Article
Multidisciplinary Sciences
Matthew T. Patrick, Qinmengge Li, Rachael Wasikowski, Nehal Mehta, Johann E. Gudjonsson, James T. Elder, Xiang Zhou, Lam C. Tsoi
Summary: This study identifies shared genetic loci between psoriasis and coronary artery disease through trans-disease meta-analysis, and prioritizes genes associated with inflammatory signaling. It also suggests that chronic systemic inflammation can increase the risk of psoriasis and cause coronary artery disease.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Derek Klarin, Philip S. Tsao, Scott M. Damrauer
Summary: Peripheral artery disease is a common and complex disease with both environmental and genetic determinants. Recent advances in genetic analysis have focused on identifying disease genes, rare variant and structural variant analysis, and the inclusion of individuals with diverse genetic ancestries in future studies.
CIRCULATION RESEARCH
(2021)
Article
Clinical Neurology
Ana Luiza Vieira de Araujo, Raul D. Santos, Marcio Sommer Bittencourt, Roberto Nery Dantas, Carlos Andre Oshiro, Cesar Higa Nomura, Edson Bor-Seng-Shu, Marcelo de Lima Oliveira, Claudia da Costa Leite, Maria da Graca Morais Martin, Maramelia Miranda Alves, Gisele Sampaio Silva, Victor Marinho Silva, Adriana Bastos Conforto
Summary: The frequency of coronary calcification is higher in patients with stroke or transient ischemic attack caused by large-artery atherosclerosis than in controls. CAC scores are even higher in patients with stenosis in both cervical and intracranial arteries.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Hakon Ihle-Hansen, Hege Ihle-Hansen, Else Charlotte Sandset, Guri Hagberg
Summary: The presence of carotid artery atherosclerosis is a promising marker for risk stratification, with recent evidence suggesting it affects cognitive function. Non-invasive ultrasound can easily visualize it, potentially enabling early management to preserve cognitive function. As the population ages, there is a need to identify individuals at risk.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Sadiya S. Khan, Wendy S. Post, Xiuqing Guo, Jingyi Tan, Fang Zhu, Daniel Bos, Bahar Sedaghati-Khayat, Jeroen van Rooij, Aaron Aday, Norrina B. Allen, Maxime M. Bos, Andre G. Uitterlinden, Matthew J. Budoff, Donald M. Lloyd-Jones, Jonathan D. Mosley, Jerome I. Rotter, Philip Greenland, Maryam Kavousi
Summary: Coronary artery calcium score and polygenic risk score were evaluated for their ability to predict risk of coronary heart disease (CHD) in two population-based studies. The results showed that coronary artery calcium score had better discrimination and improved risk prediction when added to traditional risk factors compared to the polygenic risk score.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Alessandra Scoccia, Guglielmo Gallone, Alberto Cereda, Anna Palmisano, Davide Vignale, Riccardo Leone, Valeria Nicoletti, Chiara Gnasso, Alberto Monello, Arif Khokhar, Alessandro Sticchi, Andrea Biagi, Carlo Tacchetti, Gianluca Campo, Claudio Rapezzi, Francesco Ponticelli, Gian Battista Danzi, Marco Loffi, Gianluca Pontone, Daniele Andreini, Gianni Casella, Gianmarco Iannopollo, Davide Ippolito, Giacomo Bellani, Gianluigi Patelli, Francesca Besana, Claudia Costa, Luigi Vignali, Giorgio Benatti, Mario Iannaccone, Paolo Giacomo Vaudano, Alberto Pacielli, Caterina Chiara De Carlini, Stefano Maggiolini, Pietro Andrea Bonaffini, Michele Senni, Elisa Scarnecchia, Fabio Anastasio, Antonio Colombo, Roberto Ferrari, Antonio Esposito, Francesco Giannini, Marco Toselli
Summary: In hospitalized COVID-19 patients, the presence and extent of coronary artery disease (CAD) are associated with in-hospital mortality and MI/CVA events, and they appear to be better prognostic indicators compared to clinical cardiovascular risk assessment.
Article
Clinical Neurology
Felice Lin, Judy Pa, Roksana Karim, Howard N. Hodis, S. Duke Han, Victor W. Henderson, Jan A. St John, Wendy J. Mack
Summary: The study aimed to investigate the association between subclinical atherosclerosis and changes in cognitive function in older adults. The results showed an association between subclinical atherosclerosis and changes in global cognitive function over 2.5 years in healthy older adults.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Editorial Material
Medicine, General & Internal
Michael McDermott, David E. Newby
Summary: In this study, Fuchs et al. analyzed the outcomes of 9533 adults who underwent coronary computed tomography angiography. The unique data provided by this study on the natural history of coronary artery disease will be valuable for informing prevention strategies.
ANNALS OF INTERNAL MEDICINE
(2023)
Review
Medicine, General & Internal
Alyssa L. S. Chow, Saad D. Alhassani, Andrew M. Crean, Gary R. Small
Summary: The article discusses the roles of CCTA and CAC-scoring in subclinical atherosclerosis, as well as their applications in screening and guiding therapy, suggesting that CCTA plays an essential role in the detection and management of clinical coronary artery disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Laurits Juhl Heinsen, Gokulan Pararajasingam, Thomas Rueskov Andersen, Soren Auscher, Hussam Mahmoud Sheta, Helle Precht, Jess Lambrechtsen, Kenneth Egstrup
Summary: This study found a high prevalence of HRP in asymptomatic T2D patients, with HRP detection associated with specific patient characteristics. HRP was not correlated with high CACS, as HRP could be found even in patients with zero CACS.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Ruijun Liu, Jing Shao
Summary: The article reviews the reasons for the increasing number of cardiovascular and cerebrovascular disease patients in recent years, as well as the related risk factors, providing a theoretical basis for early detection and treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Tim R. Sakkers, Michal Mokry, Mete Civelek, Jeanette Erdmann, Gerard Pasterkamp, Ernest Diez Benavente, Hester M. den Ruijter
Summary: Sex differences in coronary artery disease have been extensively studied, but the genetic and molecular mechanisms underlying these differences remain fragmented. Through genetic and epigenetic studies, over 40 sex-differential candidate genes have been identified, which may explain the differences in vascular remodeling, lipid metabolism, and endothelial dysfunction. Further research is needed to unravel the complex mechanisms driving these sex differences.
Article
Multidisciplinary Sciences
Helena Eriksson, Kjell Toren, Annika Rosengren, Eva Andersson, Mia Soderberg
Summary: The study suggests that exposure to high strain or active job situations may increase the risk of coronary artery calcium in men, while in women, it may be more associated with exposure to passive job.
Article
Medical Informatics
Tyler Hyungtaek Rim, Chan Joo Lee, Yih-Chung Tham, Ning Cheung, Marco Yu, Geunyoung Lee, Youngnam Kim, Daniel S. W. Ting, Crystal Chun Yuen Chong, Yoon Seong Choi, Tae Keun Yoo, Ik Hee Ryu, Su Jung Baik, Young Ah Kim, Sung Kyu Kim, Sang-Hak Lee, Byoung Kwon Lee, Seok-Min Kang, Edmund Yick Mun Wong, Hyeon Chang Kim, Sung Soo Kim, Sungha Park, Ching-Yu Cheng, Tien Yin Wong
Summary: This study developed a novel cardiovascular risk stratification system based on deep-learning-predicted coronary artery calcium (CAC) from retinal photographs, which showed promising results in predicting cardiovascular events and improving current risk stratification approaches.
LANCET DIGITAL HEALTH
(2021)
Article
Medicine, Research & Experimental
Ignacio Fernando Hall, Montserrat Climent, Chiara Viviani Anselmi, Laura Papa, Vinicius Tragante, Luca Lambroia, Floriana Maria Farina, Marcus E. Kleber, Winfried Maerz, Carlo Biguori, Gianluigi Condorelli, Leonardo Elia
Summary: The study identifies a SNP, rs41291957 (A), near the miR-143/145 cluster that upregulates miR-143 and miR-145, modulating vascular smooth cell phenotype and acting as a protective factor against coronary artery disease.
EMBO MOLECULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Martijn J. Tilly, Sven Geurts, Angelo M. Pezzullo, Wichor M. Bramer, Natasja M. S. de Groot, Maryam Kavousi, Moniek P. M. de Maat
Summary: This study aims to summarize and analyze the evidence on the associations between coagulation factors and atrial fibrillation (AF) in both longitudinal and cross-sectional studies. The findings suggest that higher levels of coagulation factors are associated with both prevalent and incident AF, with the associations being more pronounced in cross-sectional studies. Limited evidence from longitudinal studies suggests a prothrombotic state underlying AF development.
Article
Geriatrics & Gerontology
Sara R. A. Wijnant, Elizabeth Benz, Annemarie Luik, Fernando Rivadeneira, Trudy Voortman, Guy G. Brusselle, Lies Lahousse
Summary: Frailty transitions are more common in participants with PRISm or COPD, and physical frailty assessment improves risk stratification for predicting increased life years in patients with impaired spirometry.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Robert Clarke, Adam Von Ende, Lukas E. Schmidt, Xiaoke Yin, Michael Hill, Alun D. Hughes, Raimund Pechlaner, Johann Willeit, Stefan Kiechl, Hugh Watkins, Konstantinos Theofilatos, Jemma C. Hopewell, Manuel Mayr
Summary: This study assessed the relevance of 13 apolipoproteins measured using a single mass-spectrometry assay for risk of coronary heart disease (CHD), and found that some apolipoproteins were independently associated with CHD. These results suggest that apolipoproteins could help identify patients with residual lipid-related risk and guide personalized approaches to CHD risk reduction.
CIRCULATION RESEARCH
(2023)
Article
Clinical Neurology
Madeleine Johansson, Artur Fedorowski, Jens Jordan, Gunnar Engstrom, Peter M. Nilsson, Viktor Hamrefors
Summary: This study investigated the relationship between orthostatic blood pressure adaptations, central aortic hemodynamics, and aortic stiffness in a younger population. The findings suggest that altered blood pressure responses to orthostatic challenges are independently and inversely associated with markers of aortic stiffness.
CLINICAL AUTONOMIC RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Uxio Hermida, David Stojanovski, Betty Raman, Rina Ariga, Alistair A. Young, Valentina Carapella, Gerry Carr-White, Elena Lukaschuk, Stefan K. Piechnik, Christopher M. Kramer, Milind Y. Desai, William S. Weintraub, Stefan Neubauer, Hugh Watkins, Pablo Lamata
Summary: This study aimed to identify the left ventricular end-diastolic morphology underlying obstructive hypertrophic cardiomyopathy (oHCM). The results suggest that LV anatomy of oHCM consists of basal septal hypertrophy, apical dilatation, LV lengthening, and LVOT inward remodelling. Significant differences were observed between oHCM cases at rest and stress. Genotype negative cases tended to have more severe obstructive phenotypes at both rest and stress.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Juliana Alexandra Hernandez Vargas, Silvia Juliana Trujillo-Caceres, Julieth Pilar Uriza-Pinzon, Oscar H. Franco
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Banafsheh Arshi, Hamid A. Aliahmad, M. Arfan Ikram, Daniel Bos, Maryam Kavousi
Summary: A larger epicardial fat volume (EFV) is associated with increased risks of cardiovascular disease and atrial fibrillation. This study found that EFV is also associated with impaired cardiac function and an increased risk of heart failure (HF).
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Letter
Critical Care Medicine
Guy Brusselle, Sebastian Riemann
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Guy Brusselle, Sebastian Riemann
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Z. Ashkir, S. Johnson, A. J. Lewandowski, A. Hess, E. Wicks, M. Mahmod, S. Myerson, T. Ebbers, H. Watkins, S. Neubauer, C. J. Carlhall, B. Raman
Summary: Non-obstructive hypertrophic cardiomyopathy (HCM) is characterized by altered blood flow haemodynamics and increased risk of adverse clinical events. Four-dimensional flow cardiac magnetic resonance (4D-flow CMR) enables comprehensive characterization of ventricular blood flow patterns. This study assessed flow component changes in non-obstructive HCM and their relationship with phenotypic severity and sudden cardiac death (SCD) risk.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Clinical Neurology
Elin Dybjer, Atul Kumar, Katarina Nagga, Gunnar Engstrom, Niklas Mattsson-Carlgren, Peter M. Nilsson, Olle Melander, Oskar Hansson
Summary: Dybjer et al. found that the polygenic risk of type 2 diabetes is associated with the risk of dementia, especially vascular dementia. However, further analysis did not support a causal relationship between type 2 diabetes and vascular dementia. It is still unclear whether the genetic risk markers for type 2 diabetes and dementia are the same or if there is a causal link between the two diseases.
BRAIN COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Sven Geurts, Martijn J. Tilly, Jan A. Kors, Jaap W. Deckers, Bruno H. C. Stricker, Natasja M. S. de Groot, M. Arfan Ikram, Maryam Kavousi
Summary: The study aims to assess the association and sex differences in electrocardiographic parameters with new-onset atrial fibrillation (AF). A total of 12,212 participants from the Rotterdam Study were included. The findings showed that the associations between electrocardiographic parameters and new-onset AF were mostly U- and N-shaped, with significant sex differences observed. Longitudinal measures of PR and QTc interval were significantly associated with new-onset AF, especially in men.
Editorial Material
Cardiac & Cardiovascular Systems
Vicente Artola Arita, Juliana Alexandra Hernandez Vargas, Oscar H. Franco
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Fang Zhu, Danielle Noordermeer, Elif Aribas, Maxime Bos, Eric Boersma, Maryam Kavousi
Summary: Hypertension, diabetes, and lipoprotein metabolism disorders mediate the association between miscarriage and various cardiovascular outcomes. Hypertension plays the largest role in mediating the relationship between miscarriage and atherosclerotic cardiovascular events. Women who have experienced miscarriage should be regularly monitored for blood pressure, blood lipids, and glucose to reduce their long-term cardiovascular risk.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jeanine E. Roeters van Lennep, Lale S. Tokgozoglu, Lina Badimon, Sandra M. Dumanski, Martha Gulati, Connie N. Hess, Kirsten B. Holven, Maryam Kavousi, Meral Kayikcioglu, Esther Lutgens, Erin D. Michos, Eva Prescott, Jane K. Stock, Anne Tybjaerg-Hansen, Marieke J. H. Wermer, Marianne Benn
Summary: Cardiovascular disease is the leading cause of death globally, with women experiencing the fastest relative increase in middle-aged mortality. In addition to missed or delayed diagnosis and undertreatment, sex-specific factors contribute to increased cardiovascular risk in women. The European Atherosclerosis Society's position statement focuses on the impact of gender-specific factors and the effects of these factors on women's lifelong lipid profiles, including lipoprotein(a). Sociocultural components further compound these effects. Early identification and treatment of modifiable cardiovascular risk factors in women, especially those related to sex-specific conditions, are necessary to reduce the high burden of cardiovascular disease in women.
EUROPEAN HEART JOURNAL
(2023)
