Article
Plant Sciences
Yunfeng Zhou, Mingzhu Yan, Ruile Pan, Zhi Wang, Xue Tao, Chenchen Li, Tianji Xia, Xinmin Liu, Qi Chang
Summary: Radix Polygalae (RP) demonstrated remarkable antidepressant activity in behavioral despair mice and chronic restraint stress (CRS)-induced rats, possibly by promoting autophagy and inhibiting neuroinflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zubeyde Ercan, Ozgur Bulmus, Emine Kacar, Ihsan Serhatlioglu, Gokhan Zorlu, Haluk Kelestimur
Summary: This study found that chronic treadmill exercise can effectively reverse behavioral impairments caused by CRS and induce molecular changes in the brain. This suggests that exercise has positive effects on emotion and mood and can improve stress-induced anomalies.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Barbara A. Laraia, Cindy W. Leung, A. Janet Tomiyama, Lorrene D. Ritchie, Patricia B. Crawford, Elissa S. Epel
Summary: The study found that the drive for thinness in adolescence can persist into adulthood and predict reward-based compulsive eating behavior and higher weight status in adults. Adolescent drive for thinness has long-term effects on adult eating behaviors, while reward-based eating drive is not related to adult weight status.
Article
Biochemistry & Molecular Biology
Giulia Sbrini, Sabrina I. Hanswijk, Paola Brivio, Anthonieke Middelman, Michael Bader, Fabio Fumagalli, Natalia Alenina, Judith R. Homberg, Francesca Calabrese
Summary: Peripheral serotonin levels have an influence on brain functions under basal and dynamic situations. The lack of peripheral serotonin can reduce anxiety-like behavior, as well as neuronal activation and the expression of brain plasticity-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Giridhari Pal, Khalid Anwer, Abdullah Alshetaili, Jyotirmoyee Jena, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Aditi Sharma, Ashraf Al-Brakati, Simona Bungau, Tapan Behl
Summary: The study evaluated the effects of NO modulators and antioxidant treatments on endocrine, cellular, and oxidative stress markers in repetitively stressed rats. The results showed that these treatments have different impacts on cellular markers, and the complex interaction between NO and cellular markers plays a crucial modulatory role in this phenomenon.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Neurosciences
Kristen R. Montgomery, Morgan S. Bridi, Lillian M. Folts, Ruth Marx-Rattner, Hannah C. Zierden, Andreas B. Wulff, Emmanuela A. Kodjo, Scott M. Thompson, Tracy L. Bale
Summary: Trauma and chronic stress exposure are strong predictors of lifetime neuropsychiatric disease presentation, with significant sex biases. Understanding how stress exposure increases disease vulnerability is crucial for developing new interventions.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Multidisciplinary
Melanie Bamert, Jennifer Inauen
Summary: This study investigated the effectiveness of the vagal tank theory's predictions on heart rate variability (HRV) during naturalistic stressful events in daily life. The results showed that HRV before stressful events could predict adaptive HRV during the events, but not in the recovery phase.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Endocrinology & Metabolism
Elizabeth A. Thomas, Adnin Zaman, Kelsey J. Sloggett, Sheila Steinke, Laura Grau, Victoria A. Catenacci, Marc-Andre Cornier, Corey A. Rynders
Summary: The study found that early time-restricted eating plus daily caloric restriction did not result in significantly different weight loss and body composition changes compared to daily caloric restriction alone over 39 weeks. There were also no significant differences between the two groups in dietary adherence, energy intake, physical activity, and other measured outcomes at week 12.
Article
Neurosciences
Zihu Tan, Jing Qiu, Yuting Zhang, Qiong Yang, Xixi Yin, Jia Li, Guangya Liu, Hengfei Li, Guang Yang
Summary: A rat BPSD model was successfully established, and TMP was found to alleviate anxiety, enhance cognitive and social abilities, improve learning and memory, potentially through activating the TrkB/ERK/CREB signaling pathway for synaptic remodeling. This study expands the therapeutic potential of TMP in neurodegenerative disorders and offers promising candidates for treating BPSD, particularly in vascular dementia.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Zhong-hua Wu, Hua Fan, Shang-yan Gao, Yan-fei Jin, Bo Jiang, Jian Shen
Summary: Depression is a mood disorder with a significant economic burden. Oroxylin A, an active component from Scutellariae radix, has potential antidepressant effects by increasing hippocampal brain-derived neurotrophic factor (BDNF) levels and neurogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Xinyu Shui, Mi Zhang, Zhuoran Li, Xin Hu, Fei Wang, Dan Zhang
Summary: By utilizing smartphones-based ambulatory assessment and wrist-worn physiological recording devices, the DAPPER dataset provides momentary self-reports and physiological data of people's emotional experiences in their daily life to promote emotion researches in real-life, daily settings.
Article
Clinical Neurology
Bin Li, Lei-Lei Chang, Kang Xi
Summary: The central neurotensin system plays a vital role in regulating anxiety-related behaviors in rats, particularly in the prelimbic region of the medial prefrontal cortex. Activation or blockade of NTS1 in the PrL has different effects on anxiety, and downregulating NTS1 expression in the PrL also influences anxiety behaviors.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Josimar Macedo de Castro, Joice Soares de Freitas, Dirson Joao Stein, Isabel Cristina de Macedo, Wolnei Caumo, Iraci L. S. Torres
Summary: This study investigated the effects of tDCS on biometric, behavioral, and neurochemical parameters in chronically stressed rats fed a hyper-palatable cafeteria diet (CAFD). The results showed that CAFD increased body weight, caloric consumption, adiposity, and liver weight, and also altered central parameters. The chronic restraint stress model (CRS) resulted in increased adrenals in rats with standard diet (SD), and anxiety-like and anhedonic behaviors in rats with CAFD. tDCS provided neurochemical shifts in CAFD-fed stressed rats, while in stressed rats SD-fed induced a decrease in adrenals weight, relative visceral adiposity, and serum NPY levels. These findings highlight the potential of tDCS technique for stress-related eating disorders.
NEUROCHEMICAL RESEARCH
(2023)
Article
Immunology
Karina S. MacDowell, David Martin-Hernandez, Cristina Ulecia-Moron, Alvaro G. Bris, Jose L. M. Madrigal, Borja Garcia-Bueno, Javier R. Caso
Summary: This study investigated the potential involvement of inflammasomes in stress-induced neuroinflammation and the modulatory effects of paliperidone. The findings suggest that chronic stress induces inflammasome complexes in the frontal cortex of rats, and pre-treatment with paliperidone can normalize this response, highlighting its inhibitory action on stress-induced inflammasomes. Targeting inflammasome pathways could be a promising approach for future therapeutic interventions in neuropsychiatric diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Neurosciences
Felipe A. Olave, Felipe Aguayo, Luciano P. Roman-Albasini, Wladimir A. Corrales, Juan P. Silva, Pablo Gonzalez, Sara Lagos, Maria A. Garcia, Matias Alarcon-Mardones, Paulina S. Rojas, Xiaojiang Xu, John A. Cidlowski, Esteban Aliaga, Jenny Fiedler
Summary: Stress-related disorders display differences between males and females. This study found that chronic restraint stress produces different somatic responses in adult male and female rats. The molecular responses in the hippocampus also showed sex-specific differences, with the signaling pathways mainly influenced by sex rather than stress. The study suggests that female rats are resilient and males are susceptible to stress exposure, while the activity of canonical signaling pathways is primarily determined by sex in the hippocampus.
NEUROBIOLOGY OF STRESS
(2022)