Article
Medicine, General & Internal
Ioana-Patricia Rodean, Luminita Lazar, Vasile-Bogdan Halatiu, Carmen Biris, Imre Benedek, Theodora Benedek
Summary: This study aimed to investigate the association between periodontal disease severity, coronary calcifications, and unstable plaque features in patients with unstable angina. Patients with high periodontal index had larger plaque and noncalcified plaque volume. Vulnerability features in atheromatous plaques were significantly correlated with periodontal index. Gingival attachment loss and papillary bleeding index were strongly associated with high-risk plaques. Periodontal index correlated significantly with coronary calcium score, but not with traditional markers of subclinical atherosclerosis. Subgroup analysis showed that patients with advanced periodontal disease and unstable angina presented with a higher amount of coronary calcium and a more vulnerable plaque phenotype.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Agnieszka Kregielczak, Barbara Dorocka-Bobkowska, Ryszard Slomski, Grzegorz Oszkinis, Zbigniew Krasinski
Summary: The aim of this study was to investigate the periodontal status of patients with atherosclerosis and abdominal aortic aneurysms. The results showed that the majority of patients had chronic severe generalized periodontitis, and multiple periodontopathogens were detected in the periodontal pockets.
Article
Dentistry, Oral Surgery & Medicine
Paavai Ilango, Jaideep Mahendra, Little Mahendra, Sanjay M. Cherian, Vasugi Suresh, Arulpari Mahalingam, Vinoth Khanna, Abirami Thanigaimalai
Summary: The study aimed to evaluate the prevalence of Epstein-Barr virus (EBV), cytomegalovirus (CMV), and herpes simplex virus (HSV) in patients with periodontitis and/or coronary artery disease (CAD) and compare it with their healthy controls. The results showed a higher prevalence of EBV and CMV in patients with periodontitis, indicating the significant role of these viruses in periodontitis. The study also found that HSV was more prevalent in patients with CAD, suggesting a potential link between CAD and periodontitis.
Article
Medicine, Research & Experimental
Mircea Catalin Cosarca, Emoke Horvath, Calin Molnar, Gyopar-Beata Molnar, Eliza Russu, Vasile Adrian Muresan
Summary: This comparative study focused on mineral patterns in human atherosclerotic plaques, revealing significant differences in the calcification characteristics and deposits between different arterial segments. The mineralized surface area in femoral-popliteal axis plaques increased with narrowing of the vascular lumen diameter.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Xiaomeng Wang, Ying-Hwey Nai, Julian Gan, Cheryl Pei Ling Lian, Fraser Kirwan Ryan, Forest Su Lim Tan, Dexter Yak Seng Chan, Jun Jie Ng, Zhiwen Joseph Lo, Tze Tec Chong, Derek John Hausenloy
Summary: Peripheral artery disease (PAD) is a common and debilitating condition characterized by the narrowing of limb arteries. Non-invasive imaging techniques such as CT, MRI, and nuclear imaging have proven valuable in assessing PAD plaques and vessel walls. This review explores the advantages, limitations, and recent advancements of these imaging techniques, as well as the importance of molecular markers in PAD pathophysiology. Integrating molecular and imaging markers holds potential for improving our understanding of PAD, but technical constraints and the need for new molecular markers pose challenges.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Alfonso Corrales, Nuria Vegas-Revenga, Belen Atienza-Mateo, Cristina Corrales-Selaya, Diana Prieto-Pena, Javier Rueda-Gotor, Virginia Portilla, Ricardo Blanco, Santos Castaneda, Ivan Ferraz-Amaro, Javier Llorca, Miguel A. Gonzalez-Gay
Summary: The combination of QRISK3 and EULAR mSCORE allows for the identification of most RA patients at high risk of carotid plaques.
Article
Multidisciplinary Sciences
W. Johnston, B. T. Rosier, A. Artacho, M. Paterson, K. Piela, C. Delaney, J. L. Brown, G. Ramage, A. Mira, S. Culshaw
Summary: This study demonstrates that current non-surgical periodontal therapy in periodontitis patients results in significant health-associated alterations in microbial composition and diversity, accompanied by clinical improvement and reduction in salivary inflammation markers. Despite reductions in disease-associated microbes, certain genera remain present in some patients and are associated with residual disease.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Microbiology
Jan Claesen, J. Mark Brown
Summary: This study comprehensively cataloged pathways involved in trimethylamine metabolism and identified key bacterial players in the process. It also discovered new TMA-reducing genera that have potential for probiotic strategies or targeted microbiome interventions.
Article
Medicine, General & Internal
Thomas J. T. Leung, Nina Nijland, Victor E. A. Gerdes, Bruno G. Loos
Summary: There is a global increase in individuals with multimorbidity, but the causes of combinations of diseases remain unclear. This pilot study found that periodontal disease (PD) is highly prevalent in multimorbid patients and significantly more common in patients with cardiovascular diseases (CVD).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Siqin Liu, Guofang Xie, Meifeng Chen, Yukun He, Wenyi Yu, Xiaobo Chen, Weigang Mao, Nanxia Liu, Yuanjie Zhang, Qin Chang, Yingying Qiao, Xinqian Ma, Jianbo Xue, Mengtong Jin, Shuming Guo, Yudong Hou, Zhancheng Gao
Summary: This study compared and investigated the bacterial signatures in periodontitis and chronic obstructive pulmonary disease (COPD), providing potential information for the prediction, screening, and treatment strategies of individuals. The results showed higher bacterial richness in individuals with periodontitis and identified differentially abundant genera as potential biomarkers for each group. The findings may contribute to the prediction, screening, and treatment strategies for individuals with periodontitis and COPD.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jeneen Panezai, Ambereen Ghaffar, Mohammad Altamash, Mikael Aberg, Thomas E. Van Dyke, Anders Larsson, Per-Erik Engstrom
Summary: Periodontal disease enhances the expression of CVD-related biomarkers in RA patients through shared pathological clusters, concurrently enhancing metabolic and skeletal disease protein interactions, independent of autoimmune status.
Article
Microbiology
Laura Sisk-Hackworth, Adrian Ortiz-Velez, Micheal B. Reed, Scott T. Kelley
Summary: Periodontal disease (PD) is a chronic, progressive polymicrobial disease that induces a strong host immune response. Next-generation sequencing (NGS) studies have shown that PD biodiversity increases with pocket depth and PD communities are highly host-specific. By applying compositional data analysis (CoDA) methods, new features associated with PD, including genera Schwartzia and Aerococcus, and the cytokine C-reactive protein, have been identified. Network analysis revealed lower connectivity among taxa in deeper periodontal pockets, indicating a more random microbiome.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Julie Caroline Saether, Elisabeth Kleivhaug Vesterbekkmo, Maria Dalen Taraldsen, Bruna Gigante, Turid Follestad, Helge Rorvik Rosjo, Torbjorn Omland, Rune Wiseth, Erik Madssen, Anja Bye
Summary: This study investigated the association between circulating miRs and lipid-rich coronary plaques. The results showed that miR-133b was the miR most strongly associated with lipid-rich plaques, with an estimated 18% increase in odds of lipid-rich plaques per unit increase in miR-133b. Although the evidence is modest, miR-133b could be a potential biomarker of vulnerable coronary plaques and risk of future MI, but further evaluation is needed in larger cohorts.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Sara Perez-Luz, Nerea Matamala, Gema Gomez-Mariano, Sabina Janciauskiene, Beatriz Martinez-Delgado
Summary: Non-alcoholic fatty liver disease (NAFLD) is associated with obesity, dyslipidemia, hypertension, and diabetes, while other diseases like alpha-1 antitrypsin deficiency (AATD) are also linked to liver steatosis. The causes of hepatic lipid deposits can be genetic and epigenetic, with outcomes ranging from benign steatosis to liver failure and extrahepatic diseases. This review explores the similarities and differences between NAFLD and AATD molecular pathways, and highlights the potential of hepatic organoids as novel models for studying liver steatosis.
Article
Dentistry, Oral Surgery & Medicine
Aysegul Sari, Vedat Davutoglu, Emrullah Bozkurt, Ibrahim Levent Taner, Kamile Erciyas
Summary: The study showed that periodontitis and atherosclerosis may increase systemic oxidative stress, with a more pronounced effect when they coexist. Periodontitis may be associated with increased systemic TOS and OSI values in patients with atherosclerosis.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mabelle Freitas Monteiro, Marcio Zaffalon Casati, Enilson Antonio Sallum, Karina Gonzales Silverio, Francisco Humberto Nociti-Jr, Renato Correa Viana Casarin
Summary: This study found that aggressive periodontitis (GAgP) patients and their children have a different local inflammatory response compared to healthy controls, and there is a familial aggregation. The cytokine profile and subgingival response imbalance characterized by decreased IFN-gamma/IL-4 and IL-10/IL-1 beta ratios were observed in both GAgP patients and their children.
Article
Dentistry, Oral Surgery & Medicine
Camila Lopes Ferreira, Maria Aparecida Neves Jardini, Camilla Magnoni Moretto Nunes, Daniella Vicensotto Bernardo, Renato Correa Viana Casarin, Estevao dos Santos Gedraite, Marcio Antonio Mathias, Fei Liu, Gustavo Mendonca, Daniela Baccelli Silveira Mendonca, Mauro Pedrine Santamaria
Summary: Electrical stimulation (ES) has a positive effect on early palatal wound closure outcomes and inflammatory markers in Swiss mice.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Cecilia C. C. Ribeiro, Cadidja D. S. Carmo, Bruno B. Benatti, Renato V. C. Casarin, C. M. C. Alves, Gustavo G. Nascimento, A. R. O. Moreira
Summary: This study examined the association between systemic inflammatory burden of cardiovascular disease (CVD) risk and periodontitis in adolescents. The results showed that lower socioeconomic status and smoking triggered initial periodontitis, while systemic inflammatory burden of CVD risk played a mediating role. Sensitivity analysis revealed a dose-response relationship between systemic inflammatory burden of CVD risk and moderate periodontitis.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Susilena Arouche Costa, Cecilia Claudia Costa Ribeiro, Kheops Renoir de Oliveira, Claudia Maria Coelho Alves, Erika Barbara Abreu Fonseca Thomaz, Renato Correa Viana Casarin, Soraia de Fatima Carvalho Souza
Summary: This study evaluated the association between low bone mineral density (BMD) and severe periodontitis in adolescents. The results showed that low BMD was associated with the severity and extent of periodontitis, indicating that adolescents with low BMD are more likely to have severe periodontitis.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Giselle A. Silva, Andre L. G. Moreira, Pedro H. F. Silva, Sergio L. Salvador, Renato C. Casarin, Raphael M. Vicente, Graziele C. Ferreira, Jose E. Tanus-Santos, Flavia A. C. Furlaneto, Michel R. Messora
Summary: The study found that the use of B. lactis HN019 in rats can reduce the severity of periodontitis while regulating systemic metabolic and immunoinflammatory parameters. The use of probiotics has a beneficial effect on dyslipidemia parameters in rats with or without metabolic syndrome.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Camila S. Stolf, Catharina M. Sacramento, Helvis E. S. Paz, Renato A. Machado, Lucas P. Ramos, Luciane D. de Oliveira, Karina Cogo-Muller, Mauro P. Santamaria, Karina G. S. Ruiz, Renato C. V. Casarin
Summary: This study demonstrated the association between the IL10 promoter rs6667202 SNP and IL10 expression and production. In patients with periodontal health, the AA and AC genotypes were associated with lower levels of IL10, while in patients with Perio4C, other factors may be affecting the IL-10 response despite the genetic variation.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Helvis E. S. Paz, Mabelle F. Monteiro, Camila S. Stolf, Khaled Altabtbaei, Marcio Z. Casati, Renato C. Casarin, Purnima S. Kumar
Summary: This study evaluated the taxonomic and predicted functional content of the subgingival microbiome of young patients with Grade C periodontitis under supportive periodontal therapy. The results showed that despite clinical improvements, the microbiome of these patients remained different from individuals without a history of disease.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sandro Santana, Pedro H. F. Silva, Sergio L. Salvador, Renato C. Casarin, Flavia A. C. Furlaneto, Michel R. Messora
Summary: This clinical trial evaluated the effects of a multispecies probiotic as an adjunct to mechanical debridement on changes in bleeding on probing in edentulous patients with peri-implant mucositis. The results showed that the probiotic group had a higher prevalence of restored peri-implant health and lower bleeding on probing at 24 weeks compared to the placebo group.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Naira M. R. B. Andere, Nidia C. Castro dos Santos, Cassia F. Araujo, Helvis E. S. Paz, Luciana M. Shaddox, Renato C. Casarin, Mauro P. Santamaria
Summary: The study compared the efficacy of aPDT and OFD in treating residual periodontal pockets in non-furcation sites. OFD was more effective in reducing PPD in deep pockets, but resulted in greater GR. Both treatments decreased levels of P. gingivalis, but only OFD reduced levels of A. actinomycemtemcomitans.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Luiz Fernando Ferreira de Oliveira, Pedro Henrique Felix Silva, Sergio Luiz Salvador, Edilson Ervolino, Renato Casarin, Luciene Figueiredo, Milla Tavares Ricoldi, Sergio Luis Scombatti de Souza, Flavia Furlaneto, Michel Reis Messora
Summary: This study evaluated the effects of administering Bifidobacterium animalis subsp. lactis HN019 on rats with experimental periodontitis. The results showed that the rats treated with HN019 had less alveolar bone loss, lower proinflammatory/anti-inflammatory cytokine ratios, and a different composition of oral biofilm compared to the control group. The consumption of HN019 promoted a protective effect against alveolar bone loss by modifying local and systemic microbiological and immunoinflammatory parameters.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Rafaela Videira Clima da Silva, Thiago Perez Rangel, Monica Grazieli Correa, Mabelle de Freitas Monteiro, Marcio Zaffalon Casati, Karina Gonzales Ruiz, Enilson Antonio Sallum, Renato Correa Viana Casarin, Antonio Wilson Sallum
Summary: Smokers showed unfavorable clinical, microbiological, and immunological responses at 3 and 6 months after treatment with FMUD associated with AMX + MTZ.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Renato C. V. Casarin, Cristiane R. Salmon, Camila S. Stolf, Helvis E. S. Paz, Thiago P. Rangel, Romenia R. Domingues, Bianca A. Pauletti, Adriana F. Paes-Leme, Cassia Araujo, Mauro P. Santamaria, Karina S. Ruiz, Mabelle F. Monteiro
Summary: The aim of this study was to compare the salivary proteomic profile of periodontitis-affected parents and their offspring to periodontally healthy dyads in order to find potential biomarkers for early diagnosis of this disease. The results showed that ANXA1, KRT4, GSTP1, HPX, A2M, and KRT13 were lower in periodontitis-affected parents and their children, while IGHG1, CSTB, KRT9, SMR3B, IGHG4, and SERPINA1 were higher. ANXA1 had the lowest abundance and was selected as a potential biomarker for periodontitis. The in vitro assay also confirmed lower ANXA1 production in cells of periodontitis patients.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Aurelio Amorim Reis, Mabelle Freitas Monteiro, Gabriela Martin Bonilha, Luciana Saraiva, Cassia Araujo, Mauro Pedrine Santamaria, Marcio Zaffalon Casati, Purnima Kumar, Renato Correa Viana Casarin
Summary: The aim of this study was to evaluate microbial colonization in different dentition phases among individuals from 0 to 18 years old with a family history of periodontitis compared to descendants of periodontally healthy parents. The results showed that the parents' periodontal status significantly affected the microbiome composition of their offspring, and descendants with a family history of periodontitis exhibited different microbial diversity and a higher prevalence of periodontitis-associated species in the mixed and permanent dentition phases.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Tamires Pereira Dutra, Mabelle Freitas Monteiro, Isabela Lima Franca-Grohmann, Renato Correa Viana Casarin, Marcio Zaffalon Casati, Karina Gonzalez Silverio Ruiz, Purnima S. Kumar, Enilson Antonio Sallum
Summary: This study compared individuals with a history of periodontitis to periodontally healthy subjects in terms of immunological and microbiological changes during experimental peri-implant mucositis and gingivitis. The results showed that different microbial shifts contribute to the onset and progression of inflammatory responses around teeth and implants, while the history of periodontal disease plays a role in modulating the immune response.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Mauro Pedrine Santamaria, Ingrid Fernandes Mathias-Santamaria, Lais Fernanda Ferreira Ferraz, Renato Correa Viana Casarin, Giuseppe Alexandre Romito, Enilson Antonio Sallum, Giovan Paolo Pini-Prato, Marcio Zaffalon Casati
Summary: This study critically reviewed treatment protocols for combined soft tissue/tooth defects (CDs) and proposed a new decision-making process based on different classifications of NCCLs. The depth of root surface discrepancy plays a vital role in influencing soft tissue adaptation post-healing and treatment options.
BRAZILIAN ORAL RESEARCH
(2021)
