Article
Biochemistry & Molecular Biology
Bomin Son, Wesuk Kang, Soyoon Park, Dabin Choi, Taesun Park
Summary: Skin dermis aging is caused by reduced collagen synthesis, with olfactory receptors playing a role in cell survival and collagen synthesis. Among the studied ORs, OR51B5 stands out as a key player in cell survival and collagen synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Alla Zorina, Vadim Zorin, Dmitry Kudlay, Pavel Kopnin
Summary: Skin aging is a multi-factorial process that involves impairment of skin structures and functions, particularly in the dermal extracellular matrix (ECM), leading to disrupted functioning of dermal fibroblasts (DFs). The integrity of the collagen matrix (CM) is crucial for proper adhesion and mechanical tension in DFs, allowing them to maintain collagen homeostasis. Impaired CM integrity disrupts mechanotransduction and impairs DF functioning, contributing to the progression of aging processes in skin tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yulia Solomonov, Nurit Hadad, Oleg Pikovsky, Rachel Levy
Summary: Collagen, a major protein in skin, is damaged by UV exposure, which accelerates photo-aging. Lumenato protects against collagen-3 damage caused by activated neutrophils and induces collagen-3 synthesis.
Article
Endocrinology & Metabolism
Cecile Guillon, Sandra Ferraro, Sophie Clement, Marielle Bouschbacher, Dominique Sigaudo-Roussel, Christelle Bonod
Summary: The study found that glyoxal glycation significantly reduced the proliferation and migration capabilities of fibroblasts, while increasing cellular tensile strength. Glyoxal did not affect the secretion of type I collagen, but disrupted its maturation and prevented deposition in the extracellular matrix, while also promoting the accumulation of lipid droplets.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Biochemistry & Molecular Biology
Ji Eun Lee, Yong Chool Boo
Summary: The study introduces a new strategy utilizing glycianamide and ascorbic acid (AA) to enhance collagen production in cells, leading to improved wound healing capabilities.
Article
Biochemistry & Molecular Biology
Viktoriya Shishkina, Andrey Kostin, Artem Volodkin, Vera Samoilova, Igor Buchwalow, Markus Tiemann, Dmitri Atiakshin
Summary: This study analyzed the skin dermis of C57BL/6J mice after a long stay in space flight and found that weightlessness resulted in an increase in type III collagen-rich fibers and a decrease in co-localization of mast cells with fibroblasts and impregnated fibers. The potential molecular and cellular mechanisms for the changes in fibrillogenesis activity and the decrease in fibrous structures with a predominant content of type-I collagen under zero-gravity conditions are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nina Xue, Ying Liu, Jing Jin, Ming Ji, Xiaoguang Chen
Summary: This study found that chlorogenic acid can increase collagen synthesis and secretion while reducing collagen degradation during the process of photoaging. Additionally, chlorogenic acid can inhibit the production of reactive oxygen species induced by UV radiation, alleviate DNA damage, and promote cell repair, ultimately reducing cell apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Zhengkun Chen, Sina Kheiri, Albert Gevorkian, Edmond W. K. Young, Valerie Andre, Ted Deisenroth, Eugenia Kumacheva
Summary: Skin cell organotypic micrometre-size 3D aggregates, known as multicellular spheroids, have potential to replace animal models in testing skincare products. A microfluidic platform for dermal fibroblast spheroids (DFSs) growth has been developed to screen active ingredients (AIs) like vitamin C efficiently. The computational simulation suggests that DFSs can serve as a reliable in vitro dermal model for skincare product screening.
Article
Biochemistry & Molecular Biology
Pietro Felice, Emira D'Amico, Tania Vanessa Pierfelice, Morena Petrini, Carlo Barausse, Maryia Karaban, Antonio Barone, Giovanna Iezzi
Summary: The features and biological activities of an acellular porcine dermis collagen matrix membrane applicable during dental surgery were investigated, and the effects of hydration with NaCl were evaluated. Results showed that the hydrated membrane promoted cell proliferation and attachment, and increased mineralization and gene expression related to osteoblasts in oral cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Su Jin Hwang, Su Hwan Kim, Woo-Young Seo, Yelin Jeong, Min Cheol Shin, Dongryeol Ryu, Sang Bae Lee, Young Jin Choi, KyeongJin Kim
Summary: Type I collagen, the most abundant form in human tissues, has been found to promote collagen synthesis, cell proliferation and migration, and elastin production. The effective domain of human collagen alpha-1 type I (hCOL1A1-CED) may have potential use as a preventive agent against skin aging.
Article
Nutrition & Dietetics
Fabien Wauquier, Line Boutin-Wittrant, Elodie Bouvret, Julie Le Faouder, Veronique Roux, Nicolas Macian, Gisele Pickering, Yohann Wittrant
Summary: Due to environmental factors, the skin undergoes changes known as photoaging, resulting in dryness and loss of elasticity. Supplementation with fish cartilage hydrolysate (FCH) can improve skin functionality by enhancing hydration, elasticity, and limiting the expression of factors involved in photoaging.
Article
Biochemistry & Molecular Biology
Tugba Soydas, Muge Sayitoglu, Elif Yaprak Sarac, Suzan Cinar, Seyhun Solakoglu, Tunc Tiryaki, Gonul Kanigur Sultuybek
Summary: The study found that metformin can not only inhibit apoptosis of human dermal fibroblasts during skin aging at high glucose concentrations, but also reverse the impact on NF-kB through regulating the expression of COL1A1 and COL3A1.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Integrative & Complementary Medicine
Wan-jun Guo, Yi Wang, Yu Deng, Lin-yan Cheng, Xin Liu, Ruo-fan Xi, Sheng-jie Zhu, Xin-yi Feng, Liang Hua, Kan Ze, Jian-yong Zhu, Dong-jie Guo, Fu-lun Li
Summary: This study investigates the biological role of Cyr61 in psoriasis and the mechanism by which SC extract alleviates psoriasis. The results showed that Cyr61 expression is increased in psoriatic lesions, and SC significantly improves the inflammatory phenotype of psoriasis and reduces the levels of Cyr61 and ICAM-1.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Article
Dermatology
Kyung-Il Kim, Chang-Il Kwon, Jeung-Hoon Lee, Chang-Deok Kim, Tae-Jin Yoon
Summary: This study found that mitoxantrone reduces collagen synthesis by inhibiting TGF-(3/SMAD signaling and LARP6 expression in fibroblasts.
ANNALS OF DERMATOLOGY
(2022)
Article
Oncology
Yi-Rong Gan, Ling Wei, Yan-Zhen Wang, Zong-Ke Kou, Tian-Xiang Liang, Guan-Waner Ding, Yan-Hong Ding, Ding-Xiong Xie
Summary: This study found that knockdown of CCN1 can alleviate PA-induced inflammation and apoptosis of endothelial cells by inhibiting activation of the Wnt/beta-catenin signaling pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Dermatology
Taihao Quan, Yaping Xiang, Yingchun Liu, Zhaoping Qin, Yan Yang, George Bou-Gharios, John J. Voorhees, Andrzej A. Dlugosz, Gary J. Fisher
Summary: The aging process affects the structure and function of dermal collagen, leading to thinning, fragility, wrinkles, laxity, impaired wound healing, and a microenvironment conducive to cancer. CCN1 protein is elevated in aged human skin, and transgenic mice expressing CCN1 in dermal fibroblasts display accelerated skin dermal aging. This mouse model provides a novel tool for understanding and studying the mechanisms of skin aging.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Dayan Cao, Ying Liu, Xin Chen, Jie Liu, Jie Liu, Wenjing Lai, Shuhui Li, Wenjia Wang, Wenjun Zhang, Deyong Xiao, Kai Yang, Baiyan Li, Zhongjun Zhou, Chen-Leng Cai, Xiaohui Li, Weinian Shou
Article
Biochemistry & Molecular Biology
Wei Jin, Yi He, Tuo Li, Fei Long, Xin Qin, Yuan Yuan, Ge Gao, Hosen Md Shakhawat, Xinguang Liu, Guoxiang Jin, Zhongjun Zhou
Summary: The study established an efficient method for deriving MSCs from both human iPSCs and ESCs, which showed high tri-lineage differentiation potential and transcriptional similarity to primary MSCs derived from bone marrow. This method could be potentially used for disease modeling and clinical applications, as demonstrated in generating MSCs from patients with Hutchinson-Gilford progeria syndrome and mutation-rectified cells.
CELL AND BIOSCIENCE
(2022)
Review
Cell Biology
Mingyue Zheng, Guoxiang Jin, Zhongjun Zhou
Summary: Lamins, ancient intermediate filament proteins, are functionally regulated by post-translational modifications, contributing to various biological functions. Deregulation of lamins is associated with abnormal nuclear morphology and chromatin disorganization, leading to diseases. Understanding these modifications provides new insights into the molecular mechanisms underlying diseases and potential therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yan Wang, Binbin Ma, Xiaoxu Liu, Ge Gao, Zhuanzhuan Che, Menghan Fan, Siyan Meng, Xiru Zhao, Rio Sugimura, Hua Cao, Zhongjun Zhou, Jing Xie, Chengqi Lin, Zhuojuan Luo
Summary: ZFP281 cooperates with BRCA2 to prevent R-loop accumulation and facilitate DNA replication in embryonic stem cells. ZFP281 interacts with BRCA2 and recruits it to the bivalent chromatin regions at the genome-wide scale.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Xuanming Guo, Pallavi Asthana, Susma Gurung, Shuo Zhang, Sheung Kin Ken Wong, Samane Fallah, Chi Fung Willis Chow, Sijia Che, Lixiang Zhai, Zening Wang, Xin Ge, Zhixin Jiang, Jiayan Wu, Yijing Zhang, Xiaoyu Wu, Keyang Xu, Cheng Yuan Lin, Hiu Yee Kwan, Aiping Lyu, Zhongjun Zhou, Zhao-Xiang Bian, Hoi Leong Xavier Wong
Summary: Insulin sensitivity declines with age due to increased activity of MT1-MMP, which cleaves the insulin receptor. Inhibiting MT1-MMP restores insulin receptor expression and improves insulin sensitivity. MT1-MMP activity is also involved in obesity-induced insulin resistance and metabolic dysfunctions in diabetes. Circulating MT1-MMP and soluble insulin receptor are positively correlated in plasma.
NATURE COMMUNICATIONS
(2022)
Article
Pediatrics
Qi Peng, Keze Ma, Linsheng Wang, Yinghua Zhu, Yaozhong Zhang, Chunbao Rao, Dong Luo, Zaixue Jiang, Wei Lai, Huiling Lu, Chaohui Duan, Zhongjun Zhou, Xiaomei Lu
Summary: This study describes an infant with mitochondrial encephalopathy carrying a novel intronic variant in the AIFM1 gene. The variant was found to disrupt normal mRNA splicing through analysis of mRNA extracted from the patient's cells.
FRONTIERS IN PEDIATRICS
(2022)
Article
Dermatology
Taihao Quan, Wei Xia, Tianyuan He, Kenneth Calderone, George Bou-Gharios, John J. Voorhees, Andrzej A. Dlugosz, Gary J. Fisher
Summary: Fragmentation, disorganization, and depletion of the collagen-rich dermal extracellular matrix are characteristic of aged human skin. Increased expression of matrix metalloproteinase-1 (MMP1) in dermal fibroblasts is found in aged skin and is thought to be a critical factor in skin aging. A mouse model expressing human MMP1 showed similar features of aged human skin and increased susceptibility to skin papilloma development.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Cell Biology
Lian Zhang, Yujiao He, Yi Jiang, Qi Wu, Yanchen Liu, Qingqiang Xie, Yuxiu Zou, Jiaqian Wu, Chundong Zhang, Zhongjun Zhou, Xiu-Wu Bian, Guoxiang Jin
Summary: This study reveals the dual role of PRMT1-mediated RIP3 methylation in necroptotic cancer cell death and tumor immune escape. PRMT1 methylates RIP3 and inhibits its interaction with RIP1, thereby suppressing necrosome complex formation and necroptosis activation. The protein levels of PRMT1 and RIP3(ADMA) are positively correlated in cancer tissues and both serve as valuable prognostic markers for colon cancer.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Ge Gao, Xiaoping Li, Zhixin Jiang, Liliana Osorio, Ying Lam Tang, Xueqing Yu, Guoxiang Jin, Zhongjun Zhou
Summary: Loss of Ism1 in mice leads to kidney defects similar to those found in human kidney diseases. Ism1 acts as a ligand of Integrin alpha 8 beta 1 in the metanephric mesenchyme, promoting mesenchyme condensation during early renal branching morphogenesis. Ism1 modulates Gdnf/Ret signaling, which is critical for proper kidney development.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Tsz Long Chu, Peikai Chen, Anna Xiaodan Yu, Mingpeng Kong, Zhijia Tan, Kwok Yeung Tsang, Zhongjun Zhou, Kathryn Song Eng Cheah
Summary: This study reveals that MMP14 plays a crucial role in the regulation of PTH signaling, thus contributing to bone homeostasis. During the development of osteoblasts from HC-descendent cells, MMP14 and the PTH pathway are activated. MMP14 cleaves PTH1R to dampen PTH signaling, thereby regulating bone synthesis.
Article
Biology
Lian Zhang, Jing Yu, Mingyue Zheng, Hui Zhen, Qingqiang Xie, Chundong Zhang, Zhongjun Zhou, Guoxiang Jin
Summary: The lysosome protein RAGA interacts with and promotes lysosome localization and degradation of the macrophage-specific immune checkpoint protein CD47, with possible relevance to lung adenocarcinoma. RAGA deficiency leads to CD47 accumulation, increased membrane/intracellular CD47 expression ratio, and reduced phagocytic clearance of cancer cells, promoting tumor growth. Clinical analysis shows a negative correlation between RAGA and CD47 proteins in lung adenocarcinoma patient samples, with high RAGA protein level associated with longer patient survival. RAGA(high)CD47(low) patients exhibit the longest overall survival, suggesting RAGA as a potential diagnostic biomarker of lung adenocarcinoma.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cell Biology
Kaiqiang Zhao, Mingyue Zheng, Zezhuo Su, Shrestha Ghosh, Chao Zhang, Wenzhao Zhong, Joshua Wing Kei Ho, Guoxiang Jin, Zhongjun Zhou
Summary: The tumor-suppressive function of SIRT6 in non-small cell lung cancer (NSCLC) is regulated by acetylation, specifically by males absent on the first (MOF) protein. The MOF-SIRT6-ZEB2 axis may represent a promising therapeutic target for the management of NSCLC.
Review
Biochemistry & Molecular Biology
Taihao Quan
Summary: As the most extensive and abundant tissue in the human body, the skin undergoes gradual atrophy during the aging process, causing disruptions to its structure and functionality. Recent molecular discoveries related to skin aging emphasize the importance of preventive approaches, such as the use of topical retinoids, which show promise in enhancing skin texture and thickness.
Article
Endocrinology & Metabolism
Chi Fung Willis Chow, Xuanming Guo, Pallavi Asthana, Shuo Zhang, Sheung Kin Ken Wong, Samane Fallah, Sijia Che, Susma Gurung, Zening Wang, Ki Baek Lee, Xin Ge, Shiyang Yuan, Haoyu Xu, Jacque Pak Kan Ip, Zhixin Jiang, Lixiang Zhai, Jiayan Wu, Yijing Zhang, Arun Kumar Mahato, Mart Saarma, Cheng Yuan Lin, Hiu Yee Kwan, Tao Huang, Aiping Lyu, Zhongjun Zhou, Zhao-Xiang Bian, Hoi Leong Xavier Wong
Summary: The GDF15-GFRAL axis plays a key role in energy homeostasis and body weight regulation. In this study, the membrane-bound matrix metalloproteinase 14 (MT1-MMP/MMP14) was found to negatively regulate GFRAL, and its downregulation protected against diet-induced obesity by increasing GDF15 signaling. This finding provides mechanistic insights into the regulation of GDF15 sensitivity and identifies MT1-MMP as a potential therapeutic target against obesity.