Detecting cathepsin activity in human osteoarthritis via activity-based probes

Cysteine cathepsins and extracellular matrix degradation

(2014) Marko Fonović et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A novel Bruch's membrane-mimetic electrospun substrate scaffold for human retinal pigment epithelium cells

(2014) Ping Xiang et al.   BIOMATERIALS

A Lipidomic Study of Phospholipid Classes and Species in Human Synovial Fluid

(2013) Marta Krystyna Kosinska et al.   ARTHRITIS AND RHEUMATISM

Effects of Cysteine Proteases on the Structural and Mechanical Properties of Collagen Fibers

(2013) Preety Panwar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Set7/9 ImpactsCOL2A1Expression Through Binding and Repression of SirT1 Histone Deacetylation

(2013) Hanna Oppenheimer et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice

(2012) Odile Gabay et al.   ANNALS OF THE RHEUMATIC DISEASES

The proinflammatory cytokines interleukin-1α and tumor necrosis factor α promote the expression and secretion of proteolytically active cathepsin S from human chondrocytes

(2012) Dejan Caglič et al.   BIOLOGICAL CHEMISTRY

Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis

(2012) Tadashi Hayami et al.   BONE

Osteoarthritis year 2012 in review: biomarkers

(2012) A. Mobasheri   OSTEOARTHRITIS AND CARTILAGE

Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes

(2011) Mona Dvir-Ginzberg et al.   ARTHRITIS AND RHEUMATISM

Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model

(2011) Anna K. Clark et al.   ARTHRITIS AND RHEUMATISM

75-kd sirtuin 1 blocks tumor necrosis factor α-mediated apoptosis in human osteoarthritic chondrocytes

(2011) Hanna Oppenheimer et al.   ARTHRITIS AND RHEUMATISM

Non-Invasive Imaging of Cysteine Cathepsin Activity in Solid Tumors Using a 64Cu-Labeled Activity-Based Probe

(2011) Gang Ren et al.   PLoS One

Optimization of matrix metalloproteinase fluorogenic probes for osteoarthritis imaging

(2010) Ju Hee Ryu et al.   AMINO ACIDS

Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis

(2010) Urška Požgan et al.   BIOLOGICAL CHEMISTRY

Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions

(2010) Norifumi Fujita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis

(2010) J.J. McDougall et al.   OSTEOARTHRITIS AND CARTILAGE

Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis

(2009) J.R. Connor et al.   OSTEOARTHRITIS AND CARTILAGE

Comparative Assessment of Substrates and Activity Based Probes as Tools for Non-Invasive Optical Imaging of Cysteine Protease Activity

(2009) Galia Blum et al.   PLoS One

Regulation of Cartilage-specific Gene Expression in Human Chondrocytes by SirT1 and Nicotinamide Phosphoribosyltransferase

(2008) Mona Dvir-Ginzberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of collagenous matrix assembly in a chondrocyte model system

(2008) Sorcha Yingst et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A