Article
Multidisciplinary Sciences
Hyun-Ji Park, Jessica R. Hoffman, Milton E. Brown, Sruti Bheri, Olga Brazhkina, Young Hoon Son, Michael E. Davis
Summary: Small extracellular vesicles (sEVs) play a critical role in cardiac cell therapy by delivering molecular cargo and mediating cellular signaling. Knocking down miR-192-5p and miR-432-5p in cardiac c-kit+ cell-derived sEVs enhances their therapeutic capabilities and improves cardiac function, reducing fibrosis and necrotic inflammatory responses. This study suggests that targeting deleterious miRNAs in sEVs could be a promising therapeutic strategy for chronic myocardial infarction.
Article
Biochemistry & Molecular Biology
Xueke Li, Yi Zhong, Wuqi Zhou, Yishu Song, Wenqu Li, Qiaofeng Jin, Tang Gao, Li Zhang, Mingxing Xie
Summary: LIPUS stimulation on BMSCs increases the secretion of EVs, which possess stronger anti-inflammatory function. RNA-seq analysis reveals upregulation of miR-328-5p and miR-487b-3p in LIPUS-EVs, potentially suppressing the MAPK signaling pathway to enhance the anti-inflammatory effects.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Huiying Shi, Chen Jiang, Hailing Yao, Yurui Zhang, Qin Zhang, Xiaohua Hou, Rong Lin
Summary: Fucosylation modification of CD44 on BMSCs enhances their homing ability to the gastrointestinal tract and promotes gastrointestinal motility and ENS remodeling in diabetic mice.
CELL AND BIOSCIENCE
(2021)
Article
Endocrinology & Metabolism
Ziyi Li, Yafei Wang, Shilun Li, Yukun Li
Summary: Bone regeneration is a complex process involving the coordination of osteogenesis and osteoclastogenesis, with the balance between osteogenesis and adipogenesis of BMSCs playing a critical role. Recent studies have shown that exosomes from M2 macrophages facilitate osteogenesis and reduce adipogenesis through the miR-690/IRS-1/TAZ axis, potentially serving as a therapeutic tool for bone loss diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell & Tissue Engineering
Jiahui Jin, Qingjian Ou, Zhe Wang, Haibin Tian, Jing-Ying Xu, Furong Gao, Shuqin Hu, Jie Chen, Juan Wang, Jieping Zhang, Lixia Lu, Caixia Jin, Guo-Tong Xu, Jingjun Zhao
Summary: BMSC-derived EVs, carrying miRNAs, have shown similar efficacy to BMSCs in treating skin dysfunction in SSc, by regulating the WNT and TGF beta signaling pathways.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, General & Internal
Tao Yang, Wei Li, Anquan Peng, Jia Liu, Qin Wang
Summary: In this study, it was found that hypoxic BMSCs-derived exosomes (hypBMSC-Exo) could alleviate cisplatin-induced ototoxicity and had better therapeutic effects compared to BMSC-Exo. This may be achieved by up-regulating the expression of SOD1 and SOD2 to protect auditory function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Injoo Hwang, Eun Ju Lee, Hyomin Park, Dodam Moon, Jong Nam Park, Keun Cheon Kim, Areum Cha, Hyunji Yun, Jaewon Lee, Hwan-Woo Park, Mi-Sook Chang, Hyo-Soo Kim
Summary: The application of EDN1 in treating hMSC organotypic spinal cord slice cultures enhances neuronal outgrowth through whole-genome demethylation and euchromatin. APOBEC1 is identified as a key player in global demethylation and OCT4 gene activation induced by EDN1, suggesting a potential novel therapeutic target for improving hMSC regenerative capability.
Article
Cell Biology
Yang Yu, Meng Chen, Shiyao Yang, Bingyi Shao, Liang Chen, Lei Dou, Jing Gao, Deqin Yang
Summary: Autologous bone marrow-derived mesenchymal stem cells (BMSCs) have promising potential for immunosuppressive therapy, but their immunomodulatory properties are often impaired in patients. Osthole has gained clinical attention for its biological activities, and in this study, it successfully restored the immunosuppressive ability of osteoporotic BMSCs in treating inflammatory colitis and osteoporosis. Enhancing the immune regulatory performance of BMSCs through pharmacological modification, such as osthole, may significantly improve targeted strategies for immunosuppressive therapy.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Maria Yoshida, Ayumu Nakashima, Naoki Ishiuchi, Kisho Miyasako, Keisuke Morimoto, Yoshiki Tanaka, Kensuke Sasaki, Satoshi Maeda, Takao Masaki
Summary: Both adipose-derived and bone marrow-derived mesenchymal stem cells (ADSCs and BMSCs) can suppress renal fibrosis, with ADSCs showing a stronger effect under serum-containing culture conditions. However, ADSC infusion in mice may lead to a higher death rate from pulmonary embolism. Therefore, the selection of ADSCs or BMSCs for clinical applications should consider the target disease and culture method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hyun Hee Jang, Youngsook Son, Gabee Park, Ki-Sook Park
Summary: This study demonstrates that bone marrow-derived mesenchymal stem cells (MSCs) have vasculogenic properties. Different populations of MSCs vary in angiogenic factor expression and vasculogenic properties. The vasculogenic MSCs (vMSCs), distinct from endothelial progenitor cells (EPCs), may contribute to neovascularization and could be a promising cellular therapy for cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Jingwen Zhuang, Ruiyue Hang, Ruoyue Sun, Yanshu Ding, Xiaohong Yao, Ruiqiang Hang, Hui Sun, Long Bai
Summary: Exosomes secreted by bone marrow mesenchymal stem cells have multifaceted effects on osseointegration and hold great promise as a safe, efficient, and ethically unrestricted therapy.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Szu-Hsien Wu, Yu-Ting Liao, Chi-Han Huang, Yi-Chou Chen, En-Rung Chiang, Jung-Pan Wang
Summary: ADSCs tend to spontaneously differentiate into neuron-like cells during high confluence culture, with enhanced expression of neuronal markers and neurotrophins, while BMSCs do not show this tendency. Additionally, ADSCs do not exhibit spontaneous adipogenic and osteogenic differentiation during this process.
Article
Cell & Tissue Engineering
Stefano Negri, Yiyun Wang, Takashi Sono, Qizhi Qin, Ginny Ching-Yun Hsu, Masnsen Cherief, Jiajia Xu, Seungyong Lee, Robert J. Tower, Victoria Yu, Abhi Piplani, Carolyn A. Meyers, Kristen Broderick, Min Lee, Aaron W. James
Summary: Research has shown that anti-DKK1 neutralizing antibodies can enhance the osteogenic differentiation of human adipose-derived stem cells, aiding in bone repair, and demonstrating potential beneficial effects in a mouse model.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Tiemei Li, Xiaotao Su, Pinglan Lu, Xinmei Kang, Mengyan Hu, Chunyi Li, Shisi Wang, Danli Lu, Shishi Shen, Huipeng Huang, Yuxin Liu, Xiaohui Deng, Wei Cai, Lei Wei, Zhengqi Lu
Summary: Pneumonia is a common cause of death in patients with acute ischemic stroke (AIS), and antibiotics are not effective in improving the prognosis due to the negative impact on the immune system. However, a recent study found that bone marrow mesenchymal stem cells (BM-MSC) can reduce bacterial load in the lungs of stroke mice, and this is achieved by modulating the activities of pulmonary macrophages. The study also identified that BM-MSC releases migrasomes, which contain the antibacterial peptide dermcidin (DCD) and enhance the phagocytosis of macrophages.
Article
Biochemistry & Molecular Biology
Hui Hu, Xiaowei Hu, Lin Li, Yan Fang, Yan Yang, Jingjing Gu, Jiadong Xu, Lisheng Chu
Summary: Exosomes derived from bone mesenchymal stem cells (BMSC-Exos) can promote angiogenesis and improve neurological functions in ischemic stroke mice via upregulation of miR-21-5p. In vitro experiments show that BMSC-Exos also enhance the functions of human umbilical vein endothelial cells (HUVECs).
Article
Biotechnology & Applied Microbiology
Chunsheng Hu, Yuxin Lu, Xiaochen Cheng, Yufang Cui, Zuze Wu, Qinglin Zhang
JOURNAL OF GENE MEDICINE
(2017)
Article
Genetics & Heredity
Haoyu Meng, Bo Chen, Zhengxian Tao, Zhihui Xu, Liansheng Wang, Ju Weizhu, Yongyong Hong, Xiang Liu, Hua Wang, Lisheng Wang, Zuze Wu, Zhijian Yang
CURRENT GENE THERAPY
(2018)
Article
Anesthesiology
C. Hu, Y. Lu, X. Chen, Z. Wu, Q. Zhang
EUROPEAN JOURNAL OF PAIN
(2018)
Article
Biotechnology & Applied Microbiology
Fanxuan Kong, Xuefeng Shi, Fengjun Xiao, Yuefeng Yang, Xiaoyan Zhang, Li-Sheng Wang, Chu-Tse Wu, Hua Wang
HUMAN GENE THERAPY
(2018)
Article
Cell & Tissue Engineering
Xin Li, Qian Wang, Li Ding, Yu-Xing Wang, Zhi-Dong Zhao, Ning Mao, Chu-Tse Wu, Hua Wang, Heng Zhu, Shou-Bin Ning
STEM CELL RESEARCH & THERAPY
(2019)
Article
Cell & Tissue Engineering
Xin Li, Li Ding, Yu-Xing Wang, Zhong-Li Li, Qian Wang, Zhi-Dong Zhao, Sen Zhao, Hua Wang, Chu-Tse Wu, Ning Mao, Heng Zhu
STEM CELLS TRANSLATIONAL MEDICINE
(2020)
Article
Cell & Tissue Engineering
Hongfang Meng, Lei Hu, Ying Zhou, Zhiqiang Ge, Hua Wang, Chu-Tse Wu, Jide Jin
STEM CELLS AND DEVELOPMENT
(2020)
Letter
Medicine, Research & Experimental
Qingsong Ye, Hua Wang, Xia Xia, Chenliang Zhou, Zhiming Liu, Zun-en Xia, Zhan Zhang, Yang Zhao, Jun Yehenala, Si Wang, Gangqiao Zhou, Ke Hu, Bin Wu, Chu-Tse Wu, Songling Wang, Yan He
Article
Cell & Tissue Engineering
Xiwen Dong, Fanxuan Kong, Chao Lu, Shiyun Dai, Yuning Zhang, Fengjun Xiao, Huan Zhang, Chu-Tse Wu, Hua Wang
STEM CELL RESEARCH & THERAPY
(2020)
Article
Cell & Tissue Engineering
Panpan Geng, Yuning Zhang, Huan Zhang, Xiwen Dong, Yuefeng Yang, XiaoNa Zhu, Chu-Tse Wu, Hua Wang
Summary: Paraquat poisoning can lead to acute lung injury, pulmonary fibrosis, and potential death. Mesenchymal stem cells and hepatocyte growth factor have shown promise in reversing this damage. By utilizing DPSCs-HGF, a more effective treatment method has been developed to mitigate lung inflammation and collagen accumulation, leading to improved survival rates in paraquat-poisoned mice.
STEM CELLS INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Yongquan Gu, Shijun Cui, Changjian Liu, Jichun Zhao, Ming Li, Yiqing Li, Xinglong Yang, Bonan Lv, Mingzhang Li, Wenguang Zhao, Wei Guo, Jianhua Huang, Wen Huang, Zhenming Qiu, Jun Zhao, Ping Yin, Tingting Qin, Dan Zhu, Wenjie Sun, Keyun Ren, Yuxin Lu, Xiaochen Cheng, Li Du, Fengjun Xiao, Qinglin Zhang, Zuze Wu
Summary: The phase II clinical trial showed that intramuscular injection of pUDK-HGF in patients with critical limb ischemia was effective in relieving resting pain and promoting ulcer healing, with no significant differences in safety compared to the placebo group. The mid-dose of 6 mg pUDK-HGF was found to be the most efficacious and is recommended for further testing in a phase III clinical trial.
HUMAN GENE THERAPY
(2021)
Article
Cell & Tissue Engineering
Hongfang Meng, Fen Wei, Ying Zhou, Lei Hu, Zhiqiang Ge, Jide Jin, Hua Wang, Chu-tse Wu
Summary: This study demonstrated that overexpression of HGF enhanced the immunoregulatory abilities of DPSCs, leading to a reduction in inflammatory responses and improvement in psoriatic skin lesions.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Cell & Tissue Engineering
Youfeng Li, Yuning Zhang, Hua Wang, Chengfeng Sun, Dongmei Liu, Hongying Liu, Jia He, Furong Chen, Weiting Wang, Xi Jiang, Chu-tse Wu, Yuefeng Yang
Summary: DP-MSCs and BM-MCSs exhibit impressive therapeutic effects in treating CLI by improving limb functions and promoting angiogenesis.
STEM CELLS INTERNATIONAL
(2021)
Article
Cell & Tissue Engineering
Fanxuan Kong, Chu-Tse Wu, Panpan Geng, Chao Liu, Fengjun Xiao, Li-Sheng Wang, Hua Wang
Summary: DPSCs-derived EVs show potential in reducing radiation-induced haematopoietic damage, promoting cell proliferation and inhibiting apoptosis. EVs can comparably accelerate the recovery of long-term HSCs in vivo, correct alterations in miRNA expression caused by radiation in bone marrow cells, and exhibit a similar ability to regulate haematopoietic regeneration as EGF.
STEM CELL REVIEWS AND REPORTS
(2021)
Article
Geriatrics & Gerontology
Linsha Ma, Jingchao Hu, Yu Cao, Yilin Xie, Hua Wang, Zhipeng Fan, Chunmei Zhang, Jinsong Wang, Chu-Tse Wu, Songlin Wang