Article
Dermatology
H. Yu, X. Lin, J. Cen, H. Cheng, O. Seifert
Summary: The expression of TLR7 and TLR9 was found to be increased in vitiligo melanocytes, accompanied by higher levels of IL-8, IL-6, sICAM-1, and apoptosis, as well as lower tyrosinase activity and melanin content, suggesting a correlation between TLR expression and melanocyte dysfunction in vitiligo.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Article
Cell & Tissue Engineering
Rishi Man Chugh, Hang-soo Park, Abdeljabar El Andaloussi, Amro Elsharoud, Sahar Esfandyari, Mara Ulin, Lale Bakir, Alshimaa Aboalsoud, Mohamed Ali, Dalia Ashour, Prosper Igboeli, Nahed Ismail, Jan McAllister, Ayman Al-Hendy
Summary: The study showed that BM-hMSC and its secretome can effectively suppress androgen-producing gene expression, alleviate inflammation, and restore fertility in PCOS animal models.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Food Science & Technology
Theerawat Dobutr, Wirapong Kantamala, Suphaporn Phimwapi, Nisachon Jangpromma, Patcharaporn Tippayawat, Sophon Boonlue, Jureerut Daduang, Sompong Klaynongsruang, Saowanee Poopornchai, Sakda Daduang
Summary: This study investigated the immunomodulatory effect of edible bird's nest (EBN) in vitro and in vivo studies. The results showed that EBN specifically enhanced the expansion of CD3(+) T-cells and restored lymphocyte subpopulations under immunosuppressive drug influence. EBN treatments also increased the number of peripheral blood T-cells in rats and affected the numbers of lymphoid cells in specific areas. The elevation of serum interleukin-2 (IL-2) was correlated with T-cell proliferation. These findings are important for developing therapeutic strategies to improve immunity and T-cell homeostasis under immunosuppressive therapy.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Hana M. Zegallai, Ejlal Abu-El-Rub, Laura K. Cole, Jared Field, Edgard M. Mejia, Joseph W. Gordon, Aaron J. Marshall, Grant M. Hatch
Summary: The study revealed that deficiency of the essential mitochondrial function enzyme tafazzin significantly alters the metabolic activity and response to activation in mouse B cells. This suggests a key role for tafazzin in regulating B cell function and metabolic activity through modulation of mitochondrial function.
Article
Cell Biology
Olga Witkowska-Pilaszewicz, Rafal Pingwara, Jaroslaw Szczepaniak, Anna Winnicka
Summary: Clenbuterol is gaining popularity for weight loss and bodybuilding, but is prohibited in anti-doping control. Research suggests that clenbuterol can inhibit the inflammatory process. Beta 2-adrenoceptor stimulation has enhanced anti-inflammatory properties in well-trained horses, but can create a pro-inflammatory environment in inexperienced horses.
Article
Neurosciences
Ramasamy Vasantharekha, Hannah P. Priyanka, Rahul S. Nair, Lalgi Hima, Uday P. Pratap, Avathvadi V. Srinivasan, Srinivasan ThyagaRajan
Summary: The neuroendocrine-immune network deficit in the periphery is associated with the onset and progression of mild cognitive impairment (MCI) and Alzheimer's disease (AD). The study investigates the correlation between cell-mediated immune responses, stress hormones, amyloid precursor protein (APP) expression, peripheral blood mononuclear cells (PBMC), and intracellular signaling molecules in the pathology of MCI and AD. The results suggest that changes in specific intracellular signaling pathways may influence alterations in cell-mediated immunity to promote disease progression in MCI and AD patients.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Critical Care Medicine
Thomas Daix, Armelle Mathonnet, Scott Brakenridge, Pierre-Francois Dequin, Jean-Paul Mira, Frederique Berbille, Michel Morre, Robin Jeannet, Teresa Blood, Jacqueline Unsinger, Jane Blood, Andrew Walton, Lyle L. Moldawer, Richard Hotchkiss, Bruno Francois
Summary: CYT107 is effective in improving lymphocyte function and reversing lymphopenia in septic patients. However, intravenous administration of CYT107 may cause adverse reactions, making intramuscular administration a more preferable option.
ANNALS OF INTENSIVE CARE
(2023)
Article
Oncology
Hwa Kyung Byun, Seung Yeun Chung, Kyoung-Jin Kim, Jinsil Seong
Summary: Radiation-induced lymphopenia, especially acute severe lymphopenia (ASL), impacts overall survival in hepatocellular carcinoma patients. IL-7 levels play a crucial role in the development and recovery from ASL, with higher levels associated with reduced risk of ASL development. IL-7 may be a potential novel strategy to overcome radiation-induced lymphopenia.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Pharmacology & Pharmacy
E. A. Innis, C. Levinger, M. A. Szaniawski, E. S. C. P. Williams, J. Alcami, A. Bosque, J. T. Schiffer, M. Coiras, A. M. Spivak, V Planelles
Summary: This study investigated FDA-approved oncology drugs and found that dasatinib, ponatinib, and trametinib can significantly reduce proliferation of memory CD4 T cells in HIV-infected individuals. Dasatinib, in particular, blocks both homeostatic and antigen-driven proliferation and aids in reducing the reservoir size. By inhibiting STAT5 phosphorylation, dasatinib hinders IL-7 induced proliferation and prevents spontaneous rebound in cells from people living with HIV-1.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei Zheng, Yaqin Li, Yanwei Xu, Tao Zhou, Dezhi Li, Xianyi Cheng, Yu Xiong, Shaobin Wang, Zaizhong Chen
Summary: The study explored the cellular behavior and properties of growth hormone (GH) and its receptor in mesenchymal stem cells (MSCs), revealing that nuclear-targeted GHR drives cell proliferation through a specific signaling pathway. This research has laid an important foundation for further investigation into the regulatory effects of GH on MSCs.
Article
Oncology
Ke-Wei Zhang, Dong Wang, Hao Cai, Man-Qing Cao, Yuan-Yuan Zhang, Peng-Yuan Zhuang, Jun Shen
Summary: Sorafenib promotes metastasis and EMT progression in liver cancer cells by increasing IL-6 expression, and the IL-6/STAT3 signaling pathway may present a novel therapeutic strategy for liver cancer.
Article
Immunology
Fernando Janczur Velloso, Anna Wadhwa, Ekta Kumari, Ioana Carcea, Ozlem Gunal, Steven W. Levison
Summary: Epidemiological studies have shown that infections during pregnancy increase the risk of psychiatric disorders in offspring, and interleukin-6 (IL-6) has been implicated as a causal agent. This study aimed to investigate whether elevating IL-6 during a specific period of neural development would affect neurogenesis and lead to behavioral changes associated with neurodevelopmental disorders. The results demonstrate that transient increase in IL-6 during postnatal days 3-6 reduced neurogenesis and astrogliogenesis, and affected behavioral traits in adult male mice.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Cell Biology
Yijia Zhang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
Summary: This study reveals that melatonin modulates a combination of green and blue light-induced B-lymphocyte proliferation in chickens by reducing oxidative stress and activating the Mel1a/PI3K/AKT and Mel1c/PKC/ERK pathways. The G -> B group showed significant increases in various physiological indicators and promoted B-lymphocyte proliferation compared to other light-treated groups.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biology
Nathanael A. Caveney, Caleb R. Glassman, Kevin M. Jude, Naotaka Tsutsumi, K. Christopher Garcia
Summary: Interleukin 27 (IL-27) is a heterodimeric cytokine that plays an important role in immune homeostasis. This study used cryogenic-electron microscopy to determine the quaternary structure of IL-27 and its receptor complex, providing insights into the receptor assembly mechanism and distinguishing it from related cytokines.
Article
Multidisciplinary Sciences
Wei Qiao, Karen H. M. Wong, Jie Shen, Wenhao Wang, Jun Wu, Jinhua Li, Zhengjie Lin, Zetao Chen, Jukka P. Matinlinna, Yufeng Zheng, Shuilin Wu, Xuanyong Liu, Keng Po Lai, Zhuofan Chen, Yun Wah Lam, Kenneth M. C. Cheung, Kelvin W. K. Yeung
Summary: This study reveals a biphasic mode of action of magnesium ion (Mg2+) in bone repair. During the early inflammation phase, Mg2+ can contribute to pro-osteogenic effects by promoting an immune microenvironment for bone formation; however, in the later remodeling phase, Mg2+ has negative effects on bone maturation and repair.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Oncology
Viviane Regina Hernandez Nunes, Isabella Silva Pimentel, Mariana Nassif Kerbauy, Carolina Cristina Pellegrino Feres, Jade Zezzi Martins do Nascimento, Andreza Alice Feitosa Ribeiro, Amanda Inacio Dias dos Santos, Marcelo Langer Wroclawski, Larissa Lane Cardoso Teixeira, Nelson Hamerschlak
HEMATOLOGY TRANSFUSION AND CELL THERAPY
(2023)
Article
Nutrition & Dietetics
Ludmila de Oliveira Muniz Koch, Andrea Z. Pereira, Nelson Hamerschlak, Adham do Amaral e Castro, Adriano Tachibana, Elivane da Silva Victor, Reynaldo Jesus Garcia Filho
Summary: This study evaluates the impact of body composition on morbidity and mortality in older adults undergoing HSCT, using computed tomography (CT) images to assess muscle mass and density outcomes.
NUTRITION IN CLINICAL PRACTICE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Fernanda P. Eduardo, Luciana Correa, Fernanda Mansur, Carlos Benitez, Nelson Hamerschlak, Jaoa Renato Rebello Pinho, Debora Heller, Leticia Mello Bezinelli
Summary: This study investigated the short-term effect of toothpastes containing antimicrobial properties on patients with COVID-19. The results showed that using these toothpastes immediately after brushing could reduce the viral load in saliva.
INTERNATIONAL DENTAL JOURNAL
(2022)
Article
Cell Biology
Raquel M. Alves-Paiva, Sabrina do Nascimento, Denise De Oliveira, Larissa Coa, Kelen Alvarez, Nelson Hamerschlak, Oswaldo Keith Okamoto, Luciana C. Marti, Andrea T. Kondo, Jose Mauro Kutner, Maria Augusta Tezelli Bortolini, Rodrigo Castro, Juliana A. Preto de Godoy
Summary: This study reports a case where MSCs derived from an elderly donor entered a senescence state after three passages. MSCs cultured with AS displayed an early senescence state, and there were more senescence cells and altered gene expression compared to cells cultured with FBS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Eduardo Cerello Chapchap, Marisa Petrucelli Doher, Lucila Nassif Kerbauy, Talita Rantin Belucci, Fabio Pires de Souza Santos, Andreza Alice Feitosa Ribeiro, Nelson Hamerschlak
Summary: This study analyzed the survival and risk factors associated with hemodialysis in hematopoietic stem cell transplantation patients. The results showed that hemodialysis was significantly associated with male gender, age, grade II-IV acute GVHD, various drug exposures, microangiopathy, septic shock, and steroid exposure. The HD group had a higher mortality rate.
HEMATOLOGY TRANSFUSION AND CELL THERAPY
(2023)
Editorial Material
Hematology
Laiz Cameirao Bento, Bruna Garcia Nogueira, Newton de Freitas Centuriao, Nelson Hamerschlak, Elizabeth Xisto Souto, Nydia Strachman Bacal
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Hematology
Marilia Fernandes Mascarenhas Sirianni, Emilia Sippert, Bruna Blos, Flavia Ricioli Vaz Goncalves, Nelson Hamerschlak, Jose Kutner, Lilian Castilho, Luciana Carvalheiro Marti, Carolina Bonet-Bub
Summary: This study found no association between HLA-DRB1 alleles and the risk or protection of RBC alloimmunization in Brazilian MDS patients. However, IL17A 197G>A, IL4 intron 3, and IL4-590C>T single nucleotide polymorphisms were significantly associated with the risk of RBC alloimmunization in this cohort.
TRANSFUSION MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Mariana P. Nucci, Javier B. Mamani, Fernando A. Oliveira, Igor S. Filgueiras, Arielly H. Alves, Matheus H. Theinel, Luiz D. Rodrigues, Luciana Marti, Lionel F. Gamarra
Summary: This study aims to optimize the labeling conditions for human bone marrow mesenchymal stem cells (hBM-MSC) using multifunctional nanoparticles (MFNP) in order to monitor these cells in vivo. The results show that the use of a magnetic field and higher concentration of MFNP during cell labeling can significantly increase the iron load and improve the detection of cells by near-infrared fluorescence (NIRF) technique without compromising cellular viability.
Article
Cell & Tissue Engineering
Maria Susana Joya Marodin, Juliana A. Godoy, Raquel M. Alves-Paiva, Kelen Alvarez, Thiago Giove Mitsugi, Ana Cristina Victorino Krepischi, Nelson Hamerschlak, Maria Augusta Tezelli Bortolini, Rodrigo Castro, Andrea T. Kondo, Jose Mauro Kutner, Oswaldo Keith Okamoto
Summary: Cytogenetic aberrations, such as trisomy 5, may occur in human mesenchymal stromal cells (MSC) during ex vivo expansion. It is still unclear how these aberrations affect the neoplastic transformation threshold or medicinal properties of MSC products. In this study, MSC cultures with clonal trisomy 5 showed reduced cell proliferation, increased senescence-associated beta-galactosidase activity, and poor tumor initiating capability. However, subcutaneous injection of these MSC populations did not generate tumors in immunodeficient mice within a six-month follow-up period. Importantly, MSC populations with clonal trisomy 5 maintained their immunomodulatory properties similar to euploid MSC upon interferon gamma (IFN gamma) licensing. These findings suggest that bone marrow MSC products with clonal trisomy 5 may still retain their therapeutic potential and support the definition of release criteria for autologous MSC products in critical clinical scenarios.
STEM CELLS INTERNATIONAL
(2022)
Article
Microbiology
Leticia Mello Bezinelli, Luciana Correa, Stephany Beyerstedt, Erika Bevilaqua Rangel, Carlos Benitez, Nelson Hamerschlak, Joao Renato Rebello Pinho, Debora Heller, Fernanda de Paula Eduardo
Summary: This study investigated the effectiveness of an oral hygiene protocol in reducing the SARS-CoV-2 viral load in the oral cavity. The results showed that using chlorhexidine (CHX) and hydrogen peroxide (HP) in the oral rinse immediately after the procedure significantly reduced the viral load.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Article
Cell Biology
Messias Oliveira Pacheco, Fernanda Agostini Rocha, Thiago Pinheiro Arrais Aloia, Luciana Cavalheiro Marti
Summary: ACKR2, ACKR3, and ACKR4 receptors are expressed by different subsets of T lymphocytes in varying proportions. These receptors are highly expressed in the cytoplasmic milieu of all T lymphocyte subsets, suggesting that their expression on the plasma membrane is regulated and dependent on stimulation.
Article
Medicine, General & Internal
Lara Faria Souza Dias, Carolina Leme de Moura Pereira, Newton de Freitas Centuriao, Jade Zezzi Martins do Nascimento, Andreza Alice Feitosa Ribeiro, Nelson Hamerschlak, Carolina Perrone Marques, Ana Carolina Vieira de Lima, Luana Nobrega da Costa, Anderson Felipe da Silva, Viviane de Jesus Torres Lima, Mariana Nassif Kerbauy, Lucila Nassif Kerbauy, Leonardo Javier Arcuri, Paulo Vidal Campregher, Juliana Dall Agnol da Rocha, Tarcila Santos Datoguia, Fabio Pires de Souza Santos
Summary: This study analyzed the karyotype test and myeloid panel with next-generation sequencing findings in patients with myelofibrosis, and compared transplant characteristics in patients referred for bone marrow transplantation. The results showed that patients with high-risk molecular mutations were more suitable for bone marrow transplant. Molecular analysis is an important tool for guiding therapy in myelofibrosis.
EINSTEIN-SAO PAULO
(2023)
Article
Pharmacology & Pharmacy
Murilo M. Garrigos, Fernando A. Oliveira, Mariana P. Nucci, Javier B. Mamani, Olivia F. M. Dias, Gabriel N. A. Rego, Mara S. Junqueira, Cicero J. S. Costa, Lucas R. R. Silva, Arielly H. Alves, Nicole M. E. Valle, Luciana Marti, Lionel F. Gamarra
Summary: Bone marrow transplantation is a treatment for various diseases, and this study proposes a new method to evaluate the engraftment and behavior of hematopoietic stem cells. The method involves the use of bioluminescence imaging and inductively coupled plasma mass spectrometry associated with superparamagnetic iron oxide nanoparticles. The study found that the administration of Fluorouracil enriched the population of hematopoietic stem cells in the bone marrow, and labeling the cells with nanoparticles provided information on their internalization status. The study also utilized blood count and bioluminescence imaging to monitor the reconstitution of hematopoiesis and evaluate the transplantation effectiveness.
Article
Parasitology
Juliano Cordova Vargas, Patricia Nunes Bezerra, Murilo Sequeira, Gabriella Haydee de Oliveira, Carlos Eduardo Pegolo, Lucas Fiore, Nelson Hamerschlak, Paulo Roberto Abrao Ferreira
Summary: Extrapulmonary tuberculosis is rare with immune thrombocytopenia (ITP). A case of ITP associated with pulmonary and lymph node tuberculosis in a 29-year-old male patient was reported. After tuberculosis treatment, the platelet count effectively normalized, suggesting an association between tuberculosis and ITP.
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2023)
Article
Hematology
Leonardo Javier Arcuri, Mariana Nassif Kerbauy, Lucila Nassif Kerbauy, Fabio Pires de Souza Santos, Andreza Alice Feitosa Ribeiro, Nelson Hamerschlak
Summary: This study analyzed the impact of anti-T-cell globulin (ATG) in HLA-matched and unrelated donor peripheral blood stem cell transplantation (PBSC HCT). The results showed that ATG can reduce the occurrence of chronic graft-versus-host disease (GVHD) and improve the quality of life of patients, but it may increase the relapse rate. Therefore, ATG should be considered as a standard treatment in this population.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)