Article
Medicine, General & Internal
Eleni Chouri, Maojie Wang, Maarten R. Hillen, Chiara Angiolilli, Sandra C. Silva-Cardoso, Catharina G. K. Wichers, Maarten van der Kroef, Cornelis P. J. Bekker, Marta Cossu, Lenny van Bon, Alsya J. Affandi, Tiago Carvalheiro, Aridaman Pandit, Joel A. G. van Roon, Lorenzo Beretta, Boudewijn M. T. Burgering, Timothy R. D. J. Radstake, Marzia Rossato
Summary: The study found that miRNA expression levels are altered in pDCs of early-stage SSc patients and may contribute to the observed pDC activation in patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Qiuhong Wu, Yang Liu, Yan Xie, Shixiong Wei, Yi Liu
Summary: This study is the first to construct a potential ceRNA regulatory network and analyze the composition of infiltrating immune cells in lung tissues of SSc-ILD patients, which enhances our understanding of the pathogenesis of SSc-ILD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Cinthia Mariel Olexen, Diego Alfredo Rosso, Wand Nowak, Daniel Fortunati, Andrea Emilse Errasti, Eugenio Antonio Carrera Silva
Summary: This study aimed to develop a sensitive tracing method to monitor circulating CD207(+) and CD1a(+) cells in patients with LCH. Through flow cytometry and a scoring system, the presence of CD207(+) and CD1a(+) cells was found to be associated with the diagnosis and treatment response of LCH, and these cells could also be detected in some patients without obvious clinical symptoms.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Dermatology
Yuki Fukui, Kouki Nakamura, Megumi Hirabayashi, Takuya Miyagawa, Satoshi Toyama, Jun Omatsu, Kentaro Awaji, Tetsuya Ikawa, Yuta Norimatsu, Ayumi Yoshizaki, Shinichi Sato, Yoshihide Asano
Summary: The study found that VASH-1 levels were higher in patients with systemic sclerosis (SSc), especially in those with diffuse skin involvement and interstitial lung disease. Serum VASH-1 levels were positively correlated with skin score, negatively correlated with lung function parameters and KL-6 levels, and unrelated to surfactant protein D levels. In SSc, upregulation of VASH-1 in skin and sera is linked to dermal and pulmonary fibrotic changes, while its contribution to SSc vasculopathy appears limited.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Immunology
Aurelien Chepy, Solange Vivier, Fabrice Bray, Camille Ternynck, Jean-Pascal Meneboo, Martin Figeac, Alexandre Filiot, Lucile Guilbert, Manel Jendoubi, Christian Rolando, David Launay, Sylvain Dubucquoi, Guillemette Marot, Vincent Sobanski
Summary: This study investigated the effect of purified immunoglobulin G (IgG) from systemic sclerosis (SSc) patients on protein and mRNA expression of dermal fibroblasts (FBs) using a multi-omics approach. The results showed that SSc sera and purified IgG induced unique protein profile patterns, and this effect depended on the serotype of the patient.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Songlei Zhou, Yukun Huang, Yu Chen, Yipu Liu, Laozhi Xie, Yang You, Shiqiang Tong, Jianpei Xu, Gan Jiang, Qingxiang Song, Ni Mei, Fenfen Ma, Xiaoling Gao, Hongzhuan Chen, Jun Chen
Summary: The authors developed a nanoplatform consisting of cannabidiol and LIGHT to improve the immune response against glioblastoma. The nanoplatform increased the number of systemic T cells and improved T-cell infiltration in GBM models, leading to successful long-term survival. This work highlights the importance of reprogramming both systemic and local immune function for T-cell based immunotherapy and provides a clinically translatable option for treating brain tumors.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Meiling Zheng, Zhi Hu, Xiaole Mei, Lianlian Ouyang, Yang Song, Wenhui Zhou, Yi Kong, Ruifang Wu, Shijia Rao, Hai Long, Wei Shi, Hui Jing, Shuang Lu, Haijing Wu, Sujie Jia, Qianjin Lu, Ming Zhao
Summary: This study compares the differences between cutaneous lesions from DLE and SLE patients and healthy controls using single-cell RNA sequencing data. The findings reveal differential immune cell recruitment, cell type, and gene expression, highlighting potential therapeutic targets for lupus erythematosus.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Daniel Levin, Mohammed S. Osman, Caylib Durand, Hyein Kim, Iman Hemmati, Kareem Jamani, Jonathan G. Howlett, Kerri A. Johannson, Jason Weatherald, Matthew Woo, Jason Lee, Jan Storek
Summary: Systemic sclerosis is a complex connective tissue disease with limited efficacy from conventional therapies. Autologous hematopoietic stem cell transplantation shows promise but comes with associated risks. Patient selection, efficacy, and toxicity are vital considerations for treatment.
Review
Immunology
Wei Jin, Yan Zheng, Ping Zhu
Summary: Systemic sclerosis is an autoimmune disease with a poor prognosis. T cell abnormalities play a crucial role in its pathogenesis and treatment. Understanding the role of T cells may lead to more targeted treatment options for systemic sclerosis patients.
AUTOIMMUNITY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Immacolata Pietraforte, Alessia Butera, Lucia Gaddini, Anna Mennella, Raffaella Palazzo, Doriana Campanile, Katia Stefanantoni, Valeria Riccieri, Roberto Lande, Loredana Frasca
Summary: CXCL4 is an important biomarker of systemic sclerosis (SSc) and its presence is linked to an unfavorable prognosis. CXCL4-RNA complexes can protect RNA from enzymatic degradation and circulate in SSc plasma, correlating with IFN-I and TNF-alpha levels. These findings suggest a role for CXCL4-RNA complexes in immune amplification and modulation of myeloid dendritic cell effector functions in SSc and normal immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Maya Malaab, Ludivine Renaud, Naoko Takamura, Kip D. Zimmerman, Willian A. da Silveira, Paula S. Ramos, Sandra Haddad, Marc Peters-Golden, Loka R. Penke, Bethany Wolf, Gary Hardiman, Carl D. Langefeld, Thomas A. Medsger, Carol A. Feghali-Bostwick
Summary: Our study identified distinct molecular features in dermal fibroblasts of systemic sclerosis patients, including dysregulated transcription factors and microRNAs, suggesting a role for epigenetic dysregulation in disease susceptibility. This highlights the potential for using epigenetic modifiers as future therapies in systemic sclerosis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Soichiro Sawamura, Katsunari Makino, Maho Ide, Shuichi Shimada, Ikko Kajihara, Takamitsu Makino, Masatoshi Jinnin, Satoshi Fukushima
Summary: In patients with systemic sclerosis (SSc), the levels of alpha 2(I) collagen are higher than alpha 1(I) collagen in fibroblasts. Further investigation of the overall regulatory mechanisms of type I collagen may help to understand the aberrant collagen metabolism in SSc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Claire F. Beesley, Nina R. Goldman, Taher E. Taher, Christopher P. Denton, David J. Abraham, Rizgar A. Mageed, Voon H. Ong
Summary: Systemic sclerosis (SSc) is an immune-mediated rheumatic disease characterized by excessive extracellular matrix deposition. B cells play a fundamental role in the pathogenesis and development of SSc, as they infiltrate lesional sites and produce profibrotic cytokines. B cell counts are increased in SSc patients and show differences in various B cell compartments. B cell signaling is impaired in SSc patients, and B cell depletion therapy has shown therapeutic benefits.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Barbara Russo, Julia Borowczyk, Pietro Cacialli, Philippe Moguelet, Marie-Elise Truchetet, Ali Modarressi, Nicolo C. Brembilla, Julien Bertrand, Wolf-Henning Boehncke, Carlo Chizzolini
Summary: IL-25 plays a role in regulating skin fibrosis, and its decreased expression in systemic sclerosis may contribute to the excessive accumulation of extracellular matrix and progress of fibrosis.
Article
Dentistry, Oral Surgery & Medicine
Ana Guadalupe Gama-Cuellar, Ana Lucia Noronha Francisco, Joao Figueira Scarini, Fernanda Viviane Mariano, Luiz Paulo Kowalski, Rogerio Gondak
Summary: This study investigated the impact of HPV on DCs in TSCC and found that tumor activity leads to a depletion of DCs regardless of HPV positivity. Patients with HPV-positive TSCC have a better overall survival rate.
JOURNAL OF APPLIED ORAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Sho Mokuda, Tatsuhiko Miyazaki, Yuki Ito, Satoshi Yamasaki, Hiroko Inoue, Yun Guo, Weng-Sheng Kong, Masamoto Kanno, Kiyoshi Takasugi, Eiji Sugiyama, Junya Masumoto
SCIENTIFIC REPORTS
(2015)
Article
Medicine, General & Internal
Van Minh Ho, Nobuyuki Hirohashi, Weng-Sheng Kong, Guo Yun, Kohei Ota, Junji Itai, Satoshi Yamaga, Kei Suzuki, Koichi Tanigawa, Masamoto Kanno, Nobuaki Shime
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Biochemistry & Molecular Biology
Tomoyuki Osawa, Yuko Atsumi, Eiji Sugihara, Hideyuki Saya, Masamoto Kanno, Fumio Tashiro, Mitsuko Masutani, Ken-ichi Yoshioka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2013)
Article
Immunology
Masaki Miyazaki, Kazuko Miyazaki, Manarni Itoi, Yuko Katoh, Yun Guo, Rieko Kanno, Yuko Katoh-Fukui, Hiroaki Honda, Takashi Amagai, Maarten van Lohuizen, Hiroshi Kawamoto, Masamoto Kanno
Letter
Rheumatology
Sho Mokuda, Tatsuhiko Miyazaki, Yukari Saeki, Junya Masumoto, Masamoto Kanno, Kiyoshi Takasugi
MODERN RHEUMATOLOGY
(2015)
Article
Biochemistry & Molecular Biology
E. Sugihara, T. Shimizu, K. Kojima, N. Onishi, K. Kai, J. Ishizawa, K. Nagata, N. Hashimoto, H. Honda, M. Kanno, M. Miwa, S. Okada, M. Andreeff, H. Saya
Article
Biochemistry & Molecular Biology
T Nitta, M Nasreen, T Seike, A Goji, I Ohigashi, T Miyazaki, T Ohta, M Kanno, Y Takahama
Article
Biochemistry & Molecular Biology
T Yasuda, M Kanno, M Kawamoto, O Yuge, Y Ninomiya
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2005)
Article
Immunology
M Miyazaki, H Kawamoto, Y Kato, M Itoi, K Miyazaki, K Masuda, S Tashiro, H Ishihara, K Igarashi, T Amagai, R Kanno, M Kanno
JOURNAL OF IMMUNOLOGY
(2005)
Article
Hematology
T Kajiume, Y Ninomiya, H Ishihara, R Kanno, M Kanno
EXPERIMENTAL HEMATOLOGY
(2004)
Article
Biochemistry & Molecular Biology
L Yuge, A Okubo, T Miyashita, T Kumagai, T Nikawa, S Takeda, M Kanno, Y Urabe, M Sugiyama, K Kataoka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2003)
Article
Biochemistry & Molecular Biology
S Fujisaki, Y Ninomiya, H Ishihara, M Miyazaki, R Kanno, T Asahara, M Kanno
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2003)
Article
Medicine, General & Internal
Sho Mokuda, Masamoto Kanno, Kiyoshi Takasugi, Chikara Okumura, Yuki Ito, Junya Masumoto
SAGE OPEN MEDICAL CASE REPORTS
(2014)
Article
Cell Biology
LanLan Liu, Hiroko Inoue, Hirofumi Nakayama, Rieko Kanno, Masamoto Kanno