Molecular Switch Role of Akt in Polygonatum odoratum Lectin-Induced Apoptosis and Autophagy in Human Non-Small Cell Lung Cancer A549 Cells

A systems biology analysis of autophagy in cancer therapy

(2013) Zheng Shi et al.   CANCER LETTERS

Molecular mechanisms ofLycoris aureaagglutinin-induced apoptosis and G2/M cell cycle arrest in human lung adenocarcinoma A549 cells, bothin vitroandin vivo

(2013) C.-Y. Li et al.   CELL PROLIFERATION

Modeling, docking and dynamics simulations of a non-specific lipid transfer protein from Peganum harmala L.

(2013) Zheng Shi et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Autophagy and cancer

(2012) Kyeong Sook Choi   EXPERIMENTAL AND MOLECULAR MEDICINE

Agaricus bisporus lectins mediates islet β-cell proliferation through regulation of cell cycle proteins

(2012) Yi Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Antihyperglycemic Effect of Ginsenoside Rh2 by Inducing Islet β-cell Regeneration in Mice

(2011) Y. Wang et al.   HORMONE AND METABOLIC RESEARCH

Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics

(2011) Chun-yang Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Plant lectins: Targeting programmed cell death pathways as antitumor agents

(2011) Lei-lei Fu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Molecular modeling, docking and dynamics simulations of GNA-related lectins for potential prevention of influenza virus (H1N1)

(2011) Huai-long Xu et al.   JOURNAL OF MOLECULAR MODELING

Activation of PI3K/Akt/IKK-α/NF-κB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: its inhibition by quercetin

(2010) Zhi-Jun Sun et al.   APOPTOSIS

Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras–Raf and PI3K–Akt signaling pathways

(2010) Bo Liu et al.   BIOCHIMIE

The mTOR Pathway: A New Target in Cancer Therapy

(2010) L. Ciuffreda et al.   CURRENT CANCER DRUG TARGETS

Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway

(2010) Yi-Chieh Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Characterization, molecular cloning, and in silico analysis of a novel mannose-binding lectin from Polygonatum odoratum (Mill.) with anti-HSV-II and apoptosis-inducing activities

(2010) Yun Yang et al.   PHYTOMEDICINE

Recombinant expression of Polygonatum cyrtonema lectin with anti-viral, apoptosis-inducing activities and preliminary crystallization

(2010) Chun-yang Li et al.   PROCESS BIOCHEMISTRY

Induction of apoptosis by Polygonatum odoratum lectin and its molecular mechanisms in murine fibrosarcoma L929 cells

(2009) Bo Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Antiproliferative activity and apoptosis-inducing mechanism of Concanavalin A on human melanoma A375 cells

(2008) Bo Liu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

ERK and JNK mediate TNFα-induced p53 activation in apoptotic and autophagic L929 cell death

(2008) Yan Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS–p38–p53 pathway

(2008) Bo Liu et al.   CANCER LETTERS

ROS and p53: A versatile partnership

(2008) Bin Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE