Article
Multidisciplinary Sciences
Maira Bonini, Gianna Serafina Monti, Matteo Maria Pelagatti, Valentina Ceriotti, Elisabetta Elena Re, Barbara Brame, Paolo Bottero, Anna Tosi, Adriano Vaghi, Alberto Martelli, Giovanni Maria Traina, Loredana Rivolta, Federica Rivolta, Claudio Maria Ortolani
Summary: In this study, the correlation between ragweed pollen concentration and symptom severity in patients allergic to ragweed pollen was investigated. The effectiveness of ragweed allergen immunotherapy was also assessed. The results showed a significant correlation between pollen load and symptom intensity, and patients treated with immunotherapy had significantly reduced symptom levels.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Merlijn van Breugel, Cancan Qi, Zhongli Xu, Casper-Emil T. Pedersen, Ilya Petoukhov, Judith M. Vonk, Ulrike Gehring, Marijn Berg, Marnix Buegel, Orestes A. Carpaij, Erick Forno, Andreanne Morin, Anders U. Eliasen, Yale Jiang, Maarten Van den Berge, Martijn C. Nawijn, Yang Li, Wei Chen, Louis J. Bont, Klaus Bonnelykke, Juan C. Celedon, Gerard H. Koppelman, Cheng-Jian Xu
Summary: The study demonstrates that nasal DNA methylation is the most accurate predictor for diagnosing childhood allergic diseases, identifying multimorbidity and IgE sensitization, with findings replicated in children of different ages and ethnicities.
NATURE COMMUNICATIONS
(2022)
Article
Allergy
Conny Hoeflich, Galina Balakirski, Zuzanna Hajdu, Jens Malte Baron, Katharina Fietkau, Hans F. Merk, Ulrich Strassen, Henning Bier, Wolfgang Dott, Hans-Guido Muecke, Wolfgang Straff, Gerda Wurpts, Amir S. Yazdi, Adam Chaker, Stefani T. M. Roeseler
Summary: The study showed varying sensitization rates to both common and non-frequent pollen allergens in adult patients from two German federal states. Sensitization to non-frequent pollen allergens needs to be considered for patients with seasonal symptoms, and availability of test allergens for these less common allergies is important for patient management. Data on sensitization correlated partly with each other and with symptom periods, showing a seasonal pattern similar to pollen data.
CLINICAL AND TRANSLATIONAL ALLERGY
(2021)
Article
Immunology
Yanlu Che, Nan Wang, Qianzi Ma, Junjie Liu, Zhaonan Xu, Qiuying Li, Jingting Wang, Yanan Sun
Summary: This study investigated the differences in nasal flora composition between patients with allergic rhinitis (AR) and non-allergic rhinitis (nAR) and their role in pathogenesis. The results showed that AR patients had a significantly higher abundance of Vibrio vulnificus and Acinetobacter baumanni in the nasal cavity compared to nAR patients, while the abundance of Lactobacillus murinus, Lactobacillus iners, Proteobacteria, Pseudomonadales, and Escherichia coli was lower. The study also identified specific bacterial models associated with AR and nAR, providing new insights for their treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Joan Domenech Witek, Rosario Gonzalez Mendiola, Vicente Jover Cerda, Javier Pereira Gonzalez, Clara Carballas Vazquez, Felicitas Villas Martinez, Ramon Rodriguez Pacheco
Summary: This study aims to report the sensitivities to environmental, food allergens, and panallergens in patients with eosinophilic oesophagitis with atopic background, as well as characterizing other markers or analytical parameters. We suspect that the prevalence of sensitization to panallergens will be high and this will probably be relevant in terms of the onset and clinical course of the disease.
SCIENTIFIC REPORTS
(2023)
Article
Allergy
Nicholas J. Campion, Sergio Villazala-Merino, Ryan S. Thwaites, Victoria Stanek, Helen Killick, Eleftheria Pertsinidou, Mohammed Zghaebi, Josef Toth, Renate Froschl, Thomas Perkmann, Katharina Gangl, Sven Schneider, Robin Ristl, Ian C. Scott, Emma Suzanne Cohen, Magnus Molin, Margit Focke-Tejkl, Guenther Regelsberger, Trevor T. Hansel, Rudolf Valenta, Verena Niederberger-Leppin, Julia Eckl-Dorna
Summary: This study aimed to characterize the immunologic and clinical nasal responses to birch pollen allergen challenge, with a special focus on the late allergic response.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tatsuro Nakamura, Yuri Tachibana, Takahisa Murata
Summary: The study revealed that 8-iso-prostaglandin E-2 (PGE(2)) may serve as a ligand for TP-mediated nasal obstruction in mice.
Article
Allergy
Andreas Horn, David I. Bernstein, Kimihiro Okubo, Terrie Dalgaard, Ole Hels, Helle Frobose Sorensen, Marianne Henriksen, Ryuji Azuma, Jan Mikler, Hendrik Nolte
Summary: The MT-18 trial demonstrated the safety of HDM sublingual immunotherapy tablet in European adolescents with allergic rhinitis. The results showed that the efficacy and safety of the treatment in adolescents were similar to those in adults.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Elena Cantone, Aikaterini Detoraki, Eugenio De Corso
Summary: This review discusses the features of local allergic rhinitis (LAR) as an independent endotype. Allergic rhinitis (AR) and nonallergic rhinitis (NAR) are two subtypes of chronic rhinitis, while LAR is a subtype of AR characterized by a localized nasal allergic response with negative skin prick testing to allergens in the absence of serum-specific IgE.
APPLIED SCIENCES-BASEL
(2022)
Article
Medicine, General & Internal
Siti Muhamad Nur Husna, Norasnieda Md Shukri, Hern-Tze Tina Tan, Noor Suryani Mohd Ashari, Kah Keng Wong
Summary: This study investigated the association between SPT wheal sizes of common house dust mite allergens and demographic, clinical, and environmental characteristics, as well as nasal and non-nasal symptom severity scores in AR patients. The results showed that SPT wheal sizes were not associated with clinical, demographic, and environmental characteristics, but significant correlations were observed between SPT wheal sizes of D. farinae sensitization and severity scores of nasal and non-nasal symptoms. Increased SPT wheal sizes for D. farinae sensitization may predict more severe nasal and, to a lesser extent, non-nasal manifestations in AR patients.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Hahn Jin Jung, Young-Kyung Ko, Woo Sub Shim, Hyun Jik Kim, Dong-Young Kim, Chae-Seo Rhee, Moo Kyun Park, Doo Hee Han
Summary: This study investigated the effect of DEP exposure on allergic rhinitis using a mouse model sensitized to house dust mite. The results showed that mice co-exposed to HDM and DEP exhibited increased allergic symptom scores compared to mice exposed to HDM alone. This suggests that DEP may exacerbate allergic rhinitis by increasing levels of interleukin-17A in the nasal mucosa.
SCIENTIFIC REPORTS
(2021)
Review
Microbiology
Tetsuya Terada, Ryo Kawata
Summary: Local allergic rhinitis (LAR) is a unique form of chronic rhinitis that is neither classical allergic rhinitis (AR) nor non-AR. LAR is often underdiagnosed and affects children and adults worldwide. It shares many features with AR, including positive nasal allergen provocation test (NAPT) and presence of type 2 inflammatory markers.
Review
Otorhinolaryngology
Navarat Kasemsuk, Premyot Ngaotepprutaram, Dichapong Kanjanawasee, Triphoom Suwanwech, Stephen R. Durham, Giorgio Walter Canonica, Pongsakorn Tantilipikorn
Summary: LNIT is a safe and effective alternative route for allergen immunotherapy without significant adverse events. It improves clinical symptoms, reduces medication usage, and increases the nasal provocation threshold.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2022)
Letter
Otorhinolaryngology
Gennaro Liccardi, Matteo Martini, Maria Beatrice Bilo, Manlio Milanese, Paola Rogliani
Summary: The scientific quantification of symptoms in pollen-related allergic rhinitis requires considering the aerobiological data of the geographical area.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Erdem Mengi, Cuneyt Orhan Kara, Ugur Alpturk, Bulent Topuz
Summary: This study found that the use of face masks reduced both nasal and ocular allergic rhinitis symptoms in individuals with pollen allergy during the covid-19 pandemic. The most significant improvements were seen in sneezing and nasal discharge symptoms. These results support the hypothesis that face masks could alleviate the severity of allergic rhinitis symptoms.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)