Edaravone Protects against Methylglyoxal-Induced Barrier Damage in Human Brain Endothelial Cells

Serum methylglyoxal level and its association with oxidative stress and disease severity in patients with psoriasis

(2013) Sirje Kaur et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Novel effects of edaravone on human brain microvascular endothelial cells revealed by a proteomic approach

(2013) Hidetaka Onodera et al.   BRAIN RESEARCH

Safety, Tolerability and Pharmacokinetics of MCI-186 in Patients with Acute Ischemic Stroke: New Formulation and Dosing Regimen

(2013) Markku Kaste et al.   CEREBROVASCULAR DISEASES

In vitro and in vivo characterization of meloxicam nanoparticles designed for nasal administration

(2013) Levente Kürti et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Kinetic Analysis of the Toxicity of Pharmaceutical Excipients Cremophor EL and RH40 on Endothelial and Epithelial Cells

(2013) Lóránd Kiss et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Intravenous Thrombolysis with Neuroprotective Therapy by Edaravone for Ischemic Stroke Patients Older than 80 Years of Age

(2013) Syoichiro Kono et al.   Journal of Stroke & Cerebrovascular Diseases

Aromatic Sulfonamides Containing a Condensed Piperidine Moiety as Potential Oxidative Stress-Inducing Anticancer Agents

(2013) Ramóna Madácsi et al.   Medicinal Chemistry

Hydroxysafflor yellow A protects methylglyoxal-induced injury in the cultured human brain microvascular endothelial cells

(2013) Wenlu Li et al.   NEUROSCIENCE LETTERS

Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier In Vitro

(2013) Roberta Paolinelli et al.   PLoS One

Edaravone Protected Human Brain Microvascular Endothelial Cells from Methylglyoxal-Induced Injury by Inhibiting AGEs/RAGE/Oxidative Stress

(2013) Wenlu Li et al.   PLoS One

Free Radical Scavenger Edaravone Administration Protects against Tissue Plasminogen Activator Induced Oxidative Stress and Blood Brain Barrier Damage

(2012) Violeta Lukic-Panin et al.   CURRENT NEUROVASCULAR RESEARCH

Retinoic acid and hydrocortisone strengthen the barrier function of human RPMI 2650 cells, a model for nasal epithelial permeability

(2012) Levente Kürti et al.   CYTOTECHNOLOGY

Where does plasma methylglyoxal originate from?

(2012) Miklós Péter Kalapos   DIABETES RESEARCH AND CLINICAL PRACTICE

Acute carbonyl stress induces occludin glycation and brain microvascular endothelial barrier dysfunction: Role for glutathione-dependent metabolism of methylglyoxal

(2012) Wei Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

West Nile virus-induced disruption of the blood-brain barrier in mice is characterized by the degradation of the junctional complex proteins and increase in multiple matrix metalloproteinases

(2012) K. Roe et al.   JOURNAL OF GENERAL VIROLOGY

Exploring Mechanisms of Diabetes-Related Macrovascular Complications: Role of Methylglyoxal, a Metabolite of Glucose on Regulation of Vascular Contractility

(2012) Masashi Mukohda et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Methylglyoxal, Cognitive Function and Cerebral Atrophy in Older People

(2012) Velandai Srikanth et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Methylglyoxal promotes oxidative stress and endothelial dysfunction

(2012) Cristina M. Sena et al.   PHARMACOLOGICAL RESEARCH

Exposure to Lipopolysaccharide and/or Unconjugated Bilirubin Impair the Integrity and Function of Brain Microvascular Endothelial Cells

(2012) Filipa L. Cardoso et al.   PLoS One

Hyperhomocysteinemia increases permeability of the blood-brain barrier by NMDA receptor-dependent regulation of adherens and tight junctions

(2011) R. S. Beard et al.   BLOOD

Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome

(2011) Jianghai Liu et al.   CARDIOVASCULAR RESEARCH

Glycation of LDL by Methylglyoxal Increases Arterial Atherogenicity: A Possible Contributor to Increased Risk of Cardiovascular Disease in Diabetes

(2011) N. Rabbani et al.   DIABETES

Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals

(2011) Michal Schnaider Beeri et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Advanced glycation endproducts and their pathogenic roles in neurological disorders

(2010) Gerald Münch et al.   AMINO ACIDS

Deleterious effects of reactive aldehydes and glycated proteins on macrophage proteasomal function: Possible links between diabetes and atherosclerosis

(2010) Fatemeh Moheimani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Diabetes Mellitus, Acute Hyperglycemia, and Ischemic Stroke

(2010) Askiel Bruno et al.   Current Treatment Options in Neurology

Advanced glycation end products on stored red blood cells increase endothelial reactive oxygen species generation through interaction with receptor for advanced glycation end products

(2010) Nilam S. Mangalmurti et al.   TRANSFUSION

Preservation of Cellular Glutathione Status and Mitochondrial Membrane Potential by N-Acetylcysteine and Insulin Sensitizers Prevent Carbonyl Stress-Induced Human Brain Endothelial Cell Apoptosis

(2009) Masahiro Okouchi et al.   CURRENT NEUROVASCULAR RESEARCH

Involvement of ROS in BBB dysfunction

(2009) Pamela B. L. Pun et al.   FREE RADICAL RESEARCH

Dissociation and Protection of the Neurovascular Unit after Thrombolysis and Reperfusion in Ischemic Rat Brain

(2009) Toru Yamashita et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Methylglyoxal mediates vascular inflammation via JNK and p38 in human endothelial cells

(2008) Hideyuki Yamawaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress

(2008) Naila Rabbani et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The tandem of free radicals and methylglyoxal

(2007) Miklós Péter Kalapos   CHEMICO-BIOLOGICAL INTERACTIONS