Article
Medicine, General & Internal
Jeff Choi, Edward B. Vendrow, Michael Moor, David A. Spain
Summary: In this study, a practical model was developed using a limited number of injury patterns to quantify injury severity through 3 intuitive outcomes.
Article
Immunology
Haiyan Ge, Xuanqi Liu, Wenchao Gu, Xiumin Feng, Fengying Zhang, Fengfeng Han, Yechang Qian, Xiaoyan Jin, Beilan Gao, Li Yu, Hong Bao, Min Zhou, Shengqing Li, Zhijun Jie, Jian Wang, Zhihong Chen, Jingqing Hang, Jingxi Zhang, Huili Zhu
Summary: Comorbidities play a significant role in acute exacerbations among COPD patients, with specific comorbidities identified as risk factors for exacerbation within a year. A novel risk score combining BODEx and four diseases shows great prognostic value in identifying high-risk exacerbation patients.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Engineering, Civil
V. Y. Palagala, V. Singhal
Summary: Assessing the seismic vulnerability of existing RC frame buildings is essential for evaluating their performance in future earthquakes and planning risk mitigation strategies. The proposed technique provides both qualitative and quantitative assessment by assigning a structural score, defining the building's probability of collapse. Nonlinear-static pushover analysis on archetype buildings is used to develop the structural score, considering irregularities like open ground storey and short columns.
ENGINEERING STRUCTURES
(2021)
Article
Electrochemistry
Ariel Friedman, Rifael Z. Snitkoff-Sol, Hilah C. Honig, Lior Elbaz
Summary: The development of platinum group metal-free catalysts is crucial for reducing the cost of low-temperature fuel cells. Recent research has demonstrated that Fourier-transformed alternating current voltammetry can accurately measure the electrochemically active site density of catalysts in fuel cells, resolving the previous lack of activity descriptors. A simplified analysis of this method showed that under specific operating conditions, a single equation with the peak current of the 5th harmonic as the variable can be used to quantify electrochemically active site density with high accuracy.
ELECTROCHIMICA ACTA
(2023)
Article
Environmental Sciences
Miguel Inacio, M. Conceicao Freitas, Ana Graca Cunha, Carlos Antunes, Manel Leira, Vera Lopes, Cesar Andrade, Tiago Adriao Silva
Summary: This study presents a simplified model (SMRM) that combines field and remote sensing data to quantify the evolution of salt marshes under sea-level rise scenarios. The results show that sea-level rise is the most important parameter, followed by accretion rates. The model performs well under conservative sea-level rise scenarios but indicates that salt marshes may not be resilient to more severe projections.
Article
Critical Care Medicine
Jai N. Darvall, Rinaldo Bellomo, Michael Bailey, James Anstey, David Pilcher
Summary: A study in 23 ICUs in Victoria, Australia found that low-priority patients admitted to the ICU had higher long-term survival rates and lower in-hospital mortality compared to high-priority patients according to current pandemic triage criteria. These findings suggest the need for evidence-based ICU triage protocols.
Article
Biochemistry & Molecular Biology
Mirko Parasiliti-Caprino, Fabio Bioletto, Chiara Lopez, Martina Bollati, Francesca Maletta, Marina Caputo, Valentina Gasco, Antonio La Grotta, Paolo Limone, Giorgio Borretta, Marco Volante, Mauro Papotti, Anna Pia, Massimo Terzolo, Mario Morino, Barbara Pasini, Franco Veglio, Ezio Ghigo, Emanuela Arvat, Mauro Maccario
Summary: This study aimed to develop a simplified scoring system to help assess the recurrence risk of pheochromocytoma patients after surgery. Analysis of previous data revealed tumor size, genetic testing result, age, and PASS value as independent variables associated with recurrence.
Article
Medicine, Legal
Carole Charmeau-Genevois, Satinder Sarang, Melissa Perea, Nathalie Mayer, Charles Eadsforth, Tom Austin, Paul Thomas
Summary: This study developed a Simplified Irritation Index (SIIEYE) based only on corneal opacity and conjunctival redness to simplify the scoring calculation. A correlation was observed between MMAS and SIIEYE, allowing for harmonisation of classification for existing data. The SIIEYE index proved to be useful in the development of in silico models.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Hematology
Shlomo Elias, Samantha Brown, Sean M. Devlin, Juliet N. Barker, Christina Cho, David J. Chung, Parastoo B. Dahi, Sergio Giralt, Boglarka Gyurkocza, Ann A. Jakubowski, Oscar B. Lahoud, Heather Landau, Richard J. Lin, Esperanza B. Papadopoulos, Ioannis Politikos, Doris M. Ponce, Michael Scordo, Brian C. Shaffer, Gunjan L. Shah, Roni Tamari, James W. Young, Miguel-Angel Perales, Roni Shouval
Summary: Comorbidity assessment is important before allogeneic haematopoietic cell transplantation (allo-HCT) to estimate non-relapse mortality (NRM) risk. The Simplified Comorbidity Index (SCI), which includes a small number of comorbidities and older age, has been shown to predict NRM. In this study, we validated the SCI in patients receiving reduced-intensity conditioning followed by allo-HCT from HLA-matched donors. Higher SCI scores were associated with increased NRM risk and reduced overall survival. These findings suggest that the SCI is a reliable tool for risk stratification in allo-HCT candidates.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, Legal
Carole Charmeau-Genevois, Satinder Sarang, Charles Eadsforth, Tom Austin, Paul Thomas
Summary: The aim of the study was to determine if substance classification can be driven by just one observed effect, erythema, to create a Simplified Irritation Index (SIISKIN) that showed significant correlation with harmonized classification and a proportionate relationship with the corresponding Primary Irritation Index (PII), proving useful in developing an in silico model.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Critical Care Medicine
Ernest Shen, Janet S. Lee, Richard A. Mularski, Phillip Crawford, Alan S. Go, Sue H. Sung, Grace H. Tabada, Michael K. Gould, Huong Q. Nguyen
Summary: Distinct comorbidity profiles can be identified in COPD patients and are associated with subsequent acute and post-acute care utilization.
Review
Endocrinology & Metabolism
Tanuj Puri, Michelle L. Frost, Amelia E. B. Moore, Ananya Choudhury, Sobhan Vinjamuri, Abhishek Mahajan, Claire Fynbo, Marie Vrist, Jorn Theil, Kalevi Kairemo, James Wong, Habib Zaidi, Mona-Elisabeth Revheim, Thomas J. Werner, Abass Alavi, Gary J. R. Cook, Glen M. Blake
Summary: This article reviews the rationale, methodology, and clinical utility of quantitative [F-18] sodium fluoride positron emission tomography-computed tomography (PET-CT) imaging in measuring bone metabolic flux. It explains the bone remodeling cycle and the aspects of bone remodeling addressed by [F-18]NaF PET-CT. The article discusses the technique, measurements involved, and the usefulness of [F-18]NaF PET-CT in studying bone remodeling. It also explores simplified measurement methods and highlights key clinical applications and potential future developments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Respiratory System
Catherine Riou, Georgia Schafer, Elsa du Bruyn, Rene T. Goliath, Cari Stek, Huihui Mou, Deli Hung, Katalin A. Wilkinson, Robert J. Wilkinson
Summary: This study presents a scalable alternative method for quantifying and phenotyping SARS-CoV-2-specific T-cell responses using a minimal amount of blood. The results show detectable T-cell responses in asymptomatic individuals, which may be valuable for monitoring adaptive immunity due to natural infection or vaccine trials.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Jonas F. Ludvigsson, Peter Appelros, Johan Askling, Liisa Byberg, Juan-Jesus Carrero, Anna Mia Ekstrom, Magnus Ekstrom, Karin Ekstrom Smedby, Hannes Hagstrom, Stefan James, Bengt Jarvholm, Karl Michaelsson, Nancy L. Pedersen, Helene Sundelin, Kristina Sundquist, Johan Sundstrom
Summary: This study adapted the Charlson comorbidity index for use in Swedish medical register-based research, creating a cohesive coding system to enhance efficiency in distinguishing different disease severities. This work may provide an integrated and efficient coding algorithm for reliable data collection in Sweden.
CLINICAL EPIDEMIOLOGY
(2021)
Article
Nutrition & Dietetics
Federica Sabia, Alessandra Borgo, Alessandra Lugo, Paola Suatoni, Daniele Morelli, Silvano Gallus, Anna Villarini, Ugo Pastorino
Summary: The aim of this study was to assess the relationship between adherence to a healthy diet, such as the Mediterranean diet, and C-reactive protein (CRP) levels in heavy smokers. The study found that simplified questionnaire scores were inversely associated with CRP levels, suggesting that targeted nutritional intervention could reduce CRP levels.
Review
Oncology
Felix Schmidt, Dario Kohlbrenner, Stefan Malesevic, Alice Huang, Sabine D. Klein, Milo A. Puhan, Malcolm Kohler
Summary: Lung cancer is the leading cause of global cancer death, mainly due to late-stage detection. Low-dose CT screening provides an initial clinical solution, but further innovations are needed to overcome limitations. Breath analysis (BA) has great potential as a non-invasive and fast technology to supplement low-dose CT, but its adoption in clinical practice is limited. This scoping review provides a comprehensive summary of BA methods and biomarkers in lung cancer, and offers a framework for future research and translation into clinical workflows.
Article
Biochemistry & Molecular Biology
Anja Domenghino, Carmen Walbert, Dominique Lisa Birrer, Milo Puhan, Pierre-Alain Clavien
Summary: Postoperative complications are a significant global public health burden. The lack of standardized and universally applied endpoints for evaluating surgical interventions leads to inconsistent and biased interpretations, hindering patient-centered healthcare delivery. A jury-based consensus conference was conducted to develop recommendations for postoperative outcome assessment, incorporating the perspectives of different stakeholders. The Outcome4Medicine consensus group provides a framework for surgical outcome assessment and quality improvement, integrating the perspectives of the main stakeholders, with the goal of enhancing care quality and patient health.
Article
Multidisciplinary Sciences
Tala Ballouz, Dominik Menges, Marco Kaufmann, Rebecca Amati, Anja S. Frei, Viktor von Wyl, Jan A. Fehr, Emiliano Albanese, Milo Puhan, Dong Keon Yon
Summary: This study aimed to evaluate the prevalence and severity of post COVID-19 condition (PCC) with novel SARS-CoV-2 variants and after prior vaccination. The findings revealed that vaccinated individuals infected with the Omicron variant had lower odds of developing PCC compared to non-vaccinated individuals. Furthermore, the severity of PCC-related symptoms was lower among vaccinated individuals infected with Omicron.
Article
Medicine, General & Internal
Tala Ballouz, Dominik Menges, Alexia Anagnostopoulos, Anja Domenghino, Helene E. Aschmann, Anja Frei, Jan S. Fehr, Milo A. Puhan
Summary: This study evaluated longer term symptoms and health outcomes associated with a SARS-CoV-2 infection. The results showed that 22.9% of individuals infected with SARS-CoV-2 did not fully recover by six months, but the proportion decreased to 17.2% at 24 months. Most participants had continued recovery or overall improvement over time, while a small percentage had worsening or alternating periods. The prevalence and severity of COVID-19 related symptoms also decreased over time, with 18.1% reporting symptoms at 24 months. Infected individuals had higher symptom risk compared with controls at six months.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Clinical Neurology
Mina Stanikic, Eric Twomey, Milo A. Puhan, Christian P. Kamm, Anke Salmen, Vladeta Ajdacic-Gross, Chiara Zecca, Claudio Gobbi, Viktor von Wyl
Summary: The Swiss MS Registry conducted a survey on Covid-19 vaccine hesitancy, self-reported side effects, and changes in MS symptoms among people with MS. The results showed that vaccine hesitancy was low, and younger individuals, those with a history of Covid-19 infection, and those without regular contact with healthcare professionals were more likely to be hesitant.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Sabatini Serena, Pacifico Deborah, Frei Anja, Graf Gwendolyn, Milo A. Puhan, Emiliano Albanese
Summary: This study aimed to investigate the impact of COVID-19 infection on cognitive functioning. It found that serologically confirmed COVID-19 infection was associated with cognitive decline. Participants who received COVID-19 vaccination had better cognitive functioning, while those with a history of infection had poorer cognitive functioning. This study strengthens the evidence of COVID-19-related cognitive decline and highlights the importance of addressing it in clinical and public health areas.
FRONTIERS IN NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Deborah Pacifico, Serena Sabatini, Maddalena Fiordelli, Anna Maria Annoni, Anja Frei, Milo Puhan, Gwendolyn Graf, Emiliano Albanese
Summary: The study found that speaking multiple languages and having higher language proficiency were positively associated with better cognitive functioning in community-dwelling older adults, but not in institutionalized older adults. Multilingualism may contribute to cognitive reserve and delay cognitive decline in late life.
Review
Endocrinology & Metabolism
Nikolaos Perakakis, Hani Harb, Benjamin G. Hale, Zsuzsanna Varga, Charlotte Steenblock, Waldemar Kanczkowski, Vasileia Ismini Alexaki, Barbara Ludwig, Peter Mirtschink, Michele Solimena, Nicole Toepfner, Sebastian Zeissig, Manuel Gado, Irene Alma Abela, Felix Beuschlein, Giatgen A. Spinas, Claudia Cavelti-Weder, Philipp A. Gerber, Michael Huber, Alexandra Trkola, Milo A. Puhan, Wendy Wei-Lynn Wong, Andreas Linkermann, Viswanathan Mohan, Hendrik Lehnert, Peter Nawroth, Triantafyllos Chavakis, Geltrude Mingrone, Christian Wolfrum, Annelies S. Zinkernagel, Stefan Bornstein
Summary: This review explores the strong bidirectional feedback loop between viral infections and metabolic diseases, discussing the impact on human health and the challenges faced by the scientific and health communities.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Urology & Nephrology
Dominik Menges, Michela C. Piatti, Aurelius Omlin, Richard Cathomas, Daniel Benamran, Stefanie Fischer, Christophe Iselin, Marc Kung, Anja Lorch, Lukas Prause, Christian Rothermundt, Alix O'Meara Stern, Deborah Zihler, Max Lippuner, Julia Braun, Thomas Cerny, Milo A. Puhan
Summary: This study evaluated patient preferences for systemic treatments in metastatic hormone-sensitive prostate cancer and identified preference heterogeneity between individuals and subgroups. The results showed that patients with prostate cancer had a stronger preference for survival benefits compared to the general population, and there was significant variation in preferences among individuals.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)
Review
Public, Environmental & Occupational Health
Javier Munoz Laguna, Milo A. Puhan, Fernando Rodriguez Artalejo, Robby De Pauw, Grant M. A. Wyper, Brecht Devleesschauwer, Joao V. Santos, Cesar A. Hincapie
Summary: This study describes and assesses the risk of bias of the primary input studies for low back pain, neck pain, and knee osteoarthritis in the Global Burden of Disease Study 2019. It also evaluates the certainty of the modelled prevalence evidence in the GBD study.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Article
Respiratory System
Claudia Steurer-Stey, Kaba Dalla Lana, Alexandra Strassmann, Stefanie Gonin-Spahni, Michelle Borgmann, Ursina Brun del Re, Sebastian Haas, Eliane Sarasin, Andrea Burri, Anja Frei, Milo A. Puhan
Summary: This study aims to develop a tool that facilitates communication and counseling on sexuality in persons with chronic obstructive pulmonary disease (COPD). The survey showed that both patients and healthcare professionals (HCPs) wanted to talk about sexuality, but there were communication barriers in doing so. The developed instrument, COmmunication about SexualitY in COPD (COSY), consists of four tools to help address these barriers and promote a more holistic consideration of quality of life.
CHRONIC OBSTRUCTIVE PULMONARY DISEASES-JOURNAL OF THE COPD FOUNDATION
(2023)
Article
Public, Environmental & Occupational Health
Anja Domenghino, Roxane Diane Staiger, Fariba Abbassi, Miquel Serra-Burriel, Kim Leutwyler, Guillaume Aeby, Matthias Turina, Christian Alexander Gutschow, Pierre-Alain Clavien, Milo Alan Puhan
Summary: This study compared patient selection and postoperative outcomes for gastrointestinal surgeries before and during the SARS-CoV-2 pandemic. The results showed a reduction in caseload during certain periods, but no significant decrease in overall procedures. The population characteristics differed, with lower Body Mass Indices and more patients smoking and having diabetes in 2020. Delivering surgical care to COVID-19 patients in the same hospital was found to be safe, and healthcare officials should consider continuing surgical care during future health crises.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Frances M. Wang, Henock G. Yebyo, Shoshana H. Ballew, Miguel Cainzos-Achirica, Cynthia Boyd, Milo A. Puhan, Kunihiro Matsushita, Michael J. Blaha, Nancy L. Schoenborn
Summary: Personalizing preventive therapies for atherosclerotic cardiovascular disease (ASCVD) is crucial for older adults who have multiple chronic conditions and may have different preferences when considering health outcomes. However, little is known about outcome preferences related to ASCVD preventive therapies in older adults.
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Marta Fadda, Matilde Melotto, Maria Caiata-Zufferey, Milo Alan Puhan, Anja Frei, Emiliano Albanese, Anne-Linda Camerini
Summary: This scoping review maps the evidence of COVID-19 lockdown impact on parents of children and adolescents, identifying affected parenting domains, describing challenges and opportunities, and defining factors modulating the effect of lockdown measures.
PUBLIC HEALTH REVIEWS
(2023)
Article
Surgery
Guillaume Giudicelli, Daniel Gero, Lind Romulo, Vasu Chirumamilla, Pouya Iranmanesh, Christopher K. Owen, Wayne Bauerle, Amador Garcia, Lisa Lucas, Anne-Sophie Mehdorn, Dhananjay Pandey, Abdullah Almuttawa, Francisco Cabral, Abhishek Tiwari, Virginia Lambert, Beniamino Pascotto, Celine De Meyere, Marouan Yahyaoui, Thomas Haist, Oliver Scheffel, Maud Robert, Frederiek Nuytens, Santiago Azagra, Lilian Kow, Arun Prasad, Carlos Vaz, Michel Vix, Vivek Bindal, Jan H. Beckmann, David Soussi, Ramon Vilallonga, Maher El Chaar, Erik B. Wilson, Arif Ahmad, Andre Teixeira, Monika E. Hagen, Christian Toso, Pierre-Alain Clavien, Milo Puhan, Marco Bueter, Minoa K. Jung
Summary: This retrospective study aimed to establish the "best possible" outcomes for robotic bariatric surgery and compare them with laparoscopic benchmarks. The results suggest that robotic bariatric surgery may enhance surgical safety, although the duration of the operation is longer.
BRITISH JOURNAL OF SURGERY
(2023)