Article
Veterinary Sciences
Lorena Franco-Martinez, Alba Ortin-Bustillo, Camila P. Rubio, Damian Escribano, Marina Lopez-Arjona, Edgar Garcia-Manzanilla, Jose J. Ceron, Silvia Martinez-Subiela, Asta Tvarijonaviciute, Fernando Tecles
Summary: The study evaluated the effects of pen faeces and feed on biomarker measurement in porcine oral fluid. It was found that pen faeces and feed can interfere with the measurement of several biomarkers, but centrifugation, filtration, or chemical clarification can mitigate this interference.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Anders Holt, Paul Blanche, Bochra Zareini, Peter Vibe Rasmussen, Jarl Emanuel Strange, Deepthi Rajan, Mads Hashiba Jensen, Mohammed El-Sheikh, Anne-Marie Schjerning, Morten Schou, Gunnar Gislason, Christian Torp-Pedersen, Patricia McGettigan, Morten Lamberts
Summary: This study investigated the risk of gastrointestinal bleeding associated with concomitant treatment of non-vitamin K oral anticoagulants and oral glucocorticoids. The results showed that the coexposure of these medications was linked to a higher short-term risk of gastrointestinal bleeding compared to patients solely on anticoagulants, suggesting the need for closer monitoring or risk mitigation strategies during combined treatment.
Review
Pharmacology & Pharmacy
Catiane Costa Viana, Marcus Fernando da Silva Praxedes, Waleska Jaclyn Freitas Nunes de Sousa, Frederico Bartolazzi, Mayara Sousa Vianna, Jose Luiz Padilha da Silva, Maria Auxiliadora Parreiras Martins
Summary: The study found that women had worse oral anticoagulation control compared to men with coumarin derivatives. Further research is needed to investigate sex-related factors influencing oral anticoagulation control. Innovative strategies focused on women's health may be useful to improve patient-centered care.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Engineering, Multidisciplinary
Michal Wrobel, Gennady Mishuris, Panos Papanastasiou
Summary: The study investigates the spatial and temporal evolution of fluid flow and resulting fracture geometry in a hydraulic fracture driven by a non-Newtonian shear-thinning fluid. The analysis demonstrates that rheological properties of fluids significantly impact the hydraulic fracturing process.
INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE
(2021)
Article
Medicine, General & Internal
Ditte B. Iversen, Maja Hellfritzsch, Tore B. Stage, Rune M. Aabenhus, Bent S. Lind, Anton Pottegard
Summary: The study found that the use of systemic fluconazole and miconazole oral gel was associated with a significant increase in INR in warfarin users, while nystatin oral solution had no impact on INR.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Hematology
Bethany T. Samuelson Bannow, Vivia Chi, Paul Sochacki, Owen J. T. McCarty, Maureen K. Baldwin, Alison B. Edelman
Summary: The study investigated rates of heavy menstrual bleeding (HMB) in users of rivaroxaban and apixaban, finding an association between rivaroxaban use and the need for medical or surgical intervention for HMB. Most women did not have a documented menstrual history, indicating that many providers do not inquire about menstrual bleeding when initiating anticoagulant therapy. Menstruating women, especially those with a history of HMB, may be at increased risk for HMB requiring medical treatment depending on the type of OAC used.
THROMBOSIS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Tetsuji Kitano, Yosuke Nabeshima, Masaharu Kataoka, Masaaki Takeuchi
Summary: Meta-analysis may increase the risk of random errors, but Trial sequential analysis (TSA) can adjust for these errors. TSA was conducted on the efficacy and safety of DOACs and VKAs in LVT patients. The current sample size already demonstrated superiority of DOACs in LV thrombus resolution and stroke, but further trials are needed for other outcomes.
SCIENTIFIC REPORTS
(2023)
Article
Biochemical Research Methods
Jaime Millan-Santiago, Rafael Lucena, Soledad Cardenas
Summary: This article explores the potential of pre-cleaned bare wooden toothpicks (pb-WTs) for drug extraction from oral fluid samples and proposes a method to improve the analytical performance. The study investigates the variables affecting the extraction of antidepressant drugs and validates the optimized procedure. The results demonstrate good detection limits and precision. Furthermore, the potential of pb-WTs for in vivo sampling is outlined.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Alexander P. Benz, Stefan H. Hohnloser, John W. Eikelboom, Anthony P. Carnicelli, Robert P. Giugliano, Christopher B. Granger, Josephine Harrington, Ziad Hijazi, David A. Morrow, Manesh R. Patel, David J. Seiffge, Ashkan Shoamanesh, Lars Wallentin, Qilong Yi, Stuart J. Connolly
Summary: This study aimed to investigate the prognosis of patients with atrial fibrillation (AF) and ischemic stroke while on oral anticoagulation. The results showed that among the 1163 patients who had a post-randomization ischemic stroke while on study medication, 7.0% had a recurrent ischemic stroke within 1 year, and the all-cause mortality rate within 3 months was 12.4%.
EUROPEAN HEART JOURNAL
(2023)
Article
Multidisciplinary Sciences
Kourosh Ravvaz, John A. Weissert, Arshad Jahangir, Christian T. Ruff
Summary: The study found that patient socioeconomic status (SES) defined by area deprivation index (ADI) can predict the risk of ischemic and bleeding events in atrial fibrillation patients undergoing warfarin therapy in the first year. ADI significantly improved the predictive performance of the CHA(2)DS(2)-VASc risk score, but did not affect the HAS-BLED risk score.
Article
Medicine, General & Internal
Jonathan P. Piccini, Valeria Caso, Stuart J. Connolly, Keith A. A. Fox, Jonas Oldgren, W. Schuyler Jones, Diana A. Gorog, Vaclav Durdil, Thomas Viethen, Christoph Neumann, Hardi Mundl, Manesh R. Patel
Summary: This study compared the incidence of bleeding in patients with atrial fibrillation between Asundexian and apixaban, showing that Asundexian resulted in lower rates of bleeding compared with standard dosing of apixaban.
Article
Pharmacology & Pharmacy
Shin-Yi Lin, Sung-Chun Tang, Ching-Hua Kuo, Li-Ting Ho, Yen-Bin Liu, Yu-Fong Peng, Li-Kai Tsai, Chih-Fen Huang, Jiann-Shing Jeng
Summary: This study reports on the association between direct oral anticoagulant (DOAC) concentration and clinical outcomes in Asian patients with atrial fibrillation (AF). The proportion of DOAC concentrations falling outside the expected range was higher than reported in clinical trials. Low trough concentration was associated with increased risk of systemic thromboembolism (SSE), while high trough concentration was associated with major bleeding. Measurement of trough DOAC concentration should be considered for patients at risk of concentration deviations.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Chemistry, Analytical
Eva Pospisilova, Natalie Paskanova, Martin Kuchar, Tatiana V. V. Shishkanova
Summary: This study presents a potentiometric approach for detecting two cathinone derivatives. The cation-exchanger as the active component of the ion-selective membrane showed a near-Nernstian response and selectivity for one of the derivatives in oral fluids. The agreement between the results obtained with this approach and another method demonstrates the potential for forensic analysis.
Article
Chemistry, Analytical
Cristina Cano-Trujillo, Anna Barbaro, Fernando E. Ortega-Ojeda, Carmen Garcia-Ruiz, Gemma Montalvo
Summary: The potential of ATR FTIR was explored to determine the source of human and canine oral fluid stains on porous substrates. The main infrared bands of these stains were visible among the characteristic bands of the substrates, allowing for their identification and classification. Applying OPLS-DA models to the infrared spectra enabled the classification of oral fluid stains as human or animal, regardless of the substrate they were found on.
MICROCHEMICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Catherine G. Derington, Glenn K. Goodrich, Stanley Xu, Nathan P. Clark, Kristi Reynolds, Jaejin An, Daniel M. Witt, David H. Smith, Maureen O'Keeffe-Rosetti, Daniel T. Lang, P. Michael Ho, T. Craig Cheetham, Angela C. Comer, Jordan B. King
Summary: This cohort study compared three direct oral anticoagulant (DOAC) care models for patients with atrial fibrillation (AF) and found that neither the usual care plus a population management tool (PMT) nor pharmacist-managed care model showed appreciably better outcomes for patients receiving DOAC compared with usual care.
Article
Biochemistry & Molecular Biology
Denise Biagini, Maria Franzini, Paolo Oliveri, Tommaso Lomonaco, Silvia Ghimenti, Andrea Bonini, Federico Vivaldi, Lisa Macera, Laurence Balas, Thierry Durand, Camille Oger, Jean-Marie Galano, Fabrizio Maggi, Alessandro Celi, Aldo Paolicchi, Fabio Di Francesco
Summary: “The role of oxylipins in COVID-19 inflammation has been poorly understood. However, a recent study found that oxylipins can differentiate between samples collected from COVID-19 wards and ICU. Patients in ICU showed lower levels of anti-inflammatory and pro-resolving lipid mediators, indicating impaired inflammation response. This study highlights the importance of targeting lipid mediators for a better understanding of COVID-19 inflammation and the potential for biomarker-based prediction models.”
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemical Research Methods
Laura Colombaioni, Beatrice Campanella, Riccardo Nieri, Massimo Onor, Edoardo Benedetti, Emilia Bramanti
Summary: Mitochondria, organelles of bacterial origin, are not only responsible for energy production but also generate reactive oxygen species. They play a key role in cell defense regulation, cell stress, and damage. This study investigated the effect of hyperglycemia on the metabolome of hippocampal neurons and found that neuronal metabolism was impaired and typical fermentative compounds were produced.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Isabella Piga, Vincenzo L'Imperio, Lucrezia Principi, Claudio Bellevicine, Nicola Fusco, Fausto Maffini, Konstantinos Venetis, Mariia Ivanova, Davide Seminati, Gabriele Casati, Lisa Pagani, Stefania Galimberti, Giulia Capitoli, Mattia Garancini, Andrea-Valer Gatti, Fulvio Magni, Fabio Pagni
Summary: This study used Matrix-Assisted Laser Desorption/Ionisation (MALDI)-Mass Spectrometry Imaging (MSI) to analyze noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP). It discovered that proteomic signatures can overcome histological challenges and distinguish different types of cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Giulia Giaganini, Mario Cifelli, Denise Biagini, Silvia Ghimenti, Andrea Corti, Valter Castelvetro, Valentina Domenici, Tommaso Lomonaco
Summary: Microplastics and nanoplastics are a major environmental issue due to their ubiquity and potential danger to ecosystems and human life. This study investigates the effect of temperature and light on five types of reference polymers using a solar box. A multi-analytical approach was used to analyze the degradation products of these microplastics.
Article
Oncology
Domenico D'Arca, Leda Severi, Stefania Ferrari, Luca Dozza, Gaetano Marverti, Fulvio Magni, Clizia Chinello, Lisa Pagani, Lorenzo Tagliazucchi, Marco Villani, Gianluca d'Addese, Isabella Piga, Vincenza Conteduca, Lorena Rossi, Giorgia Gurioli, Ugo De Giorgi, Lorena Losi, Maria Paola Costi
Summary: In this study, mass spectrometry and molecular pathway analysis were used to analyze serum samples from patients with ovarian serous carcinoma before the second cycle of FOLFOX-4 therapy. A total of 291 shared expressed proteins were identified, and 12 proteins were found to be significantly associated with treatment response and sample collection time. Network enrichment analysis revealed that these proteins were related to drug-resistant ovarian cancer at the molecular level. This study suggests a new direction for the discovery of protein biomarkers for predicting treatment response.
Article
Agricultural Engineering
Jose Gonzalez-Rivera, Beatrice Campanella, Elena Pulidori, Emilia Bramanti, Maria Rosaria Tine, Luca Bernazzani, Massimo Onor, Paolo Barberi, Celia Duce, Carlo Ferrari
Summary: Novel green extraction method (US-IMWAE) using simultaneous ultrasound and microwave irradiation allows for full exploitation of aromatic herbs while minimizing energy consumption and extraction cost. This method has successfully yielded essential oils with appealing composition profiles for cosmetic and medical industries, as well as valuable solid residues for alternative fuel production.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Lucrezia Principi, Erica Ferrini, Roberta Ciccimarra, Lisa Pagani, Clizia Chinello, Paolo Previtali, Andrew Smith, Gino Villetti, Matteo Zoboli, Francesca Ravanetti, Franco Fabio Stellari, Fulvio Magni, Isabella Piga
Summary: This study investigated the molecular fingerprint of fibrosis progression and response to nintedanib treatment in mice with pulmonary fibrosis using mass spectrometry. The results showed that different stages of fibrosis have different protein expression patterns, and nintedanib treatment can alter the protein expression of fibrosis. These findings reveal the biological processes of pulmonary fibrosis and the mechanisms of fibrosis therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lisa Pagani, Clizia Chinello, Giulia Risca, Giulia Capitoli, Lucrezia Criscuolo, Andrea Lombardi, Riccardo Ungaro, Davide Mangioni, Isabella Piga, Antonio Muscatello, Francesco Blasi, Andrea Favalli, Martina Martinovic, Andrea Gori, Alessandra Bandera, Renata Grifantini, Fulvio Magni
Summary: By studying the plasma proteome of 43 COVID-19 patients, differentially expressed proteins related to the severity of infection were identified. Three proteins were found to be able to accurately distinguish different stages of infection. These proteins may be associated with the severity of the disease and the immune response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Beatrice Campanella, Stefano Legnaioli, Massimo Onor, Edoardo Benedetti, Emilia Bramanti
Summary: Saliva is a sample that can be easily collected and contains a wealth of biochemical information related to an individual's health status. The fast and straightforward analysis of saliva using vibrational spectroscopy provides a good basis for large-scale preclinical studies. This study explored the effects of saliva collection (spitting/swab) and processing (deproteinization procedures) and found that special care is needed when using swabs due to the significant interaction between the polymeric material and saliva components. Additionally, analyzing saliva before and after deproteinization by FTIR and Raman spectroscopy provides complementary biological information.
Article
Biochemical Research Methods
Alessio Lenzi, Denise Biagini, Silvia Ghimenti, Federico M. Vivaldi, Pietro Salvo, Fabio Di Francesco, Tommaso Lomonaco
Summary: Variations in salivary short-chain fatty acids and hydroxy acids levels can reflect the dysbiosis of human gut microbiota, which plays a role in the onset of heart failure disease. This study presents a reliable and simple method for determining these metabolites in stimulated saliva samples, using in-situ derivatization and sorptive extraction coupled to gas chromatography-tandem mass spectrometry. The optimized protocol was successfully applied to evaluate the salivary levels of these acids in different groups of patients. Rating: 9/10.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Biochemical Research Methods
F. M. Vivaldi, S. Reale, S. Ghimenti, D. Biagini, A. Lenzi, T. Lomonaco, F. Di Francesco
Summary: Solid-phase sorption is commonly used for gas sample analysis as it allows preconcentration of target analytes and sample storage. Adding internal standards (ISs) can reduce analytical variability and improve reliability.
JOURNAL OF BREATH RESEARCH
(2023)
Article
Biology
Aidonis Rammos, Aris Bechlioulis, Petros Kalogeras, Chris J. Watson, Pietro Salvo, Tommaso Lomonaco, Olga Kardakari, Evanthia E. Tripoliti, Yorgos Goletsis, Dimitris I. Fotiadis, Christos S. Katsouras, Lampros K. Michalis, Katerina K. Naka
Summary: This study found that saliva NT-proBNP correlates with serum values in patients with acute decompensated HF, but cannot differentiate between HF and other causes of dyspnea.
Article
Chemistry, Analytical
Michelle Buoso, Beatrice Campanella, Massimo Onor, Emanuela Pitzalis, Alessandro D'Ulivo
Summary: The use of BH intermediates as derivatization reagents significantly improves the tolerance to interference from transition metal ions in the generation of SbH3 and BiH3, and shows high tolerance in a wide range of acidity. The method has been successfully applied to the determination of Sb and Bi in complex samples, providing further understanding of the chemical behavior of borohydrides.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2024)
Article
Biochemistry & Molecular Biology
Giulia Capitoli, Isabella Piga, Vincenzo L'Imperio, Francesca Clerici, Davide Leni, Mattia Garancini, Gabriele Casati, Stefania Galimberti, Fulvio Magni, Fabio Pagni
Summary: Fine-needle aspiration biopsies (FNA) are commonly used to exclude the malignant nature of thyroid nodules, but a significant proportion of cases are indeterminate. A study found that matrix-assisted laser-desorption ionization mass spectrometry imaging (MALDI-MSI) can improve the diagnostic performance of FNA by separating benign and malignant cell areas. However, the performance of the model is affected by poor spectra and noise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
