Article
Medicine, Research & Experimental
Jing Song, Anja Schwenzer, Alicia Wong, Sara Turcinov, Cliff Rims, Lorena Rodriguez Martinez, David Arribas-Layton, Christina Gerstner, Virginia S. Muir, Kim S. Midwood, Vivianne Malmstrom, Eddie A. James, Jane H. Buckner
Summary: This study confirms cit-TNC as an autoantigen targeted by autoreactive CD4(+) T cells and autoantibodies in patients with RA, and suggests that coinciding epitopes recognized by both CD4(+) T cells and B cells may amplify autoimmunity and promote the development of RA.
Article
Immunology
Dylan T. Bergstedt, Wyatt J. Tarter, Ryan A. Peterson, Marie L. Feser, Mark C. Parish, Christopher C. Striebich, M. Kristen Demoruelle, LauraKay Moss, Elizabeth A. Bemis, Jill M. Norris, V. Michael Holers, Jess D. Edison, Geoffrey M. Thiele, Ted R. Mikuls, Kevin D. Deane
Summary: In rheumatoid arthritis (RA), ACPA and RF are predictive markers for future RA. This study found that changes in RF isotypes were associated with an increased risk for developing RA, and SE was associated with an increased risk of RA. These findings are important for counseling individuals at-risk for RA and designing clinical trials for RA prevention.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medical Laboratory Technology
Helena Enocsson, Tanja Lukic, Michael Ziegelasch, Alf Kastbom
Summary: The study investigated the potential of suPAR in predicting or reflecting disease outcome in early rheumatoid arthritis (RA). Results showed that suPAR levels were associated with disease activity in early untreated RA and reflected joint damage at later stages. However, suPAR levels or changes over time did not have predictive value for disease outcome.
TRANSLATIONAL RESEARCH
(2021)
Article
Rheumatology
Fenne Wouters, Marc P. Maurits, Laurette van Boheemen, Marloes Verstappen, Kulveer Mankia, Xanthe M. E. Matthijssen, Annemarie L. Dorjee, Paul Emery, Rachel Knevel, Dirkjan van Schaardenburg, Rene E. M. Toes, Annette H. M. van der Helm-van Mil
Summary: HLA-SE and smoking act at different stages in the development of rheumatoid arthritis: smoking increases the risk of autoantibody and symptom development, while HLA-SE mediates symptom and inflammatory arthritis development. These findings enhance our understanding of the timing of key risk factors in RA development.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Chao-Yi Wu, Huang-Yu Yang, Shue-Fen Luo, Jenn-Haung Lai
Summary: RA is a chronic inflammatory disease involving synovial inflammation and articular destruction. RFs, ACPAs, and anti-CarP Abs have been identified as important autoantibodies in predicting and diagnosing RA, with potential implications for treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Joe Zhuo, Qian Xia, Niyati Sharma, Sheng Gao, Sonie Lama, Jing Cui, Vivi Feathers, Nancy Shadick, Michael E. Weinblatt
Summary: Patients with rheumatoid arthritis (RA) who have the genetic risk factor shared epitope (SE) often have more severe and harder-to-treat disease, and this is associated with being positive for anti-citrullinated protein antibodies (ACPAs).
RHEUMATOLOGY AND THERAPY
(2022)
Article
Multidisciplinary Sciences
Yibo He, Changrong Ge, Alex Moreno-Giro, Bingze Xu, Christian M. Beusch, Katalin Sandor, Jie Su, Lei Cheng, Erik Lonnblom, Christina Lundqvist, Linda M. Slot, Dongmei Tong, Vilma Urbonaviciute, Bibo Liang, Taotao Li, Gonzalo Fernandez Lahore, Mike Aoun, Vivianne Malmstrom, Theo Rispens, Patrik Ernfors, Camilla I. Svensson, Hans Ulrich Scherer, Rene E. M. Toes, Inger Gjertsson, Olov Ekwall, Roman A. Zubarev, Rikard Holmdahl
Summary: Although anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA), their in vivo functions remain unclear. In this study, monoclonal ACPAs derived from RA patients were expressed in mice and their functions were analyzed. One of the antibodies, clone E4, showed a protective effect against antibody-induced arthritis in mice, suggesting therapeutic potential for ACPAs in RA.
NATURE COMMUNICATIONS
(2023)
Article
Rheumatology
Lieve Van Hoovels, Bert Vander Cruyssen, Daniela Sieghart, Carolien Bonroy, Eszter Nagy, Rille Pullerits, Sasa Cucnik, Charlotte Dahle, Ingmar Heijnen, Luca Bernasconi, Farid Benkhadra, Laura Bogaert, Stefanie Van den Bremt, Ann Van Liedekerke, Geert Vanheule, Johan Robbrecht, Lucy Studholme, Claudine Wirth, Ruediger Mueller, Diego Kyburz, Christopher Sjowall, Alf Kastbom, Rok Jese, Boja Jovancevic, Emese Kiss, Peggy Jacques, Daniel Aletaha, Guenter Steiner, Patrick Verschueren, Xavier Bossuyt
Summary: This study aimed to refine the interpretation of RF and ACPA across commercial assays. By determining thresholds for antibody levels and assigning test result interval-specific LRs, clinical interpretation can be aligned for all RF and ACPA assays.
Article
Rheumatology
Jennifer A. Seifert, Elizabeth A. Bemis, Kristina Ramsden, Cassidy Lowell, Kristen Polinski, Marie Feser, Chelsie Fleischer, M. Kristen Demoruelle, Jane Buckner, Peter K. Gregersen, Richard M. Keating, Ted R. Mikuls, James R. O'Dell, Michael H. Weisman, Kevin D. Deane, Jill M. Norris, Allen C. Steere, V. Michael Holers
Summary: This study evaluated anti-Pcopri antibody responses in individuals with rheumatoid arthritis (RA) and found that RA patients had higher levels of anti-Pcopri antibodies, especially in early-stage RA. Participants with RA who were positive for RA-related autoantibodies also showed higher levels of anti-Pcopri antibodies. These findings suggest a potential etiologic role for Pcopri in the development and pathogenesis of RA.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Immunology
Daniel Zecher, Florian Zeman, Thomas Drasch, Ineke Tieken, Sebastiaan Heidt, Geert W. Haasnoot, Serge Vogelaar, Axel Rahmel, Bernhard Banas
Summary: The assignment of unacceptable HLA mismatches (UAMs) in transplantation has been a subject of debate in the Eurotransplant Kidney Allocation System (ETKAS) and the Eurotransplant Senior Program in Germany. This study found that donor pool restriction due to UAMs significantly prolonged waiting time and reduced transplant probability in certain patients. The findings also highlighted the need for better compensation mechanisms for highly sensitized patients.
Article
Immunology
Andre Lopes Saraiva, Raphael Sanches Peres, Flavio Protasio Veras, Jhimmy Talbot, Kalil Alves de Lima, Joao Paulo Mesquita Luiz, Thiago Mattar Cunha, Paulo Louzada-Junior, Fernando Queiroz Cunha, Jose Carlos Alves-Filho
Summary: The experimental arthritis model established using citrullinated human plasma fibrinogen revealed the importance of IL-23/IL-17 immune axis-mediated inflammatory responses in the pathogenesis of rheumatoid arthritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Rheumatology
Alessandra Zaccardelli, Xinyi Liu, Julia A. Ford, Jing Cui, Bing Lu, Su H. Chu, Peter H. Schur, Cameron B. Speyer, Karen H. Costenbader, William H. Robinson, Jeremy Sokolove, Elizabeth W. Karlson, Carlos A. Camargo, Jeffrey A. Sparks
Summary: Elevated anti-citrullinated protein antibodies (ACPA) before diagnosis of rheumatoid arthritis (RA) in women were associated with increased risk of chronic obstructive pulmonary disease (COPD), while women who later developed RA were more likely to develop asthma compared to non-RA controls.
ARTHRITIS CARE & RESEARCH
(2021)
Review
Pathology
Nicole Hartwig Trier, Gunnar Houen
Summary: The serological biomarker anti-citrullinated protein antibodies (ACPAs) are important for the diagnosis of rheumatoid arthritis (RA) and can improve our understanding of the disease etiology. This review provides an overview of ACPAs and highlights their diagnostic and etiological significance in RA.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Review
Rheumatology
Anca Catrina, Akilan Krishnamurthy, Bence Rethi
Summary: ACPA may play a crucial role in the pathogenesis of RA, affecting the genetic and environmental risks in patients, leading to joint pain and bone loss. Research has shown that ACPAs can impact various cells, potentially triggering pathogenic pathways through multiple mechanisms.
Article
Immunology
Jia Jia Lim, Claerwen M. Jones, Tiing Jen Loh, Yi Tian Ting, Pirooz Zareie, Khai L. Loh, Nathan J. Felix, Anish Suri, Murray McKinnon, Frederik Stevenaert, Ravi K. Sharma, Lars Klareskog, Vivianne Malmstrom, Daniel G. Baker, Anthony W. Purcell, Hugh H. Reid, Nicole L. La Gruta, Jamie Rossjohn
Summary: This study demonstrates the role of HLA-DR4 SE in the development of rheumatoid arthritis, showing that it not only presents antigens but also directly interacts with TCRs. The interaction between HLA-DR4 and the T cell repertoire may play a role in the pathogenesis of RA.
SCIENCE IMMUNOLOGY
(2021)
Article
Rheumatology
Elias Jonsson, Lotta Ljung, Eva Norrman, Eva Freyhult, Lisbeth Arlestig, Johanna Dahlqvist, Solbritt Rantapaa Dahlqvist
Summary: This study assessed the association between pulmonary fibrosis (PF) and genetic variants and disease-related factors in rheumatoid arthritis (RA) patients. The results showed that PF in RA patients is associated with four genetic variants. Older age and RF positivity are associated with increased risk, while MTX treatment is associated with a lower risk of PF development.
Article
Rheumatology
Johanna Dahlqvist, Diana Ekman, Bengt Sennblad, Sergey Kozyrev, Jessika Nordin, Asa Karlsson, Jennifer R. S. Meadows, Erik Hellbacher, Solbritt Rantapaa-Dahlqvist, Ewa Berglin, Bernd Stegmayr, Bo Baslund, Oyvind Palm, Hilde Haukeland, Iva Gunnarsson, Annette Bruchfeld, Marten Segelmark, Sophie Ohlsson, Aladdin J. Mohammad, Anna Svard, Rille Pullerits, Hans Herlitz, Annika Soderbergh, Gerli Rosengren Pielberg, Lina Hultin Rosenberg, Matteo Bianchi, Eva Muren, Roald Omdal, Roland Jonsson, Maija-Leena Eloranta, Lars Ronnblom, Peter Soderkvist, Ann Knight, Per Eriksson, Kerstin Lindblad-Toh
Summary: Genetic association analyses identified multiple loci associated with PR3-ANCA(+) AAV and MPO-ANCA(+) AAV, including a novel susceptibility locus that may have mechanistic importance.
Article
Rheumatology
Theresa Kissel, Lise Hafkenscheid, Tineke J. Wesemael, Mami Tamai, Shin-ya Kawashiri, Atsushi Kawakami, Hani S. El-Gabalawy, Dirkjan Schaardenburg, Solbritt Rantapaa-Dahlqvist, Manfred Wuhrer, Annette H. M. van der Helm-van Mil, Cornelia F. Allaart, Diane Woude, Hans U. Scherer, Rene E. M. Toes, Tom W. J. Huizinga
Summary: The abundance of N-linked glycans in the variable domain of IgG ACPA increases towards the onset of rheumatoid arthritis (RA), and is associated with the maturation of the ACPA response and disease development.
ARTHRITIS & RHEUMATOLOGY
(2022)
Letter
Rheumatology
Sanne Reijm, Astrid S. Brehler, Solbritt Rantapaa-Dahlqvist, Atsushi Kawakami, Takahiro Maeda, Shin-Ya Kawashiri, Mami Tamai, Diane van der Woude, Rene E. M. Toes
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Mikael Brink, Lotta Ljung, Monika Hansson, Johan Ronnelid, Rickard Holmdahl, Karl Skriner, Guy Serre, Lars Klareskog, Solbritt Rantapaa-Dahlqvist
Summary: This study found that the presence of certain ACPA and the number of ACPA specificities were associated with the development of PF in early RA patients. These findings contribute to a better understanding of the mechanisms and risk factors for PF development in RA patients.
Article
Microbiology
Anders Esberg, Linda Johansson, Ewa Berglin, Aladdin J. Mohammad, Andreas P. Jonsson, Johanna Dahlqvist, Bernd Stegmayr, Ingegerd Johansson, Solbritt Rantapaa-Dahlqvist
Summary: Oral microbiota is associated with the pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). Pre-symptomatic individuals with AAV had higher levels of IgG antibodies against oral bacteria, and established AAV patients were more likely to have periodontitis. The saliva microbiota of acute AAV patients had lower levels of detectable amplicon-sequence variants and taxa in their core microbiota, but higher within-sample diversity.
Article
Rheumatology
Anna Sodergren, Solbritt Rantapaa-Dahlqvist, Lotta Ljung
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2023)
Article
Rheumatology
Despina Michailidou, Linda Johansson, Runa Kuley, Ting Wang, Payton Hermanson, Solbritt Rantapaa-Dahlqvist, Christian Lood
Summary: The study aimed to evaluate the increased levels of neutrophil activation markers in PMR patients. The results showed that calprotectin and neutrophil extracellular traps (NETs) were elevated in PMR patients, and neutrophil activation was associated with immune complexes and Fc gamma RIIA. The levels of immune complexes correlated with the expression of CD66b and CD11b, and decreased after glucocorticoid therapy. Calprotectin can be used as a biomarker for treatment response in PMR patients.
Article
Rheumatology
Mikael Brink, Ewa Berglin, Aladdin J. J. Mohammad, Anders Lundquist, Inger Gjertsson, Andrey Alexeyenko, Kristina Lejon, Solbritt Rantapaa-Dahlqvist
Summary: This study identified protein markers prior to symptom onset in ANCA-associated vasculitis (AAV) patients, providing important insights into the underlying mechanisms and subphenotypes of the disease.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Antonia Boman, Heidi Kokkonen, Ewa Berglin, Gerd-Marie Alenius, Solbritt Rantapaa-Dahlqvist
Summary: Hormonal and reproductive factors play a role in the risk of cardiovascular events (CVE) in the general population. However, little is known about the impact of hormonal factors on CVE in patients with rheumatoid arthritis (RA).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Heidi Kokkonen, Linda Johansson, Hans Stenlund, Solbritt Rantapaa-Dahlqvist
Summary: The increased comorbidity and mortality in rheumatoid arthritis (RA) patients are largely due to cardiovascular disease (CVD). Risk factors for CVD present in pre-RA individuals were associated with future cardiovascular events, and even after adjustments for these risk factors and treatments after RA onset, pre-RA individuals had a higher risk of cardiovascular events compared with controls.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Diana Ekman, Bengt Sennblad, Ann Knight, Asa Karlsson, Solbritt Rantapaa-Dahlqvist, Ewa Berglin, Bernd Stegmayr, Bo Baslund, Oyvind Palm, Hilde Haukeland, Iva Gunnarsson, Annette Bruchfeld, Marten Segelmark, Sophie Ohlsson, Aladdin J. Mohammad, Anna Svard, Rille Pullerits, Hans Herlitz, Annika Soderbergh, Roald Omdal, Roland Jonsson, Lars Ronnblom, Per Eriksson, Kerstin Lindblad-Toh, Johanna Dahlqvist
Summary: The study aims to identify and genetically characterize subgroups of patients with ANCA-associated vasculitides (AAV) based on sex and ANCA subtype. The research analyzed a SNP dataset derived from DNA sequencing and genotyping of AAV cases and controls. The results showed that there are differences in genetic predisposition and disease mechanisms between males and females with MPO-ANCA-positive AAV, and that double ANCA-positive AAV cases are genetically similar to PR3-ANCA-positive cases, providing implications for clinical follow-up and treatment.
Article
Rheumatology
Anton Oberg Sysojev, Saedis Saevarsdottir, Lina-Marcela Diaz-Gallo, Gilad N. Silberberg, Lars Alfredsson, Lars Klareskog, Eva Baecklund, Lena Bjorkman, Alf Kastbom, Solbritt Rantapaa-Dahlqvist, Carl Turesson, Ingileif Jonsdottir, Kari Stefansson, Thomas Frisell, Leonid Padyukov, Johan Askling, Helga Westerlind
Summary: This study investigates the influence of genetic factors on the persistence of MTX monotherapy in patients with early RA. The results indicate that while no individual SNP was significantly associated, genetic factors do have a modest heritability impact on MTX treatment persistence.
Article
Endocrinology & Metabolism
Christian Lundtoft, Daniel Eriksson, Matteo Bianchi, Maribel Aranda-Guillen, Nils Landegren, Solbritt Rantapaa-Dahlqvist, Peter Soderkvist, Jeniffer R. S. Meadows, DISSECT Consortium, Immunoarray Consortium, Swedish Addison Registry Study Grp, Gerli Rosengren Pielberg, Sophie Bensing, Gerli Rosengren Pielberg, Kerstin Lindblad-Toh, Lars Ronnblom, Olle Kampe
Summary: Autoantibodies against the adrenal enzyme 21-hydroxylase are a hallmark manifestation in autoimmune Addison's disease (AAD). This study identified strong associations between copy number variants in the CYP21 region and the risk of AAD, most likely due to linkage disequilibrium with disease-associated HLA class II alleles.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)