Synergism between Basic Asp49 and Lys49 Phospholipase A2 Myotoxins of Viperid Snake Venom In Vitro and In Vivo

Role of enzymatic activity in muscle damage and cytotoxicity induced byBothrops asperAsp49 phospholipase A2myotoxins: are there additional effector mechanisms involved?

(2014) Diana Mora-Obando et al.   PeerJ

Muscle phospholipid hydrolysis byBothrops asperAsp49 and Lys49 phospholipase A2myotoxins - distinct mechanisms of action

(2013) Julián Fernández et al.   FEBS Journal

Snake venom Lys49 myotoxins: From phospholipases A2 to non-enzymatic membrane disruptors

(2012) Bruno Lomonte et al.   TOXICON

The venom optimization hypothesis revisited

(2012) David Morgenstern et al.   TOXICON

Phospholipases A2: Unveiling the secrets of a functionally versatile group of snake venom toxins

(2012) José María Gutiérrez et al.   TOXICON

Synergism between baltergin metalloproteinase and Ba SPII RP4 PLA2 from Bothrops alternatus venom on skeletal muscle (C2C12) cells

(2011) Soledad Bustillo et al.   TOXICON

Comparison between apo and complexed structures of bothropstoxin-I reveals the role of Lys122 and Ca2+-binding loop region for the catalytically inactive Lys49-PLA2s

(2010) Carlos A.H. Fernandes et al.   JOURNAL OF STRUCTURAL BIOLOGY

Snake bite

(2010) David A Warrell   LANCET

Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain

(2010) M. Cintra-Francischinelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural, functional, and bioinformatics studies reveal a new snake venom homologue phospholipase A2class

(2010) Juliana I. dos Santos et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Isolation of an acidic phospholipase A2 from the venom of the snake Bothrops asper of Costa Rica: Biochemical and toxicological characterization☆

(2009) Julián Fernández et al.   BIOCHIMIE

Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors

(2009) M. Cintra-Francischinelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Intriguing Phospholipases A2 Homologues: Relevant Structural Features on Myotoxicity and Catalytic Inactivity

(2009) Juliana dos Santos et al.   PROTEIN AND PEPTIDE LETTERS

The Phospholipase A2 Homologues of Snake Venoms: Biological Activities and Their Possible Adaptive Roles

(2009) Bruno Lomonte et al.   PROTEIN AND PEPTIDE LETTERS

The C-terminal region of a Lys49 myotoxin mediates Ca2+ influx in C2C12 myotubes

(2009) Mariana Cintra-Francischinelli et al.   TOXICON

Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action

(2008) C. Montecucco et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Biochemistry and toxicology of toxins purified from the venom of the snake Bothrops asper

(2008) Yamileth Angulo et al.   TOXICON