Article
Clinical Neurology
Nahal Mavaddat, Euan Sadler, Lisa Lim, Kate Williams, Elizabeth Warburton, Ann Louise Kinmonth, Chris Mckevitt, Jonathan Mant
Summary: The study found discrepancies between self-reported health and objectively measured disability levels among stroke survivors, which are related to individual psychological factors and social support.
Article
Clinical Neurology
Liying Xing, Li Jing, Yuanmeng Tian, Weizhong Wang, Jixu Sun, Cuiqin Jiang, Lei Shi, Dong Dai, Shuang Liu
Summary: The study found a significant burden of stroke in urban northeast China, with higher rates in men and a high prevalence of hypertension, dyslipidemia, and diabetes in stroke patients. However, the control rates of these comorbidities were low.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Health Care Sciences & Services
Wen-Jun Tu, Yang Hua, Feng Yan, Hetao Bian, Yi Yang, Min Lou, Dezhi Kang, Li He, Lan Chu, Jingsheng Zeng, Jian Wu, Huisheng Chen, Jianfeng Han, Lin Ma, Lei Cao, Longde Wang
Summary: The prevalence of stroke in China has been increasing over the past 7 years, particularly among males, older individuals, and those residing in rural and northeast areas. These findings are important for improving stroke prevention and addressing related risk factors.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Article
Dentistry, Oral Surgery & Medicine
Diego Gomez-Costa, Jesus San-Roman-Montero, Rosa Rojo, Angel Gil, Rafael Gomez de Diego, Antonio F. Lopez-Sanchez
Summary: This study found that immigrants in Spain have a lower probability of developing signs associated with periodontal disease compared to the Spanish population. Among immigrants, females and adults had lower prevalence rates of periodontal disease.
Article
Public, Environmental & Occupational Health
Yanjin Huang, Qi Wang, Ping Zou, Guoping He, Ying Zeng, Jing Yang
Summary: This study evaluated the cognitive status of stroke patients in Hunan Province, China and identified potential risk factors for post-stroke cognitive impairment (PSCI) in older adults. The findings highlight the high prevalence of PSCI among Chinese older adults, particularly those aged 80 years or older. The identified risk factors could assist in early identification and promote healthy aging.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Immunology
Dimitrios Papagiannis, Eleftherios Thireos, Anargiros Mariolis, Antonios Katsioulis, Konstantina Gartzonika, Niki Malliaraki, Christos Agnantis, Konstantinos Tsaras, Foteini Malli, Erasmia C. Rouka, Ioanna Tsiaousi, Emmanouil K. Symvoulakis, Georgios Rachiotis, Konstantinos Gourgoulianis
Summary: This study aimed to measure the prevalence of Bordetella pertussis in Greece and found that the herd immunity level among Greek adults is suboptimal.
Article
Geriatrics & Gerontology
Anna L. Parks, Sun Y. Jeon, W. John Boscardin, Michael A. Steinman, Alexander K. Smith, Margaret C. Fang, Sachin J. Shah
Summary: This study found that older adults with atrial fibrillation experienced significant loss of function over time, regardless of stroke. While stroke was associated with functional decline and an increased likelihood of moving to a nursing home, it did not accelerate subsequent disability accumulation.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Rehabilitation
Janina Kaarre, Tamar Abzhandadze, Katharina S. Sunnerhagen
Summary: Impaired cognition early after stroke could not predict self-reported feeling of depression 3 months post-stroke. Female patients had twice the odds of self-reported feeling of depression compared with male patients.
JOURNAL OF REHABILITATION MEDICINE
(2021)
Article
Allergy
Kleomenis D. Benidis, Eleni Tzortzaki, Andreas Georgiou, Theodora Zachariadou, Tonia Adamidi, Savvas Zannetos, Petros Bakakos, Nikolaos G. Koulouris, Nikoletta Rovina
Summary: This study aimed to estimate the prevalence of asthma in adults in urban and rural areas of Cyprus, taking into consideration gender and age. A population-based, random-digit dialing, telephone survey was conducted, and 572 participants met the criteria for valid screening. The study revealed an overall asthma prevalence of 5.57%, with higher rates in urban areas and among men compared to women. Interestingly, a significant proportion of patients were under-treated.
JOURNAL OF ASTHMA AND ALLERGY
(2023)
Article
Medicine, General & Internal
Shangrong Han, Dongling Sun, Bin Jiang, Haixin Sun, Xiaojuan Ru, Aoming Jin, Yilong Wang, Wenzhi Wang
Summary: This study reports on the prevalence and distribution of lacunar stroke in China at a population level. Special attention and prevention should be given to the age, sex, and geographical groups that are vulnerable to lacunar stroke.
Article
Health Care Sciences & Services
Vanessa Machado, Patricia Lyra, Catarina Santos, Luis Proenca, Jose Joao Mendes, Joao Botelho
Summary: This study explored the accuracy of self-reporting for predicting the prevalence of periodontitis in a Portuguese population. The results showed that factors such as gum health, loose teeth, tooth appearance, and use of dental floss were associated with the severity of periodontitis. Multiple self-reporting setups showed elevated performance levels for predicting periodontitis in Portuguese patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
M. Barral, H. Rabier, A. Termoz, H. Serrier, C. Colin, J. Haesebaert, L. Derex, N. Nighoghossian, A-M Schott, M. Viprey
Summary: The study found that in the first year after a stroke, patients' productivity losses and informal care costs represent a significant economic burden for society, comparable to direct costs. These costs should be considered in economic evaluations to avoid underestimating the societal stroke economic burden.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Environmental Sciences
Walid Q. Alali, Joseph C. Longenecker, Rehab Alwotyan, Hessa AlKandari, Fahd Al-Mulla, Qais Al Duwairi
Summary: The study in Kuwait found that smoking prevalence is higher in men than women, with the majority of smokers being current smokers. Additionally, exposure to secondhand smoke at home and work poses serious health risks to the population.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Mosepele Mosepele, Kara Bennett, Tendani Gaolathe, Joseph M. Makhema, Mompati Mmalane, Molly Pretorius Holme, Refeletswe Lebelonyane, Omolola Ometoruwa, Lisa A. Mills, Kathleen M. Powis, Jean Leidner, Joseph N. Jarvis, Neo M. Tapela, Tiny Masupe, Lucky Mokgatlhe, Virginia A. Triant, Kathleen E. Wirth, Thato Moshomo, Shahin Lockman
Summary: In a population-based study in Botswana, it was found that 1 in 4 adults had high blood pressure, with lower prevalence among individuals with HIV. The study also revealed low levels of awareness and control of hypertension, emphasizing the urgent need for community level screening and management.
SCIENTIFIC REPORTS
(2023)
Review
Geriatrics & Gerontology
Jennifer K. Burton, Jennifer Stewart, Mairi Blair, Sinead Oxley, Amy Wass, Martin Taylor-Rowan, Terence J. Quinn
Summary: Despite limited knowledge of frailty in stroke, studies show that frailty is common in patients with acute stroke and associated with poor outcomes.
Article
Neurosciences
Bahne Hendrik Bahners, Gunnar Waterstraat, Silja Kannenberg, Gabriel Curio, Alfons Schnitzler, Vadim Nikulin, Esther Florin
Summary: The subthalamic nucleus (STN) receives input from various cortical areas via the hyperdirect pathway (HDP), which is important for deep brain stimulation (DBS). Cortical responses evoke three different latencies, and the medium-latency responses may represent antidromic cortical activations via the HDP. These responses can be used as biomarkers for evaluating the efficacy and side effects of DBS.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Endocrinology & Metabolism
Helge Jorn Zollner, Thomas A. A. Thiel, Nur-Deniz Fuellenbach, Markus S. Joerdens, Sinyeob Ahn, Lena M. M. Wilms, Alexandra Ljimani, Dieter Haeussinger, Markus Butz, Hans-Joerg Wittsack, Alfons Schnitzler, Georg Oeltzschner
Summary: Using GABA-edited MRS, this study investigates metabolic abnormalities in the cerebello-thalamo-cortical system of HE patients, finding changes in GABA+ levels in the cerebellum and motor cortex that are closely linked to disease severity, CFF, motor performance, and blood ammonia levels.
METABOLIC BRAIN DISEASE
(2023)
Article
Clinical Neurology
Serge Pinto, Adelheid Nebel, Jorn Rau, Robert Espesser, Pauline Maillochon, Oliver Niebuhr, Paul Krack, Tatiana Witjas, Alain Ghio, Marie-Charlotte Cuartero, Lars Timmermann, Alfons Schnitzler, Helke Hesekamp, Niklaus Meier, Julia Muellner, Thomas D. Haelbig, Bettina Moeller, Steffen Paschen, Laura Paschen, Jens Volkmann, Michael T. Barbe, Gereon R. Fink, Johannes Becker, Paul Reker, Andrea A. Kuehn, Gerd-Helge Schneider, Valerie Fraix, Eric Seigneuret, Andrea Kistner, Olivier Rascol, Christine Brefel-Courbon, Fabienne Ory-Magne, Christian J. Hartmann, Lars Wojtecki, Anne Fradet, David Maltete, Philippe Damier, Severine Le Dily, Friederike Sixel-Doering, Petra Benecke, Daniel Weiss, Tobias Waechter, Marcus O. Pinsker, Jean Regis, Stephane Thobois, Gustavo Polo, Jean-Luc Houeto, Andreas Hartmann, Karina Knudsen, Marie Vidailhet, Michael Schuepbach, Gunther Deuschl
Summary: This study compared speech intelligibility assessment and other outcomes between subthalamic nucleus deep brain stimulation (STN-DBS) and best medical treatment (BMT) in early-stage Parkinson's disease patients over a 2-year period. The results showed no significant differences in speech intelligibility and patient-reported outcomes between the STN-DBS and BMT groups, but there was a trend towards worsening in both groups.
MOVEMENT DISORDERS
(2023)
Article
Multidisciplinary Sciences
Carlos Trenado, Matthias Boschheidgen, Karim N'Diaye, Alfons Schnitzler, Luc Mallet, Lars Wojtecki
Summary: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is effective in treating motor symptoms in Parkinson's disease (PD), but its impact on high cognitive processes such as metacognition remains unclear. This study found no significant effect of STN-DBS on reversal learning (RL) or metacognition.
SCIENTIFIC REPORTS
(2023)
Article
Neuroimaging
Matthias Sure, Sean Mertiens, Jan Vesper, Alfons Schnitzler, Esther Florin
Summary: The stun effect from deep brain stimulation (DBS) electrodes in Parkinson's disease (PD) patients can temporarily improve motor symptoms. However, the network changes induced by the stun effect have not been well characterized. This study investigated whether the DBS-related stun effect also modulated resting-state networks (RSNs) and found that it alters different functional RSNs throughout the brain.
NEUROIMAGE-CLINICAL
(2023)
Editorial Material
Clinical Neurology
Bahne H. Bahners, Rachel K. Spooner, Christian J. Hartmann, Alfons Schnitzler, Esther Florin
Article
Clinical Neurology
Marius Kroesche, Silja Kannenberg, Markus Butz, Christian J. Hartmann, Esther Florin, Alfons Schnitzler, Jan Hirschmann
Summary: This study investigated the spectral properties of atypical parkinsonism (APS) by measuring resting-state magnetoencephalography in patients with corticobasal syndrome (CBS), progressive supranuclear palsy (PSP), idiopathic Parkinson's disease (PD), and healthy controls. The results showed that APS was associated with spectral slowing, with a shift in beta peaks towards lower frequencies in the frontal areas. Additionally, increased theta/alpha power was observed in both APS and PD compared to controls. The findings suggest that spectral slowing might be an electrophysiological marker of neurodegeneration and could aid in the differential diagnosis of parkinsonian syndromes in the future.
MOVEMENT DISORDERS
(2023)
Article
Chemistry, Analytical
Jeroen G. V. Habets, Rachel K. Spooner, Varvara Mathiopoulou, Lucia K. Feldmann, Johannes L. Busch, Jan Roediger, Bahne H. Bahners, Alfons Schnitzler, Esther Florin, Andrea A. Kuehn
Summary: An open-source tool called ReTap was developed to predict finger tapping scores in Parkinson's disease patients. The tool successfully detected tapping blocks in over 94% of cases and extracted clinically relevant kinematic features per tap. The study demonstrated that ReTap can provide accessible and reliable finger tapping scores, which may have important implications for the diagnosis and treatment of Parkinson's disease.
Article
Neurosciences
Rachel K. Spooner, Bahne H. Bahners, Alfons Schnitzler, Esther Florin
Summary: Research shows that optimal contact orientations in subthalamic deep brain stimulation can lead to larger cortical responses and smoother hand movements in patients with Parkinson's disease. These findings have clinical implications for optimizing DBS parameter settings to alleviate motor symptoms.
NPJ PARKINSONS DISEASE
(2023)
Article
Psychology, Experimental
Julia Henkel, Christian Hartmann, Valentina Niccolai, Ruben van de Vijver, Alfons Schnitzler, Katja Biermann-Ruben
Summary: Parkinson's disease not only affects the motor system, but also language abilities, particularly syntactic subordination. This study found that patients with Parkinson's disease showed a significant reduction in subordinating structures compared to a healthy control group, while the number of non-embedding sentences remained unaffected. Additionally, the medication status of levodopa did not have a significant effect on language abilities. These results suggest a contribution of the basal ganglia to language processing, which is not dopamine dependent.
Article
Neurosciences
Frederick Benjamin Junker, Tobias Schmidt-Wilcke, Alfons Schnitzler, Joachim Lange
Summary: This study explores the nonlexical components of language decoding using Morse code as a model. Magnetoencephalography was employed to investigate the brain regions associated with Morse code decoding and word comprehension. The findings provide insights into the neural mechanisms underlying language decoding.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Anne A. Koy, Andrea Kuehn, Petra Schiller, Julius Huebl, Gerd-Helge Schneider, Matthias Eckenweiler, Cornelia Rensing-Zimmermann, Volker Arnd K. Coenen, Joachim Krauss, Assel Saryyeva, Hans Hartmann, Delia Lorenz, Jens Volkmann, Cordula Matthies, Alfons Schnitzler, Jan Vesper, Alireza Gharabaghi, Daniel Weiss, Andrea Bevot, Warren Marks, Angela Howser, Elegast Monbaliu, Joerg Mueller, Reinhild Prinz-Langenohl, Veerle Visser-Vandewalle, Lars Timmermann
Summary: This study assessed the efficacy and safety of deep brain stimulation (DBS) in pediatric patients with dyskinetic cerebral palsy (DCP). The results showed that DBS significantly improved dyskinesia, but other outcome parameters did not change significantly. Investigations of larger homogeneous cohorts are needed to further ascertain the impact of DBS and guide treatment decisions in DCP.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Johannes L. Busch, Jonathan Kaplan, Bahne H. Bahners, Jan Roediger, Katharina Faust, Gerd-Helge Schneider, Esther Florin, Alfons Schnitzler, Patricia Krause, Andrea A. Kuehn
Summary: Stimulation-induced beta power suppression is superior to directional beta power in selecting the most effective contact for programming deep brain stimulation systems in patients with Parkinson's disease.
MOVEMENT DISORDERS
(2023)
Letter
Psychiatry
Ana S. Costa, Carolin Balloff, Julia Bungenberg, Simone C. Tauber, Ann-Kathrin Telke, Carolina Bandlow, Stefan J. Groiss, Christian J. Hartmann, Saskia Elben, Iris-Katharina Penner, Sven G. Meuth, Alfons Schnitzler, Kathrin Reetz, Philipp Albrecht
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Marius Kroesche, Silja Kannenberg, Markus Butz, Christian J. Hartmann, Esther Florin, Alfons Schnitzler, Jan Hirschmann
Summary: This study identified spectral slowing, particularly affecting the frontal beta oscillations, in patients with atypical parkinsonian syndromes. This finding may serve as an electrophysiological marker for the differential diagnosis of Parkinson's disease in the future.
MOVEMENT DISORDERS
(2023)