Article
Endocrinology & Metabolism
Behnaz Abiri, Amirhossein Ramezani Ahmadi, Maryam Mahdavi, Farhad Hosseinpanah, Atieh Amouzegar, Majid Valizadeh
Summary: This study examined the association between different metabolic phenotypes and the development of hypothyroidism. The results showed that both metabolic abnormalities and obesity are associated with a higher risk of hypothyroidism. On the other hand, healthy metabolic status and maintaining normal weight are associated with a lower risk of hypothyroidism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Elisa Paavilainen, Kristiina Tertti, Hilkka Nikkinen, Riitta Veijola, Marja Vaarasmaki, Britt-Marie Loo, Paivi Tossavainen, Tapani Ronnemaa, Harri Niinikoski
Summary: The offspring of mothers treated with metformin for gestational diabetes mellitus showed similar growth and glucose metabolism at age 9 compared to those treated with insulin, but had a more favorable lipid profile, including higher HDL cholesterol, lower LDL cholesterol, and lower apolipoprotein B concentrations.
DIABETES OBESITY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Soroush Masrouri, Leila Cheraghi, Niloofar Deravi, Neda Cheraghloo, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: Six-year mean lipid levels were associated with an increased future risk of incident CVD, whereas LV were not. Our findings highlight the importance of achieving normal lipid levels over time, but not necessarily consistent, for averting adverse clinical outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Anna D. Argoty-Pantoja, Rafael Velazquez-Cruz, Joacim Meneses-Leon, Jorge Salmeron, Berenice Rivera-Paredez
Summary: This study analyzed data from Mexican adults to evaluate the association between the TyG index and changes in blood pressure and hypertension incidence. The results showed that the TyG index is associated with high blood pressure in Mexican adults.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Nutrition & Dietetics
Amirreza Hadaegh, Samaneh Akbarpour, Maryam Tohidi, Niloofar Barzegar, Somayeh Hosseinpour-Niazi, Fereidoun Azizi, Farzad Hadaegh
Summary: The study found significant associations between TAG, TAG/HDL-cholesterol, and TC/HDL-cholesterol and a higher risk of incident hypertension, while HDL-cholesterol was associated with a lower risk. These associations remained independent of baseline blood pressure categories and other factors, suggesting their potential role in predicting hypertension.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Medicine, General & Internal
Soroush Masrouri, Dorsa Alijanzadeh, Mina Amiri, Fereidoun Azizi, Farzad Hadaegh
Summary: This study aimed to assess potential risk factors for kidney function decline in an Iranian cohort. The study found that factors such as age, gender, hypertension, diabetes, and cardiovascular diseases were associated with kidney function decline. This study is important for reducing the burden of kidney function decline.
ANNALS OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Farzad Hadaegh, Samaneh Asgari, Hossein Toreyhi, Fatemeh Eskandari, Noushin Fahimfar, Mohammadreza Bozorgmanesh, Farhad Hosseinpanah, Fereidoun Azizi
Summary: The study found that central obesity, smoking, and steroid medication significantly increased the risk of fractures in the Iranian population, while obesity lowered the risk of fractures. Central obesity had a more prominent impact on fracture risk in women, while prediabetes status was associated with a lower risk of major osteoporotic fractures.
Article
Public, Environmental & Occupational Health
Firoozeh Hosseini-Esfahani, Behnaz Alafchi, Zahra Cheraghi, Amin Doosti-Irani, Parvin Mirmiran, Davood Khalili, Fereidoun Azizi
Summary: A study conducted in Tehran, Iran on MetS found that the incidence rate of MetS was significantly higher in men than in women. The most important determinants of MetS included history of diabetes, high BMI, older age, male gender, and low dietary monounsaturated fatty acid intake.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2021)
Article
Endocrinology & Metabolism
Atieh Amouzegar, Mohammadjavad Honarvar, Safdar Masoumi, Maryam Tohidi, Ladan Mehran, Fereidoun Azizi
Summary: The study found that there is an association between insulin resistance and chronic kidney disease. The increasing trend of insulin resistance is associated with a higher risk of developing CKD. Other clinical markers of insulin resistance, such as TyG and VAI, are also associated with a higher risk of CKD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, Research & Experimental
Fatemeh Koohi, Nooshin Ahmadi, Farzad Hadaegh, Siavash Safiee, Fereidoun Azizi, Davood Khalili
Summary: The study identified different trajectories of cardiovascular disease (CVD) risk with varying trends in risk factors over time, emphasizing the importance of targeted interventions for each risk factor and implementing strategies to optimize CVD risk factors besides the overall CVD risk.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Soroush Masrouri, Seyyed Saeed Moazzeni, Neda Cheraghloo, Fereidoun Azizi, Farzad Hadaegh
Summary: The impact of different definitions of metabolic syndrome (MetS) on the risk of sudden cardiac death (SCD) in the Iranian population was evaluated. MetS, except when defined with ATP III criteria, is a marker for identifying individuals at higher risk for SCD, but not independent of its components.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Atieh Amouzegar, Samaneh Asgari, Fereidoun Azizi, Amir Abbas Momenan, Mohammadreza Bozorgmanesh, Farzad Hadaegh
Summary: The study found a significant gender difference in the association between metabolic syndrome and the risk of fracture. Central adiposity in women increased the risk of hospitalized fracture, while high fasting plasma glucose in men may decrease the risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Rahele Rasooli, Azra Ramezankhani, Davood Khalili, Maryam Tohidi, Mitra Hasheminia, Fereidoun Azizi, Farzad Hadaegh
Summary: The relationship between different glucose intolerance statuses at baseline and all-cause hospitalization over a 20-year period was assessed among Iranian men and women. Pre-diabetes, newly diagnosed diabetes, and known diabetes mellitus were associated with higher rates of hospitalization, especially due to cardiovascular diseases in patients with diabetes. Men with diabetes had a higher rate of hospitalization for cardiovascular diseases compared to women.
ANNALS OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Iris C. M. Pelsma, Nienke R. Biermasz, Wouter R. van Furth, Alberto M. Pereira, Herman M. Kroon, Margreet Kloppenburg, Kim M. J. A. Claessen
Summary: This study evaluated the long-term course of acromegalic arthropathy, revealing significant radiographic progression over 9.1 years in patients in remission, while clinical progression was observed less frequently.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Ladan Mehran, Atieh Amouzegar, Hengameh Abdi, Negar Delbari, Elham Madreseh, Maryam Tohidi, Mohammad Ali Mansournia, Fereidoun Azizi
Summary: The study found no significant association between metabolic syndrome (MetS) and thyroid dysfunction (TD) over a 10-year follow-up period. Additionally, there were no differences in the trends of thyroid hormones and the incidence of TD between MetS and non-MetS subjects during the study period.
EUROPEAN THYROID JOURNAL
(2021)
Article
Health Care Sciences & Services
Noushin Fahimfar, Akbar Fotouhi, Mohammad Ali Mansournia, Reza Malekzadeh, Nizal Sarrafzadega, Fereidoun Azizi, Marjan Mansourian, Sadaf G. Sepanlou, Mohammad Hassan Emamian, Farzad Hadaegh, Hamidreza Roohafza, Hassan Hashemi, Hossein Poustchi, Akram Poursham, Tahereh Samavat, Maryam Sharafkhah, Mohamma Talaei, David Van Klaveren, Ewout W. Steyerberg, Davood Khalili
Summary: By evaluating the performance of the SCORE and Globorisk models in a country in the Middle East, we found that the original models overestimated the cardiovascular disease (CVD) risk in that region. Through recalibration, we can predict CVD mortality more accurately. The Globorisk model showed better clinical performance among high-risk women.
INTERNATIONAL JOURNAL OF HEALTH POLICY AND MANAGEMENT
(2022)
Article
Psychology, Developmental
Sara Jalali-Farahani, Parisa Amiri, Fariba Zarani, Fereidoun Azizi
Summary: This study used qualitative methods to explore the perceptions of Iranian adolescents regarding their bodies, focusing on the psychological aspects that contribute to their body image perceptions. The findings revealed various beliefs, body evaluations, emotions, and behaviors among the participants.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2023)
Article
Medicine, General & Internal
Parvin Mirmiran, Marjan Ramezan, Hossein Farhadnejad, Golaleh Asghari, Zhaleh Tahmasebinejad, Fereidoun Azizi
Summary: This study aimed to investigate the association between dietary diabetes risk reduction score (DDRRS) and chronic kidney disease (CKD) in an Iranian adult population. The findings suggest that adherence to a dietary pattern with a higher score of DDRRS may be associated with a lower risk of CKD incident.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Health Care Sciences & Services
Noushin Fahimfar, Reza Malekzadeh, Akbar Fotouhi, Mohammad Ali Mansournia, Nizal Sarrafzadegan, Fereidoun Azizi, Sadaf G. Sepanlou, Marjan Mansourian, Farzad Hadaegh, Mohammad Hassan Emamian, Hossein Poustchi, Mohammad Talaei, Akram Pourshams, Hamidreza Roohafza, Maryam Sharafkhah, Tahereh Samavat, Mojtaba Lotfaliany, Ewout W. Steyerberg, Davood Khalili
Summary: This study aimed to develop and validate a non-laboratory model for predicting cardiovascular disease (CVD) mortality in middle-income countries. The results showed that the model had good discrimination and calibration in both men and women, and could be used for screening in low-middle income countries.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Maryam Barzin, Shayan Aryannezhad, Mohammad Bagheri, Maryam Mahdavi, Majid Valizadeh, Fereidoun Azizi, Farhad Hosseinpanah
Summary: This study examined the association between age, period, and birth cohort with body mass index (BMI) and waist circumference (WC) changes in participants of the Tehran Lipid and Glucose Study from 1999 to 2015. The results showed that BMI and WC increased with age in both men and women, and younger men from recent birth cohorts and older women from earlier birth cohorts had the most concerning BMI and WC trends. These findings highlight the importance of implementing obesity prevention policies, especially targeting younger men.
Article
Endocrinology & Metabolism
Fatemeh Ahmadian, Elham Razmpoosh, Hanieh-Sadat Ejtahed, Maryam Javadi, Parvin Mirmiran, Fereidoun Azizi
Summary: This study evaluated the effects of probiotic supplementation on cardiovascular disease (CVD)-related parameters in patients with type-2 diabetes. The results showed that probiotic supplementation significantly improved blood pressure, atherogenic index, and CVD risk score, but had no significant impact on antioxidant markers.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Health Care Sciences & Services
Sohila Sadeghi, Fatemeh Mahani, Parisa Amiri, Shahram Alamdari, Davood Khalili, Navid Saadat, Seyed Alireza Ebadi, Ali Reza Mahdavi Hazaveh, Mohammad Karim Shahrzad, Fereidoun Azizi
Summary: Despite the achievements of the national program for the prevention and control of diabetes in Iran over the past two decades, high prevalence of the disease is still observed. The qualitative study identified implementation barriers and inefficient policy-making/planning as the main obstacles to the program's success. Efforts need to be made to prioritize the NPPCD, promote intersectoral collaboration, and establish an effective evaluation system for better program implementation.
INTERNATIONAL JOURNAL OF HEALTH POLICY AND MANAGEMENT
(2023)
Article
Cardiac & Cardiovascular Systems
Parisa Amiri, Fataneh Ghadirian, Parnian Parvin, Leila Cheraghi, Davood Khalili, Shahram Alamdari, Fereidoun Azizi
Summary: Previous studies have shown that spiritual experience may reduce cardiovascular disease (CVDs). However, little is known about the relationship between spiritual health and the gender-specific risk of CVDs in communities with different cultures. The current results indicate a gender-specific association between spiritual health and cardiovascular disease risk. Our findings imply that promoting spiritual health can be considered an effective strategy in future preventive interventions, primarily by controlling the desire to smoke in men.
Article
Medicine, General & Internal
Elahe Zare Borzeshi, Majid Valizadeh, Mohammad Hossein Panahi, Davood Khalili, Mostafa Mousavizadeh, Yadollah Mehrabi
Summary: This study proposes a data-driven framework for classifying individuals at risk of cardiovascular outcomes based on obesity and metabolic syndrome. By analyzing a population-based cohort study, 8 distinct endophenotypes were identified with significant differences in clinical characteristics and outcomes.
Article
Cardiac & Cardiovascular Systems
Noushin Fahimfar, Karim Kohansal, Samaneh Asgari, Afshin Ostovar, Farzad Hadaegh, Davood Khalili
Summary: This study aimed to determine the changes in the World Health Organization (WHO) cardiovascular disease (CVD) risk during the last decade using national representative data. The results showed significant declining trends in the mean CVD risk in both laboratory and non-laboratory models for men and women.
Article
Environmental Sciences
Arash Derakhshan, Huan Shu, Maarten A. C. Broeren, Andreas Kortenkamp, Christian H. Lindh, Barbara Demeneix, Robin P. Peeters, Carl-Gustaf Bornehag, Tim I. M. Korevaar
Summary: This study investigated the association between concentrations of endocrine disrupting chemicals (EDCs) in urine and blood during pregnancy and serum human chorionic gonadotropin (hCG) concentrations. The results showed that higher exposure to bisphenol A was associated with lower hCG concentrations, while higher triclosan exposure was associated with higher hCG concentrations. Higher exposure to certain phthalates and polychlorinated biphenyls (PCBs) was also associated with lower hCG concentrations. These findings suggest that EDC exposure may have negative effects on placental hCG production and secretion, warranting further experimental studies.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Endocrinology & Metabolism
Federica Sileo, Joris A. J. Osinga, W. Edward Visser, Toyah A. Jansen, Wichor M. Bramer, Arash Derakhshan, Valeria Citterio, Henning Tiemeier, Luca Persani, Tim I. M. Korevaar
Summary: Postpartum depression (PPD) has a significant impact on maternal and offspring well-being. This study found no association between thyroid function/TPOAb positivity and PPD through a population-based prospective cohort study, systematic literature review, and meta-analysis.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Joris A. J. Osinga, Arash Derakhshan, Ulla Feldt-Rasmussen, Kun Huang, Tanja G. M. Vrijkotte, Tuija Mannisto, Judit Bassols, Abel Lopez-Bermejo, Ashraf Aminorroaya, Marina Vafeiadi, Maarten A. C. Broeren, Glenn E. Palomaki, Ghalia Ashoor, Liangmiao Chen, Xuemian Lu, Peter N. Taylor, Fang-Biao Tao, Suzanne J. Brown, Georgiana Sitoris, Lida Chatzi, Bijay Vaidya, Polina Popova, Elena A. Vasukova, Maryam Kianpour, Eila Suvanto, Elena N. Grineva, Andrew Hattersley, Victor J. M. Pop, Scott M. Nelson, John P. Walsh, Kypros H. Nicolaides, Mary E. D'Alton, Kris G. Poppe, Layal Chaker, Sofie Bliddal, Tim I. M. Korevaar
Summary: The study found that using alternative methods to define reference intervals for thyroid hormones in pregnant women can result in overdiagnosis and underdiagnosis compared to population- and trimester-specific reference intervals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Arash Derakhshan, Tuija Mannisto, Liangmiao Chen, Joris A. J. Osinga, Ghalia Ashoor, Xuemian Lu, Sofie Bliddal, Fang-Biao Tao, Suzanne J. Brown, Bijay Vaidya, Andrew T. Hattersley, Sachiko Itoh, Polina Popova, Ashraf Aminorroaya, Reiko Kishi, Maryam Kianpour, Elena A. Vasukova, Abel Lopez-Bermejo, Emily Oken, Leda Chatzi, Marina Vafeiadi, Wichor M. Bramer, Judit Bassols, Aitana Lertxundi, Ana Fernandez-Somoano, Paula Carrasco, Juha Auvinen, Kun Huang, Ulla Feldt-Rasmussen, Elena N. Grineva, Erik K. Alexander, Elizabeth N. Pearce, Layal Chaker, John P. Walsh, Robin P. Peeters, Monica Guxens, Eila Suvanto, Kypros H. Nicolaides, Tim I. M. Korevaar
Summary: This study explores the association between gestational FT3 and TT3 levels and adverse obstetric outcomes. The findings suggest that FT3 and TT3 levels have different associations with various adverse obstetric outcomes, with high TT3 associated with an increased risk of gestational hypertension and low TT3 associated with a higher risk of very preterm birth.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Yanning Xu, Arash Derakhshan, Ola Hysaj, Lea Wildisen, Till Ittermann, Alessandro Pingitore, Nazanin Abolhassani, Marco Medici, Lambertus A. L. M. Kiemeney, Niels P. Riksen, Robin P. F. Dullaart, Stella Trompet, Marcus Doerr, Suzanne J. Brown, Boerge Schmidt, Dagmar Fuehrer-Sakel, Mark P. J. Vanderpump, Axel Muendlein, Heinz Drexel, Howard A. Fink, M. Kamran Ikram, Maryam Kavousi, Connie M. Rhee, Isabela M. Bensenor, Fereidoun Azizi, Graeme J. Hankey, Massimo Iacoviello, Misa Imaizumi, Graziano Ceresini, Luigi Ferrucci, Jose A. Sgarbi, Douglas C. Bauer, Nick Wareham, Kristien Boelaert, Stephan J. L. Bakker, J. Wouter Jukema, Bert Vaes, Giorgio Iervasi, Bu B. Yeap, Rudi G. J. Westendorp, Tim I. M. Korevaar, Henry Voelzke, Salman Razvi, Jacobijn Gussekloo, John P. Walsh, Anne R. Cappola, Nicolas Rodondi, Robin P. Peeters, Layal Chaker
Summary: This study aimed to define the optimal healthy ranges of TSH and FT4 based on the risk of cardiovascular disease and mortality. The study found that the 20-40th percentiles of FT4 and the 60-80th percentiles of TSH could represent the optimal healthy ranges of thyroid function.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
