Article
Multidisciplinary Sciences
Josephine M. Forbes, Selena Le Bagge, Samuel Righi, Amelia K. Fotheringham, Linda A. Gallo, Domenica A. McCarthy, Sherman Leung, Tracey Baskerville, Janelle Nisbett, Adam Morton, Stephanie Teasdale, Neisha D'Silva, Helen Barrett, Timothy Jones, Jennifer Couper, Kim Donaghue, Nicole Isbel, David W. Johnson, Leigh Donnellan, Permal Deo, Lisa K. Akison, Karen M. Moritz, Trisha O'Moore-Sullivan
Summary: The study found that skin autofluorescence and risk for kidney disease were positively associated in young adults with type 1 diabetes, while eGFR and diabetes duration were closely related to DKD risk.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Tomi Suomi, Inna Starskaia, Ubaid Ullah Kalim, Omid Rasool, Maria K. Jaakkola, Toni Gronroos, Tommi Valikangas, Caroline Brorsson, Gianluca Mazzoni, Sylvaine Bruggraber, Lut Overbergh, David Dunger, Mark Peakman, Piotr Chmura, Seren Brunak, Anke M. Schulte, Chantal Mathieu, Mikael Knip, Riitta Lahesmaa, Laura L. Elo
Summary: This study aimed to identify transcriptional changes associated with disease progression in patients with recent-onset type 1 diabetes. They found that genes and pathways related to innate immunity were downregulated during the first year after diagnosis. Associations between gene expression changes and ZnT8A autoantibody positivity were also observed. Additionally, changes in the expression of 16 genes were found to predict the decline in C-peptide at 24 months, and increased B cell levels and decreased neutrophil levels were associated with rapid progression, consistent with previous reports.
Article
Endocrinology & Metabolism
Bruce A. Perkins, Ionut Bebu, Ian H. de Boer, Mark Molitch, Bernard Zinman, John Bantle, Gayle M. Lorenzi, David M. Nathan, John M. Lachin
Summary: This study aimed to determine a simple screening schedule based on risk factors that optimizes early detection and testing frequency. The results showed that personalized screening can significantly reduce the time with undetected kidney disease and the frequency of urine testing, improving treatment outcomes.
Article
Nursing
Jiaxin Luo, Hongjuan Wang, Xia Li, Zhiguang Zhou, Maritta Valimaki, Robin Whittemore, Margaret Grey, Jia Guo
Summary: This study investigated specific domains of diabetes distress and associated factors among adolescents with type 1 diabetes in China, finding that adolescents experienced the highest levels of distress in regimen-related and physician-related domains. Older age, female gender, more diabetes problem-solving, and higher perceived stress were associated with higher regimen-related distress.
JOURNAL OF CLINICAL NURSING
(2021)
Article
Plant Sciences
Maria Graca Miguel, Carina Isabel da Silva, Luana Farah, Fernao Castro Braga, Ana Cristina Figueiredo
Summary: This study evaluated the effect of 20 essential oils on the release of CCL2 and TNF-alpha by LPS-stimulated THP-1 cells. Some essential oils showed toxicity to cells, while T. capitata and L. luisieri essential oils exhibited good inhibitory effects on TNF-alpha release.
Article
Endocrinology & Metabolism
Katie M. Sullivan, James Scholey, Rahim Moineddin, Etienne Sochett, Brandy Wicklow, Yesmino Elia, Feng Xiao, Thalia Mederios, Pusha Sadi, Dylan Burger, Farid H. Mahmud, Alison B. Dart
Summary: The study found significant associations between podocyte MPE, blood glucose levels and eGFR in youth with type 1 diabetes, but not in those with type 2 diabetes, despite increased renal pathology in the type 2 diabetes cohort.
Article
Medicine, General & Internal
Shengxin Liu, Tyra Lagerberg, Jonas F. Ludvigsson, Mark J. Taylor, Zheng Chang, Brian M. D'Onofrio, Henrik Larsson, Paul Lichtenstein, Soffia Gudbjornsdottir, Ralf Kuja-Halkola, Agnieszka Butwicka
Summary: This cohort study examined the trends and patterns of psychotropic medication dispensation among children and adolescents with type 1 diabetes (T1D) in Sweden from 2006 to 2019. The study found an increasing trend in psychotropic medication dispensation, which was consistently higher than those without T1D. These findings highlight the importance of further investigations into the benefits and risks of psychotropic medications in this population, as well as the integration of pediatric diabetes care and mental health care.
Article
Endocrinology & Metabolism
Sherry A. Ferguson, John J. Panos, Daniel Sloper, Vijayalakshmi Varma, Sumit Sarkar
Summary: Recent research indicates that African Americans in the United States have a higher prevalence and severity of Alzheimer's disease compared to Caucasians, with significant differences in neurodegenerative proteins and cytokine levels between the two ethnic groups. Through analysis of postmortem cerebrospinal fluid and diabetes-related markers, it was found that ethnicity plays a critical role in the manifestation of AD.
METABOLIC BRAIN DISEASE
(2021)
Article
Psychology, Clinical
Caroline Cummings, Natalie E. Benjamin, Hema Y. Prabhu, Laura B. Cohen, Billie Jo Goddard, Astrida S. Kaugars, Tori Humiston, Amy Hughes Lansing
Summary: The development of habit and automaticity for goal-directed health behaviors can improve daily health behavior engagement. Higher perceived automaticity for diabetes self-management was associated with better self-management, fewer self-regulation failures in glucose checking, and lower average daily blood glucose levels in adolescents with Type 1 diabetes. Further research is needed to explore the benefits and mechanisms of automaticity for diabetes self-management.
Article
Pharmacology & Pharmacy
Rongrong Wang, Yanan Zhou, Yan Zhang, Shaoqing Li, Runzhou Pan, Yongcai Zhao
Summary: Integrated bioinformatic analysis of gene expression in type 1 diabetes and the effective logistic regression model built in our study may provide promising diagnostic methods for type 1 diabetes.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Article
Allergy
Anders O. Petersen, Martta Jokinen, Damian R. Plichta, Gerhard Liebisch, Wolfram Gronwald, Katja Dettmer, Peter J. Oefner, Hera Vlamakis, Daniel C. Chung, Annamari Ranki, Ramnik J. Xavier
Summary: The gut microbiome in APS-1 patients is correlated with APS-1 symptoms, and probiotic intervention can alleviate some gastrointestinal symptoms. Furthermore, autoantibodies against cytokines appear to shape the gut microbiome by positively correlating with a taxonomically consistent group of bacteria.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Daisuke Chujo, Akitsu Kawabe, Maya Matsushita, Chiharu Tsutsumi, Fumitaka Haseda, Akihisa Imagawa, Toshiaki Hanafusa, Kohjiro Ueki, Hiroshi Kajio, Kunimasa Yagi, Kazuyuki Tobe, Masayuki Shimoda
Summary: The study revealed significantly upregulated IGRP and ZnT8-specific CD8+ T cell responses in FT1D and AT1D patients, with higher frequencies of IGRP-specific Tc1 cells in the FT1D group. These findings suggest a significant role of IGRP-specific CD8+ T cells in the pathogenesis of FT1D.
CLINICAL IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Francisca Ugarte, Daniela Santapau, Vivian Gallardo, Carolina Garfias, Anahi Yizmeyian, Soledad Villanueva, Carolina Sepulveda, Jocelyn Rocco, Consuelo Pasten, Cinthya Urquidi, Gabriel Cavada, Pamela San Martin, Francisco Cano, Carlos E. Irarrazabal
Summary: This study evaluated early tubulointerstitial damage biomarkers in pediatric patients with T1DM and their correlation with classical DKD parameters. The findings suggest that urinary exosome-like extracellular vesicles can serve as a new source for early detection of tubular injury biomarkers of DKD in T1DM patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Shengxin Liu, Jonas F. Ludvigsson, Paul Lichtenstein, Soffia Gudbjornsdottir, Mark J. Taylor, Henrik Larsson, Ralf Kuja-Halkola, Agnieszka Butwicka
Summary: This study aims to investigate educational outcomes in children and adolescents with type 1 diabetes (T1D) with and without psychiatric disorders. The findings suggest that while children with T1D alone have minor difficulties with their educational outcomes, those with both T1D and psychiatric disorders experience universal long-term educational underachievement.
Article
Pediatrics
Lynn Thomson, Daniela Elleri, Simon Bond, James Howlett, David B. Dunger, Kathryn Beardsall
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2019)
Article
Obstetrics & Gynecology
Shelley Macaulay, Eckhart J. Buchmann, David B. Dunger, Shane A. Norris
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2019)
Article
Endocrinology & Metabolism
William L. Lowe, Denise M. Scholtens, Alan Kuang, Barbara Linder, Jean M. Lawrence, Yael Lebenthal, David McCance, Jill Hamilton, Michael Nodzenski, Octavious Talbot, Wendy J. Brickman, Peter Clayton, Ronald C. Ma, Wing Hung Tam, Alan R. Dyer, Patrick M. Catalano, Lynn P. Lowe, Boyd E. Metzger, Chaicharn Deerochanawong, Thadchanan Tanaphonpoonsuk, Sukeeta Binratkaew, Uraiwan Chotigeat, Wanee Manyam, Martinette Forde, Andre Greenidge, Kathleen Neblett, Paula Michele Lashley, Desiree Walcott, Katie Corry, Loraine Francis, Jo-anne Irwin, Anne Langan, David R. McCance, Maureen Mousavi, Ian Young, Jennifer Gutierrez, Jennifer Jimenez, Jean M. Lawrence, David A. Sacks, Harpreet S. Takhar, Elizabeth Tanton, Wendy J. Brickman, Jennifer Howard, Jami L. Josefson, Lauren Miller, Jacqui Bjaloncik, Patrick M. Catalano, Ajuah Davis, Michaela Koontz, Larraine Presley, Shoi Smith, Amanda Tyhulski, Albert Martin Li, Ronald C. Ma, Risa Ozaki, Wing Hung Tam, Michelle Wong, Cindy Siu Man Yuen, Peter E. Clayton, Aysha Khan, Avni Vyas, Michael Maresh, Hadasse Benzaquen, Naama Glickman, Alona Hamou, Orna Hermon, Orit Horesh, Yael Keren, Yael Lebenthal, Shlomit Shalitin, Kristina Cordeiro, Jill Hamilton, Hahn Y. Nguyen, Shawna Steele, Fei Chen, Alan R. Dyer, Wenyu Huang, Alan Kuang, Maria Jimenez, Lynn P. Lowe, William L. Lowe, Boyd E. Metzger, Michael Nodzenski, Anna Reisetter, Denise Scholtens, Octavious Talbot, Paul Yim, David Dunger, Alicia Thomas, Mary Horlick, Barbara Linder, Aynur Unalp-Arida, Gilman Grave
Article
Endocrinology & Metabolism
Denise M. Scholtens, Alan Kuang, Lynn P. Lowe, Jill Hamilton, Jean M. Lawrence, Yael Lebenthal, Wendy J. Brickman, Peter Clayton, Ronald C. Ma, David McCance, Wing Hung Tam, Patrick M. Catalano, Barbara Linder, Alan R. Dyer, William L. Lowe, Boyd E. Metzger, Chaicharn Deerochanawong, Thadchanan Tanaphonpoonsuk, Sukeeta Binratkaew, Uraiwan Chotigeat, Wanee Manyam, Martinette Forde, Andre Greenidge, Kathleen Neblett, Paula Michele Lashley, Desiree Walcott, Katie Corry, Loraine Francis, Jo-anne Irwin, Anne Langan, David R. McCance, Maureen Mousavi, Ian Young, Jennifer Gutierrez, Jennifer Jimenez, Jean M. Lawrence, David A. Sacks, Harpreet S. Takhar, Elizabeth Tanton, Wendy J. Brickman, Jennifer Howard, Jami L. Josefson, Lauren Miller, Jacqui Bjaloncik, Patrick M. Catalano, Ajuah Davis, Michaela Koontz, Larraine Presley, Shoi Smith, Amanda Tyhulski, Albert Martin Li, Ronald C. Ma, Risa Ozaki, Wing Hung Tam, Michelle Wong, Cindy Siu Man Yuen, Peter E. Clayton, Aysha Khan, Avni Vyas, Michael Maresh, Hadasse Benzaquen, Naama Glickman, Alona Hamou, Orna Hermon, Orit Horesh, Yael Keren, Yael Lebenthal, Shlomit Shalitin, Kristina Cordeiro, Jill Hamilton, Hahn Y. Nguyen, Shawna Steele, Fei Chen, Alan R. Dyer, Wenyu Huang, Alan Kuang, Maria Jimenez, Lynn P. Lowe, William L. Lowe
Article
Endocrinology & Metabolism
Marco Colombo, Helen C. Looker, Bassam Farran, Sibylle Hess, Leif Groop, Colin N. A. Palmer, Mary Julia Brosnan, R. Neil Dalton, Max Wong, Charles Turner, Emma Ahlqvist, David Dunger, Felix Agakov, Paul Durrington, Shona Livingstone, John Betteridge, Paul M. McKeigue, Helen M. Colhoun
Article
Endocrinology & Metabolism
Anna Prats-Puig, Silvia Xargay-Torrent, Gemma Carreras-Badosa, Berta Mas-Pares, Judit Bassols, Clive J. Petry, Michael Girardot, Francis D. E. Zegher, Lourdes Ibanez, David B. Dunger, Robert Feil, Abel Lopez-Bermejo
INTERNATIONAL JOURNAL OF OBESITY
(2020)
Review
Endocrinology & Metabolism
David Dunger, Feyza Darendeliler, Nurgun Kandemir, Mark Harris, Ali Rabbani, Anne-Marie Kappelgaard
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2020)
Article
Endocrinology & Metabolism
Veena Mazarello Paes, Jessica K. Barrett, David B. Dunger, Evelien F. Gevers, David C. Taylor-Robinson, Russell M. Viner, Terence J. Stephenson
PEDIATRIC DIABETES
(2020)
Article
Medicine, General & Internal
Charlotte Boughton, Janet M. Allen, Martin Tauschmann, Sara Hartnell, Malgorzata E. Wilinska, Gianluca Musolino, Carlo L. Acerini, David Dunger, Fiona Campbell, Atrayee Ghatak, Tabitha Randell, Rachel Besser, Nicola Trevelyan, Daniela Elleri, Elizabeth Northam, Korey Hood, Eleanor Scott, Julia Lawton, Stephane Roze, Judy Sibayan, Craig Kollman, Nate Cohen, John Todd, Roman Hovorka
Article
Endocrinology & Metabolism
Antigoni Eleftheriou, Clive J. Petry, Ieuan A. Hughes, Ken K. Ong, David B. Dunger
Summary: The study found variable associations of DR3, DR4, and DQ8 alleles with growth measures and IGF-I levels in infants from the general population, which could explain the heterogeneous growth trajectories observed in genetically at-risk cohorts. These findings suggest distinct mechanisms involving endocrine pathways related to the HLA-conferred type 1 diabetes risk.
Article
Nutrition & Dietetics
Clive J. Petry, Ken K. Ong, Ieuan A. Hughes, David B. Dunger
Summary: Iron supplementation during pregnancy was found to be associated with an increased risk of developing GDM and impacting offspring birth weight and adiposity. These findings suggest that iron supplementation may mediate the effects of multiple micronutrient supplementation during pregnancy in a high-income country.
Article
Nutrition & Dietetics
Laurentya Olga, Clive J. Petry, Janna A. van Diepen, Philippa M. Prentice, Ieuan A. Hughes, Jacques Vervoort, Jos Boekhorst, Maciej Chichlowski, Gabriele Gross, David B. Dunger, Ken K. Ong
Summary: The study aims to investigate the impact of early growth and nutrition on future health and metabolic risks through long-term observation and data collection of 2229 mother-infant pairs. Strict inclusion criteria were applied, only retaining exclusively breastfed infants meeting the requirements for analysis.
Article
Endocrinology & Metabolism
Robert Moulder, Tommi Valikangas, M. Karoliina Hirvonen, Tomi A. Suomi, Caroline A. Brorsson, Niina Lietzen, Sylvaine F. A. Bruggraber, Lut Overbergh, David B. Dunger, Mark Peakman, Piotr J. Chmura, Soren Brunak, Anke M. Schulte, Chantal Mathieu, Mikael Knip, Laura L. Elo, Riitta Lahesmaa
Summary: There is a growing need for markers that could indicate the decline in beta cell function in type 1 diabetes. This study evaluated a panel of proteins in serum from newly diagnosed individuals and found associations between certain proteins and beta cell function. The findings suggest that these proteins may be useful in future studies of beta cell function in type 1 diabetes.
Article
Nutrition & Dietetics
Clive J. Petry, Ken K. Ong, Ieuan A. Hughes, David B. Dunger
Article
Biochemistry & Molecular Biology
Samuel Furse, Sara L. White, Claire L. Meek, Benjamin Jenkins, Clive J. Petry, Matias C. Vieira, Susan E. Ozanne, David B. Dunger, Lucilla Poston, Albert Koulman