Article
Immunology
Xiongfeng Pan, Atipatsa C. Kaminga, Sanjay Kinra, Shi Wu Wen, Hongying Liu, Xinrui Tan, Aizhong Liu
Summary: This study summarized the associations of different chemokines with T1DM, revealing that circulating concentrations of CCL5 and CXCL1 were significantly higher in T1DM patients compared to controls. Circulating CCL5 ranked highest among all the chemokines investigated in T1DM.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Xi Peng, Guocheng Rao, Xinqiong Li, Nanwei Tong, Yan Tian, Xianghui Fu
Summary: This article comprehensively summarizes and discusses the applications, advantages, and limitations of commonly used animal models for human T1DM, as well as provides an overview of the latest human tissue bioengineering models for T1DM research. By combining these models with a better understanding of the pathophysiology of T1DM, we can gain deeper insights into disease development and ultimately improve therapeutic responses and outcomes.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Endocrinology & Metabolism
Haipeng Pang, Wenqi Fan, Xiajie Shi, Jiaqi Li, Yimeng Wang, Shuoming Luo, Jian Lin, Gan Huang, Xia Li, Zhiguo Xie, Zhiguang Zhou
Summary: This study identified differentially expressed exosomal lncRNAs in T1DM patients, with further bioinformatics analysis suggesting their potential roles in T1DM pathogenesis. The results highlight the importance of exosomal lncRNAs in understanding the molecular mechanisms of T1DM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Acoustics
Vinh T. Pham, M. A. R. K. Ciccaglione, David G. Ramirez, Richard K. P. Benninger
Summary: The researchers previously found that measurements of pancreas perfusion dynamics can predict disease progression in type 1 diabetes (T1D). Now they tested whether these measurements can predict the success of therapeutic prevention of T1D.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Xuan Chen, Alison H. Affinati, Yungchun Lee, Adina F. Turcu, Norah Lynn Henry, Elena Schiopu, Angel Qin, Megan Othus, Dan Clauw, Nithya Ramnath, Lili Zhao
Summary: This study found that the risk of developing ICI-T1DM is associated with the type of ICI therapy, patient age, and preexisting non-T1DM diabetes. The development of ICI-T1DM does not seem to significantly impact patient survival.
Article
Endocrinology & Metabolism
Robert French, Dylan Kneale, Justin T. Warner, Holly Robinson, James Rafferty, Adrian Sayers, Peter Taylor, John W. Gregory, Colin M. Dayan
Summary: There is no strong evidence to suggest a significant association between type 1 diabetes and educational outcomes. However, the level of blood glucose control (HbA(1c)) is related to academic achievements.
Article
Endocrinology & Metabolism
Brittany S. Bruggeman, Martha Campbell-Thompson, Stephanie L. Filipp, Matthew J. Gurka, Mark A. Atkinson, Desmond A. Schatz, Laura M. Jacobsen
Summary: Access to human pancreas samples from organ donors has greatly advanced our understanding of type 1 diabetes pathogenesis. Substance use impacts the pancreata of donors with type 1 diabetes more than controls, resulting in higher rates of acute pancreatitis, chronic pancreatitis, and chronic exocrine changes in type 1 diabetes donors. Further study of the pathophysiology of these changes is needed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Emil F. Coccaro, Sophie Lazarus, Joshua Joseph, Kathline Wyne, Tina Drossos, Louis Phillipson, Mary de Groot
Summary: The study found that negative emotional experience is positively related to diabetes-related distress, while the skill at regulating these emotions is negatively related to diabetes-related distress, with a medium-size relationship between these emotional regulation variables and diabetes-related distress. The data suggest that diabetes-related distress in adults with diabetes is meaningfully linked to negative emotionality and skill at regulating such emotions, with a stronger relationship than perceived psychological stress or diabetes self-care.
Article
Cell & Tissue Engineering
Yanju Li, Feiqing Wang, Huiling Liang, Dongxin Tang, Mei Huang, Jianing Zhao, Xu Yang, Yanqing Liu, Liping Shu, Jishi Wang, Zhixu He, Yang Liu
Summary: The meta-analysis included 10 studies with a total of 239 participants, evaluating the efficacy of mesenchymal stem cells (MSCs) therapy in treating diabetes mellitus. The results showed that MSC treatment led to significantly lower HbA1c levels, higher fasting C-peptide levels, and reduced insulin requirement in T1DM patients.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Endocrinology & Metabolism
Silja Schrader, Alexander Perfilyev, Emma Ahlqvist, Leif Groop, Allan Vaag, Mats Martinell, Sonia Garcia-Calzon, Charlotte Ling
Summary: This study identified differential epigenetic patterns between subgroups of T2D and developed subgroup-specific methylation risk scores (MRSs). These MRSs can predict diabetic complications. Different MRSs are associated with different risks of cardiovascular and renal diseases.
Review
Biochemistry & Molecular Biology
Stephen T. O'Brien, Orla M. Neylon, Timothy O'Brien
Summary: Cardiovascular disease is the leading cause of death in Type 1 Diabetes, with the molecular basis for atherosclerosis heavily influenced by hyperglycaemia. Current tools for assessing CVD risk in Type 1 Diabetes patients are limited, posing challenges for selecting appropriate lipid-lowering therapies. Best practice guidance for managing dyslipidaemia in Type 1 Diabetes is mainly based on evidence from Type 2 Diabetes patients and expert opinions.
Article
Cardiac & Cardiovascular Systems
Araz Rawshani, Naveed Sattar, Darren K. McGuire, Oskar Wallstrom, Ulf Smith, Jan Boren, Goran Bergstrom, Elmir Omerovic, Annika Rosengren, Bjorn Eliasson, Deepak L. Bhatt, Aidin Rawshani
Summary: The study found that the incidence of valvular disease is increasing among patients with diabetes. In type 2 diabetes, systolic blood pressure, body mass index, and renal function were found to be associated with valvular lesions.
Article
Biochemistry & Molecular Biology
Martina Brunner, Othmar Moser, Reingard Raml, Maximilian Haberlander, Beate Boulgaropoulos, Barbara Obermayer-Pietsch, Eva Svehlikova, Thomas R. Pieber, Harald Sourij
Summary: Methods for glucagon analysis in the past were not specific and had a narrow sensitivity range, leading to inaccurate results. Newer methods have shown that actual glucagon levels are lower than previously thought. This study compared glucagon levels in healthy individuals and diabetes patients using two different methods and found that the choice of method can significantly affect the results.
Review
Endocrinology & Metabolism
Alfonso Galderisi, Alice L. J. Carr, Mariangela Martino, Peter Taylor, Peter Senior, Colin Dayan
Summary: Clinically symptomatic type 1 diabetes is preceded by a pre-symptomatic phase, during which there is a progressive loss of functional beta cell mass and potential changes in glucose profile. Identifying metabolic tests to track beta cell function is crucial for understanding disease progression and treatment effectiveness.
Article
Medicine, Research & Experimental
Melissa Jean, Arvind Raghavan, Matthew L. Charles, Mark S. Robbins, Eric Wagner, Georges-Etienne Rivard, Xavier Charest-Morin, Francois Marceau
Article
Immunology
Pujya Agarwal, Arvind Raghavan, Sarada L. Nandiwada, Julie M. Curtsinger, Paul R. Bohjanen, Daniel L. Mueller, Matthew F. Mescher
JOURNAL OF IMMUNOLOGY
(2009)
Article
Multidisciplinary Sciences
Lilia Maneva-Radicheva, Christina Amatya, Camille Parker, Jacob Ellefson, Ilian Radichev, Arvind Raghavan, Matthew L. Charles, Mark S. Williams, Mark S. Robbins, Alexei Y. Savinov
Article
Pharmacology & Pharmacy
Xavier Charest-Morin, Arvind Raghavan, Matthew L. Charles, Tadeusz Kolodka, Johanne Bouthillier, Melissa Jean, Mark S. Robbins, Francois Marceau
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2015)
Article
Biochemistry & Molecular Biology
Lisa K. Mullany, Christopher J. Nelsen, Eric A. Hanse, Melissa M. Goggin, Chelsea K. Anttila, Mark Peterson, Peter B. Bitterman, Arvind Raghavan, Gretchen S. Crary, Jeffrey H. Albrecht
JOURNAL OF BIOLOGICAL CHEMISTRY
(2007)
Article
Virology
JA Smith, SC Schmechel, A Raghavan, M Abelson, C Reilly, MG Katze, RJ Kaufman, PR Bohjanen, LA Schiff
JOURNAL OF VIROLOGY
(2006)
Article
Biotechnology & Applied Microbiology
IA Vlasova, J McNabb, A Raghavan, C Reilly, DA Williams, KA Bohjanen, PR Bohjanen
Article
Biotechnology & Applied Microbiology
A Raghavan, M Dhalla, T Bakheet, RL Ogilvie, IA Vlasova, KSA Khabar, BRG Williams, PR Bohjanen
Article
Biochemistry & Molecular Biology
A Raghavan, RL Ogilvie, C Reilly, ML Abelson, S Raghavan, J Vasdewani, M Krathwohl, PR Bohjanen
NUCLEIC ACIDS RESEARCH
(2002)
Article
Biochemistry & Molecular Biology
A Raghavan, RL Robison, J McNabb, CR Miller, DA Williams, PR Bohjanen
JOURNAL OF BIOLOGICAL CHEMISTRY
(2001)