Article
Medicine, Research & Experimental
Kensuke Suzuki, Yasunori Masuike, Rei Mizuno, Uma M. Sachdeva, Priya Chatterji, Sarah F. Andres, Wenping Sun, Andres J. Klein-Szanto, Sepideh Besharati, Helen E. Remotti, Michael P. Verzi, Anil K. Rustgi
Summary: The study uncovered the critical role of the LIN28B/CDX2 signaling axis in mediating colorectal cancer differentiation, with potential implications. LIN28B overexpression enhanced CRC cell differentiation by binding to CDX2 mRNA, contributing to the formation and spread of metastatic tumors.
Article
Medicine, Research & Experimental
Kensuke Sugiura, Yasunori Masuike, Kensuke Suzuki, Alice E. Shin, Nozomu Sakai, Hisahiro Matsubara, Masayuki Otsuka, Peter A. Sims, Christopher J. Lengner, Anil K. Rustgi
Summary: The RNA-binding protein LIN28B is overexpressed in a significant portion of patients with colorectal cancer (CRC) and is associated with poor prognosis. This study uncovered a potentially novel mechanism by which LIN28B regulates colonic epithelial cell-cell junctions and CRC metastasis. LIN28B directly binds to and posttranscriptionally regulates CLDN7 mRNA, leading to enhanced invasion, cell migration, and metastatic liver tumor formation. NOTCH3 was identified as a downstream effector of the LIN28B/CLDN1 axis and necessary for invasion and metastatic liver tumor formation. This discovery provides a promising new therapeutic option for metastatic CRC to the liver.
Article
Genetics & Heredity
Jiani Xu, Yan Zhou, Jianshui Yang, Yayun Gu, Erbao Zhang, Wenwen Yuan, Cheng Wang, Guangfu Jin, Hongxia Ma, Zhibin Hu
Summary: This study identified the CT gene LIN28B as being activated through hypomethylation in gastric cancer, affecting patient prognosis. It was found that accurate mediation of p methylation could activate LIN28B expression. Knockout of LIN28B suppressed proliferation, metastasis, and invasion of gastric cancer cells, while over-expression promoted metastasis and invasion.
Article
Biochemistry & Molecular Biology
Jiwei Wang, Xi Ouyang, Zhiyong Zhou, Shengxun Mao, Xiaoqiang Niu, Huizi Li, Wei Xu, Yi Song, Jiaqing Cao, Bin Lai
Summary: This study demonstrated the oncogenic role of Ring finger protein 2 (RNF2) in colon cancer by promoting tumor growth, proliferation, migration, and invasion of cancer cells. RNF2 interacted with and degraded interferon regulatory factor 4 (IRF4), leading to increased tumorigenicity. RNF2 may serve as a potential therapeutic target for colon cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Oncology
Tong-peng Xu, Tao Yu, Meng-yan Xie, Yuan Fang, Ting-ting Xu, Yu-tian Pan, Pei Ma, Yong-qian Shu
Summary: This study reveals that LIN28B can stabilize c-MYC mRNA by recognizing its m6A modification, thereby promoting the Warburg effect in gastric cancer. The study also identifies an interaction between LOC101929709 and LIN28B/IGF2BP3, with LOC101929709 enriching in the cytoplasm to stabilize c-MYC mRNA and promote the proliferation, migration, and glycolysis of gastric cancer. Additionally, LOC101929709 is found to activate the PI3K/AKT pathway. This study provides a novel potential target for the treatment of gastric cancer.
Article
Biochemistry & Molecular Biology
Anpei Huang, Ruizhi Wang, Ji Cui, Ying Gao, Zheng Yin, Lianzhou Chen, Meifang He, Wen Li
Summary: This study found that GOLPH3 is overexpressed in colorectal cancer tissues and cells, and it promotes the metastasis and progression of colorectal cancer by facilitating STAT3 activation and regulating the expression of EMT transcription factor ZEB1 and integrin alpha 3.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Chunli OuYang, Guang Shu, Jiaxin Liu, Shumin Deng, Pengyan Lu, Yimin Li, Yaqi Gan, Bintao Xie, Junwen Liu, Gang Yin
Summary: HDAC5 overexpression is associated with tumor progression and cell migration in colon adenocarcinoma, which can be inhibited by miR-148a-3p.
Article
Biotechnology & Applied Microbiology
Yongjun Ren, Caixia Zhao, Yi He, Xuli Min, Hao Xu, Xiao Hu
Summary: The study revealed that RPARP-AS1 was up-regulated in CRC tissues and cell lines, correlating with poor prognosis. Knockdown of RPARP-AS1 inhibited CRC cell proliferation, migration, and invasion. RPARP-AS1 functions as a ceRNA to sponge miR-125a-5p, promoting CRC progression.
ONCOTARGETS AND THERAPY
(2021)
Article
Cell Biology
Salem Baldi, Qianshi Zhang, Zhenyu Zhang, Mohammed Safi, Hassan Khamgan, Han Wu, Mengyan Zhang, Yuanyuan Qian, Yina Gao, Abdullah Shopit, Abdullah Al-Danakh, Mohammed Alradhi, Murad Al-Nusaif, Yunfei Zuo
Summary: Based on our findings, decreased expression of ARID1A in colon cancer is associated with poor prognosis. In this study, we investigated the role of the ARID1A-VIM/CDH1 signaling axis in colon cancer proliferation and migration. We identified differentially expressed genes controlled by ARID1A using database screening and analyzed the expression levels of ARID1A and EMT markers in colon cancer. We found that ARID1A depletion promotes cell migration, invasion, and proliferation in vitro, and identified its molecular mechanism in regulating VIM and CDH1. Our findings suggest that ARID1A inactivation contributes to tumor progression and metastasis in colon cancer, and targeting downstream effects of ARID1A may improve cancer treatment outcomes.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Immunology
Tianli Chen, Yue Wang, Zhaodi Nan, Jie Wu, Ailu Li, Tingguo Zhang, Xun Qu, Chen Li
Summary: METs are a potential biomarker for CC patient prognosis and there is a positive feedback loop between CC cells and METs, which can be inhibited by PAD2-IN-1 inhibitors in vitro and in vivo.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Amin Esmaeilniakooshkghazi, Eric Pham, Sudeep P. George, Afzal Ahrorov, Fabian R. Villagomez, Michael Byington, Srijita Mukhopadhyay, Srinivas Patnaik, Jacinta C. Conrad, Monali Naik, Saathvika Ravi, Niall Tebbutt, Jennifer Mooi, Camilla M. Reehorst, John M. Mariadason, Seema Khurana
Summary: This study investigates the molecular mechanism of adherens junction (AJ) remodeling in colon cancer cells and the function of fascin1 in AJ remodeling. The researchers discovered that fascin1 renders AJs less stable but more dynamic by remodeling junctional actin and actomyosin contractility, which drives cell migration and mechanosensitive WNT/beta-catenin signaling activation. These findings highlight the role of AJ remodeling and mechanosensitive WNT/beta-catenin signaling in the growth and dissemination of colorectal carcinomas.
Article
Medicine, Research & Experimental
Chen Luo, Kang Lin, Cegui Hu, Xiaojian Zhu, Jinfeng Zhu, Zhengming Zhu
Summary: The study reveals that LINC01094 is significantly overexpressed in pancreatic cancer tissues and promotes cell proliferation and metastasis by acting as an endogenous miR-577 sponge to upregulate LIN28B expression through the PI3K/AKT pathway.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Shengbo Han, Decai Wang, Yan Huang, Zhu Zeng, Peng Xu, Hewei Xiong, Zunxiang Ke, Ya Zhang, Yuhang Hu, Fan Wang, Jie Wang, Yong Zhao, Wenfeng Zhuo, Gang Zhao
Summary: Research has shown that the emergence of Schwann cells around premalignant lesions of colon cancer may be an early indicator promoting tumorigenesis. This study explored the communication between colon cancer cells and Schwann cells, and identified NGF and exosomal miR-21-5p as potential therapeutic targets for colon cancer treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Xiao-Jun Li, Charles Morgan, Loyal A. Goff, Angelika Doetzlhofer
Summary: This study found that transient activation of the progenitor-specific RNA binding protein LIN28B and Activin antagonist follistatin (FST) enhances regenerative competence of maturing/mature cochlear supporting cells (SCs) by reprogramming them into progenitor-like cells in organoid culture. LIN28B drives SC reprogramming, while FST is required to counterbalance hyperactivation of transforming growth factor-beta-type signaling by LIN28B.
Article
Biotechnology & Applied Microbiology
Haitao Gu, Zhiquan Xu, Jianbo Zhang, Yanbing Wei, Ling Cheng, Jijian Wang
Summary: circ_0038718 is highly expressed in colon cancer and can sponge miR-195-5p in the cytoplasm, facilitating malignant progression of colon cancer cells through the miR-195-5p/Axin2 axis.
Article
Geosciences, Multidisciplinary
Yixuan Liu, Xiaolin Hou, Jixin Qiao, Weichao Zhang, Miao Fang, Mu Lin
Summary: Soil erosion poses a serious threat to the sustainability of natural ecosystems worldwide, particularly in the Loess Plateau in China. This study analyzed soil samples from different land use types in a typical watershed in the region and estimated widespread soil erosion rates over the past six decades. The study discussed the impacts of human activities, land utilization types, vegetation coverage, and terrain on soil erosion, as well as the accumulation of eroded soil.
Article
Engineering, Environmental
Wenya Tai, Junqiang Yang, Fei Wu, Keliang Shi, Yaowen Zhang, Shaodong Zhu, Xiaolin Hou
Summary: In this study, a novel ligand, BisDBDGA-DB18C6, was successfully synthesized and used for the extraction of TcO4- /ReO4- from molybdenum. The results showed that BisDBDGA-DB18C6 exhibited excellent selectivity for TcO4-, with a high separation factor against Mo. The extraction process was rapid and the capacity was high.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Environmental
Mu Lin, Jun She, Jens Murawski, Xiaolin Hou, Jixin Qiao
Summary: This study examines the long-term memory effect of the Baltic Sea on pollutants and nutrients using simulation and tracer analysis. The results highlight the continuous export of pollutants and nutrients from the Baltic Sea to downstream areas, emphasizing the importance of understanding and managing marine environment in the North-Baltic Sea region.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Analytical
Ning Chen, Weijian Zhou, Yukun Fan, Luyuan Zhang, Shan Xing, Qi Liu, Xiaolin Hou
Summary: A method of separating iodine in waters associated with coalbed methane (CBM) was developed using evaporation and solvent extraction for the determination of I-129 and exploration of CBM resources. The I-129/I-127 ratios in water samples from a CBM field were found to be (1.6-2.4) x 10(-11), which are lower than environmental samples in Xi'an but higher than the procedural blank, indicating no measurable contamination during sample analysis and some input of modern water in the CBM water.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yixuan Liu, Xiaolin Hou
Summary: Ten soil cores were collected from the Loess Plateau in China to investigate the source, level, and distribution of plutonium isotopes. The analysis revealed that global fallout is the main source of plutonium in the area and severe soil erosion has resulted in significant loss of plutonium. Land use types, vegetation coverage, and topography play important roles in the preservation and redistribution of plutonium, and alfalfa shows promise as a restoration plant for mitigating soil erosion in the northern Loess Plateau.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Chemistry, Analytical
Tong Zhang, Huan Jiang, Ning Chen, Yongchang Wang, Mengting Zhang, Xiaolin Hou
Summary: A sensitive method for the determination of low-level tritium in seawater samples was established by enriching tritium from a large volume of seawater using electrolysis and ultra-low level liquid scintillation counting measurement. Through controlling the electrolysis conditions and optimizing the measurement parameters, a constant and optimal overall measurement efficiency of tritium was obtained. The method achieved a detection limit of 0.45 TU for tritium using 700 mL seawater samples, allowing for the determination of tritium in most seawater samples except for deep seawater. The developed method has been applied to determine tritium in the East China Sea.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Geosciences, Multidisciplinary
Peng Chen, Markus Czymzik, Zhongbo Yu, Ala Aldahan, Jinguo Wang, Peng Yi, Xiaolin Hou, Shouyan Guo, Minjie Zheng
Summary: Soil erosion has caused landscape problems in many parts of the world, especially in cold regions where permafrost conditions have changed due to climate warming. The Tibetan Plateau, strongly affected by global warming and human activities, has been a case of such erosion. Monitoring technologies, such as remote sensing and field surveys, have limitations in exploring soil erosion rates in this region due to resolution and disturbance factors.
Article
Geochemistry & Geophysics
Luyuan Zhang, Xiaolin Hou, Justin P. Gwynn, Michael Karcher, Ning Chen, Yukun Fan, Qi Liu
Summary: The study investigated the spatial distributions of anthropogenic 129I and natural 127I species in the upper central Arctic Ocean. It was found that the ratios of reductive iodide (I-) to oxidative iodate (IO-3) varied in different regions, with higher concentrations and ratios observed over certain ridges. Along the main transport pathway of Atlantic water, the ratios gradually decreased, indicating the slow oxidation of I- back to IO-3. This research provides insights into the marine geochemical cycling of iodine and highlights the potential of iodine species, particularly 129I, as indicators of changes in surface water redox conditions in the Arctic Ocean due to climate change.
EARTH AND PLANETARY SCIENCE LETTERS
(2023)
Article
Environmental Sciences
Mingli Zhang, Zihan Zhao, Yanhua Wang, Yan Chen, Xiaolin Hou
Summary: This study investigated the vertical distribution of plutonium isotopes and 240Pu/239Pu atom ratios in sediment cores from both floodplain and lacustrine areas of Poyang Lake. The results showed different activity concentrations and atom ratios in the two types of sediments, with a higher activity observed in the lacustrine sediments. The 240Pu/239Pu atom ratios indicated that the global fallout is the major source of plutonium in the studied region.
JOURNAL OF ENVIRONMENTAL RADIOACTIVITY
(2023)
Editorial Material
Chemistry, Analytical
Xiaolin Hou, Wangsuo Wu
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Geography, Physical
Xue Zhao, Xiaolin Hou, Zhao Huang, Chengjun Zhang, Peng Cheng
Summary: Understanding hydrological changes in the past 2 kyr is crucial for determining the impact and causes of climate change, especially in arid areas. Sediment analysis provides valuable information for reconstructing past hydrology, but there are challenges in selecting appropriate proxies and interpreting their implications in specific lake environments. This study analyzes iodine and uranium concentrations in a sediment core from Keluke Lake, China, and finds a significant correlation between the two elements, suggesting their potential as hydrological proxies for studying dry-wet changes over the past 2200 years.
PALAEOGEOGRAPHY PALAEOCLIMATOLOGY PALAEOECOLOGY
(2023)
Article
Environmental Sciences
Yukun Fan, Huan Jiang, Junli Ren, Xingxing Liu, Jianghu Lan, Peng Cheng, Qi Liu, Liangcheng Tan, Cheng Xue, Youbin Sun, Xiaolin Hou
Summary: Radionuclides are widely used for dating recent sediments, but their applicability can be limited by differences in sources, half-lives, environmental behavior, and measurement techniques. However, 239,240Pu shows significant advantages in sediment dating. Our study suggests that 239,240Pu can be a reliable tracer for rapidly accumulated sediment, and the input from surrounding soil erosion is an important source of sediment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Yongming Han, Zhisheng An, Dewen Lei, Weijian Zhou, Luyuan Zhang, Xue Zhao, Dongna Yan, Richard Arimoto, Neil L. Rose, Sarah L. Roberts, Li Li, Yalan Tang, Xingqi Liu, Xuewu Fu, Tobias Schneider, Xiaolin Hou, Jianghu Lan, Liangcheng Tan, Xingxing Liu, Jing Hu, Yunning Cao, Weiguo Liu, Feng Wu, Tianli Wang, Xiaoke Qiang, Ning Chen, Peng Cheng, Yifei Hao, Qiyuan Wang, Guoqiang Chu, Meiling Guo, Mei Han, Zhihai Tan, Chong Wei, Ulrike Dusek
Summary: Sihailongwan Maar Lake in Northeast China is a potential candidate for the Global boundary Stratotype Section and Point (GSSP) of the Anthropocene. Its sediments provide a detailed chronology of environmental and human impacts, with a tipping point observed in the mid-20th century (1954 CE).
ANTHROPOCENE REVIEW
(2023)
Article
Chemistry, Analytical
Zhao Huang, Xiaolin Hou, Jixin Qiao, Xue Zhao
Summary: An analytical method based on ICP-MS/MS was developed to determine femtogram levels of 237Np, 239Pu, and 240Pu in environmental samples. By controlling the valence states of Np and Pu, consistent behavior was achieved and 242Pu was used as the chemical yield tracer. The method achieved a high decontamination factor and effectively eliminated interferences and peak tailing. It enables accurate determination of femtogram levels of 237Np, 239Pu, and 240Pu in samples with high U/Np and U/Pu atom ratios.
Article
Chemistry, Analytical
Shan Xing, Chenyang Peng, Marcus Christl, Keliang Shi, Hans-Arno Synal, Xiaolin Hou
Summary: Accelerator mass spectrometry (AMS) is a highly sensitive technique for measuring long-lived actinides. A new method was developed for simultaneous determination of transuranium nuclides (Np, Pu, Am, and Cm isotopes) using 300 kV AMS. The method uses sequential chemical separation and tracers for monitoring yield. The established method has high detection efficiency and has been successfully applied in nuclear forensic investigation.
ANALYTICAL CHEMISTRY
(2023)
