epidemiological studies.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Amen Keshawarz, Roby Joehanes, Jiantao Ma, Gha Young Lee, Ricardo Costeira, Pei-Chien Tsai, Olatz M. Masachs, Jordana T. Bell, Rory Wilson, Barbara Thorand, Juliane Winkelmann, Annette Peters, Jakob Linseisen, Melanie Waldenberger, Terho Lehtimaeki, Pashupati P. Mishra, Mika Kahonen, Olli Raitakari, Mika Helminen, Carol A. Wang, Phillip E. Melton, Rae-Chi Huang, Craig E. Pennell, Therese A. O'Sullivan, Carolina Ochoa-Rosales, Trudy Voortman, Joyce B. J. van Meurs, Kristin L. Young, Misa Graff, Yujie Wang, Douglas P. Kiel, Caren E. Smith, Paul F. Jacques, Daniel Levy
Summary: Through meta-analysis of epigenome-wide association studies, we found significant associations between dietary and supplemental intake of vitamins C and E with DNA methylation. Vitamin C intake was associated with 4,656 CpG sites, while vitamin E intake was associated with 160 CpG sites. Vitamin C intake was found to be related to systems development and the immune response, while no significant associations were found for vitamin E intake with any biological pathways investigated.
Article
Multidisciplinary Sciences
Tobias Haueise, Fritz Schick, Norbert Stefan, Christopher L. Schlett, Jakob B. Weiss, Johanna Nattenmueller, Katharina Goebel-Gueniot, Tobias Norajitra, Tobias Nonnenmacher, Hans -Ulrich Kauczor, Klaus H. Maier-Hein, Thoralf Niendorf, Tobias Pischon, Karl-Heinz Joeckel, Lale Umutlu, Annette Peters, Susanne Rospleszcz, Thomas Kroencke, Norbert Hosten, Henry Voelzke, Lilian Krist, Stefan N. Willich, Fabian Bamberg, Juergen Machann
Summary: This study demonstrates the feasibility of deep learning-based image segmentation for the assessment of adipose tissue and spatial distribution of visceral and subcutaneous fat in a large population-based cohort in Germany. The results show significant differences in fat distribution between genders and age/body mass index-related displacements. Deep learning-based image segmentation provides a robust and fast quantification of adipose tissue and assessment of its spatial distribution in large cohort studies.
Article
Psychology, Biological
Iain Mathieson, Felix R. Day, Nicola Barban, Felix C. Tropf, David M. Brazel, Ahmad Vaez, Natalie van Zuydam, Barbara D. Bitarello, Eugene J. Gardner, Evelina T. Akimova, Ajuna Azad, Sven Bergmann, Lawrence F. Bielak, Dorret Boomsma, Kristina Bosak, Marco Brumat, Julie E. Buring, David Cesarini, Daniel Chasman, Jorge E. Chavarro, Massimiliano Cocca, Maria Pina Concas, George Davey Smith, Gail Davies, Ian J. Deary, Tonu Esko, Jessica D. Faul, Oscar Franco, Andrea Ganna, Audrey J. Gaskins, Andrea Gelemanovic, Eco J. C. de Geus, Christian Gieger, Giorgia Girotto, Bamini Gopinath, Hans Joergen Grabe, Erica P. Gunderson, Caroline Hayward, Chunyan He, Diana van Heemst, W. David Hill, Eva R. Hoffmann, Georg Homuth, Jouke Jan Hottenga, Hongyang Huang, Elina Hyppoenen, M. Arfan Ikram, Rick Jansen, Magnus Johannesson, Zoha Kamali, Sharon L. R. Kardia, Maryam Kavousi, Annette Kifley, Tuomo Kiiskinen, Peter Kraft, Brigitte Kuehnel, Claudia Langenberg, Gerald Liew, Penelope A. Lind, Jian'an Luan, Reedik Magi, Patrik K. E. Magnusson, Anubha Mahajan, Nicholas G. Martin, Hamdi Mbarek, Mark McCarthy, George McMahon, Sarah E. Medland, Thomas Meitinger, Andres Metspalu, Evelin Mihailov, Lili Milani, Stacey A. Missmer, Paul Mitchell, Stine Mollegaard, Dennis O. Mook-Kanamori, Anna Morgan, Peter van der Most, Renee de Mutsert, Matthias Nauck, Ilja M. Nolte, Raymond Noordam, Brenda W. J. H. Penninx, Annette Peters, Patricia A. Peyser, Ozren Polasek, Chris Power, Ajka Pribisalic, Paul Redmond, Janet W. Rich-Edwards, Paul M. Ridker, Cornelius A. Rietveld, Susan M. Ring, Lynda M. Rose, Rico Rueedi, Vallari Shukla, Jennifer A. Smith, Stasa Stankovic, Kari Stefansson, Doris Stoeckl, Konstantin Strauch, Morris A. Swertz, Alexander Teumer, Gudmar Thorleifsson, Unnur Thorsteinsdottir, A. Roy Thurik, Nicholas J. Timpson, Constance Turman, Andre G. Uitterlinden, Melanie Waldenberger, Nicholas J. Wareham, David R. Weir, Gonneke Willemsen, Jing Hau Zhao, Wei Zhao, Yajie Zhao, Harold Snieder, Marcel den Hoed, Ken K. Ong, Melinda C. Mills, John R. B. Perry
Summary: Identifying genetic determinants of reproductive success can reveal the mechanisms underlying fertility and identify genes that are currently under natural selection. A genome-wide association study on individuals of European ancestry identified 43 genomic loci associated with the number of children ever born or childlessness. These loci are involved in various aspects of reproductive biology, such as puberty timing, age at first birth, sex hormone regulation, endometriosis, and age at menopause. Additionally, missense variants in ARHGAP27 were found to be associated with higher number of children ever born but shorter reproductive lifespan, suggesting a trade-off at this locus. Other genes, including PIK3IP1, ZFP82, and LRP4, were also implicated by coding variants, and a new role for the melanocortin 1 receptor (MC1R) in reproductive biology was suggested. Furthermore, integration with data from historical selection scans revealed an allele in the FADS1/2 gene locus that has been undergoing selection for thousands of years. These findings highlight the diverse biological mechanisms contributing to reproductive success.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Environmental Sciences
Masna Rai, Susanne Breitner, Veronika Huber, Siqi Zhang, Annette Peters, Alexandra Schneider
Summary: This study examined the association between short-term exposure to air temperature and cause-specific cardiovascular and respiratory mortality in the 15 largest German cities over a 24-year period. The results showed that population susceptibility to cold and heat-related cardiovascular and respiratory mortality risk increased from 1993 to 2016.
ENVIRONMENTAL RESEARCH
(2023)
Article
Cell Biology
Yipeng Cheng, Danni A. Gadd, Christian Gieger, Karla Monterrubio-Gomez, Yufei Zhang, Imrich Berta, Michael J. Stam, Natalia Szlachetka, Evgenii Lobzaev, Nicola Wrobel, Lee Murphy, Archie Campbell, Cliff Nangle, Rosie M. Walker, Chloe Fawns-Ritchie, Annette Peters, Wolfgang Rathmann, David J. Porteous, Kathryn L. Evans, Andrew M. McIntosh, Timothy I. Cannings, Melanie Waldenberger, Andrea Ganna, Daniel L. McCartney, Catalina A. Vallejos, Riccardo E. Marioni
Summary: This study developed 10-year risk prediction models for incident type 2 diabetes (T2D) using blood-based DNA methylation data, showing improved performance beyond standard risk factors typically used for T2D prediction.
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthias Jung, Susanne Rospleszcz, Maximilian T. Loeffler, Sven S. Walter, Elke Maurer, Pia M. Jungmann, Annette Peters, Johanna Nattenmueller, Christopher L. Schlett, Fabian Bamberg, Lena S. Kiefer, Thierno D. Diallo
Summary: This study assessed the association between lumbar bone marrow adipose tissue fat fraction (BMAT-FF) and paraspinal muscle proton density fat fraction (PDFF) with intervertebral disc degeneration (IVDD). The results showed a significant correlation between BMAT-FF and PDFF, and both factors were found to be independent and additive risk factors for IVDD. The findings suggest that quantitative MRI measurements of paraspinal myosteatosis and vertebral bone marrow fatty infiltration can serve as imaging biomarkers to assess the individual risk for IVDD.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Maximilian Iglesias Morcillo, Dennis Freuer, Annette Peters, Margit Heier, Christine Meisinger, Jakob Linseisen
Summary: This study investigated the relationship between BMI and waist circumference with plasma concentrations of coagulation factors in the general population. The results showed significant associations between BMI and waist circumference with various coagulation factors, suggesting that the modification of the coagulation profile could be a potential target for primary prevention in obese individuals.
MEDICINA-LITHUANIA
(2023)
Correction
Peripheral Vascular Disease
Seryan Atasoy, Martin Middeke, Hamimatunnisa Johar, Annette Peters, Margit Heier, Karl-Heinz Ladwig
JOURNAL OF HUMAN HYPERTENSION
(2023)