Article
Biochemistry & Molecular Biology
Marcus Hoering, Georg Peschel, Jonathan Grimm, Sabrina Krautbauer, Martina Mueller, Kilian Weigand, Gerhard Liebisch, Christa Buechler
Summary: This study demonstrates the associations between serum ceramide levels and liver cirrhosis as well as viral genotype. Specific ceramide species are also correlated with factors such as diabetes and age. The serum ceramide profile changes following direct-acting antiviral therapy, with different effects observed for long-chain and very-long-chain ceramides in the liver.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jie Li, Hwai- Yang, Ming-Lun Yeh, Michael H. Le, An K. Le, Yee Hui Yeo, Chia-Yen Dai, Scott Barnett, Jian Q. Zhang, Jee-Fu Huang, Huy N. Trinh, Christopher Wong, Clifford Wong, Joseph K. Hoang, Ramsey Cheung, Ming-Lung Yu, Mindie H. Nguyen
Summary: This study found that concurrent FL in patients with CHB significantly reduces the risk of cirrhosis and HCC, as well as increases the rate of HBsAg seroclearance. Further research is needed to confirm these findings and investigate the underlying mechanisms of FL on CHB.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Gastroenterology & Hepatology
Andre Goemer, Mara Kloehn, Michelle Jagst, Maximilian K. Nocke, Sven Pischke, Thomas Horvatits, Julian Schulze zur Wiesch, Tobias Mueller, Svenja Hardtke, Markus Cornberg, Heiner Wedemeyer, Patrick Behrendt, Eike Steinmann, Daniel Todt
Summary: Chronic HEV infections are a significant issue in immunocompromised patients due to the absence of specifically approved antiviral drugs. A 24-week trial evaluated the efficacy of the nucleotide analog sofosbuvir in treating chronically HEV-infected patients, revealing the emergence of variants with lower sensitivity to the drug.
Article
Biochemistry & Molecular Biology
Georg Peschel, Kilian Weigand, Jonathan Grimm, Martina Mueller, Sabrina Krautbauer, Marcus Hoering, Gerhard Liebisch, Christa Buechler
Summary: This study analyzed the composition of sphingomyelin (SM) in the serum of patients with chronic hepatitis C virus (HCV) infection, and found differences in SM species among different genders, genotypes, and patients with liver cirrhosis. The levels of SM were more closely associated with liver function in male patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Diren Arda Karaoglu, Meral Uner, Cem Simsek, Ali Osmay Gure, Secil Demirkol-Canli
Summary: This study aims to identify patients with hepatitis B infection who are at a higher risk of developing cancer. The results show that liver tissues from hepatitis B patients can be classified based on the levels of messenger RNA produced from genes related to proliferation and inflammation. A subgroup of genes in this panel is associated with cancer development and shorter lifetimes in liver cancer patients. This new gene list has the potential to be used for molecular identification of patients with hepatitis B virus-infected livers and at risk of liver cancer development.
Letter
Gastroenterology & Hepatology
Kenneth I. Zheng, Ming-Hua Zheng
Summary: This article is linked to the paper by Estes et al. Visit the link to view the article.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Microbiology
Jan-Hendrik Bockmann, Matin Kohsar, John M. Murray, Vanessa Hamed, Maura Dandri, Stefan Luth, Ansgar W. Lohse, Julian Schulze-zur-Wiesch
Summary: The combination of metabolic diseases and CHB significantly increases the rates of liver cirrhosis and liver-related events. Diabetes is the most significant predictor for cirrhosis.
Article
Gastroenterology & Hepatology
Helenie Kefalakes, Xylia J. Horgan, Min Kyung Jung, Georgios Amanakis, Devika Kapuria, Fabian J. Bolte, David E. Kleiner, Christopher Koh, Theo Heller, Barbara Rehermann
Summary: This study found that patients infected with HDV had reduced but more activated innate immune cell populations in the liver, and an activated, memory-like, tissue-resident HDV-specific CD8(+) T-cell cluster was identified. Antigen-nonspecific activation of liver-resident CD8(+) T cells may contribute to inflammation and disease progression in HDV infection.
Article
Virology
Mohammad Alkhatib, Velia Chiara Di Maio, Valentina De Murtas, Ennio Polilli, Martina Milana, Elisabetta Teti, Gianluca Fiorentino, Vincenza Calvaruso, Silvia Barbaliscia, Ada Bertoli, Rossana Scutari, Luca Carioti, Valeria Cento, Maria Mercedes Santoro, Alessandro Orro, Ivana Maida, Ilaria Lenci, Loredana Sarmati, Antonio Craxi, Caterina Pasquazzi, Giustino Parruti, Sergio Babudieri, Luciano Milanesi, Massimo Andreoni, Mario Angelico, Carlo Federico Perno, Francesca Ceccherini-Silberstein, Valentina Svicher, Romina Salpini
Summary: Specific mutations in the HCV NS5A domain-1 are significantly associated with hepatocellular carcinoma (HCC), potentially impacting viral fitness and interactions with cellular proteins. Further investigation is warranted to understand the molecular basis of HCV-mediated oncogenesis and the persistence of pro-oncogenic stimuli despite sustained virological response.
Article
Gastroenterology & Hepatology
Hye Yeon Chon, Han Ah Lee, Sang Jun Suh, Jung Il Lee, Byung Seok Kim, In Hee Kim, Chang Hyeong Lee, Byoung Kuk Jang, Hyun Woong Lee, Jae Seok Hwang, Chang Hun Lee, Jin-Woo Lee, Jung Hwan Yu, Yeon Seok Seo, Hyung Joon Yim, Seung Up Kim
Summary: The predictive accuracies of the PAGE-B and mPAGE-B models were validated in Korean patients with CHB receiving AVT. However, the modified PAGE(LS)-B model featuring the addition of LS value showed higher predictability than the PAGE-B and mPAGE-B models. Participants with higher risk scores showed significantly higher cumulative HCC incidence compared to those in the intermediate-risk or low-risk groups.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Francesco Paolo Russo, Alberto Zanetto, Elisa Pinto, Sara Battistella, Barbara Penzo, Patrizia Burra, Fabio Farinati
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related death, with chronic viral hepatitis being a significant contributing factor. The pathophysiology of viral-related HCC involves liver inflammation, oxidative stress, and deregulation of cell signaling pathways. Regular ultrasound surveillance is recommended for patients with cirrhosis and high-risk individuals with chronic HBV infection. Antiviral therapy reduces the risks of HCC development and recurrence. Various scoring systems have been developed to predict the risk of HCC development in patients with chronic hepatitis B.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Georg Peschel, Jonathan Grimm, Martina Mueller, Marcus Hoering, Sabrina Krautbauer, Kilian Weigand, Gerhard Liebisch, Christa Buechler
Summary: The study investigates the associations between serum triglycerides and viral genotype as well as markers of liver disease severity in patients with chronic hepatitis C. The results suggest that there are sex-specific changes in lipid metabolism, with lower serum triglycerides observed in HCV-infected women compared to men. Male patients with liver cirrhosis and genotype 3a infection have reduced levels of certain triglycerides. These genotype-related changes disappear after direct-acting antiviral therapy. Interestingly, the levels of serum triglycerides remain unchanged during therapy in both sexes.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Microbiology
Alexis Jose-Abrego, Sonia Roman, Joao Renato Rebello Pinho, Vanessa Fusco Duarte de Castro, Arturo Panduro
Summary: Infection with mixtures of HBV genotypes is common in HIV patients, particularly in cases with triple genotype mixtures, leading to significant hepatic fibrosis. Triple-mixed infection is associated with high viral load and severe liver fibrosis in this population.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Gustaf E. Rydell, Kasthuri Prakash, Simon B. Larsson, Catarina Skoglund, Johan Ringlander, Maria Andersson, Maria Castedal, Helene Norder, Magnus Lindh
Summary: Hepatitis B virus (HBV) RNA levels showed significant variation between different tissue samples, with up to a 1000-fold difference. When replication was high, core RNA and S RNA levels were similar, indicating transcription from covalently closed circular DNA (cccDNA). In patients with medium-high or low replication, enhanced expression of S RNA relative to cccDNA and core RNA suggested that HBsAg can be primarily expressed from integrated HBV DNA.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Economics
Hannah E. Carter, Gary P. Jeffrey, Grant A. Ramm, Louisa G. Gordon
Summary: The study found that risk-stratified screening and all-inclusive screening for HCC in Australia are more cost-effective compared to no formal screening, with all-inclusive screening being the most likely cost-effective option at a WTP threshold of A$50,000 per QALY. Risk-stratified screening using a serum biomarker test may be cost-effective at lower WTP thresholds, such as between A$25,000 and A$35,000 per QALY.
Article
Surgery
Arkadeep Dhali, Sukanta Ray, Avik Sarkar, Sujan Khamrui, Somak Das, Tuhin Subhra Mandal, Dijendra Nath Biswas, Gopal Krishna Dhali
Summary: This study retrospectively analyzed patients with bleeding pseudoaneurysms in the setting of chronic pancreatitis, showing that both embolization and surgery are important in its management, with the choice of procedure depending on local availability and feasibility of a particular technique. Intraoperative blood transfusion, surgical time, and blood loss were important indicators in the management of PSA.
UPDATES IN SURGERY
(2022)
Article
Medicine, General & Internal
Arkadeep Dhali, Sukanta Ray, Tuhin Subhra Mandal, Somak Das, Avik Sarkar, Sujan Khamrui, Gopal Krishna Dhali
Summary: This study retrospectively reports the experience of surgical intervention for pancreatic ascites and pancreatic pleural effusions caused by chronic pancreatitis. The results show that in experienced hands, surgery can be performed with acceptable perioperative morbidity and mortality and long-term satisfactory outcomes.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Surgery
Arkadeep Dhali, Sukanta Ray, Tuhin S. Mandal, Somak Das, Ranajoy Ghosh, Sujan Khamrui, Gopal K. Dhali, Avik Sarkar
Summary: This study explored the clinical profile of Brunner's gland hamartomas (BGH) from the surgeon's point of view. Although endoscopic management is the first-line treatment, surgery plays an important role, particularly if endoscopic treatment fails or is not feasible.
Article
Medicine, General & Internal
Arkadeep Dhali, Sukanta Ray, Gopal Krishna Dhali, Sujan Khamrui, Ranajoy Ghosh
Summary: Extrahepatic mucinous biliary cystadenoma is a rare condition with vague clinical signs and symptoms. Gastric outlet obstruction caused by this condition has not been reported before. The article highlights the diagnostic dilemma faced when radiological investigations cannot determine the origin of the disease.
CLINICAL CASE REPORTS
(2022)
Article
Physiology
Alyssa D. Brown, Matthew J. Fogarty, Leah A. Davis, Debanjali Dasgupta, Carlos B. Mantilla, Gary C. Sieck
Summary: Two weeks of diaphragm inactivity caused by C2SH resulted in reduced mitochondrial volume density, mitochondrial fragmentation, and a reduction of SDHmax in type I and IIa DIAm fibers. Type I and IIa DIAm fibers were more sensitive to inactivation compared to type IIx/IIb fibers. These findings suggest that mitochondria in DIAm fibers are adaptable to varying levels of activity.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Surgery
Arkadeep Dhali, Sukanta Ray, Somak Das, Tuhin Subhra Mandal, Sujan Khamrui, Arunesh Gupta, Zuber Ansari, Ranajoy Ghosh, Gopal Krishna Dhali
Summary: This retrospective study reports the experience of handling SPN in a tertiary center of Eastern India over a 14-year period. Most of the 28 patients were female, and the common symptoms were abdominal pain and palpable abdominal mass. Despite the large size of the tumors, complete surgical resection was possible. The postoperative complications were relatively high, but no patients developed recurrence during the follow-up period.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Arkadeep Dhali, Sukanta Ray, Ranajoy Ghosh, Debashis Misra, Gopal Krishna Dhali
Summary: This study retrospectively analyzed the experience of performing Whipple's procedure for groove pancreatitis (GP) in Indian patients. The results showed that Whipple's procedure had acceptable perioperative outcomes and good long-term symptom control. However, there was a certain rate of postoperative complications.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Multidisciplinary Sciences
Tsuyoshi Suda, Yukihiro Shirota, Hiroaki Takimoto, Yasunori Tsukada, Kensaku Takishita, Takahiro Nadamura, Masaki Miyazawa, Yuji Hodo, Tokio Wakabayashi
Summary: This study aimed to assess whether esophagogastroduodenoscopy (EGD) using carbon dioxide (CO2) insufflation affects the image quality of subsequent abdominal ultrasonography (AUS). The results showed that the use of CO2 during EGD did not significantly deteriorate the image quality of subsequent AUS. Therefore, it is permissible to perform EGD prior to AUS, which can improve the efficiency of examination setup.
Article
Medicine, General & Internal
Jyotirmoy Biswas, Siddhartha Nath, Sukanta Ray, Arkadeep Dhali, Kankana Karpha, Gopal Krishna Dhali
Summary: Choledochal cyst (CC) is a rare congenital abnormality of the biliary system, with CC larger than 10 cm being even rarer. This case report highlights a 25 x 18 cm CC and emphasizes the good prognosis that can be achieved through timely diagnosis and definitive treatment, regardless of the size.
CLINICAL CASE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Philippe Delmotte, Jane Q. Yap, Debanjali Dasgupta, Gary C. Sieck
Summary: Airway inflammation and pro-inflammatory cytokines play a significant role in the development of respiratory diseases. In this study, we investigated the potential of the chemical chaperone 4-PBA to mitigate TNFα-induced ER stress in hASM cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Prasenjit Halder, Susree Roy, Soma Banerjee, Syamsundar Mandat, Kausik Das, Abhijit Chowdhury, Sk Mahiuddin Ahammed
Summary: The aim of this study was to investigate the clinical profile of acute on chronic liver failure (ACLF) and establish Cell-free DNA (Cf DNA) as a predictor of ACLF outcome. The results showed that alcohol and sepsis were the most common causes of acute insult. Cf DNA was found to be a better predictor of 28-day mortality, while CLIF-C ACLF was more accurate in predicting 90-day mortality.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Debanjali Dasgupta, Sanjana Mahadev Bhat, Alexis L. L. Price, Philippe Delmotte, Gary C. C. Sieck
Summary: Inflammatory cytokines like TNFa promote airway inflammation. Our study explored the mechanism by which TNFa increases mitochondrial biogenesis in human ASM cells, finding that it involves the phosphorylation of CREB and ATF1, which in turn co-activate the expression of PGC1a. We demonstrated that TNFa treatment of hASM cells resulted in increased mitochondrial volume density, biogenesis, and the activation of downstream transcription factors NRF1, NRF2, and TFAM via the pCREB(S133)/pATF1(S63)/PCG1a pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Partha Sarathi Mukherjee, Sujoy Ghosh, Pradip Mukhopadhyay, Dipesh Kumar Das, Pabak Sarkar, Saibal Majumdar, Kajal Chatterjee, Abhijit Chowdhury, Kausik Das
Summary: This study aimed to assess the prevalence of metabolically unhealthy subjects and their risk of significant NAFLD in a resource-poor community. The results showed that at least one risk factor was present in 51.4% of the subjects, and 63% of the subjects with metabolic abnormality had MU state, with 53% of MU subjects having the risk of significant NAFLD.
LANCET REGIONAL HEALTH - SOUTHEAST ASIA
(2023)
Article
Medicine, General & Internal
Jyotirmoy Biswas, Arkadeep Dhali, Sumana Panja, Kankana Karpha, Siddhartha Nath, Gopal Krishna Dhali
Summary: The study found a significant difference between the two cohorts, with the use of safety lancets reducing fear, anxiety, and pain compared to hypodermic needles. This suggests that using safety lancets in medical teaching institutions could provide psychological advantages and improve the overall quality of the process.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Meeting Abstract
Critical Care Medicine
D. Dasgupta, P. Delmotte, S. Mahadev Bhat, Y. S. Han, C. C. Creighton, C. Cortes Botero, G. C. Sieck
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
