Article
Health Care Sciences & Services
Eun-Jung Park, WooSeong Jeong, Jinseok Kim
Summary: This study aimed to evaluate radiographic outcome and prognostic factors for radiographic progression in patients with seronegative rheumatoid arthritis. It found that radiographic damage and SvdH at diagnosis were predictive factors for progression of radiographic damage in these patients, highlighting the importance of early detection and management strategies.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Sung-Eun Choi, Haimuzi Xu, Ji-Hyoun Kang, Dong-Jin Park, Sun-Seog Kweon, Young-Hoon Lee, Hye-Yeon Kim, Jung-Kil Lee, Min-Ho Shin, Shin-Seok Lee
Summary: RHR is positively associated with the radiographic severity of knee joints but not hand joints in patients with musculoskeletal diseases like osteoarthritis. Adjusted for various factors, RHR shows positive correlations with total, osteophyte, JSN, and tibial attrition scores in knee joints and JSN and subchondral cyst scores in hand joints.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Iris Paola Guzman-Guzman, Claudia Isabel Ramirez-Velez, Ramces Falfan-Valencia, Jose Eduardo Navarro-Zarza, Ilse Adriana Gutierrez-Perez, Oscar Zaragoza-Garcia, Monica Ramirez, Natividad Castro-Alarcon, Isela Parra-Rojas
Summary: The SNP of the PADI2 gene plays a crucial role in the pathogenesis and severity of rheumatoid arthritis (RA), with specific genotypes in women from southern Mexico being associated with early disease onset, positive autoantibodies, and radiographic joint damage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Irina Gessl, Claudia A. Hana, Thomas Deimel, Martina Durechova, Miriam Hucke, Victoria Konzett, Mihaela Popescu, Paul Studenic, Gabriela Supp, Michael Zauner, Josef S. Smolen, Daniel Aletaha, Peter Mandl
Summary: The study aimed to assess the predictive value of tenderness in non-swollen joints for subsequent radiographic progression in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), taking into consideration other potential risk factors. Clinical and sonographic examination of hand joints were performed on patients with RA and PsA. The results showed that tenderness in non-swollen joints was associated with radiographic progression in RA, while the impact was weaker in PsA. Other risk factors such as sonographic signs for synovitis and baseline radiographic damage also had an effect on subsequent structural damage in both diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Eric Toussirot
Summary: Inflammatory rheumatic diseases (IRDs) are characterized by chronic joint inflammation. Rheumatoid arthritis (RA) and spondyloarthritis (SpA), including axial SpA (ax SpA) and psoriatic arthritis (PsA), are the most common forms of IRD. Adipokines, including leptin, adiponectin, visfatin, and resistin, play a role in the pathophysiology of IRDs. In RA, adiponectin and resistin contribute to structural damage, while leptin's role is controversial. In ax SpA, visfatin is associated with radiographic progression, while leptin and adiponectin have negative effects on progression.
Article
Rheumatology
Hannah Bower, Thomas Frisell, Daniela di Giuseppe, Benedicte Delcoigne, Gerd-Marfie Ahlenius, Eva Baecklund, Katerina Chatzidionysiou, Nils Feltelius, Helena Forsblad-d'Elia, Alf Kastbom, Lars Klareskog, Elisabet Lindqvist, Ulf Lindstrom, Carl Turesson, Christopher Sjowall, Johan Askling
Summary: Patients with inflammatory joint diseases (IJDs) have an increased risk of serious COVID-19 outcomes, potentially due to medical conditions other than IJD itself. The COVID-19 pandemic has measurable effects on rheumatology care provision, which will require further assessment for future impact.
Article
Rheumatology
Robert Landewe, Luna Sun, Yun-Fei Chen, Daojun Mo, Desiree van der Heijde
Summary: Demonstrating the inhibition of joint damage in rheumatoid arthritis trials is commonly achieved through statistically significant differences in radiographic progression measured by the mTSS. The frequently used ANCOVA+LE method for handling missing data may not be ideal for long-term extension or paediatric studies. The RC model shows better performance in terms of bias, RMSE, power and type I error rate, making it a more sensitive and precise alternative for analysing mTSS in studies with missing data.
Article
Rheumatology
Tariq Aslam, Farrouq Mahmood, Anetha Sabanathan, Robin Waxman, Philip S. Helliwell
Summary: This study compared the clinical and radiographic phenotypes of PsA patients of South Asian and North European origin, finding that South Asian patients tended to have more severe disease and worse impact on their quality of life compared to North European patients.
Article
Rheumatology
Emil Rydell, Kristina Forslind, Jan-Ake Nilsson, Magnus Karlsson, Kristina E. Akesson, Lennart T. H. Jacobsson, Carl Turesson
Summary: Radiographic damage in rheumatoid arthritis (RA) includes erosions and joint space narrowing (JSN). This study found that rheumatoid factor (RF) is a robust predictor of both progression of erosions and JSN scores, while anti-CCP antibodies and erythrocyte sedimentation rate are predictive of erosions and both outcomes respectively. Overweight/obesity was negatively associated with JSN score progression, particularly in older women.
ARTHRITIS RESEARCH & THERAPY
(2021)
Article
Nutrition & Dietetics
Frank Piva, Philippe Gervois, Youness Karrout, Famara Sane, Marie-Benedicte Romond
Summary: This study investigates the protective potential of Bifidobacterium longum cell wall lipoproteins (Lpps) in rheumatoid arthritis (RA) and finds that they can modulate the gut microbiota and alleviate arthritis symptoms. The dosage of Lpps is critical for preventing arthritis progression and appropriately modulating the microbiome. The results also suggest that Lpps may trigger the immune system.
Article
Rheumatology
Sascha L. Heckert, Sytske Anne Bergstra, Xanthe M. E. Matthijssen, Yvonne P. M. Goekoop-Ruiterman, Faouzia Fodili, Saskia Ten Wolde, Cornelia F. Allaart, Tom W. J. Huizinga
Summary: In patients with rheumatoid arthritis, baseline joint swelling was significantly associated with swelling in the same joint during follow-up, and it was found to better predict local joint swelling compared to baseline swelling in other joints. This suggests that local factors play a role in the recurrence of joint swelling over time.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Ted R. Mikuls, Rohit Gaurav, Geoffrey M. Thiele, Bryant R. England, Madison G. Wolfe, Brianna P. Shaw, Kristina L. Bailey, Todd A. Wyatt, Amy J. Nelson, Michael J. Duryee, Carlos D. Hunter, Dong Wang, Debra J. Romberger, Dana P. Ascherman, Jill A. Poole
Summary: Airborne biohazards, such as LPS, can exacerbate rheumatoid arthritis and contribute to associated lung diseases. Patients exposed to LPS may be more susceptible to developing interstitial lung diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Yasemin Ogul, Fatma Gur, Mustafa Cengiz, Bahri Gur, Refik Ali Sari, Ahmet Kiziltunc
Summary: This study evaluated the oxidant and anti-oxidant levels of RA patients and their impacts on disease activity through in silico studies. Results showed increased oxidative stress, weakened defense system, and increased ROS production in RA patients. Additionally, molecular docking studies confirmed the results on SOD and CAT activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Orthopedics
Guodong Xia, Yetian Li, Wei Pan, Chengmei Qian, Lin Ma, Jingli Zhou, Henggui Xu, Chen Cheng
Summary: This study found that the SLAMF6 gene is associated with susceptibility and severity of rheumatoid arthritis (RA) in the Chinese population. A functional variant of SLAMF6 may regulate the tissue expression of SLAMF6 in RA patients. Further research is recommended to fully understand the contribution of this variant to the development of RA.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Rheumatology
Taotao Li, Changrong Ge, Alexander Kramer, Outi Sareila, Monica Leu Agelii, Linda Johansson, Kristina Forslind, Erik Lonnblom, Min Yang, Bingze Xu, Qixing Li, Lei Cheng, Goran Bergstrom, Gonzalo Fernandez, Alf Kastbom, Solbritt Rantapaa-Dahlqvist, Inger Gjertsson, Rikard Holmdahl
Summary: In this study, the arthritogenic B cell epitopes of the autoantigen glucose-6-phosphate isomerase (GPI) associated with rheumatoid arthritis (RA) were identified. These epitopes play a crucial role in the development of the disease and joint damage.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Quirine A. Dumoulin, Xanthe M. E. Matthijssen, Fenne Wouters, Doortje Krijbolder, Ellis Niemantsverdriet, Annette H. M. van der Helm-van Mil
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Sarah J. H. Khidir, Anna M. P. Boeren, Annelies Boonen, Pascal H. P. de Jong, Elise van Mulligen, Annette H. M. van der Helm-van Mil
Summary: This study provides evidence that lower educational attainment is associated with a higher risk of progressing from arthralgia to inflammatory arthritis (IA). This effect is partially mediated by subclinical joint inflammation.
Letter
Rheumatology
C. Rogier, M. C. Kortekaas, A. H. M. van der Helm-van Mil, P. H. P. de Jong, E. van Mulligen
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Lotte van Ouwerkerk, Maarten Boers, Paul Emery, Pascal H. P. de Jong, Robert B. M. Landewe, Willem Lems, Josef S. Smolen, Patrick Verschueren, Tom W. J. Huizinga, Cornelia F. Allaart, Sytske Anne Bergstra
Summary: This study investigated whether patients with rheumatoid arthritis (RA) can discontinue glucocorticoids (GC) after GC 'bridging' in the initial treatment step and identified factors that may affect this. The probability of using GC decreased over time after bridging therapy ended, while the probability of continuous GC use increased. In oral GC bridging studies, the probabilities of later and continuous GC use and the cumulative GC doses were higher compared to studies that included parenteral GC bridging.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Kevin L. Winthrop, John D. Isaacs, Philip J. Mease, Dimitrios T. Boumpas, Xenofon Baraliakos, Jacques-Eric Gottenberg, Stefan Siebert, Marta Mosca, Neil Basu, Dana Orange, R. Lories, Daniel Aletaha, Iain B. McInnes, Tom W. J. Huizinga, Reinhard E. Voll, Ellen M. Gravallese, Ferry C. Breedveld, Josef S. Smolen
Summary: This article summarizes the unmet clinical and scientific needs in the field of rheumatology. It highlights the importance of clinical trial design innovation and the need to better understand the natural history of rheumatic diseases. The article also identifies the specific unmet needs in different rheumatological disease-specific groups and emphasizes the importance of developing therapies and therapeutic strategies for treatment-refractory disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Julien Duquesne, Vincent Bouget, Paul Henry Cournede, Bruno Fautrel, Francis Guillemin, Pascal H. P. de Jong, Judith W. Heutz, Marloes Verstappen, Annette H. M. van der Helm-van Mil, Xavier Mariette, Samuel Bitoun
Summary: The study aims to use routine clinical and biological data to build machine learning models for predicting EULAR inadequate response to MTX and identifying simple predictive biomarkers. The results show that the algorithm can accurately predict whether patients have an inadequate response to MTX and can guide new therapeutic strategies.
Article
Orthopedics
Anna M. P. Boeren, Ellis Niemantsverdriet, Marloes Verstappen, Fenne Wouters, Johannes L. Bloem, Monique Reijnierse, Annette H. M. van der Helm-van Mil
Summary: Objective MRI of small joints is crucial for early detection and treatment of rheumatoid arthritis. A modified Dixon sequence is introduced to improve the feasibility of MRI implementation in clinical practice, which does not require contrast and reduces total acquisition time. The results show good reliability and correlation between the modified Dixon and conventional sequences.
SKELETAL RADIOLOGY
(2023)
Article
Rheumatology
Rory C. Monahan, Liesbeth J. J. van de Voorde, Rolf Fronczek, Jeroen de Bresser, Jeroen Eikenboom, Margreet Kloppenburg, Huub A. M. Middelkoop, Gisela M. Terwindt, Nic J. A. van der Wee, Tom W. J. Huizinga, Gerda M. Steup-Beekman
Summary: This study investigated the short-term and long-term outcomes of inflammatory NPSLE with immunosuppressive treatment. The results showed that approximately 70% of cases had improvement in neuropsychiatric symptoms after treatment.
LUPUS SCIENCE & MEDICINE
(2023)
Article
Rheumatology
Sarah J. H. Khidir, Maaike Boonstra, Sytske Anne Bergstra, Gerry W. M. Boerrigter, Elles M. Voog-van der Harst, Maarten K. Ninaber, Nina Ajmone Marsan, Tom W. J. Huizinga, Annette H. M. van der Helm-van Mil, Jeska K. de Vries-Bouwstra
Summary: This study aimed to investigate the course of maximal mouth opening in systemic sclerosis patients and determine the factors associated with smaller maximal mouth opening over time. The results showed that a majority of patients had stable maximal mouth opening, but those with more severe organ involvement had a smaller maximal mouth opening over time. Smaller maximal mouth opening was also associated with more mouth handicap.
JOURNAL OF SCLERODERMA AND RELATED DISORDERS
(2023)
Article
Rheumatology
Diana Ekman, Bengt Sennblad, Ann Knight, Asa Karlsson, Solbritt Rantapaa-Dahlqvist, Ewa Berglin, Bernd Stegmayr, Bo Baslund, Oyvind Palm, Hilde Haukeland, Iva Gunnarsson, Annette Bruchfeld, Marten Segelmark, Sophie Ohlsson, Aladdin J. Mohammad, Anna Svard, Rille Pullerits, Hans Herlitz, Annika Soderbergh, Roald Omdal, Roland Jonsson, Lars Ronnblom, Per Eriksson, Kerstin Lindblad-Toh, Johanna Dahlqvist
Summary: The study aims to identify and genetically characterize subgroups of patients with ANCA-associated vasculitides (AAV) based on sex and ANCA subtype. The research analyzed a SNP dataset derived from DNA sequencing and genotyping of AAV cases and controls. The results showed that there are differences in genetic predisposition and disease mechanisms between males and females with MPO-ANCA-positive AAV, and that double ANCA-positive AAV cases are genetically similar to PR3-ANCA-positive cases, providing implications for clinical follow-up and treatment.
Article
Rheumatology
Doortje I. Krijbolder, Xanthe M. E. Matthijssen, Bastiaan T. van Dijk, Hanna W. van Steenbergen, Debbie M. Boeters, Annemiek Willemze, Anne A. Schouffoer, Annette H. M. van der Helm-van Mil
Summary: The progression of subclinical inflammation in different joint tissues was studied in patients with clinically suspect arthralgia (CSA) who develop rheumatoid arthritis (RA) and in patients with spontaneous resolution of pain. It was found that in RA progressors, synovitis, tenosynovitis, and osteitis increased simultaneously, with osteitis increasing just before RA development. In patients with pain resolution, simultaneous decreases in synovitis, tenosynovitis, and osteitis occurred, with tenosynovitis decreasing first.
ARTHRITIS & RHEUMATOLOGY
(2023)
Letter
Rheumatology
Doortje Krijbolder, Fenne Wouters, Ellis Niemantsverdriet, Annette H. M. van der Helm-van Mil
Article
Rheumatology
Lotte van Ouwerkerk, Patrick Verschueren, Maarten Boers, Paul Emery, Pascal Hendrik Pieter de Jong, Robert B. M. Landewe, Willem Lems, Josef S. Smolen, Tom W. J. Huizinga, Cornelia F. Allaart, Sytske Anne Bergstra
Summary: In patients with rheumatoid arthritis (RA), the use of glucocorticoids (GC) as bridging therapy resulted in a more rapid clinical improvement and fewer changes in medication, but similar long-term GC use compared with patients who did not receive bridging therapy.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Endocrinology & Metabolism
Christian Lundtoft, Daniel Eriksson, Matteo Bianchi, Maribel Aranda-Guillen, Nils Landegren, Solbritt Rantapaa-Dahlqvist, Peter Soderkvist, Jeniffer R. S. Meadows, DISSECT Consortium, Immunoarray Consortium, Swedish Addison Registry Study Grp, Gerli Rosengren Pielberg, Sophie Bensing, Gerli Rosengren Pielberg, Kerstin Lindblad-Toh, Lars Ronnblom, Olle Kampe
Summary: Autoantibodies against the adrenal enzyme 21-hydroxylase are a hallmark manifestation in autoimmune Addison's disease (AAD). This study identified strong associations between copy number variants in the CYP21 region and the risk of AAD, most likely due to linkage disequilibrium with disease-associated HLA class II alleles.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Rheumatology
N. K. den Hollander, M. Verstappen, B. T. van Dijk, A. H. M. van der Helm-van Mil, H. W. van Steenbergen
Summary: Using clinical features, this study identified five subgroups within undifferentiated arthritis (UA) and investigated their relationship with outcomes such as spontaneous resolution of arthritis and development of rheumatoid arthritis (RA). It was found that patients with persistent disease were nearly absent in the monoarthritis subgroups, while patients who developed RA were infrequent in these subgroups.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
